Molecular diagnostics key personalized (12 Ergebnisse)

Hardcover. Zustand: Very Good. 1st Edition. Hardcover, x + 351 pages, NOT ex-library. Book is clean and bright with unmarked text, free of inscriptions and stamps, firmly bound. External shelfwear; short creases to the lower outer corner of the front board. Issued without a dust jacket. -- The book provides a technical and strategic overview of the role of diagnostic testing in the era of targeted oncology. This edited volume addresses the fundamental shift from broad-spectrum chemotherapy toward stratified treatment regimes based on the specific molecular profile of a patient's tumour. It frames molecular diagnostics - referred to throughout as "pharmacodiagnostics" - as the central mechanism for the implementation of precision medicine, ensuring that the right drug is delivered to the right patient at the right time. The volume details a wide range of analytical methodologies used to identify predictive and prognostic biomarkers. Technical chapters explore established techniques such as immunohistochemistry (IHC) and fluorescence in situ hybridisation (FISH), alongside technologies like DNA microarrays and high-throughput genomic platforms. A significant portion of the work is dedicated to the concept of companion diagnostics (CDx), illustrating the co-development process where a drug and its associated test are brought through clinical trials and regulatory approval simultaneously. Specific emphasis is placed on the co-development of trastuzumab and the HercepTest for HER2 testing in breast cancer as the foundational model for this approach. Other case studies, such as estrogen and progesterone receptors and EGFR mutations in lung cancer, demonstrate the practical application of these protocols. Beyond the laboratory, the analysis extends to the regulatory and economic challenges of personalised medicine. It examines the criteria used by agencies such as the FDA and EMA for the validation of biomarkers and the integration of diagnostic data into clinical decision-making. In a contemporary context, the book remains a vital foundational resource for understanding the origins of modern oncology and the technical basis for the targeted therapies and immunotherapy protocols that define current cancer care. Areas of interest: precision oncology, companion diagnostics, pharmacodiagnostics, biomarker validation, targeted therapy.…

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Zustand: New. Brand New! Fast Delivery This is an International Edition and ship within 24-48 hours. Deliver by FedEx and Dhl, & Aramex, UPS, & USPS and we do accept APO and PO BOX Addresses. Order can be delivered worldwide within 6-10 days and we do have flat rate for up to 2LB. Extra shipping charges will be requested if the Book weight is more than 5 LB. This Item May be shipped from India, United states & United Kingdom. Depending on your location and availability.…

N.A. Zustand: New. ISBN:9789814241441.