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  • C. Bradley Hager, James A. Jackson, Ames Company, Ames Technical Services Laboratory

    Verlag: Indiana: Ames Company, 1975, 1975

    Anbieter: Books on the Web, Winnipeg, MB, Kanada

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    Paper bound, blue wrappers, illustrated, Pp41. Tight and unmarked - a very good or better copy. 100 grams. Scarce. We welcome all reasonable offers on our books and also offer local curbside pick-up. All books in stock and available for immediate shipment from Winnipeg, Manitoba.

  • Werhun, Alex

    Sprache: Englisch

    Verlag: Scholars' Press, 2015

    ISBN 10: 363985957X ISBN 13: 9783639859577

    Anbieter: Books Puddle, New York, NY, USA

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  • Sprache: Englisch

    Verlag: Springer, 2012

    ISBN 10: 1461425751 ISBN 13: 9781461425755

    Anbieter: Books Puddle, New York, NY, USA

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    Zustand: New. pp. 306.

  • Werhun, Alex

    Sprache: Englisch

    Verlag: Scholars* Press, 2015

    ISBN 10: 363985957X ISBN 13: 9783639859577

    Anbieter: Mispah books, Redhill, SURRE, Vereinigtes Königreich

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    paperback. Zustand: Like New. LIKE NEW. SHIPS FROM MULTIPLE LOCATIONS. book.

  • Brent, Gregory A. (Edited by)

    Sprache: Englisch

    Verlag: Springer, 2012

    ISBN 10: 1461425751 ISBN 13: 9781461425755

    Anbieter: Revaluation Books, Exeter, Vereinigtes Königreich

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    Paperback. Zustand: Brand New. 402 pages. 9.25x6.10x0.69 inches. In Stock.

  • Bild des Verkäufers für Thyroid Function Testing zum Verkauf von preigu

    Gregory A. Brent

    Sprache: Englisch

    Verlag: Springer, 2012

    ISBN 10: 1461425751 ISBN 13: 9781461425755

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    Taschenbuch. Zustand: Neu. Thyroid Function Testing | Gregory A. Brent | Taschenbuch | Endocrine Updates | x | Englisch | 2012 | Springer | EAN 9781461425755 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu.

