Progress in Tryptophan and Serotonin Research 1986: Proceedings, Fifth Meeting of the International Study Group for Tryptophan Research Istry, Cardiff, Wales U. K., July 28-august 1, 1986

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Frontmatter -- PREFACE -- CONTENTS -- THE INTERNATIONAL STUDY GROUP FOR TRYPTOPHAN RESEARCH (ISTRY) A BRIEF HISTORY / Brown, R. R. -- OPENING ADDRESS BY THE PRESIDENT OF ISTRY / Allegri, Graziella -- HOPKINS AND THE DISCOVERY OF TRYPTOPHAN / Curzon, G. -- METABOLIC ASPECTS OF TRYPTOPHAN -- MOLECULAR GENETICS OF L-TRYPTOPHAN 2,3-DIOXYGENASE IN RAT LIVER / Renkawitz, Rainer -- BIOSYNTHESIS OF TETRAHYDROBIOPTERIN, THE COFACTOR FOR THE AROMATIC AMINO ACID HYDROXYLASES / Smith, Gary K. -- RAT BRAIN TRYPTOPHAN HYDROXYLASE : PURIFICATION, ACTIVATION AND STABILISATION / Cash, C. D. / Ehret, M. A. / Maitre, M. -- EFFECTS OF INTERFERONS AND INTERLEUKIN-2 ON TRYPTOPHAN METABOLISM IN HUMANS / Brown, R. R. / Borden, E. C. / Sondel, P. M. / Lee, C. M. -- THE SIGNIFICANCE OF KYNURENINE DETERMINATION IN HUMAN SERUM / Badawy, A. A.-B. / Evans, M. -- AN EXAMINATION OF THE CIRCADIAN OSCILLATION OF HEPATIC HOLOTRYPTOPHAN PYRROLASE IN MICE / Ghosh, D. / Anyanwu, B. O. / Martin, Ezall / Guilford, J. / Bennett, C. H. / Henderson, L. L. -- ENZYMIC DEGRADATION OF TRYPTOPHAN BY HUMAN PLACENTAL SLICES / Yamazaki, Fumio / Takikawa, Osamu / Kuroiwa, Takekiyo / Kido, Ryo -- PURIFICATION AND CHARACTERIZATION OF INDOLEAMINE 2,3-DIOXYGENASE FROM HUMAN PLACENTA / Yamazaki, Fumio / Takikawa, Osamu / Kuroiwa, Takekiyo / Kido, Ryo -- PREPARATION AND CHARACTERIZATION OF MONOCLONAL ANTIBODY TO HUMAN PLACENTAL TRYPTOPHAN PYRROLASE (INDOLEAMINE 2,3-DIOXYGENASE) / Kuroiwa, T. / Takikawa, O. / Yamazaki, F. / Kido, R. -- FUNCTION AND REGULATION OF EXTRAHEPATIC TRYPTOPHAN PYRROLASE (INDOLEAMINE 2,3-DIOXYGENASE): STUDIES OF ITS INDUCTION BY INTERFERON-¿ / Takikawa, O. / Kuroiwa, T. / Yamazaki, F. / Kido, R. -- EFFECTS OF IND0LE-3-PYRUVIC ACID ON TRYPTOPHAN PYRROLASE ACTIVITY "IN VITRO" AND "IN VIVO" / Lavaggi, M. V. / Politi, V. / De Luca, G. / Gorini, A. -- THE METABOLIC DEGRADATION OF KYNURENINE AT TISSUE LEVEL BY RAT / Nakamura, Masayuki / Kawai, Jun / Minatogawa, Yohsuke / Kido, Ryo -- THE MECHANISM OF DEHYDROGENATION OF TRYPTOPHAN RESIDUES BY TRYPTOPHAN SIDE-CHAIN OXIDASE II FROM PSEUDOMONAS / Takai, K. / Yoshii, H. / Yasui, H. / Sasai, Y. -- THE MECHANISM OF SPECIFIC ACCUMULATION OF L-KYNURENINE IN RAT FUR / Nagamura, Y. / Naito, J. / Ogawa, H. / Ishiguro, I. -- CONTROL OF TRYPTOPHAN UTILIZATION IN LIVER CELLS / Pogson, C. I. / Knowles, R. G. / Salter, M. -- HAEM IS NOT A REGULATOR OF TRYPTOPHAN 2,3-DIOXYGENASE IN THE RAT LIVER / Salter, M. / Pogson, C. I. -- NEUROCHEMISTRY