Neuroendocrine-Immune Axis : Towards Understanding the Pathogenesis of Neurodegenerative Disorders

This book discusses the mutual interactions between neurons and other types of cells during neurological and immunological processes within the Central Nervous System (CNS) for understanding the pathophysiology of various neurological diseases and advancing the diagnosis, prevention, and intervention. It also addresses the immune function of both glial cells and neurons, and the roles they play in regulating inflammatory processes and maintaining homeostasis of the CNS. This book also examines the role of the neuro-immune axis and its targetability in relation to major depression and autism spectrum disorder and reviews the role of nanotechnology in modulating the neuroimmune axis. Further, the book discusses the specific arms of the peripheral immune system and other types of immune responses in modulating neurodegenerative disorders. It also reviews the role of cytokines in neurodegeneration, mechanisms of expression and action, and clinical relevance. Lastly, the book reviews thedrug repurposing strategy to search for new therapeutic options against neurodegenerative diseases. This book as such is invaluable for students, researchers, and scientists of neurosciences, pharmaceutic sciences, and immunology.

Dr. Rahul Shukla is working as an Assistant Professor at Department of Pharmaceutics, NIPER Raebareli, India. Currently, he is the SERB International Research fellow for the year, 2022-2023 at School of Pharmacy and Biomedical Sciences, University of Central Lancashire, United Kingdom. He did Ph.D. in Pharmaceutical Sciences from CSIR CDRI and J.N.U New Delhi, India, M Pharm from IIT BHU, Varanasi, India and B. Pharm from Jamia Hamdard, New Delhi. He has the experience of as Research Scientist at Dr Reddy’s Laboratories, India and D.S Kothari Post-Doctoral Fellow at Panjab University, India. He has more than ten years of research and academic experience. He has more than 100 publications including book chapters to his credit. He has filed 7 Patents and 1 Copyright.  His current research interests include targeted drug delivery systems, particle engineering, controlled delivery for neurodegenerative diseases, dendrimer mediated drug delivery, solubilization andbioavailability enhancements. He is a Life member of many societies and organizations importantly, Indian Red Cross Society, Association of Pharmaceutical Teachers of India (APTI) and Indian Pharmacy Graduates' Association (IPGA).

Dr. Saba Naqvi is working as an Assistant Professor in the Department of Pharmacology & Toxicology/Regulatory Toxicology. She obtained her master’s from Jamia Hamdard, New Delhi, and her Ph.D. in 2013 from Jamia Hamdard in collaboration with AIIMS, New Delhi. She has done her post-doc from Jamia Millia Islamia and IIT Roorkee and published more than 22 papers and 8 book chapters in reputed international journals like Elsevier, Springer, Wiley and Frontiers. She has two 2 Indian patents. She is working in the field of nanomedicine, nanotoxicology, and neuropharmacology, synthesized ceramic calcium phosphate nanoparticles for “Suicide Gene Therapy” in cancer therapeutics. Dr. Saba has been honoured with the prestigious Women Scientist Award from DST, AMR DXC Summer School Winner Award sponsored by DBT, India & Univ. of Edinburgh, U.K. 

Dr. Monika S Deore is currently pursuing a Ph.D. in pharmacology and toxicology from NIPER Raebareli, India. She did her M.S. (Pharm) in regulatory toxicology from NIPER Mohali, India, B. Pharm from L.N.J.D.P College of Pharmacy, Manur. She has past research experience in C.R.O.-Syngene International Ltd. as a senior research associate. Her current research includes neurodegenerative diseases, neuroimmunology, safety assessments, nanotoxicology and nanopharmacology, Gut dysbiosis, reproductive toxicology, etc.  

Dr. Ravinder Kaundal is working as Assistant Professor at NIPER Raebareli. He has done his MS (Pharm.) and Ph.D. in Pharmacology and Toxicology from NIPER-SAS Nagar, India. He received his postdoctoral training at Yale School of Medicine, New Haven, and Icahn School of Medicine at MountSinai, New York. Dr. Ravinder has made an outstanding contribution in the field of pharmacological research and has elucidated the involvement of various pathogenic pathways like oxidative stress, PARP overactivation, inflammation, and apoptosis in cerebral ischemic-reperfusion injury and diabetic neuropathy. Gene regulation is another of his interests and he has developed various tools/methods to study the mechanisms of epigenetic memory. His work is published in journals of high repute and is highly cited. He is a reviewer and editorial board member of several international journals.

Dr. Ravinder Kaundal’s research interests are Neuropharmacology, Drug repurposing, Molecular biology, Ischemic-reperfusion Injuries, and Gene Regulation.