Predicting Solubility of New Drugs (Hardcover)

Sprache: Englisch

Verlag: Taylor & Francis Ltd, London, 2024

1032617675 / 9781032617671

Anbieter: AussieBookSeller, Truganina, VIC, AustralienAussieBookSeller

Verkäufer/-in mit 5 Sternen

Verkäufer:in bei AbeBooks seit 22. Juni 2007

Hardcover

Zustand: Neu

EUR 567,74

EUR 33,03 Versand 
Versand von Australien nach USA

Anzahl: 1 verfügbar

In den Warenkorb
30 Tage kostenlose Rückgabe

Artikelbeschreibung des Verkäufers

Hardcover. In pharmaceutical research, solubility plays a key part in the assessment of pharmacokinetic risks. Poor drug absorption, reduced efficacy, excessive metabolism, and adverse reactions are frequently related to issues of drug solubility. During early discovery research at pharmaceutical companies, many thousands of molecules are considered. Most are rejected due to perceived unfavorable properties. Here the author uses the Wiki-pS0TM database, which forms the backbone of this unique handbook. Also discussed is the emerging class of therapeutically promising research molecules called PROTACs (proteolysis-targeting chimeras), showing a propensity for undruggable targets.FEATURES A comprehensive and unique listing of measured aqueous intrinsic solubility focusing on drug-like and drug-relevant molecules. The database can be used to predict the solubility of research pharmaceutical molecules. Includes downloadable files of the database (.csv format). The mining of the database can result in a better design of solubility assay protocols, leading to better quality of measurements. Artificial intelligence and Bayesian statistics will likely be key to this subject area in the future.Alex Avdeef has been an American Association of Pharmaceutical Scientists (AAPS) Fellow since 2014, a former visiting senior research fellow at Kings College London, and is the author of Absorption and Drug Development (2nd ed., Wiley, 2012). In 2021, the book was translated into Chinese, by translators affiliated with the China Food and Drug Administration. For nearly 50 years, he has been teaching, researching, and developing methods, instruments, and analysis software for the measurement of ionization constants, solubility, dissolution, and permeability of drugs. His accomplishments in the development of instrumentation include several well-known instruments that are or recently have been manufactured by leading companies in the instrument market, including Thermo Fisher Scientific, Sirius Analytical, and Pion Inc. He has over 200 technical publications in primary scientific journals and book chapters. He has written several comprehensive technical guides and is a co-inventor on six patents. He cofounded Sirius Analytical (UK) in 1989, pION Inc. (USA) in 1996, and founded inADME Research (New York City) in 2011. His other positions were at Orion Research, Syracuse University, UC Berkeley, and Caltech. The correct amount of solubility is a key part in the search for new drugs to tackle diseases. This handbook provides data analysis of published solubility measurements of FDA recently-approved drugs methodically searched in recent years. Artificial intelligence and Bayesian statistics will likely be key to this subject area in the future. Shipping may be from our Sydney, NSW warehouse or from our UK or US warehouse, depending on stock availability.…

Bestandsnummer des Verkäufers 9781032617671

Titel
Predicting Solubility of New Drugs (Hardcover)
Autor
Alex Avdeef
Verlag
Taylor & Francis Ltd, London
Erscheinungsjahr
2024
Zustand
new
Einband
Hardcover
Sprache
Englisch
ISBN-10
1032617675
ISBN-13
9781032617671

AussieBookSeller

Truganina, VIC, Australien

Verkäufer/-in mit 5 Sternen

Verkäufer:in bei AbeBooks seit 22. Juni 2007

Versandkosten von Australien nach USA

Artikel25 bis 45 Werktage8 bis 14 Werktage
Erster ArtikelEUR 33,03EUR 39,28
Die Versandzeiten werden von den Verkäuferinnen und Verkäufern festgelegt. Sie variieren je nach Versanddienstleister und Standort. Sendungen, die den Zoll passieren, können Verzögerungen unterliegen. Eventuell anfallende Abgaben oder Gebühren sind von der Käuferin bzw. dem Käufer zu tragen. Die Verkäuferin bzw. der Verkäufer kann Sie bezüglich zusätzlicher Versandkosten kontaktieren, um einen möglichen Anstieg der Versandkosten für Ihre Artikel auszugleichen.

Zahlungsarten

  • Visa
  • Mastercard
  • American Express
  • Carte Bleue
  • Apple Pay
  • Google Pay

Unternehmensdaten der Verkäuferin bzw. des Verkäufers

The Nile Group Pty Ltd

42 Apex Drive
Truganina, VIC Australien 3029