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Zustand: Sehr gut. Zustand: Sehr gut | Sprache: Englisch | Produktart: Bücher | This volume begins with a short history of malaria and follows with a summary of its biology. It then traces the fascinating history of the discovery of quinine for malaria treatment, and then describes quinine¿s biosynthesis, its mechanism of action…, and its clinical use, concluding with a discussion of synthetic antimalarial agents based on quinine¿s structure. It also covers the discovery of artemisinin and its development as the source of the most effective current antimalarial drug, including summaries of its synthesis and biosynthesis, its mechanism of action, and its clinical use and resistance. A short discussion of other clinically used antimalarial natural products leads to a detailed treatment of additional natural products with significant antiplasmodial activity, classified by compound type. Although the search for new antimalarial natural products from Nature¿s combinatorial library is challenging, it is very likely to yield new antimalarial drugs. This book thus ends byidentifying ten natural products with development potential as clinical antimalarial agents.
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Hardcover. Zustand: new. Hardcover. This book, ''Phytochemicals of Pteridophytes: Occurrence, Structures, and Biological Activity'', explores the chemical constituents of pteridophytes (lycophytes and ferns), emphasizing their occurrence, structures, and biological functions. It covers a wide range of phytochemicals, including a…romatic compounds (e.g., acylphloroglucinols, flavonoids, lignans, selaginellins) and isoprenoids (e.g., monoterpenoids, norisoprenoids, sesquiterpenoids, diterpenoids, and steroids). The book examines the distribution of these compounds across various pteridophyte genera and species, highlights their structural diversity, and outlines their pharmacological properties. It also compares the phytochemical profiles of pteridophytes with those of algae and bryophytes. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.
Weitere BilderSprache: Englisch
Verlag: Springer, 2023
Serie: Buch 26 von 30 - Progress in the Chemistry of Organic Natural Products
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Taschenbuch. Zustand: Neu. Antimalarial Natural Products | A. Douglas Kinghorn (u. a.) | Taschenbuch | Progress in the Chemistry of Organic Natural Products | ix | Englisch | 2023 | Springer | EAN 9783030898755 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at…]springer[dot]com | Anbieter: preigu.
Antimalarial Natural Products: 117 (Progress in the Chemistry of Organic Natural Products, 117)
Kinghorn, A. Douglas (Editor) / Falk, Heinz (Editor) / Gibbons, Simon (Editor) / Asakawa, Yoshinori (Editor) / Liu, Ji-Kai (Editor) / Dirsch, Verena M. (Editor)
Sprache: Englisch
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Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - This volume begins with a short history of malaria and follows with a summary of its biology. It then traces the fascinating history of the discovery of quinine for malaria treatment, and then describes quinine's biosynthesis, its mechanism of action…, and its clinical use, concluding with a discussion of synthetic antimalarial agents based on quinine's structure. It also covers the discovery of artemisinin and its development as the source of the most effective current antimalarial drug, including summaries of its synthesis and biosynthesis, its mechanism of action, and its clinical use and resistance. A short discussion of other clinically used antimalarial natural products leads to a detailed treatment of additional natural products with significant antiplasmodial activity, classified by compound type. Although the search for new antimalarial natural products from Nature's combinatorial library is challenging, it is very likely to yield new antimalarial drugs. This book thus ends byidentifying ten natural products with development potential as clinical antimalarial agents.
Sprache: Englisch
Verlag: Springer, 2022
Serie: Buch 26 von 30 - Progress in the Chemistry of Organic Natural Products
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Hardcover. Zustand: new. Hardcover. This book, ''Phytochemicals of Pteridophytes: Occurrence, Structures, and Biological Activity'', explores the chemical constituents of pteridophytes (lycophytes and ferns), emphasizing their occurrence, structures, and biological functions. It covers a wide range of phytochemicals, including a…romatic compounds (e.g., acylphloroglucinols, flavonoids, lignans, selaginellins) and isoprenoids (e.g., monoterpenoids, norisoprenoids, sesquiterpenoids, diterpenoids, and steroids). The book examines the distribution of these compounds across various pteridophyte genera and species, highlights their structural diversity, and outlines their pharmacological properties. It also compares the phytochemical profiles of pteridophytes with those of algae and bryophytes. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability.
