The Neurovascular Unit and the Role of Astrocytes in the Regulation of Vascular Tone

Jessica A. Filosa

Verlag: Colloquium Life Science, 2015
ISBN 10: 161504678X / ISBN 13: 9781615046782
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Not Signed; Optimal cerebral blood flow is coordinated by functional hyperemia and cerebral autoregulation. These processes ensure that the metabolic demands of the brain are met at all times. Both in vivo and in vitro studies support a role for astrocytes in the regulation of cerebral blood flow. In this we re. Buchnummer des Verkäufers ria9781615046782_rkm

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Inhaltsangabe: Páginas:68Géneros:12:MJN:Neurology&clinicalneurophysiologySinopsis:Optimalcerebralbloodflowiscoordinatedbyfunctionalhyperemiaandcerebralautoregulation.Theseprocessesensurethatthemetabolicdemandsofthebrainaremetatalltimes.Bothinvivoandinvitrostudiessupportaroleforastrocytesintheregulationofcerebralbloodflow.Inthiswereviewthecellularmechanismscontributingtoastrocyte-mediatedvasodilationandvasoconstrictionofparenchymalarterioles.Primarily,wediscusshowactivity-dependentchangesinastrocyticCa2+contributetothereleaseofvasoactivesignalsinvolvedinneurovascularcoupling.FollowingtheriseinastrocyticCa2+andphospholipaseA2activation,arachidonicacidisreleasedandmetabolizedintomultiplevasoactivesignals(e.g.,prostaglandins,epoxyeicosatrienoicacids,and20-HETE).Thelevelofarterioletonealongwiththemetabolicconditionsofthetissuecanaltertheactionofthesesignalsleadingtoeithervasodilationorvasoconstriction.Moreover,increasedCa2+alsoactivateslargeconductanceCa2+-activatedK+channelsexpressedinastrocyticendfeetprocesses.DependingontheK+effluxconcentrationreleased,thispathwaycanalsoelicitvasodilationorvasoconstrictionofparenchymalarterioles.Finally,weconcludebydiscussingrecentdivergentinvivofindingswhichquestionaroleforastrocyteinfunctionalhyperemia._,

Reseña del editor: Optimal cerebral blood flow is coordinated by functional hyperemia and cerebral autoregulation. These processes ensure that the metabolic demands of the brain are met at all times. Both in vivo and in vitro studies support a role for astrocytes in the regulation of cerebral blood flow. In this we review the cellular mechanisms contributing to astrocyte-mediated vasodilation and vasoconstriction of parenchymal arterioles. Primarily, we discuss how activity-dependent changes in astrocytic Ca2+ contribute to the release of vasoactive signals involved in neurovascular coupling. Following the rise in astrocytic Ca2+ and phospholipase A2 activation, arachidonic acid is released and metabolized into multiple vasoactive signals (e.g., prostaglandins, epoxyeicosatrienoic acids, and 20-HETE). The level of arteriole tone along with the metabolic conditions of the tissue can alter the action of these signals leading to either vasodilation or vasoconstriction. Moreover, increased Ca2+ also activates large conductance Ca2+-activated K+ channels expressed in astrocytic endfeet processes. Depending on the K+ efflux concentration released, this pathway can also elicit vasodilation or vasoconstriction of parenchymal arterioles. Finally, we conclude by discussing recent divergent in vivo findings which question a role for astrocyte in functional hyperemia.

