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This Book is in Good Condition. Clean Copy With Light Amount of Wear. 100% Guaranteed. Summary: This updated and expanded translation of a 2004 German book details safety-ensuring methods and concepts employed by regulatory agencies, industry and academia in chemical safety including production, storage, transport, handling, disposal and labelling. Buchnummer des Verkäufers

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Inhaltsangabe: This book will be written by experts for professionals, scientists and all those involved in toxicological data generation and decision-making. It is the updated and expanded version of a monograph published in German in 2004.  Chemical safety is regulated on various levels including production, storage, transport, handling, disposal or labelling. This book deals comprehensively with the safety-ensuring methods and concepts employed by regulatory agencies, industry and academics. Toxicologists use experimental and scientific approaches for data collection, e.g. about chemical hazards, physicochemical features or toxicokinetics. The respective experimental methods are described in the book. Toxicologists also deal with much insecurity in the exposure and effect scenarios during risk assessment. To overcome these, they have different extrapolation methods and estimation procedures at their disposal. The book describes these methods in an accessible manner. Differing concepts from one regulation area to another are also covered. Reasons and consequences become evident when reading the book. Altogether, the book Regulatory Toxicology will serve as an excellent reference.

Über den Autor: Franz-Xaver Reichl studied Microbiology and Medicine in Munich, Germany. He is Head of the Department of Dental Toxicology at the Department of Operative/Restorative Dentistry, Periodontology and Pedodontics, LMU Munich and Head of the International Advisory Centre for the toxicology and biocompatibility of dental materials. His field of research cover studies on cytotoxic, mutagenic, carcinogenic and embryotoxic effects of chemical compounds (e.g. dental materials) in human and animal cells, abrasion of composites and elution of dental composite components during the chewing situation in the chewing simulator MUC/3 and in vitro- and in vivo studies on toxicokinetic and toxicodynamic effects of chemical compounds (e.g. dental materials). He also work on studies on the pathways and on the analysis of intermediates in the metabolism of dental composite components in biological systems and risk assessments of xenobiotics (e.g. dental materials). Michael Schwenk studied Biochemistry and Medicine in Tuebingen, Germany. He then qualifiedas a toxicologist and pharmacologist and worked in universities, industry and a health agency. He initially focused on experimental cell toxicology, but later shifted to the measurement of chemical residues in humans and to study the health effects of such exposures in different populations. He was active in various national regulatory committees, advised the colleagues of the public health service of Baden-Württemberg and received practical experience in all major areas of regulatory toxicology.

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Buchbeschreibung Springer, 2014. Hardcover. Buchzustand: Good. Volume I and II Satisfaction 100% guaranteed. Buchnummer des Verkäufers mon0001252630

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Buchbeschreibung Springer, 2014. Hardcover. Buchzustand: New. book. Buchnummer des Verkäufers 3642353738

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Buchbeschreibung Springer Mrz 2014, 2014. Buch. Buchzustand: Neu. 23.5x15.5x cm. Neuware - This book will be written by experts for professionals, scientists and all those involved in toxicological data generation and decision-making. It is the updated and expanded version of a monograph published in German in 2004. Chemical safety is regulated on various levels including production, storage, transport, handling, disposal or labelling. This book deals comprehensively with the safety-ensuring methods and concepts employed by regulatory agencies, industry and academics. Toxicologists use experimental and scientific approaches for data collection, e.g. about chemical hazards, physicochemical features or toxicokinetics. The respective experimental methods are described in the book. Toxicologists also deal with much insecurity in the exposure and effect scenarios during risk assessment. To overcome these, they have different extrapolation methods and estimation procedures at their disposal. The book describes these methods in an accessible manner. Differing concepts from one regulation area to another are also covered. Reasons and consequences become evident when reading the book. Altogether, the book Regulatory Toxicology will serve as an excellent reference. 946 pp. Englisch. Buchnummer des Verkäufers 9783642353734

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Buchbeschreibung Springer Mrz 2014, 2014. Buch. Buchzustand: Neu. 23.5x15.5x cm. Neuware - This book will be written by experts for professionals, scientists and all those involved in toxicological data generation and decision-making. It is the updated and expanded version of a monograph published in German in 2004. Chemical safety is regulated on various levels including production, storage, transport, handling, disposal or labelling. This book deals comprehensively with the safety-ensuring methods and concepts employed by regulatory agencies, industry and academics. Toxicologists use experimental and scientific approaches for data collection, e.g. about chemical hazards, physicochemical features or toxicokinetics. The respective experimental methods are described in the book. Toxicologists also deal with much insecurity in the exposure and effect scenarios during risk assessment. To overcome these, they have different extrapolation methods and estimation procedures at their disposal. The book describes these methods in an accessible manner. Differing concepts from one regulation area to another are also covered. Reasons and consequences become evident when reading the book. Altogether, the book Regulatory Toxicology will serve as an excellent reference. 946 pp. Englisch. Buchnummer des Verkäufers 9783642353734

