The second edition of this book offers an overview of the percutaneous techniques and technologies most frequently employed in structural heart intervention, focusing on patient selection, preoperative evaluation, choice of available devices and outcome optimization. Interventional procedures for aortic stenosis, mitral regurgitation, left atrial appendage closure, patent foramen ovale closure, and closure of interatrial and interventricular defects are presented in a step by step fashion, and paralleled by informative illustrations. This new edition of Percutaneous Intervention for Structural Heart Disease aims to adjourn the reader on structural heart intervention not only as per current standard practice, but also on uprising topics such as percutaneous treatment of tricuspid regurgitation and paravalvular leak closure. Advances made in recent years, including introduction and optimization of transcatheter aortic valve implantation in patients with severe aortic stenosis independently from estimated surgical risk and implementation of percutaneous edge-to-edge mitral valve repair for functional mitral regurgitation, will be taken into account. The authors are all acknowledged experts with extensive experience in catheterization laboratories and surgical operating rooms.
Bernhard Reimers is Director of the Clinical and Invasive Cardiology at Humanitas Research Hospital, Milan, Italy. Born in Germany and living in Italy since 1984, he earned his medical degree from the University of Padua in 1990. Followed by a period as Junior House Officer in internal medicine in UK and by a cardiology residency at the University Hospital of Padua (1991-1995). After a fellowship at the Thoraxcenter in Rotterdam he trained as interventional cardiologist in Milan under dr. Antonio Colombo (1995-1997). Subsequently he developed a highly successful cardiovascular program at Mirano Hospital, Venice, Italy. Since 2015 at Humanitas, he leads a high-volume program in coronary and structural heart interventions. He is a global expert in carotid angioplasty. Dr. Reimers has contributed extensively to research on complex coronary interventions and TAVR, publishing numerous articles and performing live procedures at international conferences. He also organizes major cardiology events such as TOBI (Total Occlusions and Bifurcations) and MVSIC (Milan Valve Structural and Interventions Course). He trained numerous assistants and fellows from Italy and from all over the world. Most of these, subsequently and to his pride, made a brilliant career in interventional cardiology.
Azeem Latib is System Director of Interventional Cardiology and Structural Heart Interventions at Montefiore Health System and Professor of Medicine at Albert Einstein College of Medicine, New York. An expert in interventional cardiology, he specializes in complex coronary procedures and transcatheter valve interventions (TAVR, TMVI, TTVI, and others). He earned his medical degree in 1995 from the University of Witwatersrand, South Africa, and completed advanced training in South Africa and Italy. Since 2019, he has led Montefiore’s interventional cardiology unit. His research focuses on structural heart devices, drug-coated balloons, and stents. Dr. Latib has authored over 900 peer-reviewed publications. He serves on editorial boards, international conference faculties, and is a member of the ACC and ESC. He is Global PI of multiple international and FDA-approved trials and has helped pioneer several novel interventional devices.
Antonio Mangieri, MD, is an interventional cardiologist at Humanitas Research Hospital IRCCS in Rozzano, Milan. He earned his medical degree and completed cardiology residency at Vita-Salute San Raffaele University, where he also obtained a Master’s in Interventional Cardiology. His clinical and research interests include complex percutaneous coronary interventions, structural heart disease, and transcatheter valve therapies, with expertise in TAVI, mitral and tricuspid interventions, and intracoronary imaging. Dr. Mangieri has authored over 250 peer-reviewed publications, including work on conduction disturbances, valve-in-valve procedures, and imaging in complex PCI. He participates in multicenter trials and speaks regularly at international congresses such as EuroPCR and TCT.
Issam D. Moussa is Professor and Head of the Department of Cardiovascular Medicine & Surgery at Carle Illinois College of Medicine, University of Illinois, Urbana-Champaign. He earned his medical degree from the University of Damascus and completed postgraduate studies at UC Irvine, Centro Cuore Columbus, and Lenox Hill Heart & Vascular Institute. A specialist in complex coronary and structural interventions, Dr. Moussa is a prolific researcher with numerous peer-reviewed publications. He serves on key committees of the ACC, AHA, and SCAI, including Chair of the ACC CathPCI Registry Steering Committee.
Damiano Regazzoli is an interventional cardiologist at Humanitas Research Hospital. He graduated from the University of Brescia and completed training at Vita-Salute San Raffaele University. He joined Humanitas in 2018 and is active in national and international societies (GISE, ESC, EAPCI). His research focuses on bioresorbable scaffolds, TAVI, mitral/tricuspid interventions, and mechanical circulatory support.
Andrea Pacchioni is an interventional cardiologist at Mirano Hospital, Italy. He graduated from the University of Milan and trained at the University of Verona. Since 2010, he has led interventional activities at Mirano and co-founded the CTO Club Triveneto. He is faculty at major meetings (TOBI, TCT, AIM Radial) and focuses on chronic total occlusions, transradial access, and high-risk interventions.
