Structural virology (26 Ergebnisse)
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Hardback. Zustand: New. Over the last ten years, much effort has been devoted to improving the biophysical techniques used in the study of viruses. This has resulted in the visualization of these large macromolecular assemblages at atomic level, thus providing the platform for functional interpretation and therapeutic design. St…ructural Virology covers a wide range of topics and is split into three sections. The first discusses the vast biophysical methodologies used in structural virology, including sample production and purification, confocal microscopy, mass spectrometry, negative-stain and cryo-electron microscopy, X-ray crystallography and nuclear magnetic resonance spectroscopy. The second discusses the role of virus capsid protein structures in determining the functional roles required for receptor recognition, cellular entry, capsid assembly, genome packaging and mechanisms of host immune system evasion. The last section discusses therapeutic strategies based on virus protein structures, including the design of antiviral drugs and the development of viral capsids as vehicles for foreign gene delivery. Each topic covered will begin with a review of the current literature followed by a more detailed discussion of experimental procedures, a step in the viral life cycle, or strategies for therapeutic development. With contributions from experts in the field of structural biology and virology this exceptional monograph will appeal to biomedical scientists involved in basic and /or applied research on viruses. It also provides up-to-date reference material for students entering the field of structural virology as well as scientists already familiar with the area.
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Hardback. Zustand: New. Over the last ten years, much effort has been devoted to improving the biophysical techniques used in the study of viruses. This has resulted in the visualization of these large macromolecular assemblages at atomic level, thus providing the platform for functional interpretation and therapeutic design. St…ructural Virology covers a wide range of topics and is split into three sections. The first discusses the vast biophysical methodologies used in structural virology, including sample production and purification, confocal microscopy, mass spectrometry, negative-stain and cryo-electron microscopy, X-ray crystallography and nuclear magnetic resonance spectroscopy. The second discusses the role of virus capsid protein structures in determining the functional roles required for receptor recognition, cellular entry, capsid assembly, genome packaging and mechanisms of host immune system evasion. The last section discusses therapeutic strategies based on virus protein structures, including the design of antiviral drugs and the development of viral capsids as vehicles for foreign gene delivery. Each topic covered will begin with a review of the current literature followed by a more detailed discussion of experimental procedures, a step in the viral life cycle, or strategies for therapeutic development. With contributions from experts in the field of structural biology and virology this exceptional monograph will appeal to biomedical scientists involved in basic and /or applied research on viruses. It also provides up-to-date reference material for students entering the field of structural virology as well as scientists already familiar with the area.
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Gebunden. Zustand: New. This exceptional monograph, by experts in structural biology and virology, is for biomedical scientists involved in basic and applied research.Über den AutorrnrnMavis Agbandje-McKenna is currently Director of the Center for Structural B.
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Zustand: gut. 2010. Structural Virology (Rsc Biomolecular Sciences, 21) In englischer Sprache. pages.
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Buch. Zustand: Neu. Neuware - Over the last ten years, much effort has been devoted to improving the biophysical techniques used in the study of viruses. This has resulted in the visualization of these large macromolecular assemblages at atomic level, thus providing the platform for functional interpretation and therapeutic desi…gn. Structural Virology covers a wide range of topics and is split into three sections. The first discusses the vast biophysical methodologies used in structural virology, including sample production and purification, confocal microscopy, mass spectrometry, negative-stain and cryo-electron microscopy, X-ray crystallography and nuclear magnetic resonance spectroscopy. The second discusses the role of virus capsid protein structures in determining the functional roles required for receptor recognition, cellular entry, capsid assembly, genome packaging and mechanisms of host immune system evasion. The last section discusses therapeutic strategies based on virus protein structures, including the design of antiviral drugs and the development of viral capsids as vehicles for foreign gene delivery. Each topic covered will begin with a review of the current literature followed by a more detailed discussion of experimental procedures, a step in the viral life cycle, or strategies for therapeutic development. With contributions from experts in the field of structural biology and virology this exceptional monograph will appeal to biomedical scientists involved in basic and /or applied research on viruses. It also provides up-to-date reference material for students entering the field of structural virology as well as scientists already familiar with the area.
