UV Spectroscopic Method and Method Validation of Methylphenidate

Tirthankar Choudhury

ISBN 10: 6207488342 / ISBN 13: 9786207488346

Verlag: LAP LAMBERT Academic Publishing Apr 2024, 2024

Beschreibung

Neuware -This UV-spectrophotometric technique is quite simple, accurate, precise,reproducible, and sensitive. The UV method has been developed for quantification of Methylphenidate in tablet formulation. It involves absorbance measurement at 288 nm (¿max of Methylphenidate) in Ethanol and distilled water (89:11) ratio. For the UV Spectrophotometric method, linearity was obtained in a concentration range of 1-50µg/ml for methylphenidate and with a regression value of 0.9998. Recovery was found in the range of 98-101%. The standard deviation and % RSD were found to beBooks on Demand GmbH, Überseering 33, 22297 Hamburg 72 pp. Englisch. Bestandsnummer des Verkäufers 9786207488346

Bibliografische Details

Titel: UV Spectroscopic Method and Method ...

Verlag: LAP LAMBERT Academic Publishing Apr 2024

Erscheinungsdatum: 2024

Einband: Taschenbuch

Zustand: Neu

Über diesen Titel

Inhaltsangabe:

This UV-spectrophotometric technique is quite simple, accurate, precise,reproducible, and sensitive. The UV method has been developed for quantification of Methylphenidate in tablet formulation. It involves absorbance measurement at 288 nm (ʎmax of Methylphenidate) in Ethanol and distilled water (89:11) ratio. For the UV Spectrophotometric method, linearity was obtained in a concentration range of 1-50µg/ml for methylphenidate and with a regression value of 0.9998. Recovery was found in the range of 98-101%. The standard deviation and % RSD were found to be < 2 %. It showed the high precision of the method, in accordance with ICH guidelines. The method has been successively applied to active pharmaceutical ingredients and was validated according to ICH guidelines. The method is highly accurate, reproducible and economical.