Untangling the Double Helix: DNA Entanglement and the Action of the DNA Topoisomerases

James C. Wang

ISBN 10: 0879698632 / ISBN 13: 9780879698638

Verlag: Cold Spring Harbor Laboratory, 2009

Beschreibung

Gebraucht - Sehr gut -Written by the man who discovered the first topoisomerase, this book covers the history of the DNA entanglement problem and explains how topoisomerases perform their magic in the cell and serve as therapeutic targets. Includes appendices and an index. Gebundene Ausgabe, Größe: 23.6 x 16.8 x 1.8 cm.

Bestandsnummer des Verkäufers 52901

Bibliografische Details

• Titel: Untangling the Double Helix: DNA Entanglement and the Action of the DNA Topoisomerases
• Verlag: Cold Spring Harbor Laboratory
• Erscheinungsjahr: 2009
• Sprache: Englisch
• ISBN-10: 0879698632
• ISBN-13: 9780879698638
• Einband: Hardcover
• Zustand: Sehr gut

Über diesen Titel

Inhaltsangabe

The problem of unraveling two intertwined strands during the duplication of DNA was recognized shortly after the proposal of the DNA double helix structure in 1953. A group of enzymes called DNA topoisomerases solve this problem by breaking and rejoining DNA molecules in a controlled manner, thereby allowing strands to be passed through each other and thus untangled--not just during DNA replication, but also during many other basic cellular processes. Because of their intimate involvement in the workings of the cell, topoisomerases are also the logical targets of many antibiotics (including Cipro) and anticancer agents. This book, written by James Wang, the discoverer of the first topoisomerase and a leader in the field since, presents ten chapters covering the historical backdrop of the DNA entanglement problem and the discovery of the DNA topoisomerases, how DNA topoisomerases perform their magic in DNA replication, transcription, genetic recombination and chromosome condensation, and how they are targets of therapeutic agents. The book should appeal to readers from undergraduates upwards with interests in the biological and clinical aspects of topoisomerase function, or in the mathematics and physics of topology.

Über die Autorin bzw. den Autor

Charlotte y Peter Fiell son dos autoridades en historia, teoría y crítica del diseño y han escrito más de sesenta libros sobre la materia, muchos de los cuales se han convertido en éxitos de ventas. También han impartido conferencias y cursos como profesores invitados, han comisariado exposiciones y asesorado a fabricantes, museos, salas de subastas y grandes coleccionistas privados de todo el mundo. Los Fiell han escrito numerosos libros para TASCHEN, entre los que se incluyen 1000 Chairs, Diseño del siglo XX, El diseño industrial de la A a la Z, Scandinavian Design y Diseño del siglo XXI.