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Hardcover. Zustand: gut. 1989. Never has so much progress been reported in immunology as at this congress. The full impact of new technologies, developed since the late 1970s, has come to fruition: gene isolation, mutation, transfection and expression, protein structure and peptide synthesis, cell cloning, hybridization and mono…clonal antibodies, CD serology, SCID and transgenic mice, modern immunomudulation and vaccines. An overwhelming mass of data has accumulated over the last years. The reports are up-to-date and outstanding, to a degree no journal will ever achieve, and the results are presented in a concise and lucid way. This report will serve as a guideline for generations of immunologists to come. Hundreds of new alleys have been opened, an abundance of research tools and goals are pointed to. This volume is a treasure trove of explorations ahead of our time - it is exciting reading. This progress report presents outstanding contributions, worth many prizes - a feature which is unusual for proceedings volumes. Immunology is exhibited at its best: an exciting research area and a rewarding subject to study for the benefit of mankind - today more than ever! Detailangaben zum Buch - Progress in Immunology: Vol. VII: Proceedings of the 7th International Congress Immunology Berlin 1989 (Progress in Immunology: International Congress Proceedings) EAN (ISBN-13): 9783540510536 ISBN (ISBN-10): 3540510532 Gebundene Ausgabe Erscheinungsjahr: 1989 erausgeber: Melchers, Fritz, Albert, E.D. Boehmer, H. v. Dierich, M.P. Du Pasquier, L. Eichmann, K. Gemsa, D. Götze, O. Kalden, J.R. Kaufmann, S.H.E. Kirchner, H. Resch, K. Riethmüller, G. Schimpl, A. Sorg, C. Steinmetz, M. Wagner, H. Zachau, H.G. Springer ISBN/EAN: 3540510532 ISBN: 3-540-51053-2, 978-3-540-51053-6 Autor des Buches: melchers, springer fritz, harald böhmer, riethmüller, wagner fritz, zachau, albert kaufmann, steinmetz fritz, boehmer, kirchner fritz, eichmann Titel des Buches: melchers, vii, berlin, immunology, congress proceedings Autor/in: Fritz Melchers; E.D. Albert; H. v. Boehmer; M.P. Dierich; L. Du Pasquier; K. Eichmann; D. Gemsa; O. Götze; J.R. Kalden; S.H.E. Kaufmann; H. Kirchner; K. Resch; G. Riethmüller; A. Schimpl; C. Sorg; M. Steinmetz; H. Wagner; H.G. Zachau Titel: Progress in Immunology - Vol. VII: Proceedings of the 7th International Congress Immunology Berlin 1989 Verlag: Springer; Springer Berlin 1318 Seiten Erscheinungsjahr: 1989 Berlin; Heidelberg; DE Gewicht: 1,870 kg Sprache: Englisch Medizin/Klinische Fächer; Medizin: Allergien; Verstehen; Antigen; Virologie (AIDS); Onkologie; Immuntherapie; Immunologie; transplantation; infections; Autoimmune Krankheiten; hybridization; Impfung; Medicine; C; Allergology; Immunology; Human Genetics; Biochemistry, general; Medical Microbiology; Virology; Immunologie; Genetik, Medizin; Biochemie; Mikrobiologie und Virologie; Mikrobiologie und Virologie I Structure and Function of Recognition and Effector Molecules.- The T Cell Receptor Complex.- T Cell Receptors.- Positive and Negative Selection of T Cells: A Transgenic Model.- Selection of an ?? T Cell Antigen Receptor In Vivo and Engineering a Solulizable Form.- Mice Transgenic for the T Cell Receptor C?4 Gene are Altered in T Cell Development.- Lymphocytes Bearing Either ??-TCR or ??-TCR Can Recognize Non-MHC Encoded CD1 Molecules.- Assembly of the T Cell Receptor/CD3 Complex.- MHC and Antigen Presentation.- Structural and Functional Analysis of Human Class I and Class II Major Histocompatibility Complex Proteins, with Special Emphasis on Alloreactivity.- Further Analysis of the Role of MHC Molecules in Antigen Presentation.- Studies on the Nature of Physiologically Processed Antigen.- Role of MHC Polymorphism in Autoimmune Disease.- Complex Regulation of MHC Class I Expression: Constitutive and Modulated Patterns of Expression.- Somatic Changes of Ig and T Cell Receptor Genes.- Organization and Reorganization of Antigen Receptor Genes.- The Human Immunoglobulin Kappa Genes.- Somatic Changes in the Immune Response to the Hapten 2-Phenyl Oxazolone.- The Lymphoid V (D) J Recombination Activity: Studies of Exogenous Plasmid Substrates in Whole Cells.- Early Expression of Ig-Related Genes in the Human B-Cell Lineage.- Cell Interaction Molecules.- Adhesion Receptors Regulate Antigen-Specific Interactions, Localization, and Differentiation in the Immune System.- From Marker Antigens for T Lymphocyte Subsets to Molecules that Regulate Cell Activation.- The T-Cell Antigen Receptor and CD2 in Rat T-Cell Activation and Ontogeny.- Tolerance Induction Using CD4 and CD8 Monoclonal Antibodies.- A Lymphocyte Homing Receptor: A Member of an Emerging Class of Cell Adhesion Molecules.- Complement.- to the Symposium on Complement.- The Regulators of Complement Activation (RCA) Gene Cluster.- Host Cell Protection from Complement by Glycosylphosphatidylinositol- Anchored Complement Inhibitors and Their Deficiencies in Paroxysmal Nocturnal Hemoglobinuria.- Inflammation-Promoting Complement Fragments.- Evasion Strategies of Microorganisms.- Production of Complement Component C3 by Lymphoid Cell Lines: Possible Function of C3 Fragments as Autocrine Growth Regulators.- Protein Phosphorylation as a Mechanism of Resistance Against Complement Damage.- The Mosaic Nature of the Complement Proteins.- II Cell Developments.- Development of T Cells.- 1. Phylogeny, Stem Cells, Lineages.- The Role of the Thymus in the Development of T-Cells.- Ontogeny of T Cells and a Third Lymphocyte Lineage in the Chicken.- Analysis of Hematopoietic Stem Cell Development In Vivo.- Utilization of a Bone Marrow Suspension Culture System for the Analysis and Manipulation of T-Cell Development.- Diversity, Development, Ligands and Probable Functions of ??T Cells.- Thymic Epithelial Cells Induce In Vitro Differentiation of PRO-T Lymphocyte Clones into TCR ?, ?/CD3+ and TCR ?,?/CD3+ Cells.- Expression of T Cell Receptor Associated Proteins During Human T Cell Development.- 2. Repertoire Selection.- Selection of th.
Sprache: Englisch
Verlag: Royal Society of Chemistry, 2010
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In den WarenkorbN.A. Zustand: New. ISBN:9780854041718.
