Progress in Iron Research (NATO Asi Series). Dieser Artikel ist nicht verfügbar.Progress in Iron Research (NATO Asi Series)

1) Mechanism of Fe(II) Oxidation and Core Formation in Ferritin.- 2) Chemico-Physical and Functional Differences Between H and L Chains of Human Ferritin.- 3) Iron Oxidation in Sheep, Horse and Recombinant Human Apoferritins.- 4) The Transferrin Receptor and the Release of Iron from Transferrin.- 5) The Roles of Secondary Binding Sites for Transferrin in the Liver and on Macrophages.- 6) Optimized Separation and Quantitation of Serum and Cerebrospinal Fluid Transferrin Subfractions Defined by Differences in Iron Saturation or Glycan Composition.- 7) Mechanism of Production of the Serum Transferrin Receptor.- 8) Iron Absorption and Cellular Uptake of Iron.- 9) Ferric Iron Reduction and Iron Uptake in Eucaryotes: Studies with the Yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe.- 10) Cellular Responses to Iron and Iron Compounds.- 11) The Structure and Function of Iron Regulatory Factor.- 12) Structure and Function of IREs, the Noncoding mRNA Sequences Regulating Synthesis of Ferritin, Transferrin Receptor and (Erythroid) 5-Aminolevulinate Synthase.- 13) Translational Control by Iron-Responsive Elements.- 14) The Role of Cytokines in the Regulation of Ferritin Expression.- 15) Stimulation of IRE-BP Activity of IREF by Tetrahydrobiopterin and Cytokine Dependent Induction of Nitric Oxide Synthase.- 16) Reciprocal Modulation of Aconitase Activity and RNA-binding Activity of Iron Regulatory Factor by Nitric Oxide.- 17) A New Look at Ferritin Metabolism.- 18) Bacterioferritin: A Hemoprotein Member of the Ferritin Family.- 19) Intracellular Iron.- 20) Distinct Features of Iron Metabolism in Erythroid Cells: Implications for Heme Synthesis Regulation.- 21) Cellular Ferritin Uptake: A Highly Regulated Pathway for Iron Assimilation in Human Erythroid Precursor Cells.- 22) Differential Effects of Iron and Iron Carrier on Hematopoietic Cell Differentiation and Human ADA Gene Transfer.- 23) A Hemin-Inducible Enhancer Lies 4. 5 Kb Upstream of the Mouse Ferritin H Subunit Gene.- 24) Iron Deficiency: The Global Perspective.- 25) Iron Regulation in the Brain at the Cell and Molecular Level.- 26) Pathophysiology of Iron Toxicity.- 27) Morphologic Observations in Iron Overload: An Update.- 28) Identification of Thiolic Sarcolemmal Proteins as a Primary Target of Iron Toxicity in Cultured Heart Cells.- 29) Iron Overload and the Biliary Route.- 30) Changing Concepts of Haemochromatosis.- 31) Epidemiology, Clinical Spectrum and Prognosis of Hemochromatosis.- 32) The Morbidity of Hemochromatosis Among Clinically Unselected Homozygotes: Preliminary Report.- 33) Genetics of Haemochromatosis.- 34) Localization of Seven New Genes Around the HLA-A Locus.- 35) Searching for the Hemochromatosis Grail.- 36) Iron Chelator Design.- 37) Results from a Phase I Clinical Trial of HBED.- 38) Lessons from Preclinical and Clinical Studies with 1,2-Diethyl-3-Hydroxypyridin-4-One, CP94 and Related Compounds.- 39) Iron Chelation Therapy for Malaria.- 40) The Biochemical Basis for the Selective Antimalarial Action of Iron Chelators on Plasmodium Falciparum Parasitized Cells.

Based on presentations at two conferences held in April and May 1993, respectively (the first a clinical meeting, the second a forum designed primarily for basic scientists), this volume offers a comprehensive, state-of-the-art review on most aspects of iron metabolism. Chapters on the biophysical a