9786139928507 - synthesis of new naproxen derivatives: synthesis, characterization and preliminary pharmacological evaluation of naproxen containing pyrazoline derivatives von muneer, noor; f. mahdi, monther; mohammed rasheed, ayad (5 Ergebnisse)
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Taschenbuch. Zustand: Neu. Synthesis of New Naproxen Derivatives | Synthesis, Characterization and Preliminary Pharmacological Evaluation of Naproxen Containing Pyrazoline Derivatives | Noor Muneer (u. a.) | Taschenbuch | 172 S. | Englisch | 2018 | LAP LAMBERT Academic Publishing | EAN 9786139928507 | Verantwortliche Person für…die EU: BoD - Books on Demand, In de Tarpen 42, 22848 Norderstedt, info[at]bod[dot]de | Anbieter: preigu.
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Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Non-steroidal anti-inflammatory drugs (NSAIDs) are the competitive inhibitors of cyclooxygenase (COX), the enzyme which mediates the bioconversion of arachidonic acid to inflammatory prostaglandins. Their use is associated with the si…de effects such as gastrointestinal problems. The therapeutic anti-inflammatory action of NSAIDs is produced by the inhibition of COX-2, while the undesired side effects arise from inhibition of COX-1 activity. Thus, it was thought that selective COX-2 inhibitors would have reduced side effects.Therefore, pyrazoline ring derivatives as a pharmacophore were incorporated to the naproxen; to increase its size were synthesized and preliminarly evaluated as potential anti-inflammatory agents with expected selectivity toward COX-2 enzyme.Synthesis of the target compounds (Va-f) has been successfully achieved. Purity, characterization, and identification of the synthesized compounds were detected by determination of physical properties (melting points & Rf values), Fourier transform infrared spectroscopy (FT-IR) and 1H-Nuclear magnetic resonance (1H-NMR) spectroscopy. 172 pp. Englisch.
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Zustand: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Muneer NoorNoor Muneer, pharmacist, graduated from Baghdad College of Pharmacy 2009, joined post graduate study in 2013 in pharmaceutical chemistry department in Almustansiriya university college of pharm…acy and graduated with an M.S.
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Taschenbuch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Non-steroidal anti-inflammatory drugs (NSAIDs) are the competitive inhibitors of cyclooxygenase (COX), the enzyme which mediates the bioconversion of arachidonic acid to inflammatory prostaglandins. Their use is associated with the side e…ffects such as gastrointestinal problems. The therapeutic anti-inflammatory action of NSAIDs is produced by the inhibition of COX-2, while the undesired side effects arise from inhibition of COX-1 activity. Thus, it was thought that selective COX-2 inhibitors would have reduced side effects.Therefore, pyrazoline ring derivatives as a pharmacophore were incorporated to the naproxen; to increase its size were synthesized and preliminarly evaluated as potential anti-inflammatory agents with expected selectivity toward COX-2 enzyme.Synthesis of the target compounds (Va-f) has been successfully achieved. Purity, characterization, and identification of the synthesized compounds were detected by determination of physical properties (melting points & Rf values), Fourier transform infrared spectroscopy (FT-IR) and 1H-Nuclear magnetic resonance (1H-NMR) spectroscopy.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 172 pp. Englisch.
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Taschenbuch. Zustand: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Non-steroidal anti-inflammatory drugs (NSAIDs) are the competitive inhibitors of cyclooxygenase (COX), the enzyme which mediates the bioconversion of arachidonic acid to inflammatory prostaglandins. Their use is associated with the side ef…fects such as gastrointestinal problems. The therapeutic anti-inflammatory action of NSAIDs is produced by the inhibition of COX-2, while the undesired side effects arise from inhibition of COX-1 activity. Thus, it was thought that selective COX-2 inhibitors would have reduced side effects.Therefore, pyrazoline ring derivatives as a pharmacophore were incorporated to the naproxen; to increase its size were synthesized and preliminarly evaluated as potential anti-inflammatory agents with expected selectivity toward COX-2 enzyme.Synthesis of the target compounds (Va-f) has been successfully achieved. Purity, characterization, and identification of the synthesized compounds were detected by determination of physical properties (melting points & Rf values), Fourier transform infrared spectroscopy (FT-IR) and 1H-Nuclear magnetic resonance (1H-NMR) spectroscopy.
