Natural HDAC Inhibitors for Epigenetic Combating of Cancer Progression

Natural HDAC Inhibitors for Epigenetic Combating of Cancer Progression deals only with HDAC inhibitors from natural origins including bacteria, fungi, marine organisms and, notably, from diverse plant sources. This book is unique in the sense that it is the only book that discusses wholly and solely HDAC inhibitors of natural origin in the context of cancer chemotherapy. Another peculiar feature of this book is that it debates futuristic nanotechnology approaches for escalating the aqueous solubility, cancer cell uptake, bioavailability and other favourable pharmacological parameters, including the cytotoxicity of natural HDAC inhibitors against cancer cells.

The major features of this book encompass

• General compendium of HDAC inhibitors with deep emphasis on the toxicity issues of synthetic HDAC inhibitors
• Various groups of natural HDAC inhibitors, their representatives and premier sources
• Cyclic tetrapeptides of natural origin and their importance as cancer chemotherapeutic agents
• Hydroxamates and depsipeptides from natural sources and their promising role in cancer therapy
• Natural flavonoids, their HDAC inhibitory tendency and marvellous anticancer activity
• Non-flavonoid natural HDAC inhibitors and their pleasing cytotoxic effects towards cancer models
• Combined therapy involving natural flavonoids with other anticancer molecules for synergistic and additive benefits against cancer models
• Non-flavonoid HDAC inhibitors and conventional drugs in collaborative mode against aggressive malignancies
• Nanotechnology-based delivery of natural HDAC inhibitors for greater therapeutic efficacy over traditional combinatorial therapy

This book is highly beneficial to university professors and research scholars working on epigenetic therapeutics in general, and natural HDAC inhibitors in particular. This book is equally important to medical oncologists, biochemistry as well as pharmacy candidates and students of master's and undergraduate level with a desire to do a doctorate on HDACs, natural HDAC inhibitors, HDAC inhibitor (natural)-based combinatorial chemotherapy and delivery of these inhibitors selectively to tumour sites through revolutionary nanotechnological tactics.

Dr. Shabir Ahmad Ganai has completed his Masters in Biochemistry from Bangalore University. Following this he did his Ph.D in Biochemistry from Tamil Nadu. During his doctorate Dr. Ganai remained AYUSH-JRF. Further Dr. Ganai worked as Research Associate in National Brain Research Centre Haryana. Afterwards Dr. Ganai got a big grant from Science and Engineering Research Board and Served as Principal Investigator (Young Scientist in the UoK. Dr. Ganai currently serves the FoA of SKUAST-Kashmir. Dr. Ganai has cleared National Eligibility Test (NET) exam, Jammu and Kashmir State Eligibility Test (JK-SET), GATE Life Sciences Two times (GATE XL 2020 and GATE XL-2022). Dr. Ganai has received two Best Oral Presentation Awards for Presenting his Research Work in Various Conferences.

Dr. Shabir Ahmad Ganai has Published 29 International Articles in highly Reputed SCIE Journals, two International Books in Biomedical Sciences in Springer-Nature and one National Level Book on Structural Biochemistry (Drug Designing). The current cumulative Impact Factor of articles Published by Dr. Ganai is 151. Dr. Ganai as of now has 682 citations, h-index of 16 and i10-index of 22. Dr. Ganai serves as a referee for multiple International Journals of high repute. Dr. Ganai has received certificate of appreciation from American Chemical Society. Dr. Ganai is Member of American Chemical Society and Epigenetics Society. Most notably, Dr. Shabir Ahmad Ganai figured in the list of Top 2% Scientists of the World, the Ranking being done by Stanford University USA experts and Elsevier BV.