High throughput screening chemical (12 Ergebnisse)

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Taschenbuch. Zustand: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Please note that the content of this book primarily consists of articlesavailable from Wikipedia or other free sources online. Drug discoverydepends on methods by which many different chemicals are assayed fortheir activity. These chemicals are stored as physical quantities in achemical library or libraries which are often assembled from bothoutside vendors and internal chemical synthesis efforts. These chemicallibraries are used in high-throughput screening in the drug discoveryhit to lead process.…

Taschenbuch. Zustand: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Please note that the content of this book primarily consists of articlesavailable from Wikipedia or other free sources online. DNA EncodedChemical Libraries are a new technology for the synthesis and screeningof collections of chemical compounds of unprecedented size and quality.DEL represents an advance in medicinal chemistry which bridges thefields of combinatorial chemistry and molecular biology. The drivingforce for the development of DEL technology is to improve and streamlinethe drug discovery process in particular early phase discoveryactivities such as target validation and hit discovery. DEL technologyinvolves the conjugation of chemical compounds or building blocks toshort DNA fragments that serve as identification bar codes and in somecases also direct and control the chemical synthesis. The technique, inprinciple, enables the mass creation and interrogation of libraries viaaffinity selection, typically on an immobilized protein target.…

Taschenbuch. Zustand: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Please note that the content of this book primarily consists of articlesavailable from Wikipedia or other free sources online. A lead compound(i.e. the 'leading' compound, not lead metal) in drug discovery is achemical compound that has pharmacological or biological activity andwhose chemical structure is used as a starting point for chemicalmodifications in order to improve potency, selectivity, orpharmacokinetic parameters. Lead compounds are often found inhigh-throughput screenings ('hits') or are secondary metabolites fromnatural sources. Newly invented pharmacologically active moieties mayhave poor druglikeness and may require chemical modification to becomedrug-like enough to be tested biologically or clinically.…