Oxytocin Preconditioning Of Endothelial Progenitor Cells | Effects Against Hypoxic Injury

Muhammad Umair Hanif

ISBN 10: 3659369330 / ISBN 13: 9783659369339

Verlag: LAP LAMBERT Academic Publishing, 2013

Oxytocin Preconditioning Of Endothelial Progenitor Cells | Effects Against Hypoxic Injury | Muhammad Umair Hanif | Taschenbuch | 112 S. | Englisch | 2013 | LAP LAMBERT Academic Publishing | EAN 9783659369339 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. Bestandsnummer des Verkäufers 105945288

Inhaltsangabe:

Ischemic heart disease leads to the malfunctioning of the affected tissue. Stem cell transplantation near the ischemic tissue is a possible therapeutic approach to regenerate the fibrotic tissue. The ischemic or fibrotic tissue is not able to supply the nutrients and oxygen to the transplanted cells. Therefore, the transplanted cells start to die within hours after transplantation. The ischemic and apoptotic hostile microenvironment also contributes to slow down the healing process. Strategies to enhance endothelial progenitor cells (EPCs) survival after transplantation in the ischemic tissues so far have achieved little success. Oxytocin a nano-peptide hormone and mitochondrial ATP-sensitive potassium channel opener is known to suppress cell apoptosis and promote cell survival. . In this study, the effect of oxytocin preconditioning on EPCs under hypoxic injury was studied. oxytocin preconditioning is effective to improve the survival of EPCs under oxidative stress conditions by the activation of cyto-protective genes involved in different pathways.

Über die Autorin bzw. den Autor: M.Phill Molecular Biology from National Center of Excellence in Molecular Biology University of Punjab. Assistant Professor of Molecular Biology at Gulab Devi Hospital, Lahore, Pakistan.

Bibliografische Details

Titel: Oxytocin Preconditioning Of Endothelial ...
Verlag: LAP LAMBERT Academic Publishing
Erscheinungsdatum: 2013
Einband: Taschenbuch
Zustand: Neu