Pathogenesis of Balamuthia Amoebic Encephalitis | Amoebic transversal of central nervous system through blood-brain barrier to produce disease

Abdul Matin

ISBN 10: 6200005605 / ISBN 13: 9786200005601

Verlag: LAP LAMBERT Academic Publishing, 2020

Pathogenesis of Balamuthia Amoebic Encephalitis | Amoebic transversal of central nervous system through blood-brain barrier to produce disease | Abdul Matin | Taschenbuch | 208 S. | Englisch | 2020 | LAP LAMBERT Academic Publishing | EAN 9786200005601 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. Bestandsnummer des Verkäufers 118540722

Inhaltsangabe:

Balamuthia amoebic encephalitis (BAE) is a serious human brain disease (caused by Balamuthia mandrillaris) that almost always results in death. However, the pathogenesis and pathophysiology of BAE remains incompletely understood. An important step in BAE is amoebae invasion of the bloodstream followed by their haematogenous spread. Balamuthia entry into the central nervous system most likely occurs at the blood-brain barrier (BBB) sites. However, it is not clear how circulating amoebae inside blood cross BBB. This book therefore describes the Balamuthia interactions with human brain microvascular endothelial cells (HBMEC), which constitute the BBB. It is demonstrated that Balamuthia adopt both contact dependent (adhesion to and disruptions of HBMEC monolayer followed by cell cycle arrest) and contact independent mechanism (disruption of tight junctions proteins by metalloproteases and Ecto-ATPases and degradation of extracellular matrix, which provide structural and functional support to the brain tissue leading to BBB perturbations. Future work will continue to study Balamuthia encephalitis pathogenesis which should help identify potential targets for therapeutic interventions.

Über die Autorin bzw. den Autor: Abdul Matin, PhD: studied Medical Microbiology (Parasitology) at Birkbeck, University of London, UK followed by Post Doc. with Immunopharmacology from School of Medicine, Southampton University Hospital, Southampton, UK. He is currently working as Professor at Department of Biological Sciences and Chemistry, University of Nizwa, Sultanate of Oman.

Bibliografische Details

Titel: Pathogenesis of Balamuthia Amoebic ...
Verlag: LAP LAMBERT Academic Publishing
Erscheinungsdatum: 2020
Einband: Taschenbuch
Zustand: Neu