Isbn: 9783659282942 - azole derivatives as an protein tyrosin kinase inhibitors: synthesis and antiproliferative evaluation of imatinib analogs (8 Ergebnisse)

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Taschenbuch. Zustand: Neu. Azole Derivatives as an Protein Tyrosin Kinase Inhibitors | Synthesis and Antiproliferative Evaluation of Imatinib analogs | Yogesh Agrawal (u. a.) | Taschenbuch | Englisch | LAP Lambert Academic Publishing | EAN 9783659282942 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.…

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Taschenbuch. Zustand: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - In the present book The Azoles Derivatives as Potent Protein Tyrosine Kinase Inhibitor , we provide an exhaustive literature regarding the Antiproliferative potential of Protein Tyrosine Kinase Inhibitors. Various analogous of imatinib were Designed and prepared by replacing the pyrimidine ring of imatinib with an azole nucleous like Imidazole, Benzimidazole and Benzthiazole. Imatinib an well reputed anti-cancer agent contain pyrimidine ring, composition of various biological enzymes and proteins of normal cell, as analogous of ATP inhibit the natural cell protein Kinase, hence responsible for non-specificity in activity with low selectivity and side effects. BMS-33197 an excellent Bcr-Abl kinase inhibitor contain an oxazole nucleolus responsible for its activity so various imatinib analogous were prepared isosterically. …