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Hardcover. Zustand: Very Good. 1st Edition. Oversized hardcover, xxviii + 481 pages, NOT ex-library. Neatly removed title page, otherwise very good. Book is clean and bright with unmarked text, free of inscriptions and stamps, securely bound. Issued without a dust jacket. Please note: this is a heavy book and extra shipping may be required. -- Contents: Preface; Amyloid Phenomenon and Its Significance [Nature of the Amyloid State of Proteins; Structure & Properties of Amyloid Species; Kinetics & Mechanism; Link Between Amyloid Formation & Disease; Strategies for Therapeutic Intervention; Looking to the Future]; Amyloid Structures at the Atomic Level: Insights from Crystallography [Atomic Structures of Segments of Amyloid-forming Proteins; Stability of Amyloid Fibers; Which Proteins Enter the Amyloid State?; Molecular Basis of Amyloid Polymorphism & Prion Strains; Atomic Structures of Steric Zippers Suggest Models for Amyloid Fibers of Parent Proteins; Atomic Structures of Steric Zippers Offer Approaches for Chemical Interventions Against Amyloid Formation]; What Does Solid-state Nmr Tell Us About Amyloid Structures [Principles of Solid-state Nmr Spectroscopy & Experiments for Structural Constraints; Amyloid Fibrils Investigated by Solid-state Nmr Spectroscopy]; From Molecular to Supramolecular Amyloid Structures: Contributions From Fiber Diffraction & Electron Microscopy [History; Methodology; Recent Advances in Amyloid Structure Determination]; Structures of Aggregating Species by Small-angle X-ray Scattering [Theoretical & Experimental Aspects; Data Analysis & Modeling Methods; Studying Protein Aggregation & Fibrillation Using Saxs; General Strategies for Modeling Saxs Data From Protein Complexes]; Structural & Compositional Information About Pre-amyloid Oligomers [Biophysical Techniques to Study Amyloid Oligomers; Structure & Composition of Amyloid Oligomers]; Oligomer Species: Mechanistics & Biochemistry [Structure; Toxicity Relation of Early Amyloids; Oligomer; Membrane Complex; Biochemical Modifications Underlying Amyloid Toxicity]; Pathways of Amyloid Formation [Nomenclature of Various Conformational States; Graphical Representations of the Mechanisms Leading to Amyloid; Pathways of Amyloid Fibril Formation; Nucleation Growth Versus Nucleated Conformational Conversion]; Sequence-based Prediction of Protein Behavior [Strategy of the Zyggregator Predictions; Aggregation Under Other Conditions; Prediction of the Cellular Toxicity of Protein Aggregates; Relationship to Other Methods of Predicting Protein Aggregation Propensities; Competition Between Folding & Aggregation of Proteins; Prediction of Protein Solubility From the Competition Between Folding & Aggregation; Sequence-based Prediction of Protein Interactions With Molecular Chaperones]; Kinetics & Mechanisms of Amyloid Formation [Classical Theory of Nucleated Polymerization; Theory of Filamentous Growth With Secondary Pathways; Self-consistent Solutions for the Complete Reaction Time Course]; Fluorescence Spectroscopy as a Tool to Characterize Amyloid Oligomers & Fibrils [Fluorescence Spectroscopy for Studies of Amyloid Reactions in Vitro; Cysteine-reactive Fluorescent Probes; Amyloidotropic Probes for Amyloid Fibrils & Oligomeric States; Luminescent Conjugated Poly & Oligothiophenes Lcps & Lcos]; Animal Models of Amyloid Diseases [Some Big Questions Regarding Amyloid Diseases & Some Answers From Animal Models; Identifying the Toxic Species in the Systemic Amyloidoses; Identifying the Toxic Species in Alzheimer's Disease; Infectious Protein Misfolding]; Role of Ab in Alzheimer's Disease; Experimental Approaches to Inducing Amyloid Aggregates; Fibrillar Polymorphism; Inhibitors of Amyloid & Oligomer Formation; Development of Therapeutic Strategies for the Transthyretin Amyloidoses; Hormone Amyloids in Sickness & Health; Functional Amyloids in Bacteria; Structural Properties & Applications of Self-assembling Peptides; Harnessing the Self-assembling Properties of Proteins in Spider Silk & Lung Surfactant; Index.

Hardcover. Zustand: New. New. book.