9780387301716 - n-acetylaspartate: a unique neuronal molecule in the central nervous system (advances in experimental medicine and biology, 576, band 576) (16 Ergebnisse)
Sprache: Englisch
Verlag: Springer, 2006
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Sprache: Englisch
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Sprache: Englisch
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Serie: Buch 21 von 544 - Advances in Experimental Medicine and Biology
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Sprache: Englisch
Verlag: Springer, 2006
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Sprache: Englisch
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Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - N-acetylaspartate, or NAA, is the acetylated form of the amino acid aspartate, and it is present exclusively in the nervous system. Indeed, NAA is one of the most highly concentrated chemicals found in the brain of humans and animals, and yet the functions…served by this brain-specific metabolite remain elusive, and controversial. Despite the uncertainties surrounding the functions of NAA in the development and operation of the nervous system, this molecule has attracted the attention of researchers and clinicians for two distinct reasons. First, the acetyl proton on NAA gives off a very prominent signal in water-suppressed, proton magnetic resonance spectroscopy (MRS), which permits clinicians to monitor levels of NAA in the brains of patients in a non-invasive manner. Because NAA is found primarily in neurons, and because the levels in the brain have been found to change rapidly after injury, or slowly during neurodegenerative diseases, MRS has become a preferred method of analyzing nerve cell dysfunction and death without surgical intervention. The second reason that NAA has attracted attention in recent years is that a congenital genetic disorder of NAA metabolism has been found to be the cause of the neurodegenerative disorder known as Canavan's disease. Canavan's disease is an inherited leukodystrophy that involves myelination pathologies of cortical white matter, leading to death within 10 years of birth. The genetic mutation results in a defective enzyme that de-acetylates NAA in the brain, resulting in a significant rise in NAA levels in the brain and urine. This enzyme, known as aspartoacylase (ASPA), appears to be involved in the process of myelination, such that a defective enzyme results in a disruption of the myelination of nerve fibers during development. The purpose of this symposium is to bring together investigators from around the world who are interested in the study of NAA, and the roles it plays in neuronaldevelopment and functioning. It is hoped that bringing researchers and clinicians together in such a forum will facilitate rapid progress in this emerging field, and will help lead to discoveries that can alleviate the suffering caused by a deadly, inheritable infantile disease.
Sprache: Englisch
Verlag: Springer Verlag, 2006
Serie: Buch 21 von 544 - Advances in Experimental Medicine and Biology
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Hardcover. Zustand: Brand New. 1st edition. 376 pages. 9.50x6.50x0.75 inches. In Stock.
Sprache: Englisch
Verlag: Springer, 2006
Serie: Buch 21 von 544 - Advances in Experimental Medicine and Biology
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Sprache: Englisch
Verlag: Springer US, 2006
Serie: Buch 21 von 544 - Advances in Experimental Medicine and Biology
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Gebunden. Zustand: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Covers topics that both researchers and clinicians have interest inN-acetylaspartate (NAA), the acetylated form of the amino acid aspartate, is one of the most highly concentrated chemicals in the brains of hu…mans, yet its function remains elu.
Sprache: Englisch
Verlag: Springer US Mrz 2006, 2006
Serie: Buch 21 von 544 - Advances in Experimental Medicine and Biology
- Hardcover
- Print-on-Demand
Anbieter: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, DeutschlandBuchWeltWeit Ludwig Meier e.K.
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Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -N-acetylaspartate (NAA), the acetylated form of the amino acid aspartate, is one of the most highly concentrated chemicals in the brains of humans, yet its function remains elusive. NAA is used in nonsurgical analyses of nerve cell dysfuncti…on, and it is implicated in a disorder known as Canavan's disease. This book reviews research from around the world in the study of NAA, and the roles it plays in neuronal development and functioning. 400 pp. Englisch.
Sprache: Englisch
Verlag: Springer, Springer Mär 2006, 2006
Serie: Buch 21 von 544 - Advances in Experimental Medicine and Biology
- Hardcover
- Print-on-Demand
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Buch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -N-acetylaspartate, or NAA, is the acetylated form of the amino acid aspartate, and it is present exclusively in the nervous system. Indeed, NAA is one of the most highly concentrated chemicals found in the brain of humans and animals, and yet th…e functions served by this brain-specific metabolite remain elusive, and controversial. Despite the uncertainties surrounding the functions of NAA in the development and operation of the nervous system, this molecule has attracted the attention of researchers and clinicians for two distinct reasons.First, the acetyl proton on NAA gives off a very prominent signal in water-suppressed, proton magnetic resonance spectroscopy (MRS), which permits clinicians to monitor levels of NAA in the brains of patients in a non-invasive manner. Because NAA is found primarily in neurons, and because the levels in the brain have been found to change rapidly after injury, or slowly during neurodegenerative diseases, MRS has become a preferred method of analyzing nerve cell dysfunction and death without surgical intervention.The second reason that NAA has attracted attention in recent years is that a congenital genetic disorder of NAA metabolism has been found to be the cause of the neurodegenerative disorder known as Canavan¿s disease. Canavan¿s disease is an inherited leukodystrophy that involves myelination pathologies of cortical white matter, leading to death within 10 years of birth. The genetic mutation results in a defective enzyme that de-acetylates NAA in the brain, resulting in a significant rise in NAA levels in the brain and urine. This enzyme, known as aspartoacylase (ASPA), appears to be involved in the process of myelination, such that a defective enzyme results in a disruption of the myelination of nerve fibers during development.The purpose of this symposium is to bring together investigators from around the world who are interested in the study of NAA, and the roles it plays in neuronaldevelopment and functioning. It is hoped that bringing researchers and clinicians together in such a forum will facilitate rapid progress in this emerging field, and will help lead to discoveries that can alleviate the suffering caused by a deadly, inheritable infantile disease.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 400 pp. Englisch.
