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Sexuality and the Genetics of Bacteria.

JACOB, François (1920-) & Élie L. WOLLMAN:

Verlag: New York & London: Academic Press, 1961., 1961
Zustand: Fine Hardcover
Verkäufer Ted Kottler, Bookseller (Redondo Beach, CA, USA)

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xv, 374 pp; 58 figs. Original cloth. Near Fine, in very good+ dust jacket. Bibliography, pp. 345-366. François Jacob: Nobel Prize, Medicine or Physiology, 1965 (shared with André Lwoff and Jacques Monod), 'for their discoveries concerning genetic control of enzyme and virus synthesis.' 'In order to bring the analysis of conjugation down from the level of the population to the level of the individual bacterial pair, we had to understand how the genetic material of the male is transferred to the female. In particular, one could try to interrupt conjugation after various times in order to find out when the transfer takes place. Elie Wollman had the somewhat startling idea of interrupting conjugation by placing a mating mixture in one of those blenders which ordinarily find service in the kitchen. It turned out that the shearing forces generated in the blender separate males from females; the male chromosome is broken during transit, but the chromosomal fragment that has already penetrated the female can express its potentialities and undergo recombination. In this way, it could be shown that, after pairing, the male slowly injects its chromosome into the female. This injection follows a strict schedule and, with any particular strain, the injection always starts at the same point [15]. Marvellous organism, in which conjugal bliss can last for nearly three times the life-span of the individual! With this system, it became relatively easy to analyze the genetic constitution of E. coli, to show that bacterial characters are arranged on a single linkage group, termed the bacterial chromosome, and to map them, not only by classical genetic methods, but also by physical and chemical measurements. Moreover, two new insights emerged from this study. First, the bacterial chromosome turned out to be a closed, or circular, structure. Second, it was not as fixed a unit as one might have believed: other genetic elements, termed episomes (for example, a phage chromosome or a sex factor), can be added to or subtracted from it [16]. These properties happened to be of great value in subsequent studies of the bacterial cell and of its functioning' (Jacob, 'Genetics of the bacterial cell', Nobel Lecture, December ll, 1965, p. 150 in Les Prix Nobel en 1965; [16] = the book offered here). Buchnummer des Verkäufers 17575

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Bibliografische Details

Titel: Sexuality and the Genetics of Bacteria.

Verlag: New York & London: Academic Press, 1961.

Erscheinungsdatum: 1961

Einband: Hardcover

Zustand: Fine

Zustand des Schutzumschlags: Fine

Auflage: 1st Edition

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