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Buchbeschreibung Springer Mrz 2014, 2014. Buch. Buchzustand: Neu. 23.5x15.5x cm. This item is printed on demand - Print on Demand Neuware - This book will be written by experts for professionals, scientists and all those involved in toxicological data generation and decision-making. It is the updated and expanded version of a monograph published in German in 2004. Chemical safety is regulated on various levels including production, storage, transport, handling, disposal or labelling. This book deals comprehensively with the safety-ensuring methods and concepts employed by regulatory agencies, industry and academics. Toxicologists use experimental and scientific approaches for data collection, e.g. about chemical hazards, physicochemical features or toxicokinetics. The respective experimental methods are described in the book. Toxicologists also deal with much insecurity in the exposure and effect scenarios during risk assessment. To overcome these, they have different extrapolation methods and estimation procedures at their disposal. The book describes these methods in an accessible manner. Differing concepts from one regulation area to another are also covered. Reasons and consequences become evident when reading the book. Altogether, the book Regulatory Toxicology will serve as an excellent reference. 946 pp. Englisch. Buchnummer des Verkäufers 9783642353734

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Buchbeschreibung Springer Verlag, 2014. Hardcover. Buchzustand: Brand New. 1st edition. 946 pages. 9.50x6.50x2.50 inches. In Stock. Buchnummer des Verkäufers __3642353738

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Buchbeschreibung Buchzustand: New. Publisher/Verlag: Springer, Berlin | This updated and expanded translation of a 2004 German book details safety-ensuring methods and concepts employed by regulatory agencies, industry and academia in chemical safety including production, storage, transport, handling, disposal and labelling. | This book will be written by experts for professionals, scientists and all those involved in toxicological data generation and decision-making. It is the updated and expanded version of a monograph published in German in 2004. Chemical safety is regulated on various levels including production, storage, transport, handling, disposal or labelling. This book deals comprehensively with the safety-ensuring methods and concepts employed by regulatory agencies, industry and academics.Toxicologists use experimental and scientific approaches for data collection, e.g. about chemical hazards, physicochemical features or toxicokinetics. The respective experimental methods are described in the book. Toxicologists also deal with much insecurity in the exposure and effect scenarios during risk assessment. To overcome these, they have different extrapolation methods and estimation procedures at their disposal. The book describes these methods in an accessible manner. Differing concepts from one regulation area to another are also covered. Reasons and consequences become evident when reading the book. Altogether, the book Regulatory Toxicology will serve as an excellent reference. | Foreword.- Introduction.-Operation mode of regulatory toxicology.- Aims and institutions.-Aims and mission.- Applicationareas.- National and international collaboration.- Procedures and standards.- Theregulatory process.- Quality assurance in regulatory toxcicology.- Toxicologicalrisk assessment.- Methodological repertoire.- Toxicological tests.- Characterizationof physicochemical parameters.- Examination of acute and chronic toxicity.- Examinationof organ-toxicity and of laboratory parameters.- Specific tests for neurotox ,immunotox, allergy, irritation, reprotox and carcinogenicity.- Toxicity testingin vitro.- New and future toxicological assays.- Computer-based predictionmodels.- Metabolism tests.- Toxicokinetic tests.- Toxicodynamic tests.- Omics.-International regulation for toxicological test procedures.- Data acquisitionin humans.- Epidemiological methods.- Studies in volunteers.- Chemical analysisin toxicology (New).- Toxicostatistics and models.- Statistical evaluation methods.- Dose-responseanalysis, identification of threshold levels.- Extrapolation-procedures forcarcinogenic and non-carcinogenic compounds.- Probabilistic methods.- Toxicodynamicmodels.- Toxicokinetic models.- Estimation of exposure.- Exposure analysis forindoor contaminants.- Exposure scenarios.- Use of toxiological data.- Qualitycriteria for primary literature.- Data-mining.- Paradigms use in riskevaluation.- Toxicological paradigms.- Do carcinogens have a threshold dose? proand contra.- Single compounds vs combination effects.- Biomolecules vs smallerchemicals.- Sensitive humans vs average persons.- Assessment paradigmas.- Extrapolationfactors and safety factors.- Background exposure vs additional exposure inhuman biomonitoring.- Adverse effects vs non-adverse effects.- ADI vs MOSprinciple.- Precaution principle vs hazard control.- Hygienic vs toxicologicalapproaches.- Protected property and protection level.- Risk characterizationand risk evaluation.- The risk concept.- Current role of the term "risk".- Riskcycles.- Risk minimization in drug development.- Data required for riskevaluation.- Importance of physical-chemical properties.- Importance ofintrinsic toxic properties.- Importance of metabolism and of mechanism ofaction.- Importance of the extrapolation to lower doses in risk assessment.- Importanceof exposure level for risk assessment.- Risk characterization.- Riskassessment.- Elements of risk assessment.- Risk comparison.- Risk-benefitconsiderations.- Risk assessment in different jurisdic. Buchnummer des Verkäufers K9783642353734

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Buchbeschreibung Springer, 2014. Hardback. Buchzustand: NEW. 9783642353734 This listing is a new book, a title currently in-print which we order directly and immediately from the publisher. Buchnummer des Verkäufers HTANDREE0504914

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Buchbeschreibung Springer-Verlag Berlin and Heidelberg GmbH and Co. KG, 2014. HRD. Buchzustand: New. New Book. Shipped from US within 10 to 14 business days. Established seller since 2000. Buchnummer des Verkäufers IB-9783642353734

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Buchbeschreibung Springer-Verlag Berlin and Heidelberg GmbH and Co. KG, 2014. HRD. Buchzustand: New. New Book.Shipped from US within 10 to 14 business days. Established seller since 2000. Buchnummer des Verkäufers IB-9783642353734

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