Poorly soluble drugs dissolution (20 Ergebnisse)

Taschenbuch. Zustand: Neu. Liquisolid Compacts of Amlodipine Besylate | The technique of enhancement of dissolution of poorly soluble drugs | Manpreet Kaur | Taschenbuch | Einband - flex.(Paperback) | Englisch | 2013 | LAP Lambert Academic Publishing | EAN 9783659336485 | Verantwortliche Person für die EU: OmniScriptum GmbH & Co. KG, Bahnhofstr. 28, 66111 Saarbrücken, info[at]akademikerverlag[dot]de | Anbieter: preigu.…

Taschenbuch. Zustand: Neu. Dissolution Enhancement Using Different Formulation Approaches | Dissolution Enhancement of a Poorly Soluble Model Drugs Using Different Formulation Approaches for Immediate Release | Vikas Kumar Srivastava (u. a.) | Taschenbuch | 144 S. | Englisch | 2013 | LAP LAMBERT Academic Publishing | EAN 9783659453359 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.…

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Taschenbuch. Zustand: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Amlodipine is a long-acting calcium channel blocker used as an antihypertensive and in the treatment of angina pectoris. Like other calcium channel blockers, amlodipine acts by relaxing the smooth muscle in the arterial wall, decreasing total peripheral resistance and hence reducing blood pressure; in angina, it increases blood flow to the heart muscle. It has poor water solubility, thus exhibiting the problem of variable bioavailability. With Liquisolid technique liquid formulations such as solutions or suspensions of poorly soluble drugs in a non-volatile liquid vehicle are converted into acceptably flowing and compressible powders by simple physical blending with selected excipients named the carrier and the coating material. Liquisolid compacts of poorly water soluble drug Amlodipine Besylate were prepared to enhance its dissolution rate and bioavailability. Liquisolid tablets were prepared using Propylene Glycol (PG) as a non-volatile organic solvent with Avicel PH-101 as carrier and Aerosil as coating material.…

Taschenbuch. Zustand: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The objective of this study was to design Bilayered tablets (SNFML) and to enhance the in vitro release rates. Several techniques were compared for improving the dissolution of model drugs SNFML, poorly soluble drugs. Particle size reduction was realized by jet milling (Micronization of SNML), use of solubility enhancers in the formulation like Klucel-Lf and sodium lauryl sulphate with reduction of surface energy by co-sifting, SNML with lactose showed the immediate release profile when compared with the unmicronized drug. Micronization of SNML enhanced its dissolution rate in Discriminative media (8.2% in 30 min) compared to unmicronized drug (1.3% in 30 min). SNML drug products commercially available on the German, French and Indian markets dissolved similarly to unmicronized SNML, but significantly slower than the micronized drug. The results suggest that Micronization, use of solubility enhancers and reduction of surface energy by co-sifting are powerful ways for the preparation of immediate release formulations of SNFML, and could potentially lead to improvements in the bioavailability of oral SNFML products.…

Buch. Zustand: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - This book is the first text to provide a comprehensive assessment of the application of fundamental principles of dissolution and drug release testing to poorly soluble compounds and formulations. Such drug products are, vis-à-vis their physical and chemical properties, inherently incompatible with aqueous dissolution. However, dissolution methods are required for product development and selection, as well as for the fulfillment of regulatory obligations with respect to biopharmaceutical assessment and product quality understanding. The percentage of poorly soluble drugs, defined in classes 2 and 4 of the Biopharmaceutics Classification System (BCS), has significantly increased in the modern pharmaceutical development pipeline. This book provides a thorough exposition of general method development strategies for such drugs, including instrumentation and media selection, the use of compendial and non-compendial techniques in product development, and phase-appropriate approaches to dissolution development. Emerging topics in the field of dissolution are also discussed, including biorelevant and biphasic dissolution, the use on enzymes in dissolution testing, dissolution of suspensions, and drug release of non-oral products. Of particular interest to the industrial pharmaceutical professional, a brief overview of the formulation and solubilization techniques employed in the development of BCS class 2 and 4 drugs to overcome solubility challenges is provided and is complemented by a collection of chapters that survey the approaches and considerations in developing dissolution methodologies for enabling drug delivery technologies, including nanosuspensions, lipid-based formulations, and stabilized amorphous drug formulations.…