Sprache: Englisch
Verlag: Springer, 2023
Serie: Buch 26 von 30 - Progress in the Chemistry of Organic Natural Products
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Serie: Buch 27 von 30 - Progress in the Chemistry of Organic Natural Products
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Hardback. Zustand: New. 2022 ed. This volume consists of four chapters that cover a structurally diverse range of naturally occurring compounds. Chapter 1 delves into the chemistry of pyrogallols and their oxidized products, the hydroxy-o-quinones, including their role in cycloaddition reactions in the chemical synthesis of seve…ral fungal metabolites. Chapter 2 provides an in-depth description of the constituents of agarwood essential oil and smoke samples that are used in the perfumery industry, with an emphasis on the sesquiterpenoid and chromones constituents so far known. Chapter 3 discusses the defensive chemical ecology of two North American newt species that both produce tetrodotoxin, a well-known neurotoxin that causes paralysis and death in metazoans by disrupting electrical signals in the nerves and muscles. Chapter 4 discusses the limonoids and triterpenoids from the genus Walsura of the plant family Meliaceae, of which a number of species are utilized in several southeastern Asian countries in systems of folk medicine.
Sprache: Englisch
Verlag: Springer International Publishing AG, Cham, 2023
Serie: Buch 28 von 30 - Progress in the Chemistry of Organic Natural Products
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Hardcover. Zustand: new. Hardcover. This book presents recent reports of total syntheses involving a photocatalytic reaction as a key step in the methodology. Modern photocatalysis has proven its generality for the development and functionalization of native functionalities. To date, the field has found broad applications in div…erse research areas, including the total synthesis of natural products. Among the selected examples presented in this book, it highlights how the photocatalytic process proceeds in a highly chemo-, regio-, and stereoselective manner, thereby allowing the rapid access to structurally complex architectures under light-driven conditions. This book presents recent reports of total syntheses involving a photocatalytic reaction as a key step in the methodology. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.
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Hardcover. Zustand: new. Hardcover. This book describes a unique class of secondary metabolites, the mono- and dimeric-naphthylisoquinoline alkaloids. They exclusively occur in lianas of the palaeotropical Ancistrocladaceae and Dioncophyllaceae plant families. Their unprecedented structures include stereogenic centers and rotati…onally hindered, and therefore stereogenic, axes. Extended recent investigations on six Ancistrocladus species from Asia, as reported in this contribution, shed light on their fascinating phytochemical productivity, with over 100 intriguing natural products. This high chemodiversity arises from a similarly unique biosynthesis from acetate-malonate units, following a novel polyketidic pathway to plant-derived isoquinoline alkaloids. Some of the compounds show most promising anti-parasitic activities. Additionally, strategies for the regio- and stereoselective total synthesis of the alkaloids, including the directed construction of the chiral axis, are also presented. This book describes a unique class of secondary metabolites, the mono- and dimeric-naphthylisoquinoline alkaloids. This high chemodiversity arises from a similarly unique biosynthesis from acetate-malonate units, following a novel polyketidic pathway to plant-derived isoquinoline alkaloids. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.
Sprache: Englisch
Verlag: Springer International Publishing, 2022
Serie: Buch 26 von 30 - Progress in the Chemistry of Organic Natural Products
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Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - This volume begins with a short history of malaria and follows with a summary of its biology. It then traces the fascinating history of the discovery of quinine for malaria treatment, and then describes quinine's biosynthesis, its mechanism of action, and i…ts clinical use, concluding with a discussion of synthetic antimalarial agents based on quinine's structure. It also covers the discovery of artemisinin and its development as the source of the most effective current antimalarial drug, including summaries of its synthesis and biosynthesis, its mechanism of action, and its clinical use and resistance. A short discussion of other clinically used antimalarial natural products leads to a detailed treatment of additional natural products with significant antiplasmodial activity, classified by compound type. Although the search for new antimalarial natural products from Nature's combinatorial library is challenging, it is very likely to yield new antimalarial drugs. This book thus ends byidentifying ten natural products with development potential as clinical antimalarial agents.