OF TRYPTOPHAN AND 5-HYDROXYTRYPTOPHAN -- RUNNING INCREASES BRAIN AND CEREBROSPINAL FLUID TRYPTOPHAN IN THE RAT BY INCREASING PLASMA FREE TRYPTOPHAN : CONSEQUENCES ON CENTRAL SEROTONERGIC METABOLISM / Chaouloff, F. / Laude, D. / Elghozi, J. L. -- PERTURBATIONS OF BRAIN SEROTONIN METABOLISM AND SLEEPING / WAKING PATTERN OF RATS BY ENZYMATIC DEPLETION OF BLOOD TRYPTOPHAN / Takai, K. / Yasui, H. / Yoshii, H. / Sasai, Y. -- RAT BRAIN SEROTONIN: BIOCHEMICAL AND FUNCTIONAL EVIDENCE FOR A SEX DIFFERENCE / Carlsson, M. / Svensson, K. / Eriksson, E. / Carlsson, A. -- EFFECTS OF ANALGESIC DRUGS ON BRAIN SEROTONIN METABOLISM IN / Costa, C. / Biasiolo, M. / Ceccherelli, F. / Segatto, A. -- EFFECTS OF TRYPTOPHAN LOADING ON PAIN AND MORPHINE REQUIREMENTS AFTER SURGERY / Abbotta, F. V. / English, M. J. M. / Franklin, K. B. J. / Jeansd, M. E. / Younge, S. N. -- INFLUENCES OF FEEDING OYSTERS ON THE METABOLISM OF SEROTONIN IN ALLOXAN-DIABETIC RATS / Shibata, Y. / Hattori, M. / Takeuchi, F. / Otsuka, H. / Otsuka, H. / Tsubouchi, R. / Ugata, M. / Shiraishi, S. / Ohta, T. / Sugino, N. / Sotokawa, Y. / Takahashi, R. / Kotake, Yazo / Kotake, Yahito -- EFFECT OF PREDICTABILITY OR UNPREDICTABILITY OF ELECTRIC SHOCK ON THE METABOLISM OF SEROTONIN IN RAT BRAIN / Adell, A. / Gelpí, E. -- COMPLEX INTERACTIONS BETWEEN TRYPTOPHAN AND MACRONUTRIENTS ON APPETITE, MOOD AND PERFORMANCE / Blundell, J. E. / Mavjee, V. / Hill, A. J. -- THE EFFECT OF IMMOBILISATION ON REGIONAL 5HT METABOLISM IN VEHICLE, TRYPTOPHAN AND VALINE TREATED RATS / Marcou, M. / Kennett, G. A. / Curzon, G. -- BRAIN METABOLISM OF TRYPTOPHAN / Curzon, G. -- STRESS, TRYPTOPHAN AND PAIN SENSITIVITY / Franklin, K. B. J. -- BEHAVIOURAL EFFECTS OF 5HT RECEPTOR STIMULATION / Green, A. R. -- BEHAVIOURAL ROLE OF 5-HT / Iversen, Susan D. -- NEUROCHEMISTRY OF KYNURENINE AND RELATED SUBSTANCES -- NEUROPHYSIOLOGY OF KYNÜRENINES / Stone, T. W. -- METABOLISM AND LOCALISATION OF QUINOLINIC ACID IN THE RAT BRAIN / Okuno, E. / Speciale, C. / Schwarcz, R. / Köhler, C. -- ANTICONVULSANT ACTION OF KYNURENIC ACID IN REFLEX EPILEPSY IN DBA/2 MICE AND IN PHOTOSENSITIVE BABOONS / Meldrum, B. S. / Chapman, A. G. / Mello, L. -- THE RELATIONSHIP BETWEEN KYNURENINE AND ARTERIAL BLOOD PRESSURE / Rudzite, V. / Jurika, E. / Araja, J. / Andrejev, N. -- BRADYARRYTHMIAS AND MYOCARDIAL CELL FAILURE INDUCED BY KYNURENINE / Rudzite, V. / Sileniece, G. / Jirgensons, J. / Skards, J. / Zirne, R. / Dalmane, A. -- KYNURENINE AS AN' ENDOGENOUS PHOTOSENSITIZER / Wada, Satoshi / Takahashi, Hitoshi -- KYNURENINE IN HUMAN CSF: REDUCED LEVELS IN EPILEPSY / Joseph, M. H. / Young, S. N. / Gauthier, S. -- NUTRITIONAL AND FOOD SCIENCE ASPECTS OF TRYPTOPHAN -- PELLAGRA AND