9781461349310 - triple repeat diseases of the nervous systems (advances in experimental medicine and biology, 516, band 516) von timchenko, lubov t. (11 Ergebnisse)
Sprache: Englisch
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Sprache: Englisch
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Sprache: Englisch
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Paperback. Zustand: Brand New. 131 pages. 10.00x7.00x0.31 inches. In Stock.
Weitere BilderSprache: Englisch
Verlag: Springer US, 2012
Serie: Buch 114 von 544 - Advances in Experimental Medicine and Biology
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Taschenbuch. Zustand: Neu. Triple Repeat Diseases of the Nervous Systems | Lubov T. Timchenko | Taschenbuch | x | Englisch | 2012 | Springer US | EAN 9781461349310 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.
Sprache: Englisch
Verlag: Springer US, Springer US, 2012
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Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - World of Unstable Mutations The book 'Triplet Repeat Diseases of the Nervous System' overviews the lat est data on several disorders associated with unstable mutations. This field of re search is progressing extremely fast. The number of polymorphic…mutations and diseases caused by these mutations is increasing almost every month. There is a strong interest to molecular bases of triplet repeat disorders. This is explained by growing necessity to develop molecular approaches for cure of these diseases. There fore, the authors of this book describe unstable mutations with the emphasis on molecular pathology. Broad discussion is presented on how polymorphic expan sions cause cell dysfunction. o The first chapter of the book focuses on the molecular pathological pro cesses that originate 'unstable' mutations. The authors review several avail able models by which normal 'stable' region of DNA become pathogenic and discuss possible mechanisms causing DNA instability. o The other chapters of the book describe inherited diseases associated with different types of unstable mutations. Based on the location of mutation in the disease gene, polymorphic expansions of the nervous system can be divided into two major groups. First group includes disorders with unstable expansions within the open reading frame of the gene such as Spinocer ebellar Ataxias caused by polyglutamine expansions. The second group in cludes diseases caused by expansions situated within the untranslated re gions of the gene.
Sprache: Englisch
Verlag: Springer US Sep 2012, 2012
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Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -World of Unstable Mutations The book 'Triplet Repeat Diseases of the Nervous System' overviews the lat est data on several disorders associated with unstable mutations. This field of re search is progressing extremely fast. The number… of polymorphic mutations and diseases caused by these mutations is increasing almost every month. There is a strong interest to molecular bases of triplet repeat disorders. This is explained by growing necessity to develop molecular approaches for cure of these diseases. There fore, the authors of this book describe unstable mutations with the emphasis on molecular pathology. Broad discussion is presented on how polymorphic expan sions cause cell dysfunction. o The first chapter of the book focuses on the molecular pathological pro cesses that originate 'unstable' mutations. The authors review several avail able models by which normal 'stable' region of DNA become pathogenic and discuss possible mechanisms causing DNA instability. o The other chapters of the book describe inherited diseases associated with different types of unstable mutations. Based on the location of mutation in the disease gene, polymorphic expansions of the nervous system can be divided into two major groups. First group includes disorders with unstable expansions within the open reading frame of the gene such as Spinocer ebellar Ataxias caused by polyglutamine expansions. The second group in cludes diseases caused by expansions situated within the untranslated re gions of the gene. 136 pp. Englisch.
Sprache: Englisch
Verlag: Springer, 2012
Serie: Buch 114 von 544 - Advances in Experimental Medicine and Biology
- Softcover
- Print-on-Demand
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Zustand: New. Print on Demand pp. 136.
Sprache: Englisch
Verlag: Springer US, Springer US Sep 2012, 2012
Serie: Buch 114 von 544 - Advances in Experimental Medicine and Biology
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Taschenbuch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -World of Unstable Mutations The book 'Triplet Repeat Diseases of the Nervous System' overviews the lat est data on several disorders associated with unstable mutations. This field of re search is progressing extremely fast. The number of…polymorphic mutations and diseases caused by these mutations is increasing almost every month. There is a strong interest to molecular bases of triplet repeat disorders. This is explained by growing necessity to develop molecular approaches for cure of these diseases. There fore, the authors of this book describe unstable mutations with the emphasis on molecular pathology. Broad discussion is presented on how polymorphic expan sions cause cell dysfunction. o The first chapter of the book focuses on the molecular pathological pro cesses that originate 'unstable' mutations. The authors review several avail able models by which normal 'stable' region of DNA become pathogenic and discuss possible mechanisms causing DNA instability. o The other chapters of the book describe inherited diseases associated with different types of unstable mutations. Based on the location of mutation in the disease gene, polymorphic expansions of the nervous system can be divided into two major groups. First group includes disorders with unstable expansions within the open reading frame of the gene such as Spinocer ebellar Ataxias caused by polyglutamine expansions. The second group in cludes diseases caused by expansions situated within the untranslated re gions of the gene.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 136 pp. Englisch.
Sprache: Englisch
Verlag: Springer, 2012
Serie: Buch 114 von 544 - Advances in Experimental Medicine and Biology
- Softcover
- Print-on-Demand
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Zustand: New. PRINT ON DEMAND pp. 136.