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Titel: The Neurovascular Unit and the Role of ...
Verlag: Colloquium Life Science
Erscheinungsdatum: 2015
Einband: Paperback
Zustand: New
Art des Buches: book

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Buchbeschreibung Morgan & Claypool Publishers, United States, 2015. Paperback. Zustand: New. Language: English. Brand new Book. Optimal cerebral blood flow is coordinated by functional hyperemia and cerebral autoregulation. These processes ensure that the metabolic demands of the brain are met at all times. Both in vivo and in vitro studies support a role for astrocytes in the regulation of cerebral blood flow. In this we review the cellular mechanisms contributing to astrocyte-mediated vasodilation and vasoconstriction of parenchymal arterioles. Primarily, we discuss how activity-dependent changes in astrocytic Ca2+ contribute to the release of vasoactive signals involved in neurovascular coupling. Following the rise in astrocytic Ca2+ and phospholipase A2 activation, arachidonic acid is released and metabolized into multiple vasoactive signals (e.g., prostaglandins, epoxyeicosatrienoic acids, and 20-HETE). The level of arteriole tone along with the metabolic conditions of the tissue can alter the action of these signals leading to either vasodilation or vasoconstriction. Moreover, increased Ca2+ also activates large conductance Ca2+-activated K+ channels expressed in astrocytic endfeet processes. Depending on the K+ efflux concentration released, this pathway can also elicit vasodilation or vasoconstriction of parenchymal arterioles. Finally, we conclude by discussing recent divergent in vivo findings which question a role for astrocyte in functional hyperemia. Bestandsnummer des Verkäufers APC9781615046782

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Buchbeschreibung Morgan & Claypool Publishers, United States, 2015. Paperback. Zustand: New. Language: English. Brand new Book. Optimal cerebral blood flow is coordinated by functional hyperemia and cerebral autoregulation. These processes ensure that the metabolic demands of the brain are met at all times. Both in vivo and in vitro studies support a role for astrocytes in the regulation of cerebral blood flow. In this we review the cellular mechanisms contributing to astrocyte-mediated vasodilation and vasoconstriction of parenchymal arterioles. Primarily, we discuss how activity-dependent changes in astrocytic Ca2+ contribute to the release of vasoactive signals involved in neurovascular coupling. Following the rise in astrocytic Ca2+ and phospholipase A2 activation, arachidonic acid is released and metabolized into multiple vasoactive signals (e.g., prostaglandins, epoxyeicosatrienoic acids, and 20-HETE). The level of arteriole tone along with the metabolic conditions of the tissue can alter the action of these signals leading to either vasodilation or vasoconstriction. Moreover, increased Ca2+ also activates large conductance Ca2+-activated K+ channels expressed in astrocytic endfeet processes. Depending on the K+ efflux concentration released, this pathway can also elicit vasodilation or vasoconstriction of parenchymal arterioles. Finally, we conclude by discussing recent divergent in vivo findings which question a role for astrocyte in functional hyperemia. Bestandsnummer des Verkäufers APC9781615046782

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Buchbeschreibung Morgan & Claypool Publishers, United States, 2015. Paperback. Zustand: New. Language: English. Brand new Book. Optimal cerebral blood flow is coordinated by functional hyperemia and cerebral autoregulation. These processes ensure that the metabolic demands of the brain are met at all times. Both in vivo and in vitro studies support a role for astrocytes in the regulation of cerebral blood flow. In this we review the cellular mechanisms contributing to astrocyte-mediated vasodilation and vasoconstriction of parenchymal arterioles. Primarily, we discuss how activity-dependent changes in astrocytic Ca2+ contribute to the release of vasoactive signals involved in neurovascular coupling. Following the rise in astrocytic Ca2+ and phospholipase A2 activation, arachidonic acid is released and metabolized into multiple vasoactive signals (e.g., prostaglandins, epoxyeicosatrienoic acids, and 20-HETE). The level of arteriole tone along with the metabolic conditions of the tissue can alter the action of these signals leading to either vasodilation or vasoconstriction. Moreover, increased Ca2+ also activates large conductance Ca2+-activated K+ channels expressed in astrocytic endfeet processes. Depending on the K+ efflux concentration released, this pathway can also elicit vasodilation or vasoconstriction of parenchymal arterioles. Finally, we conclude by discussing recent divergent in vivo findings which question a role for astrocyte in functional hyperemia. Bestandsnummer des Verkäufers LIE9781615046782

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