ISBN: 9783034893978 - modern methods of drug discovery (experientia supplementum, band 93) (12 Ergebnisse)

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Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Research in the pharmaceutical industry today is in many respects quite different from what it used to be only fifteen years ago. There have been dramatic changes in approaches for identifying new chemical entities with a desired biological activity. While chemical modification of existing leads was the most important approach in the 1970s and 1980s, high-throughput screening and structure-based design are now major players among a multitude of methods used in drug discov ery. Quite often, companies favor one of these relatively new approaches over the other, e.g., screening over rational design, or vice versa, but we believe that an intelligent and concerted use of several or all methods currently available to drug discovery will be more successful in the medium term. What has changed most significantly in the past few years is the time available for identifying new chemical entities. Because of the high costs of drug discovery projects, pressure for maximum success in the shortest possible time is higher than ever. In addition, the multidisciplinary character of the field is much more pronounced today than it used to be. As a consequence, researchers and project managers in the pharmaceutical industry should have a solid knowledge of the more important methods available to drug discovery, because it is the rapidly and intelligently combined use of these which will determine the success or failure of preclinical projects.…

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Paperback. Zustand: Brand New. reprint edition. 308 pages. 9.20x6.10x0.73 inches. In Stock.

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Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Research in the pharmaceutical industry today is in many respects quite different from what it used to be only fifteen years ago. There have been dramatic changes in approaches for identifying new chemical entities with a desired biological activity. While chemical modification of existing leads was the most important approach in the 1970s and 1980s, high-throughput screening and structure-based design are now major players among a multitude of methods used in drug discov ery. Quite often, companies favor one of these relatively new approaches over the other, e.g., screening over rational design, or vice versa, but we believe that an intelligent and concerted use of several or all methods currently available to drug discovery will be more successful in the medium term. What has changed most significantly in the past few years is the time available for identifying new chemical entities. Because of the high costs of drug discovery projects, pressure for maximum success in the shortest possible time is higher than ever. In addition, the multidisciplinary character of the field is much more pronounced today than it used to be. As a consequence, researchers and project managers in the pharmaceutical industry should have a solid knowledge of the more important methods available to drug discovery, because it is the rapidly and intelligently combined use of these which will determine the success or failure of preclinical projects. 308 pp. Englisch.…

Zustand: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Research in the pharmaceutical industry today is in many respects quite different from what it used to be only fifteen years ago. There have been dramatic changes in approaches for identifying new chemical entities with a desired biological activity. While .…

Taschenbuch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This volume offers a broad and interdisciplinary view of modern approaches to drug discovery as used by pharmaceutical companies and research institutes. It comprehensively covers proteomics, bioinformatics, screening techniques such as high-throughput-, natural compounds-, and NMR-based-screenings, combinatorial chemistry, compound library design, ligand- and structure-based drug design and pharmacokinetic approaches. Each of the thirteen chapters reviews the theory, background and application of a key technology in drug discovery and is complemented by an extensive list of references to the original literature.This concise source of information will be useful to workers in the pharmaceutical industry as well as researchers and students in the fields of medicinal, pharmaceutical and computational chemistry, bioinformatics, biochemistry, molecular biology and pharmacology.Springer Nature c/o IBS, Benzstrasse 21, 48619 Heek 308 pp. Englisch. …

Zustand: New. Print on Demand pp. 310.

Zustand: New. PRINT ON DEMAND pp. 310.