Deformable microparticles multiple functionsfor von thula taili (2 Ergebnisse)

Kartoniert / Broschiert. Zustand: New. Since the HIV epidemic of the 1990s, researchers nhave attempted to develop a red blood cell analog. nEven though some of these substitutes are now in nPhase III of clinical trials, their use is limited nby side effects and short half-life in the human nbo.

Taschenbuch. Zustand: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Since the HIV epidemic of the 1990s, researchershave attempted to develop a red blood cell analog.Even though some of these substitutes are now inPhase III of clinical trials, their use is limitedby side effects and short half-life in the humanbody. As a result, there is still a need for aneffective erythrocyte analog with minimumimmunogenic and side effects, so that it can be usedfor multiple applications. Finding new approachesto develop more efficient blood substitutes will notonly bring valuable advances in the clinicalapproach, but also in the area of in vitro testingof medical devices.This work examined the feasibility of creating adeformable multi-functional, biodegradablebiocompatible particle for applications in drugdelivery and device testing. As a preliminaryevaluation, different types of microcapsules weresynthesized using natural and synthetic polymersvarious cross-linking agents, and diversemanufacturing techniques. After fullycharacterizing of each system, the most promisingred blood cell analog in terms of deformabilitystability and toxicity was determined.…