  • Gregory A. Brent

    Sprache: Englisch

    Verlag: Springer US, Springer US, 2012

    ISBN 10: 1461425751 ISBN 13: 9781461425755

    Anbieter: AHA-BUCH GmbH, Einbeck, Deutschland

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    Taschenbuch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Thyroid function tests are utilized by essentially all medical practitioners, across every clinical setting, in patients from newborns to the elderly. They are the most frequently measured endocrine tests. The sensitive thyrotropin (TSH) assay reflects thyroid hormone feedback to the pituitary, and is diagnostic of both thyroid h- mone excess as well as deficiency. The log-linear relationship between serum TSH and thyroxine concentrations means that small changes in serum thyroxine are amplified by changes in serum TSH. The availability of the sensitive TSH assay in essentially all clinical laboratories has improved and simplified the assessment of thyroid function for the diagnosis of thyroid disease and to monitor treatment. Serum free thyroxine and thyrotropin concentrations, as well as other thyroid tests, can be measured utilizing an automated immunoassay platform that provides rapid and accurate results. This simplified approach to thyroid assessment, often requ- ing only a serum TSH measurement, and rapid availability of the thyroid function tests results, has expanded the scope of thyroid testing and clinicians ordering and interpretingth yroid tests. There remain, however, many challenges in selecting the appropriate thyroid function test to order, the correct interpretation of results, and applying these results to the diagnosis and management of thyroid diseases. It is especially important to be aware of limitations of thyroid function tests, as well as special clinical c- cumstances that can influence thyroid function measurements. The serum TSH concentration, for example, may not accurately reflect thyroid status in many si- ations including after prolonged hyperthyroidism when serum TSH remains s- pressed for months, in the presence of hypothalamic orpituitary disease, or due to a number of interfering medications. The serum free thyroxine, measured by the analog method, is not accurate with high or low serum binding proteins and d- ing pregnancy. Hospitalized patients often have thyroid function test abnormalities that are transient and return to normal after recovery from the acute illness. Iodine excessand deficiency candramatically influence thyroid function tests. Significant insights have been gained into the regulation of thyroid hormone synthesis and especially the role of thyroid hormone metabolism in supplying t- sues locally with an adequate supply of thyroid hormone. In a number of instances, these factors influence the selection and interpretation of thyroid function tests. Polymorphisms, common sequence variations, in genes of components that regulate thyroid function and thyroid hormone action may also contribute to variability in thyroid function tests in a population. v vi Preface This volume draws on an outstanding international panel of experts in thyroid function tests and thyroid function assessment. They represent clinicians, clinical researchers, and basic science researchers, all with a focus on some aspect of the assessment of thyroid function. The chapters all provide a clinical perspective, but are informed by themost recent scientific advancements. The first section of the book (Chaps. 1-3) presents the most recent advances in thyroid physiology, a review of genetic influences on thyroid function tests, and a discussion on the influence of iodine on thyroid function. In Chap. 1, Drs. Huang and de Castro Neves describe thyroid hormone metabolism, emphasizing the key role of thyroid hormone activation and inactivation in thyroid hormone action. Dr. Visser is a world leader in studies ofthyroid metabolism and genetic influences on thyroid function. In Chap. 2, Dr. Visser and his colleagues, Drs. van der Deure, Medici, and Peeters, provide a clear view of this important and r- idly expanding field. The population variation in the TSH 'set point' (relationship between serum TSH and thyroxine in an individual), for example, is thought to b.

  • Buch 3 von 20: Endocrine Updates

    Unbekannt

    Sprache: Englisch

    Verlag: Springer US, 2010

    ISBN 10: 1441914846 ISBN 13: 9781441914842

    Anbieter: Buchpark, Trebbin, Deutschland

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    Zustand: Gut. Zustand: Gut | Seiten: 304 | Sprache: Englisch | Produktart: Bücher | Thyroid function tests are utilized by essentially all medical practitioners, across every clinical setting, in patients from newborns to the elderly. They are the most frequently measured endocrine tests. The sensitive thyrotropin (TSH) assay reflects thyroid hormone feedback to the pituitary, and is diagnostic of both thyroid h- mone excess as well as deficiency. The log¿linear relationship between serum TSH and thyroxine concentrations means that small changes in serum thyroxine are amplified by changes in serum TSH. The availability of the sensitive TSH assay in essentially all clinical laboratories has improved and simplified the assessment of thyroid function for the diagnosis of thyroid disease and to monitor treatment. Serum free thyroxine and thyrotropin concentrations, as well as other thyroid tests, can be measured utilizing an automated immunoassay platform that provides rapid and accurate results. This simplified approach to thyroid assessment, often requ- ing only a serum TSH measurement, and rapid availability of the thyroid function tests results, has expanded the scope of thyroid testing and clinicians ordering and interpretingth yroid tests. There remain, however, many challenges in selecting the appropriate thyroid function test to order, the correct interpretation of results, and applying these results to the diagnosis and management of thyroid diseases. It is especially important to be aware of limitations of thyroid function tests, as well as special clinical c- cumstances that can influence thyroid function measurements. The serum TSH concentration, for example, may not accurately reflect thyroid status in many si- ations including after prolonged hyperthyroidism when serum TSH remains s- pressed for months, in the presence of hypothalamic or pituitary disease, or due to a number of interfering medications. The serum free thyroxine, measured by the analog method, is not accurate with high or low serum binding proteins and d- ing pregnanc.

