Fas signaling (36 Ergebnisse)

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Taschenbuch. Zustand: Neu. Fas Ligand reverse signaling: an immunmodulatory setscrew | Insights gained from 'knockout/knockin' mice that express a functional Fas Ligand molecule lacking the intracellular domain | Katharina Lückerath | Taschenbuch | 144 S. | Englisch | 2015 | Südwestdeutscher Verlag für Hochschulschriften | EAN 9783838124872 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.…

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Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Fas Signaling is focused on the signaling mechanisms and biology of the prototypic death receptor Fas, also called CD95 or APO-1. The chapters of this book cover, besides the well recognized apoptosis-related functions of Fas, its emerging role as a proinflammatory cytokine and as an inducer of alternative forms of cell death. Fas Signaling aims to provide the reader with an up-to-date survey of the various aspects of Fas biology and the open questions of the field are addressed. This title is intended for Ph.D and post-doctoral students starting to work in the field, but is also useful for everyone with an interest in the biology of this exciting molecule. …

Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Fas Signaling is focused on the signaling mechanisms and biology of the prototypic death receptor Fas, also called CD95 or APO-1. The chapters of this book cover, besides the well recognized apoptosis-related functions of Fas, its emerging role as a proinflammatory cytokine and as an inducer of alternative forms of cell death. Fas Signaling aims to provide the reader with an up-to-date survey of the various aspects of Fas biology and the open questions of the field are addressed. This title is intended for Ph.D and post-doctoral students starting to work in the field, but is also useful for everyone with an interest in the biology of this exciting molecule.…

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Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Binding of Fas Ligand (FasL) to the Fas receptor triggers apoptosis of the receptor-bearing cell, which plays a pivotal role for homeostasis of the immune system and during acute immune responses. Similar to other TNF family members, the intracellular FasL domain is able to transmit signals into the FasL-bearing cell ('reverse signaling'). Recently, we have described a Notch-like proteolytic processing of FasL by the proteases ADAM10 and SPPL2a, which leads to the release of the intracellular domain (FICD) into the cytoplasm. Following the cleavage event, FICD translocates to the nucleus and influences gene transcription. To study the physiological importance of FasL reverse signaling in vivo on the level of the endogenous proteins, we have established a knockout/knockin mouse model in which wildtype FasL was replaced with a deletion mutant lacking the intracellular portion (FasL Intra). Our ex vivo and in vivo findings demonstrate that FasL reverse signaling is a negative modulator of certain immune responses. It is tempting to speculate that FasL reverse signaling might be a fine-tuning mechanism to prevent autoimmune diseases. 144 pp. Englisch.…

Zustand: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Lueckerath KatharinaKatharina Lueckerath studied biology at the UniversityBonn-Rhein-Sieg and the University of Aberdeen (UK) and graduatedin 2006 in Biomedical sciences. She obtained her PhD in 2010 fromthe Georg-Speyer-Haus (Frankfur.…

Taschenbuch. Zustand: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Binding of Fas Ligand (FasL) to the Fas receptor triggers apoptosis of the receptor-bearing cell, which plays a pivotal role for homeostasis of the immune system and during acute immune responses. Similar to other TNF family members, the intracellular FasL domain is able to transmit signals into the FasL-bearing cell ('reverse signaling'). Recently, we have described a Notch-like proteolytic processing of FasL by the proteases ADAM10 and SPPL2a, which leads to the release of the intracellular domain (FICD) into the cytoplasm. Following the cleavage event, FICD translocates to the nucleus and influences gene transcription. To study the physiological importance of FasL reverse signaling in vivo on the level of the endogenous proteins, we have established a knockout/knockin mouse model in which wildtype FasL was replaced with a deletion mutant lacking the intracellular portion (FasL Intra). Our ex vivo and in vivo findings demonstrate that FasL reverse signaling is a negative modulator of certain immune responses. It is tempting to speculate that FasL reverse signaling might be a fine-tuning mechanism to prevent autoimmune diseases.…

Taschenbuch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Binding of Fas Ligand (FasL) to the Fas receptor triggers apoptosis of the receptor-bearing cell, which plays a pivotal role for homeostasis of the immune system and during acute immune responses. Similar to other TNF family members, the intracellular FasL domain is able to transmit signals into the FasL-bearing cell ('reverse signaling'). Recently, we have described a Notch-like proteolytic processing of FasL by the proteases ADAM10 and SPPL2a, which leads to the release of the intracellular domain (FICD) into the cytoplasm. Following the cleavage event, FICD translocates to the nucleus and influences gene transcription. To study the physiological importance of FasL reverse signaling in vivo on the level of the endogenous proteins, we have established a knockout/knockin mouse model in which wildtype FasL was replaced with a deletion mutant lacking the intracellular portion (FasL¿Intra). Our ex vivo and in vivo findings demonstrate that FasL reverse signaling is a negative modulator of certain immune responses. It is tempting to speculate that FasL reverse signaling might be a fine-tuning mechanism to prevent autoimmune diseases.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 144 pp. Englisch.…

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Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Fas Signaling is focused on the signaling mechanisms and biology of the prototypic death receptor Fas, also called CD95 or APO-1. The chapters of this book cover, besides the well recognized apoptosis-related functions of Fas, its emerging role as a proinflammatory cytokine and as an inducer of alternative forms of cell death. Fas Signaling aims to provide the reader with an up-to-date survey of the various aspects of Fas biology and the open questions of the field are addressed. This title is intended for Ph.D and post-doctoral students starting to work in the field, but is also useful for everyone with an interest in the biology of this exciting molecule. 172 pp. Englisch.…

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Fas Signaling is focused on the signaling mechanisms and biology of the prototypic death receptor Fas, also called CD95 or APO-1. The chapters of this book cover, besides the well recognized apoptosis-related functions of Fas, its emerging role as a proinflammatory cytokine and as an inducer of alternative forms of cell death. Fas Signaling aims to provide the reader with an up-to-date survey of the various aspects of Fas biology and the open questions of the field are addressed. This title is intended for Ph.D and post-doctoral students starting to work in the field, but is also useful for everyone with an interest in the biology of this exciting molecule. 172 pp. Englisch.…