Preparation of Macroporous Monoliths for Use in Liquid Chromatography

Anh Mai Nguyen

ISBN 10: 3838322347 / ISBN 13: 9783838322346

Verlag: LAP LAMBERT Academic Publishing Okt 2009, 2009

Beschreibung

Neuware -High performance liquid chromatogarphy (HPLC) is one of the major techniques in separation sciences. Faster separation and higher efficiency are required to meet ever-growing demands. Despite numerous efforts on improving mass transfer in particulate packings discontinuity seems to be the cornerstone. Macroporous continuous beds or monoliths are, therefore, a promising alternative to the particle medium. The work deals with the preparation of new monoliths used as support for HPLC stationary phase. Two different approaches were developed: one based on the polycondensation of epoxy resins which were dispersed in aqueous polyamine phase with the aid of a surfactant. The other involved a traverse of linear polyamides solutions around their upper critical solution temperatures (UCST). The polymers, dissolved in a solvent at temperatures higher than their UCSTs followed by slow cooling to below these temperatures to precipitate the polymers. Partly re-established hydrogen bonds resulted in the formation of crystallites that interconnected into a network structure. The study also deals with surface modifying for chromatographic applications.Books on Demand GmbH, Überseering 33, 22297 Hamburg 108 pp. Englisch.

Bestandsnummer des Verkäufers 9783838322346

Bibliografische Details

• Titel: Preparation of Macroporous Monoliths for Use in Liquid Chromatography
• Verlag: LAP LAMBERT Academic Publishing Okt 2009
• Erscheinungsjahr: 2009
• Sprache: Englisch
• ISBN-10: 3838322347
• ISBN-13: 9783838322346
• Einband: Taschenbuch
• Zustand: Neu

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Inhaltsangabe

High performance liquid chromatogarphy (HPLC) is one of the major techniques in separation sciences. Faster separation and higher efficiency are required to meet ever-growing demands. Despite numerous efforts on improving mass transfer in particulate packings discontinuity seems to be the cornerstone. Macroporous continuous beds or monoliths are, therefore, a promising alternative to the particle medium. The work deals with the preparation of new monoliths used as support for HPLC stationary phase. Two different approaches were developed: one based on the polycondensation of epoxy resins which were dispersed in aqueous polyamine phase with the aid of a surfactant. The other involved a traverse of linear polyamides solutions around their upper critical solution temperatures (UCST). The polymers, dissolved in a solvent at temperatures higher than their UCSTs followed by slow cooling to below these temperatures to precipitate the polymers. Partly re-established hydrogen bonds resulted in the formation of crystallites that interconnected into a network structure. The study also deals with surface modifying for chromatographic applications.