  • Buch 3 von 20: Endocrine Updates

    Gregory A. Brent

    Sprache: Englisch

    Verlag: Springer US, Springer US, 2010

    ISBN 10: 1441914846 ISBN 13: 9781441914842

    Anbieter: AHA-BUCH GmbH, Einbeck, Deutschland

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    Buch. Zustand: Neu. Druck auf Anfrage Neuware - Printed after ordering - Thyroid function tests are utilized by essentially all medical practitioners, across every clinical setting, in patients from newborns to the elderly. They are the most frequently measured endocrine tests. The sensitive thyrotropin (TSH) assay reflects thyroid hormone feedback to the pituitary, and is diagnostic of both thyroid h- mone excess as well as deficiency. The log-linear relationship between serum TSH and thyroxine concentrations means that small changes in serum thyroxine are amplified by changes in serum TSH. The availability of the sensitive TSH assay in essentially all clinical laboratories has improved and simplified the assessment of thyroid function for the diagnosis of thyroid disease and to monitor treatment. Serum free thyroxine and thyrotropin concentrations, as well as other thyroid tests, can be measured utilizing an automated immunoassay platform that provides rapid and accurate results. This simplified approach to thyroid assessment, often requ- ing only a serum TSH measurement, and rapid availability of the thyroid function tests results, has expanded the scope of thyroid testing and clinicians ordering and interpretingth yroid tests. There remain, however, many challenges in selecting the appropriate thyroid function test to order, the correct interpretation of results, and applying these results to the diagnosis and management of thyroid diseases. It is especially important to be aware of limitations of thyroid function tests, as well as special clinical c- cumstances that can influence thyroid function measurements. The serum TSH concentration, for example, may not accurately reflect thyroid status in many si- ations including after prolonged hyperthyroidism when serum TSH remains s- pressed for months, in the presence of hypothalamic orpituitary disease, or due to a number of interfering medications. The serum free thyroxine, measured by the analog method, is not accurate with high or low serum binding proteins and d- ing pregnancy. Hospitalized patients often have thyroid function test abnormalities that are transient and return to normal after recovery from the acute illness. Iodine excessand deficiency candramatically influence thyroid function tests. Significant insights have been gained into the regulation of thyroid hormone synthesis and especially the role of thyroid hormone metabolism in supplying t- sues locally with an adequate supply of thyroid hormone. In a number of instances, these factors influence the selection and interpretation of thyroid function tests. Polymorphisms, common sequence variations, in genes of components that regulate thyroid function and thyroid hormone action may also contribute to variability in thyroid function tests in a population. v vi Preface This volume draws on an outstanding international panel of experts in thyroid function tests and thyroid function assessment. They represent clinicians, clinical researchers, and basic science researchers, all with a focus on some aspect of the assessment of thyroid function. The chapters all provide a clinical perspective, but are informed by themost recent scientific advancements. The first section of the book (Chaps. 1-3) presents the most recent advances in thyroid physiology, a review of genetic influences on thyroid function tests, and a discussion on the influence of iodine on thyroid function. In Chap. 1, Drs. Huang and de Castro Neves describe thyroid hormone metabolism, emphasizing the key role of thyroid hormone activation and inactivation in thyroid hormone action. Dr. Visser is a world leader in studies ofthyroid metabolism and genetic influences on thyroid function. In Chap. 2, Dr. Visser and his colleagues, Drs. van der Deure, Medici, and Peeters, provide a clear view of this important and r- idly expanding field. The population variation in the TSH 'set point' (relationship between serum TSH and thyroxine in an individual), for example, is thought to b.

  • Sprache: Englisch

    Verlag: Springer, 2012

    ISBN 10: 1461425751 ISBN 13: 9781461425755

    Anbieter: Ria Christie Collections, Uxbridge, Vereinigtes Königreich

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    Zustand: New. In.

  • Sprache: Englisch

    Verlag: Springer, 2012

    ISBN 10: 1461425751 ISBN 13: 9781461425755

    Anbieter: Mispah books, Redhill, SURRE, Vereinigtes Königreich

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    Paperback. Zustand: Like New. LIKE NEW. SHIPS FROM MULTIPLE LOCATIONS. book.

  • Alex Werhun

    Sprache: Englisch

    Verlag: SPS Dez 2015, 2015

    ISBN 10: 363985957X ISBN 13: 9783639859577

    Anbieter: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Deutschland

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    Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -As a GP we often order thyroid function tests but do you ever wonder if it's worthwhile This book looks at clinical features that are more likely to give abnormal thyroid function results. A large general practice population in the united Kingdom was analysed for a year to give this data. The hope is to improve the efficiency of your practice and have some evidence behind discussions with patients that frequent request thyroid function tests. 116 pp. Englisch.