NIACIN BIOAVAILABILITY / Carpenter, K. J. -- PELLAGRA IN EGYPT / Hussein, L. / Mounir, Z. / Elnaggar, B. / Ashoub, A. / Arafah, A. / Saleh, A. / Abdellah, H. / Ibrahim, A. A. / Abassy, M. -- AMINO ACID IMBALANCE AND PELLAGRA / Belavady, Bhavani -- THE RELATIVE IMPORTANCE OF DIETARY TRYPTOPHAN AND PREFORMED NICOTINIC ACID AND NICOTINAMIDE AS PRECURSORS OF NICOTINAMIDE NUCLEOTIDE COENZYMES / Bender, David A. -- LOSSES OF TRYPTOPHAN DURING FOOD PROCESSING / Hurrell, Richard F. / Finot, Paul-André -- METABOLISM OF A HIGH INTAKE OF NICOTINAMIDE IN CHOLINE DEFICIENT RATS / Bender, D. A. / Clifford, E. / McCreanor, G. M. / Smith, A. D. -- ABSORPTION OP L-TRYPTOPHAÎI IN THE SMALL INTESTINE OP CHICKS / Basova, N. A. / Kushak, R. I. -- NAD METABOLISM IN DIFFERENT ORGANS OF THE RAT UNDER THE INFLUENCE OF PSYCHOTROPIC SUBSTANCES / Kröger, H. / Grätz, R. / Grahn, H. -- DIETARY PROTEINS AND SERUM TRYPTOPHAN LEVELS IN FULL-TERM NEWBORN INFANTS / Zanardo, V / Stocchero, L. / Biasiolo, M. / Costa, C. / Allegri, G. -- INFLUENCE OF DIETARY CHANGE FROM A PROTEIN-FREE DIET TO A 30% PROTEIN DIET ON NIACIN FORMATION FROM TRYPTOPHAN IN RATS / Iwai, K. / Hayakawa, T. -- EFFECTS OF STARVATION ON TRYPTOPHAN METABOLISM AND DISPOSITION IN THE RAT / Badawy, A. A.-B. / Morgan, C. J. / Davis, N. R. -- URINARY EXCRETION OF TRIGONELLINE AND N1-METHYL NICOTINAMIDE BY HUMAN BEINGS AND RATS FOLLOWING ORAL ADMINISTRATION OF NICOTINIC ACID OR TRIGONELLINE / Yuyama, S. / Suzuki, T. -- TRYPTOPHAN METABOLISM DURING REPRODUCTION / Naismith, D. J. / Maitland-Smith, K. -- PATHOLOGICAL ASPECTS OF TRYPTOPHAN -- BRAIN TRYPTOPHAN ABNORMALITIES IN HYPERAMMONEMIA AND LIVER DISEASE / Mans, Anke / Biebuyck, Julien / Hawkins, Richard -- b-HT PRECURSORS AS NEUROENDOCRINE PROBES / Cowen, P. J. -- 5-HT METABOLISM AND SOCIAL BEHAVIOUR IN THE MONKEY / Raleigh, Michael J. / McGuire, Michael T. -- THE EFFECT OF ALTERING TRYPTOPHAN LEVELS ON HUMAN MOOD AND BEHAVIOR / Young, Simon N. -- BRAIN TRYPTOPHAN ABNORMALITIES IN INBORN ERRORS OF METABOLISM / Smith, I. / Howells, D. W. / Hyland, K. -- TRYPTOPHAN IN TOXICOLOGY AND TERATOLOGY -- TRYPTOPHAN EFFECTS ON NORMAL AND INJURED LIVERS / Sidransky, H. / Verney, E. / Kurl, R. / Wang, D. -- AVAILABILITY OF TRYPTOPHAN AND FORMATION OF INDOLEAMINES DURING EMBRYOGENESIS / Huether, G. / Reimer, A. -- TRYPTOPHAN DEFICIENCY : ROLE IN ORGANOPHOSPHORUS TERATOGENESIS / Kitos, Paul A. / Tennant, Kevin D. / Kim, Hae-Young -- TRYPTOPHAN DEFICIENCY AND THE FOETAL-ALCOHOL SYNDROME / Badawy, A. A.