Isbn: 9783838129792 - mirna involvement in cell cycle control of non-small cell lung cancer (5 Ergebnisse)

Taschenbuch. Zustand: Neu. miRNA involvement in cell cycle control of non-small cell lung cancer | Nora Bandi | Taschenbuch | 120 S. | Englisch | 2015 | Südwestdeutscher Verlag für Hochschulschriften | EAN 9783838129792 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. …

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Non-small cell lung carcinoma (NSCLC) accounts for 80% of lung cancer. Despite improvements in the therapy, the overall five-year survival rate remains less than 15%. The fact that microRNAs (miRNAs) are often deregulated in many diseases including cancer opens a new field of potentially powerful therapeutic approaches. miRNAs are negative regulators of gene expression. Currently, most effort has been made to elucidate the function of individual miRNAs. However, the ability of multiple miRNAs to potentate their impact by acting in a combinatorial mode, engenders a novel way of thinking. Using the example of miR-15a/16 and miR 34a, the present work investigates the combinatorial role of functionally related miRNAs in the tumourigenesis of NSCLC. In conclusion, the results of the present thesis indicate that miR-15a/16 and miR-34a are synergistically implicated in cell cycle control and likely contribute collectively to the tumourigenesis of NSCLC. Since miR-34a and miR-15/16 are frequently down-regulated in the same tumour tissue, these findings may have important therapeutic implications for microRNA-based treatment of NSCLC. 120 pp. Englisch.…

Taschenbuch. Zustand: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Non-small cell lung carcinoma (NSCLC) accounts for 80% of lung cancer. Despite improvements in the therapy, the overall five-year survival rate remains less than 15%. The fact that microRNAs (miRNAs) are often deregulated in many diseases including cancer opens a new field of potentially powerful therapeutic approaches. miRNAs are negative regulators of gene expression. Currently, most effort has been made to elucidate the function of individual miRNAs. However, the ability of multiple miRNAs to potentate their impact by acting in a combinatorial mode, engenders a novel way of thinking. Using the example of miR-15a/16 and miR 34a, the present work investigates the combinatorial role of functionally related miRNAs in the tumourigenesis of NSCLC. In conclusion, the results of the present thesis indicate that miR-15a/16 and miR-34a are synergistically implicated in cell cycle control and likely contribute collectively to the tumourigenesis of NSCLC. Since miR-34a and miR-15/16 are frequently down-regulated in the same tumour tissue, these findings may have important therapeutic implications for microRNA-based treatment of NSCLC.…

Zustand: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Bandi NoraDr. phil. nat.: Master of Science in Cell Biology in 2007, PhD in Cellular and Biomedical Sciences in 2010 at the University of Bern (Switzerland). Currently scientific assistant at the Institute of Pathology and teacher fo.…

Taschenbuch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Non-small cell lung carcinoma (NSCLC) accounts for 80% of lung cancer. Despite improvements in the therapy, the overall five-year survival rate remains less than 15%. The fact that microRNAs (miRNAs) are often deregulated in many diseases including cancer opens a new field of potentially powerful therapeutic approaches. miRNAs are negative regulators of gene expression. Currently, most effort has been made to elucidate the function of individual miRNAs. However, the ability of multiple miRNAs to potentate their impact by acting in a combinatorial mode, engenders a novel way of thinking. Using the example of miR-15a/16 and miR 34a, the present work investigates the combinatorial role of functionally related miRNAs in the tumourigenesis of NSCLC. In conclusion, the results of the present thesis indicate that miR-15a/16 and miR-34a are synergistically implicated in cell cycle control and likely contribute collectively to the tumourigenesis of NSCLC. Since miR-34a and miR-15/16 are frequently down-regulated in the same tumour tissue, these findings may have important therapeutic implications for microRNA-based treatment of NSCLC.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 120 pp. Englisch.…