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This Book is in Good Condition. Clean Copy With Light Amount of Wear. 100% Guaranteed. Summary: Preface. 1 Modeling and Informatics in Drug Design (Prasad V. Bharatam, Smriti Khanna, and Sandrea M. Francis). 2 Computer Techniques: Identifying Similarities Between Small Molecules (Peter Meek, Guillermo Moyna, and Randy Zauhar). 3 Protein-Protein Interactions (Kamaljit Kaur, Dipankar Das, and Mavanur R. Suresh). 4 Method Development for Preclinical Bioanalytical Support (Masood Khan and Naidong Weng). 5 Analytical Chemistry Methods: Developments and Validation (Izet M. Kapetanovic and Alexander V. Lyubimov). 6 Chemical and Physical Characterizations of Potential New Chemical Entity (Adegoke Adeniji and Adeboye Adejare). 7 Permeability Assessment (Srinivas Ganta, Puneet Sharma, and Sanjay Garg). 8 How and Where Are Drugs Absorbed? (Marival Bermejo and Isabel Gonzalez-Alvarez). 9 Absorption of Drugs after Oral Administration (Luis Granero and Ana Polache). 10 Distribution: Movement of Drugs through the Body (Jayanth Panyam and Yogesh Patil). 11 The Blood-Brain Barrier and Its Effect on Absorption and Distribution (A. G. de Boer and P. J. Gaillard). 12 Transporter Interactions in the ADME Pathway of Drugs (Yan Zhang and Donald W. Miller). 13 Accumulation of Drugs in Tissues (Krishnamurthy Venkatesan, Deepa Bisht, and Mohammad Owais). 14 Salt and Cocrystal Form Selection (Ann W. Newman, Scott L. Childs, and Brett A. Cowans). 15 Dissolution (A.K. Tiwary, Bharti Sapra, and Subheet Jain). 16 Stability: Physical and Chemical (Eric M. Gorman, Brian E. Padden, and Eric J. Munson). 17 Dosage Formulation (Alexander V. Lyubimov). 18 Cytochrome P450 Enzymes (Eugene G. Hrycay and Stelvio M. Bandiera). 19 Metabolism Kinetics (Charles W. Locuson and Timothy S. Tracy). 20 Drug Clearance (Sree D. Panuganti and Craig K. Svensson). 21 In Vitro Metabolism in Preclinical Drug Development (Olavi Pelkonen, Ari Tolonen, Miia Turpeinen, and Jouko Uusitalo). 22 Utilization of In Vitro Cytochrome P450 Inhibition Data for Projecting Clinical Drug-Drug Interactions (Jane R. Kenny, Dermot F. McGinnity, Ken Grime, and Robert J. Riley). 23 In Vivo Metabolism in Preclinical Drug Development (Sevim Rollas). 24 In Vitro Evaluation of Metabolic Drug-Drug Interactions: Scientific Concepts and Practical Considerations (Albert P. Li). 25 Mechanisms and Consequences of Drug-Drug Interactions (Dora Farkas, Richard I. Shader, Lisa L. von Moltke, and David J. Greenblatt). 26 Species Comparison of Metabolism in Microsomes and Hepatocytes (Niels Krebsfaenger). 27 Metabolite Profi ling and Structural Identifi cation (Mehran F. Moghaddam). 28 Linkage between Toxicology of Drugs and Metabolism (Ruiwen Zhang and Elizabeth R. Rayburn). 29 Allometric Scaling (William L. Hayton and Teh-Min Hu). 30 Interrelationship between Pharmacokinetics and Metabolism (James W. Paxton). 31 Experimental Design Considerations in Pharmacokinetic Studies (William W. Hope, Vidmantas Petraitis, and Thomas J. Walsh). 32 Bioavailability and Bioequivalence Studies (Alexander V. Lyubimov and Ihor Bekersky). 33 Mass Balance Studies (Jan H. Beumer, Julie L. Eiseman, and Merrill J. Egorin). 34 Pharmacodynamics (Beom Soo Shin, Dhaval Shah, and Joseph P. Balthasar). 35 Physiologically Based Pharmacokinetic Modeling (Harvey J. Clewell III, Micaela B. Reddy, Thierry Lave, and Melvin E. Andersen). 36 Mathematical Modeling as a New Approach for Improving the Effi cacy/Toxicity Profi le of Drugs: The Thrombocytopenia Case Study (Zvia Agur, Moran Elishmereni, Yuri Kogan, Yuri Kheifetz, Irit Ziv, Me. Buchnummer des Verkäufers