-B. / Davis, N. R. / Morgan, C. J. / Dacey, A. / Evans, M. -- INTERACTIONS OF THE HIGH PRESSURE NEUROLOGICAL SYNDROME AND TRYPTOPHAN METABOLITES IN THE RAT / Wardley-Smith, Bridget / Halsey, M. J. / Joseph, M. H. -- 5-HYDROXYTRYPTOPHAN ADMINISTRATION AND ANOREXIA IN HYPERPHAGIC OVERWEIGTH PATIENTS / Ceci, F. / Cangiano, C. / Cascino, A. / Familiari, M. / Muscaritoli, M. / Fanelli, F.Rossi / Cairella, M. / Del Ben, M. -- PLASMA AND CSF TRYPTOPHAN IN PATIENTS WITH CANCER ANOREXIA / Cangiano, C. / Cascino, A. / Ceci, F. / Muscaritoli, M. / Fanelli, F. Rossi / Menichetti, E. T. / Mulieri, M. -- PLASMA TRYPTOPHAN A BIOCHEMICAL MARKER OF SUICIDE BEHAVIOUR? / Demling, J. / Moesler, T. A. / Langer, K. / Sauerbrei, W. -- 5HT AND 5HIAA IN THE PLATELET AND PLASMA POOLS OF HEALTHY INDIVIDUALS. DEFINITION OF AN "EX VIVO" UPTAKE INDEX / Ortiz, J. / Artigas, F. / Gelpí, E. / Martín, M. -- EVIDENCE FOR ABNORMALITIES IN THE PERIPHERAL METABOLISM OF SEROTONIN IN MELANCHOLIC (DSM III) PATIENTS: EFFECT OF ANTIDEPRESSANT TREATMENT / Sarrias, M. J. / Artigas, F. / Martínez, E. / Gelpí, E. / Alvarez, E. / Udina, C. / Casas, M. -- RAISING PLASMA TRYPTOPHAN TO SUPRA-PHYSIOLOGICAL LEVELS DOES NOT INCREASE PLASMA PROLACTIN IN HUMANS / Finer, N. / Caballero, B. / Wurtman, R. J. -- DETERMINATION OE VITAMINS B1, B2 AND B6 DEFICIENCY IN ERYTHROCYTES USING AN AUTOMATED PROCEDURE : Application in Tryptophan metabolism disorders / Tande, D. / Bigot, J. C. / Menez, J. E. / Bardou, L. G. -- TRYPTOPHAN METABOLIC STUDIES IM CALCIUM OXALATE UROLITHIASIS / Grimm, U. / Steinhauser, I. / Wulff, K. / Knapp, A. / Zschiesche, M. -- INFLUENCE OF EMBRYOTOXIC SUBSTANCES UPON THE ACTIVITY OF ADPR TRANSFERASE IN ANIMAL EMBRYOS / Kröger, H. / Grätz, R. / Dietrich, A. / Grahn, H. -- TRYPTOPHAN, 5-HYDROXYTRYPTAMINE AND SUBSTANCE-P IN CARCINOID PATIENTS / Salmon, S. A. / Curradi, C. / Geppetti, P. / Sicuteri, F. -- PRENATAL TREATMENT WITH AMINOPHYLLINE: EFFECTS ON THE LEVELS OF TRYPTOPHAN AT BIRTH AND POSSIBLE RELATIONS WITH THE CEREBRAL SEROTONIN BIOSYNTHESIS / Biasiolo, M. / Allegri, G. / Zanardo, V. / D'Aquino, M. G. / Danesin, E. -- INDOLES FROM PECAN NUTS AS INTERFERING COMPOUNDS ON CLINICAL CHEMICAL DIAGNOSIS AND AS A POSSIBLE NATURAL SUPPLY OF 5-HTP / Große, W. / Rasche, A. -- DETERMINATION OF TRYPTOPHAN IN AMNIOTIC FLUID SAMPLES AS POSSIBLE MARKER IN PRENATAL DIAGNOSIS / Weger, B. / Schloot, W. -- SEROTONIN AND 5-HYDROXYINDOLEACETIC ACID CSF LEVELS AND PLASMA TRYPTOPHAN IN NEUROLOGICAL DISEASES / Milovanovic, D. D. / Stevanovic, H-L. -- TRYPTOPHAN TRANSPORT INTO BRAIN MICROVESSELS / Bachmann, C. / Schrämli, A. / Colombo, J. P. -- STUDIES ON TRYPTOPHAN PYRROLASE ACTIVITY IN POST-MORTEM LIVER HOMOGENATES / Hansen, H-P. / Agarwal, D. P. / Gerdes, S. / Goedde, H. W. -- A CONTROLLED STUDY ON THE EFFECT OF L-TRYPTOPHAN IN MINIMAL BRAIN DYSFUNCTION / Ghose, K. -- THE ROLE OF 5HT IN AN ANIMAL MODEL OF DEPRESSION / Kennett, G. A. / Chaouloff, F. / Marcou, M. / Dourish, C. T. / Dickinson, S. L. / Curzon, G. -- POSTER COMMUNICATIONS ON METHODOLOGY -- THE ELECTROCHEMICAL ACTIVITY OF TRYPTOPHAN AND ITS METABOLITES: ANALYTICAL IMPLICATIONS IN VITRO AND IN VIVO / Joseph, M. H. -- SEPARATION OF FREE AND BOUND TRYPTOPHAN USING 4 DIFFERENT METHODS : COMPARISON OF 95 PLASMA / Bigot, J. C. / Menez, J. F. / Morin, J. F. / Bardou, L. G. -- TRYPTOPHAN CHARACTERIZATION BY SYNCHRONOUS SCANNING SPECTROMETRY / Bettero, A. / Salvalaio, L. / Costa, C. / Allegri, G. -- SELECTIVITY IN FLUORESCENCE SPECTROSCOPY: APPLICATION TO TRYPTOPHAN ANALYSIS / Bettero, A. / Battaglia, R. / Semenzato, A. / Costa, C. / Allegri, G. -- THIN-LAYER CHROMATOGRAPHIC SEPARATION OF INDOLIC AND KYNURENINE TRYPTOPHAN METABOLITES IN BIOLOGICAL FLUIDS USING A SEP-PAK C-18 EXTRACTION / Almeida, I. Tavares de / Peralta, A. Paula / Silveira, C. -- INTERACTION OF HUMAN SERUM ALBUMIN WITH 6-NITRO-L-TRYPTOPHAN STUDIED BY VISIBLE DIFFERENCE SPECTROSCOPY AND INDUCED CIRCULAR DICHROISM / Phillips, Robert S. -- PRESENCE OF A CARRIER WITH A VERY HIGH AFFINITY FOR L-TRYPTOPHAN UPTAKE IN ISOLATED RAT HEPATOCYTES / Saito, K. / Nagamura, Y. / Ohta, K. / Sasaki, E. / Ishiguro, I. -- FACILITATION OF L-TRY.PTOPHAN UPTAKE INTO RAT HEPATOCYTES BY ALBUMIN / Sasaki, E. / Saito, K. / Ohta, Y. / Nagamura, Y. / Shinohara, R. / Ishiguro, I. -- METHODOLOGICAL CONSIDERATIONS IN THE STUDY OF 5-HT RELEASE FROM NERVE ENDINGS IN VITRO / Evans, Suzanne M. / Collard, Keith J. -- THE PRESERVATION OF WHOLE BLOOD SEROTONIN (5HT), AND ITS DETERMINATION USING HPLC / Joseph, Michael H. / Lofthouse, Raymond -- IMPROVEMENTS TO THE MEASUREMENT OF INDOLEAMINES IN THE FRONTAL CORTEX OF THE FREELY MOVING RAT USING INTRACRANIAL DIALYSIS / Marsden, C. A. / Martin, K. F. / Sleight, A. J. / Palfreyman, M. G. -- APPLICATION OF IN VIVO MONITORING TECHNIQUES TO THE STUDY OF RELATIONSHIPS BETWEEN FEEDING AND BRAIN TRYPTOPHAN METABOLISM / Hutson, P. E. / Donohue, T. / Curzon, G. -- GENERAL SUBJECTS -- ISOLATION AND CHEMICAL STRUCTURE OF A YELLOW SUBSTANCE DERIVED FROM THE OXIDATIVE DEGRADATION OF 5-HYDROXYTRYPTAMINE / Uemura, T. / Yamano, T. / Miura, R. / Kanashiro, M. / Miyake, Y. / Kadota, K. -- TRYPTOPHAN AND OCULAR LENS PIGMENTS / Zigman, Seymour -- SOME CHEMICAL PROPERTIES OF THE DEEP YELLOW PIGMENT OF PAPILIO MACHAON (LEPIDOPTERA: PAPILIONIDAE) / Umebachi, Y. -- CAFFEOYLTRYPTOPHAN FROM GREEN ROBUSTA COFFEE BEANS / Morishita, H. / Takai, T. / Yamada, H. / Fukuda, F. / Sawada, M. / Iwahashi, H. / Kido, R. -- INFLUENCE OF PILOCARPINE ON THE TRYPTOPHAN LEVEL OF THE CORNEA EPITHELIUM IN BOVINE EYE / Veselovsky, J. / Kovacik, L. -- AUTHOR INDEX -- SUBJECT INDEX -- Backmatter