  • Werhun, Alex

    Sprache: Englisch

    Verlag: Scholars' Press, 2015

    ISBN 10: 363985957X ISBN 13: 9783639859577

    Anbieter: Majestic Books, Hounslow, Vereinigtes Königreich

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  • Alex Werhun

    Sprache: Englisch

    Verlag: Scholars\' Press, 2015

    ISBN 10: 363985957X ISBN 13: 9783639859577

    Anbieter: moluna, Greven, Deutschland

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    Zustand: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Werhun AlexDr Alexander Werhun (MBBCh BSc(Hons) MRCGP MRes)The author has recently completed a General Practice training scheme in Exeter, which ran alongside an Academic Clinical Fellowship based at Exeter University. The author has.

  • Brent, Gregory A.

    Sprache: Englisch

    Verlag: Springer, 2012

    ISBN 10: 1461425751 ISBN 13: 9781461425755

    Anbieter: Brook Bookstore On Demand, Napoli, NA, Italien

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    Zustand: new. Questo è un articolo print on demand.

  • Werhun, Alex

    Sprache: Englisch

    Verlag: Scholars' Press, 2015

    ISBN 10: 363985957X ISBN 13: 9783639859577

    Anbieter: Biblios, Frankfurt am main, HESSE, Deutschland

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    Zustand: New. PRINT ON DEMAND.

  • Alex Werhun

    Sprache: Englisch

    Verlag: SPS Dez 2015, 2015

    ISBN 10: 363985957X ISBN 13: 9783639859577

    Anbieter: buchversandmimpf2000, Emtmannsberg, BAYE, Deutschland

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    Taschenbuch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -As a GP we often order thyroid function tests but do you ever wonder if it's worthwhile This book looks at clinical features that are more likely to give abnormal thyroid function results. A large general practice population in the united Kingdom was analysed for a year to give this data. The hope is to improve the efficiency of your practice and have some evidence behind discussions with patients that frequent request thyroid function tests.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 116 pp. Englisch.

  • Alex Werhun

    Sprache: Englisch

    Verlag: SPS, 2015

    ISBN 10: 363985957X ISBN 13: 9783639859577

    Anbieter: AHA-BUCH GmbH, Einbeck, Deutschland

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    Taschenbuch. Zustand: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - As a GP we often order thyroid function tests but do you ever wonder if it's worthwhile This book looks at clinical features that are more likely to give abnormal thyroid function results. A large general practice population in the united Kingdom was analysed for a year to give this data. The hope is to improve the efficiency of your practice and have some evidence behind discussions with patients that frequent request thyroid function tests.

