Uday kishore (110 Ergebnisse)

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Taschenbuch. Zustand: Neu. Neuware - From a boy running barefoot in the streets of Delhi to becoming one of the greatest cricketers of all time, 'Virat Kohli's journey is the story of passion, discipline, and unbreakable spirit.'This book takes you through the defining moments of his life-his childhood struggles, the heartbreaking loss of his father, the triumph of leading India to victory in the 2008 U-19 World Cup, and his relentless rise to the top of world cricket. Along the way, you'll discover how a fiery teenager transformed into a fitness icon, a master of the chase, and a captain who reshaped Indian cricket with intensity, accountability, and fearless ambition.Through powerful stories and lessons drawn from his life, this biography reveals the man behind the records-the resilience that turned failure into fuel, the discipline that raised global fitness standards, and the leadership that inspired a generation.More than cricket, this is the story of self-belief, sacrifice, and the will to win. Virat Kohli's life reminds us that greatness is never given-it is earned, one run, one inning, and one relentless effort at a time.Whether you are a cricket lover, a dreamer chasing success, or someone looking for motivation, 'this book will inspire you to play the game of life with passion, discipline, and an unshakable belief in yourself.'.…

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Buch. Zustand: Neu. Neuware - From a boy running barefoot in the streets of Delhi to becoming one of the greatest cricketers of all time, 'Virat Kohli's journey is the story of passion, discipline, and unbreakable spirit.'This book takes you through the defining moments of his life-his childhood struggles, the heartbreaking loss of his father, the triumph of leading India to victory in the 2008 U-19 World Cup, and his relentless rise to the top of world cricket. Along the way, you'll discover how a fiery teenager transformed into a fitness icon, a master of the chase, and a captain who reshaped Indian cricket with intensity, accountability, and fearless ambition.Through powerful stories and lessons drawn from his life, this biography reveals the man behind the records-the resilience that turned failure into fuel, the discipline that raised global fitness standards, and the leadership that inspired a generation.More than cricket, this is the story of self-belief, sacrifice, and the will to win. Virat Kohli's life reminds us that greatness is never given-it is earned, one run, one inning, and one relentless effort at a time.Whether you are a cricket lover, a dreamer chasing success, or someone looking for motivation, 'this book will inspire you to play the game of life with passion, discipline, and an unshakable belief in yourself.'.…

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Hardcover. Zustand: new. Hardcover. The book starts with dissecting mechanisms underlying viral immune evasion via exploiting the host complement system by vaccinia virus, and by modulating the type 1 interferon response by RNA viruses. Yet another chapter looks into how viroporins expressed by different families of viruses causing influenza A virus, SARS, hepatitis C and HIV interact with several cellular pathways. Understanding of these mechanisms can aid the development of novel potential antiviral targets. The chapter on tuberculosis discusses the emerging importance of the innate immune mechanisms against Mycobacterium tuberculosis infection and latency. This book has a strong focus on fungal pathogenesis and immunity, starting with virulence and host factors that attain great importance in candidiasis and associated escape tricks of seriously opportunistic fungi. Two chapters on Aspergillus fumigatus elaborate on the pathogenic mechanisms: first discussing A. fumigatusairway epithelium interaction, followed by fungal and host factors that are paramount in the development of allergic and invasive aspergillosis. In the subsequent chapter, there is a general discussion on the innate and adaptive immune responses against primary and opportunistic fungal pathogens. The book starts with dissecting mechanisms underlying viral immune evasion via exploiting the host complement system by vaccinia virus, and by modulating the type 1 interferon response by RNA viruses. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.…

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Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - The topic of this book, Collectins, is a family of proteins whose major function is in innate immunity, where Collectins act as pattern recognition receptors (PRRs). In general they recognize targets such as microbial surfaces and apoptotic cells, and once bound to a target, Collectinspromote the clearance of microorganisms and damaged host tissue. New cell-surface proteins and glycoproteins, which act asCollectin receptors, are currently being identified. SomeCollectins, particularly MBL, activate the complement system, which enhances the ability of antibodies to fight pathogens, via three MBL-associated proteases, the MASPs. Additionally, recentresearch has begun to show wider-ranging activities of Collectins, such as: Their role in metabolism, and therefore their involvement in lifestyle diseases such as obesity and cardiovascular disease. Their ability to modulate the adaptive immune response, as well as to recognize and trigger apoptosis of cancer cells, which makes them effective in the annihilation of cancer cells with multiple mutations. The regulation of their expression by gonadal steroid hormones implicates them with critical roles in both male and female fertility. Altered levels of Collectins have been associated with various autoimmune diseases.This book brings together current knowledge of the structure, functions and biological activities of Collectins, to describe their integral role in human health.…

Zustand: New. 1st ed. 2021 edition NO-PA16APR2015-KAP.

Zustand: Sehr gut. Zustand: Sehr gut | Sprache: Englisch | Produktart: Bücher | Target pattern recognition in innate immunity is responsible for the immediate, usually protective, responses shown against invading microorganisms, and it is the principal feature of self and non-self recognition by virtue of the recognition of structures on the microbial pathogens, which are not found on host cells. This is an area that has been very actively researched, over approximately the past 12 years, and therefore this volume provides a timely comprehensive, and up to date, summary of the types and range of cell surface, intracellular, and secreted, host proteins involved in the recognition of microbial products, and of the protective mechanisms triggered as a result of the recognition events. The Toll-like receptors, first described in Drosophila and now well-characterised on human cells, provide an excellent demonstration of the wide range of different microbial products recognised by this family of receptors and of the signalling pathways which are triggered thus leading to induction of inflammatory cytokines and the activation of genes producing antimicrobial products. In addition, several cell surface proteins involved in target pattern recognition have been described on the surfaces of macrophages (macrophage mannose receptor and macrophage scavenger receptors), and on dendritic cells (DEC205), and to be involved with the uptake and clearance of whole microorganisms and polyanioic ligands. Pattern recognition is also utilised by intracellular receptors, with NOD-like receptors in the cytosol recognizing microbial molecules and activating the production of inflammatory cytokines or pathways that induce the production of inflammatory molecules. Secreted proteins, such as the pentraxins, which includes the acute phase reacting, C-reactive protein (CRP) and serum amyloid protein (SAP), and the collectins (mannan binding lectin, lung surfactant protein A and D) and ficolins can also readily recruit killing and clearance systems. Indeed, the serum complement system, which is one of the major defence systems in the bloodstream, is efficiently activated by CR P on its binding to the phosphocholine groups of microbial phospholipids¿and the subsequent interaction of the bound CR P with C1q¿to give classical pathway activation, or MBL, or ficolin, binding to arrays of mannose or N-acetyl-glucosamine residues, respectively, on the surfaces of microorganisms¿to give lectin pathway activation. Also, in addition to the activation and clearance events associated with complement activation by some of the secreted pattern recognition receptors, it is accepted that all these pattern recognition receptors can generally accelerate the uptake and clearance of microbes via phagocytic cells. In view of the growing interest in the cross-talk between innate and adaptive immunity, a thorough understanding of the initial recognition and triggering events, mediated via innate immune receptors, as addressed in this volume, is clearly very useful in helping to also fully understand the mechanisms of activation and control of the adaptive immune system¿and to allow a full assessment of the relative roles played by innate immunity and adaptive immunity against a particular infection in higher organisms.…

Hardcover. Zustand: Brand New. 256 pages. 9.25x6.10x9.21 inches. In Stock.