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Hardcover. Zustand: new. Hardcover. This volume presents three chapters discussing a range of topics. Chapter 1 deals with the development of efficient methods for compound dereplication that have been critical in the re-emergence of research on natural products as a source of new drug leads. It describes the main methods of der…eplication, which rely on the combined use of large natural product databases and spectral libraries, alongside the information obtained from chromatographic, UV-Vis, MS, and NMR spectroscopic analyses of the samples of interest. Chapter 2 describes 989 plant natural products and their ecological functions in plant-herbivore, plant-microorganism, and plant-plant interactions. These compounds include alkaloids, phenols, terpenoids, and other structural types. The information presented should provide the basis for in-depth research on these plant natural products and their natural functions, and also for their further development and utilization. Chapter 3 focuses on lichens, with each constituting a symbiotic association composed of a primary mycobiont and one or more photobionts living mutualistically. Covered are lichens and their bionts, taxonomic identification, and their chemical constituents as exemplified by what is found in lichen biomes, especially those endemic to North America. Extraction and isolation procedures, as well as updates on dereplication methods using mass spectrometric GNPS and NMR spectroscopic spin network fingerprint procedures, and marker-based techniques to identify lichens are discussed. The isolation and structure elucidation of secondary metabolites of an endolichenic Penicillium species that produces bioactive compounds is described in detail. It describes the main methods of dereplication, which rely on the combined use of large natural product databases and spectral libraries, alongside the information obtained from chromatographic, UV-Vis, MS, and NMR spectroscopic analyses of the samples of interest. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.
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Hardcover. Zustand: new. Hardcover. This volume explores the DielsAlder reaction, a cornerstone of organic chemistry, tracing its evolution from a classical synthesis tool to a versatile platform for constructing complex molecular architectures. It highlights the reactions historical significance, methodological advancements, an…d pivotal role in natural product synthesis. From its discovery in the early 20th century, the DielsAlder reaction revolutionized organic synthesis by enabling efficient formation of six-membered rings with remarkable stereoselectivity and regioselectivity. Over the decades, innovations such as asymmetric catalysis, organocatalysis, and inverse-electron-demand variants have expanded its scope, allowing precise synthesis of highly functionalized frameworks. The volume delves into biomimetic applications, showcasing how the reaction emulates biosynthesis pathways, bridging chemical synthesis and natural product biogenesis. It also examines the groundbreaking discovery of DielsAlderases, enzymes that catalyze pericyclic reactions in Nature, offering insights into biosynthesis and biocatalysis. Through detailed case studies, the volume illustrates the reactions strategic importance in tackling synthesis challenges posed by intricate natural products. Looking ahead, the volume discusses emerging applications in sustainable chemistry, photochemical activation, and enzyme engineering, emphasizing the adaptability and enduring relevance of this reaction. By integrating modern computational tools and cross-coupling strategies, the DielsAlder reaction continues to inspire innovation, solidifying its place as a cornerstone of chemical synthesis and retrosynthesis planning. The volume delves into biomimetic applications, showcasing how the reaction emulates biosynthesis pathways, bridging chemical synthesis and natural product biogenesis. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.
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Hardcover. Zustand: Brand New. 277 pages. 9.26x6.11x9.49 inches. In Stock.
Sprache: Englisch
Verlag: Springer, 2024
Serie: Buch 28 von 30 - Progress in the Chemistry of Organic Natural Products
- Softcover
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Taschenbuch. Zustand: Neu. Modern Photocatalytic Strategies in Natural Product Synthesis | A. Douglas Kinghorn (u. a.) | Taschenbuch | Progress in the Chemistry of Organic Natural Products | ix | Englisch | 2024 | Springer | EAN 9783031117855 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Hei…delberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.