  • Gregory A. Brent

    Sprache: Englisch

    Verlag: Springer US Mai 2012, 2012

    ISBN 10: 1461425751 ISBN 13: 9781461425755

    Anbieter: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Deutschland

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    Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -'Thyroid function tests are utilized by essentially all medical practitioners, across every clinical setting, in patients from newborns to the elderly. They are the most frequently measured endocrine tests. The sensitive thyrotropin (TSH) assay reflects thyroid hormone feedback to the pituitary, and is diagnostic of both thyroid h- mone excess as well as deficiency. The log-linear relationship between serum TSH and thyroxine concentrations means that small changes in serum thyroxine are amplified by changes in serum TSH. The availability of the sensitive TSH assay in essentially all clinical laboratories has improved and simplified the assessment of thyroid function for the diagnosis of thyroid disease and to monitor treatment. Serum free thyroxine and thyrotropin concentrations, as well as other thyroid tests, can be measured utilizing an automated immunoassay platform that provides rapid and accurate results. This simplified approach to thyroid assessment, often requ- ing only a serum TSH measurement, and rapid availability of the thyroid function tests results, has expanded the scope of thyroid testing and clinicians ordering and interpretingth yroid tests. There remain, however, many challenges in selecting the appropriate thyroid function test to order, the correct interpretation of results, and applying these results to the diagnosis and management of thyroid diseases. It is especially important to be aware of limitations of thyroid function tests, as well as special clinical c- cumstances that can influence thyroid function measurements. The serum TSH concentration, for example, may not accurately reflect thyroid status in many si- ations including after prolonged hyperthyroidism when serum TSH remains s- pressed for months, in the presence of hypothalamic or pituitary disease, or due to a number of interfering medications. The serum free thyroxine, measured by the analog method, is not accurate with high or low serum binding proteins and d- ing pregnancy. Hospitalized patients often have thyroid function test abnormalities that are transient and return to normal after recovery from the acute illness. Iodine excessand deficiency candramatically influence thyroid function tests. Significant insights have been gained into the regulation of thyroid hormone synthesis and especially the role of thyroid hormone metabolism in supplying t- sues locally with an adequate supply of thyroid hormone. In a number of instances, these factors influence the selection and interpretation of thyroid function tests. Polymorphisms, common sequence variations, in genes of components that regulate thyroid function and thyroid hormone action may also contribute to variability in thyroid function tests in a population. v vi Preface This volume draws on an outstanding international panel of experts in thyroid function tests and thyroid function assessment. They represent clinicians, clinical researchers, and basic science researchers, all with a focus on some aspect of the assessment of thyroid function. The chapters all provide a clinical perspective, but are informed by themost recent scientific advancements. The first section of the book (Chaps. 1-3) presents the most recent advances in thyroid physiology, a review of genetic influences on thyroid function tests, and a discussion on the influence of iodine on thyroid function. In Chap. 1, Drs. Huang and de Castro Neves describe thyroid hormone metabolism, emphasizing the key role of thyroid hormone activation and inactivation in thyroid hormone action. Dr. Visser is a world leader in studies of thyroid metabolism and genetic influences on thyroid function. In Chap. 2, Dr. Visser and his colleagues, Drs. van der Deure, Medici, and Peeters, provide a clear view of this important and r- idly expanding field. The population variation in the TSH 'set point' (relationship between serum TSH and thyroxin 304 pp. Englisch.

  • Brent, Gregory A.

    Sprache: Englisch

    Verlag: Springer US, 2012

    ISBN 10: 1461425751 ISBN 13: 9781461425755

    Anbieter: moluna, Greven, Deutschland

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    Zustand: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Provides clinically practical information from the most recent scientific advancesThyroid function tests are utilized by essentially all medical practitioners, across every clinical setting, in patients from newborns to the elderly. They are the .

  • Sprache: Englisch

    Verlag: Springer, 2012

    ISBN 10: 1461425751 ISBN 13: 9781461425755

    Anbieter: Majestic Books, Hounslow, Vereinigtes Königreich

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    Zustand: New. Print on Demand pp. 306 5 Illus.

  • Brent Gregory A.

    Sprache: Englisch

    Verlag: Springer, 2012

    ISBN 10: 1461425751 ISBN 13: 9781461425755

    Anbieter: Biblios, Frankfurt am main, HESSE, Deutschland

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    Zustand: New. PRINT ON DEMAND pp. 306.

