The Reeler Mouse as a Model of Brain Development

Andre M. Goffinet

ISBN 10: 3540646744 / ISBN 13: 9783540646747

Verlag: Springer Berlin Heidelberg, Springer Berlin Heidelberg Sep 1998, 1998

Beschreibung

This item is printed on demand - it takes 3-4 days longer - Neuware -Only five years ago, nobody in his right mind would have consid ered publishing a book on reeler as a model for brain develop ment. Although this interesting mutation has been with us for half a century, it is fair to say that, in spite of a wave of enthusiasm in the late sixties and early seventies, generated primarily by Sidman, Caviness and colleagues, studies of reeler mice fell pro gressively out of fashion during the next two decades. All that changed almost overnight when the cloning of the reeler gene, dubbed reelin, was reported in Tom Curran's laboratory in 1995. The fact that the same gene was identified at the same time independently by two other groups using positional cloning sug gested strongly that reelin was the right candidate. Although the key experiments of transgenic rescue have not been made (and perhaps will never be), the equation 'reeler is reelin' has been established beyond reasonable doubt, as alterations of the reelin gene and/or its expression have been found in at least five alleles of reeler and in the mutation Shaking Rat Kawasaki (SRK), an ortholog of reeler. 124 pp. Englisch.

Bestandsnummer des Verkäufers 9783540646747

Bibliografische Details

• Titel: The Reeler Mouse as a Model of Brain Development
• Verlag: Springer Berlin Heidelberg, Springer Berlin Heidelberg Sep 1998
• Erscheinungsjahr: 1998
• Sprache: Englisch
• ISBN-10: 3540646744
• ISBN-13: 9783540646747
• Einband: Taschenbuch
• Zustand: Neu
• Abmessungen: 235B x 155 H x 8 T Millimeter Breite: 235 mm, Höhe: 155 mm, Tiefe: 8 mm
• Gewicht: 201 Gramm

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Inhaltsangabe

Only five years ago, nobody in his right mind would have consid­ ered publishing a book on reeler as a model for brain develop­ ment. Although this interesting mutation has been with us for half a century, it is fair to say that, in spite of a wave of enthusiasm in the late sixties and early seventies, generated primarily by Sidman, Caviness and colleagues, studies of reeler mice fell pro­ gressively out of fashion during the next two decades. All that changed almost overnight when the cloning of the reeler gene, dubbed reelin, was reported in Tom Curran's laboratory in 1995. The fact that the same gene was identified at the same time independently by two other groups using positional cloning sug­ gested strongly that reelin was the right candidate. Although the key experiments of transgenic rescue have not been made (and perhaps will never be), the equation "reeler is reelin" has been established beyond reasonable doubt, as alterations of the reelin gene and/or its expression have been found in at least five alleles of reeler and in the mutation Shaking Rat Kawasaki (SRK), an ortholog of reeler.