Specific components of aversive odor memory in Drosophila melanogaster | Synapsin and Bruchpilot, two presynaptic proteins underlying specific phases of olfactory aversive memory in the fruit fly

Stephan Knapek

ISBN 10: 3838120612 / ISBN 13: 9783838120614

Verlag: Südwestdeutscher Verlag für Hochschulschriften, 2015

Specific components of aversive odor memory in Drosophila melanogaster | Synapsin and Bruchpilot, two presynaptic proteins underlying specific phases of olfactory aversive memory in the fruit fly | Stephan Knapek | Taschenbuch | 88 S. | Deutsch | 2015 | Südwestdeutscher Verlag für Hochschulschriften | EAN 9783838120614 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. Bestandsnummer des Verkäufers 106907219

Inhaltsangabe:

Memory is dynamic: after pairing an odor with electric shocks, flies form an aversive odor memory that lasts for several hours and consists of qualitatively different components. An anesthesia-sensitive memory component (ASM) decays rapidly, whereas a consolidated anesthesia-resistant memory component (ARM) lasts significantly longer. Here the author shows that the evolutionary conserved phosphoprotein Synapsin is selectively required for the labile ASM. Synapsin is associated with a reserve pool of vesicles at the presynapse and is required to maintain vesicle release specifically under sustained high frequency nerve stimulation. In contrast, the requirement of the active zone protein Bruchpilot is most pronounced in immediate vesicle release. The author shows that Bruchpilot is required for aversive olfactory memory and localizes the requirement of Bruchpilot to the Kenyon cells of the mushroom body, the second-order olfactory interneurons in Drosophila. He demonstrates that Bruchpilot preferentially functions for the consolidated ARM. Thus, different presynaptic proteins can dissociate consolidated and labile components of olfactory memory.

Über die Autorin bzw. den Autor: Stephan Knapek studied biology at the University of Würzburg, Germany. He did his PhD as a member of an international research training group at the department of Neurobiology and Genetics, where he studied the mechanisms underlying olfactory learning and memory. Today he works at the Max-Planck Institute of Neurobiology in Munich, Germany.

Bibliografische Details

Titel: Specific components of aversive odor memory ...
Verlag: Südwestdeutscher Verlag für Hochschulschriften
Erscheinungsdatum: 2015
Einband: Taschenbuch
Zustand: Neu