  • Gregory A. Brent

    Sprache: Englisch

    Verlag: Springer, Springer Mai 2012, 2012

    ISBN 10: 1461425751 ISBN 13: 9781461425755

    Anbieter: buchversandmimpf2000, Emtmannsberg, BAYE, Deutschland

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    Taschenbuch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Thyroid function tests are utilized by essentially all medical practitioners, across every clinical setting, in patients from newborns to the elderly. They are the most frequently measured endocrine tests. The sensitive thyrotropin (TSH) assay reflects thyroid hormone feedback to the pituitary, and is diagnostic of both thyroid h- mone excess as well as deficiency. The log-linear relationship between serum TSH and thyroxine concentrations means that small changes in serum thyroxine are amplified by changes in serum TSH. The availability of the sensitive TSH assay in essentially all clinical laboratories has improved and simplified the assessment of thyroid function for the diagnosis of thyroid disease and to monitor treatment. Serum free thyroxine and thyrotropin concentrations, as well as other thyroid tests, can be measured utilizing an automated immunoassay platform that provides rapid and accurate results. This simplified approach to thyroid assessment, often requ- ing only a serum TSH measurement, and rapid availability of the thyroid function tests results, has expanded the scope of thyroid testing and clinicians ordering and interpretingth yroid tests. There remain, however, many challenges in selecting the appropriate thyroid function test to order, the correct interpretation of results, and applying these results to the diagnosis and management of thyroid diseases. It is especially important to be aware of limitations of thyroid function tests, as well as special clinical c- cumstances that can influence thyroid function measurements. The serum TSH concentration, for example, may not accurately reflect thyroid status in many si- ations including after prolonged hyperthyroidism when serum TSH remains s- pressed for months, in the presence of hypothalamic orpituitary disease, or due to a number of interfering medications. The serum free thyroxine, measured by the analog method, is not accurate with high or low serum binding proteins and d- ing pregnancy. Hospitalized patients often have thyroid function test abnormalities that are transient and return to normal after recovery from the acute illness. Iodine excessand deficiency candramatically influence thyroid function tests. Significant insights have been gained into the regulation of thyroid hormone synthesis and especially the role of thyroid hormone metabolism in supplying t- sues locally with an adequate supply of thyroid hormone. In a number of instances, these factors influence the selection and interpretation of thyroid function tests. Polymorphisms, common sequence variations, in genes of components that regulate thyroid function and thyroid hormone action may also contribute to variability in thyroid function tests in a population. v vi Preface This volume draws on an outstanding international panel of experts in thyroid function tests and thyroid function assessment. They represent clinicians, clinical researchers, and basic science researchers, all with a focus on some aspect of the assessment of thyroid function. The chapters all provide a clinical perspective, but are informed by themost recent scientific advancements. The first section of the book (Chaps. 1-3) presents the most recent advances in thyroid physiology, a review of genetic influences on thyroid function tests, and a discussion on the influence of iodine on thyroid function. In Chap. 1, Drs. Huang and de Castro Neves describe thyroid hormone metabolism, emphasizing the key role of thyroid hormone activation and inactivation in thyroid hormone action. Dr. Visser is a world leader in studies ofthyroid metabolism and genetic influences on thyroid function. In Chap. 2, Dr. Visser and his colleagues, Drs. van der Deure, Medici, and Peeters, provide a clear view of this important and r- idly expanding field. The population variation in the TSH 'set point' (relationship between serum TSH and thyroxine in an individual), for example, is.

  • Buch 3 von 20: Endocrine Updates

    Brent, Gregory A.

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    Verlag: Springer US, 2010

    ISBN 10: 1441914846 ISBN 13: 9781441914842

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    Gebunden. Zustand: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Provides clinically practical information from the most recent scientific advancesThyroid function tests are utilized by essentially all medical practitioners, across every clinical setting, in patients from newborns to the elderly. They are the .