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Inhaltsangabe: A clear, straightforward resource to guide you through preclinical drug development

Following this book's step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic, comprehensive reference to prioritizing and optimizing leads, dose formulation, ADME, pharmacokinetics, modeling, and regulations. This authoritative, easy-to-use resource covers all the issues that need to be considered and provides detailed instructions for current methods and techniques.

Each chapter is written by one or more leading experts in the field. These authors, representing the many disciplines involved in preclinical toxicology screening and testing, give you the tools needed to apply an effective multidisciplinary approach. The editor has carefully reviewed all the chapters to ensure that each one is thorough, accurate, and clear.

Among the key topics covered are:
*

Modeling and informatics in drug design
*

Bioanalytical chemistry
*

Absorption of drugs after oral administration
*

Transporter interactions in the ADME pathway of drugs
*

Metabolism kinetics
*

Mechanisms and consequences of drug-drug interactions

Each chapter offers a full exploration of problems that may be encountered and their solutions. The authors also set forth the limitations of various methods and techniques used in determining the safety and efficacy of a drug during the preclinical stage.

This publication should be readily accessible to all pharmaceutical scientists involved in preclinical testing, enabling them to perform and document preclinical safety tests to meet all FDA requirements before clinical trials may begin.

About the Author: SHAYNE COX GAD, PhD, DABT, ATS, is the Principal of Gad Consulting Services. Dr. Gad has more than thirty years of experience as a toxicologist, statistical consultant, manager, and general consultant on research and development in the chemical, consumer product, contract testing, biotechnology, medical device, and pharmaceutical industries. He is the author of thirty-four books and numerous papers, presentations, and other publications.

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ISBN 10: 0470248475 ISBN 13: 9780470248478
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Buchbeschreibung Buchzustand: Good. This item is in good condition. All pages and covers are readable. There are no stains or tears. Dust jacket is present if applicable. May contain small amounts of writing and/or highlighting. Spine and cover may show signs of wear. May not contain supplementary items such as CD's or DVD's. We ship within 1 business day. Buchnummer des Verkäufers 34FG1S000NEV_ns

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Buchbeschreibung Wiley-Interscience, U.S.A., 2008. Hardcover. Buchzustand: Very Good Ex-Library Condition. 1st Edition. 9780470248478 | Usual library markings but otherwise clean and tight. Size: 8vo - over 7¾ - 9¾" tall. Book. Buchnummer des Verkäufers B039006

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Buchbeschreibung Wiley-Interscience. Hardcover. Buchzustand: Very Good. 0470248475 Very Good++; Hardcover; Close to new condition; Covers are still glossy with "straight" edge-corners; Unblemished textblock edges; The endpapers and all text pages are bright and unmarked; Binding is tight with a straight spine; This book will be stored and delivered in a sturdy cardboard box with foam padding; Medium-Large Format (Quatro, 9.75" - 10.75" tall); Light green and blue covers with title in light green lettering; 2008, Wiley-Interscience Publishing; 1352 pages; "Preclinical Development Handbook: ADME and Biopharmaceutical Properties," by Shayne Cox Gad. Buchnummer des Verkäufers SKU-U33DF05403307

