Isbn: 9783846582237 - development of in situ gel system for ocular drug delivery: physiologically active mucoadhesive sol to gel system (4 Ergebnisse)

Taschenbuch. Zustand: Neu. Development of in situ gel system for ocular drug delivery | Physiologically active mucoadhesive sol to gel system | Himanshu Gupta | Taschenbuch | 128 S. | Englisch | 2012 | LAP LAMBERT Academic Publishing | EAN 9783846582237 | Verantwortliche Person für die EU: BoD - Books on Demand, In de Tarpen 42, 22848 Norderstedt, info[at]bod[dot]de | Anbieter: preigu. …

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In situ gel-forming systems have drawn much attention of current researchers to overcome the poor bioavailability from the conventional eye drops. The present work described formulation and pharmacoscintigraphic evaluation of timolol-maleate-loaded chitosan/hydroxy propyl methyl cellulose(HPMC)-based polymer matrix for enhanced ocular retention. Chitosan and HPMC ratio was optimized and formulation was characterized for various in vitro parameters. The ocular retention was studied on New Zealand rabbits by gamma scintigraphy, which is a very simple and noninvasive technique. For scintigraphy study, the drug timolol maleate was radiolabeled 99mTc by direct labeling method. The labeling procedure was optimized to get maximum labeling efficiency(98%). Plain drug eliminates rapidly as significant activity was recorded in kidney and bladder after 2 h of ocular administration. It was evident from the scintigraphic images and the time activity curve plotted from the data that the plain drug solution cleared very rapidly than developed in situ gel formulation.Developed formulation cleared at a slow rate and remained at corneal surface for longer time duration proving its efficacy. 128 pp. Englisch.…

Zustand: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Gupta HimanshuHimanshu Gupta had completed his D.Pharm, B.Pharm, M.Pharm, PGDIB, PhD, Post Doc (USA). He is working on ocular drug delivery systems, biomaterials, nuclear medicines and gamma scintigraphic techniques. He published his.…

Taschenbuch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -In situ gel-forming systems have drawn much attention of current researchers to overcome the poor bioavailability from the conventional eye drops. The present work described formulation and pharmacoscintigraphic evaluation of timolol-maleate-loaded chitosan/hydroxy propyl methyl cellulose(HPMC)-based polymer matrix for enhanced ocular retention. Chitosan and HPMC ratio was optimized and formulation was characterized for various in vitro parameters. The ocular retention was studied on New Zealand rabbits by gamma scintigraphy, which is a very simple and noninvasive technique. For scintigraphy study, the drug timolol maleate was radiolabeled 99mTc by direct labeling method. The labeling procedure was optimized to get maximum labeling efficiency(VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 128 pp. Englisch.…