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Buchbeschreibung John Wiley & Sons, Inc., 2008. Hardcover. Buchzustand: Fine. Buchnummer des Verkäufers OG00388

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Editor: Shayne Cox Gad (IBS, Raleigh, North Carolina)
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Buchbeschreibung John Wiley and Sons. Buchzustand: New. Brand New. Buchnummer des Verkäufers 0470248475

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Buchbeschreibung Wileyand#8211;Blackwell, 2008. HRD. Buchzustand: New. New Book. Shipped from UK in 4 to 14 days. Established seller since 2000. Buchnummer des Verkäufers FW-9780470248478

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Verlag: John Wiley and Sons Ltd, United States (2008)
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Buchbeschreibung John Wiley and Sons Ltd, United States, 2008. Hardback. Buchzustand: New. 1. Auflage. Language: English . Brand New Book. A clear, straightforward resource to guide you through preclinical drug development Following this book s step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic, comprehensive reference to prioritizing and optimizing leads, dose formulation, ADME, pharmacokinetics, modeling, and regulations. This authoritative, easy-to-use resource covers all the issues that need to be considered and provides detailed instructions for current methods and techniques. Each chapter is written by one or more leading experts in the field. These authors, representing the many disciplines involved in preclinical toxicology screening and testing, give you the tools needed to apply an effective multidisciplinary approach. The editor has carefully reviewed all the chapters to ensure that each one is thorough, accurate, and clear. Among the key topics covered are: Modeling and informatics in drug design Bioanalytical chemistry Absorption of drugs after oral administration Transporter interactions in the ADME pathway of drugs Metabolism kinetics Mechanisms and consequences of drug-drug interactions Each chapter offers a full exploration of problems that may be encountered and their solutions. The authors also set forth the limitations of various methods and techniques used in determining the safety and efficacy of a drug during the preclinical stage. This publication should be readily accessible to all pharmaceutical scientists involved in preclinical testing, enabling them to perform and document preclinical safety tests to meet all FDA requirements before clinical trials may begin. Buchnummer des Verkäufers AAH9780470248478

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Buchbeschreibung Wiley-Interscience, 2008. Hardcover. Buchzustand: Very Good. Great condition with minimal wear, aging, or shelf wear. Buchnummer des Verkäufers P020470248475

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Verlag: John Wiley and Sons Ltd, United States (2008)
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Buchbeschreibung John Wiley and Sons Ltd, United States, 2008. Hardback. Buchzustand: New. 1. Auflage. Language: English . Brand New Book. A clear, straightforward resource to guide you through preclinical drug development Following this book s step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic, comprehensive reference to prioritizing and optimizing leads, dose formulation, ADME, pharmacokinetics, modeling, and regulations. This authoritative, easy-to-use resource covers all the issues that need to be considered and provides detailed instructions for current methods and techniques. Each chapter is written by one or more leading experts in the field. These authors, representing the many disciplines involved in preclinical toxicology screening and testing, give you the tools needed to apply an effective multidisciplinary approach. The editor has carefully reviewed all the chapters to ensure that each one is thorough, accurate, and clear. Among the key topics covered are: Modeling and informatics in drug design Bioanalytical chemistry Absorption of drugs after oral administration Transporter interactions in the ADME pathway of drugs Metabolism kinetics Mechanisms and consequences of drug-drug interactions Each chapter offers a full exploration of problems that may be encountered and their solutions. The authors also set forth the limitations of various methods and techniques used in determining the safety and efficacy of a drug during the preclinical stage. This publication should be readily accessible to all pharmaceutical scientists involved in preclinical testing, enabling them to perform and document preclinical safety tests to meet all FDA requirements before clinical trials may begin. Buchnummer des Verkäufers AAH9780470248478

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Shayne Cox Gad (editor)
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Buchbeschreibung Wiley 2008-04-29, Hoboken, N.J., 2008. hardback. Buchzustand: New. Buchnummer des Verkäufers 9780470248478

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