  • Buch 3 von 20: Endocrine Updates

    Gregory A. Brent

    Sprache: Englisch

    Verlag: Springer US Mrz 2010, 2010

    ISBN 10: 1441914846 ISBN 13: 9781441914842

    Anbieter: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Deutschland

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    Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Thyroid function tests are utilized by essentially all medical practitioners, across every clinical setting, in patients from newborns to the elderly. They are the most frequently measured endocrine tests. The sensitive thyrotropin (TSH) assay reflects thyroid hormone feedback to the pituitary, and is diagnostic of both thyroid h- mone excess as well as deficiency. The log-linear relationship between serum TSH and thyroxine concentrations means that small changes in serum thyroxine are amplified by changes in serum TSH. The availability of the sensitive TSH assay in essentially all clinical laboratories has improved and simplified the assessment of thyroid function for the diagnosis of thyroid disease and to monitor treatment. Serum free thyroxine and thyrotropin concentrations, as well as other thyroid tests, can be measured utilizing an automated immunoassay platform that provides rapid and accurate results. This simplified approach to thyroid assessment, often requ- ing only a serum TSH measurement, and rapid availability of the thyroid function tests results, has expanded the scope of thyroid testing and clinicians ordering and interpretingth yroid tests. There remain, however, many challenges in selecting the appropriate thyroid function test to order, the correct interpretation of results, and applying these results to the diagnosis and management of thyroid diseases. It is especially important to be aware of limitations of thyroid function tests, as well as special clinical c- cumstances that can influence thyroid function measurements. The serum TSH concentration, for example, may not accurately reflect thyroid status in many si- ations including after prolonged hyperthyroidism when serum TSH remains s- pressed for months, in the presence of hypothalamic or pituitary disease, or due to a number of interfering medications. The serum free thyroxine, measured by the analog method, is not accurate with high or low serum binding proteins and d- ing pregnancy. Hospitalized patients often have thyroid function test abnormalities that are transient and return to normal after recovery from the acute illness. Iodine excessand deficiency candramatically influence thyroid function tests. Significant insights have been gained into the regulation of thyroid hormone synthesis and especially the role of thyroid hormone metabolism in supplying t- sues locally with an adequate supply of thyroid hormone. In a number of instances, these factors influence the selection and interpretation of thyroid function tests. Polymorphisms, common sequence variations, in genes of components that regulate thyroid function and thyroid hormone action may also contribute to variability in thyroid function tests in a population. v vi Preface This volume draws on an outstanding international panel of experts in thyroid function tests and thyroid function assessment. They represent clinicians, clinical researchers, and basic science researchers, all with a focus on some aspect of the assessment of thyroid function. The chapters all provide a clinical perspective, but are informed by themost recent scientific advancements. The first section of the book (Chaps. 1-3) presents the most recent advances in thyroid physiology, a review of genetic influences on thyroid function tests, and a discussion on the influence of iodine on thyroid function. In Chap. 1, Drs. Huang and de Castro Neves describe thyroid hormone metabolism, emphasizing the key role of thyroid hormone activation and inactivation in thyroid hormone action. Dr. Visser is a world leader in studies of thyroid metabolism and genetic influences on thyroid function. In Chap. 2, Dr. Visser and his colleagues, Drs. van der Deure, Medici, and Peeters, provide a clear view of this important and r- idly expanding field. The population variation in the TSH 'set point' (relationship between serum TSH and thyroxine in an individual), for exampl.

  • Buch 3 von 20: Endocrine Updates

    Gregory A. Brent

    Sprache: Englisch

    Verlag: Springer, Springer Mär 2010, 2010

    ISBN 10: 1441914846 ISBN 13: 9781441914842

    Anbieter: buchversandmimpf2000, Emtmannsberg, BAYE, Deutschland

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    Buch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Thyroid function tests are utilized by essentially all medical practitioners, across every clinical setting, in patients from newborns to the elderly. They are the most frequently measured endocrine tests. The sensitive thyrotropin (TSH) assay reflects thyroid hormone feedback to the pituitary, and is diagnostic of both thyroid h- mone excess as well as deficiency. The log-linear relationship between serum TSH and thyroxine concentrations means that small changes in serum thyroxine are amplified by changes in serum TSH. The availability of the sensitive TSH assay in essentially all clinical laboratories has improved and simplified the assessment of thyroid function for the diagnosis of thyroid disease and to monitor treatment. Serum free thyroxine and thyrotropin concentrations, as well as other thyroid tests, can be measured utilizing an automated immunoassay platform that provides rapid and accurate results. This simplified approach to thyroid assessment, often requ- ing only a serum TSH measurement, and rapid availability of the thyroid function tests results, has expanded the scope of thyroid testing and clinicians ordering and interpretingth yroid tests. There remain, however, many challenges in selecting the appropriate thyroid function test to order, the correct interpretation of results, and applying these results to the diagnosis and management of thyroid diseases. It is especially important to be aware of limitations of thyroid function tests, as well as special clinical c- cumstances that can influence thyroid function measurements. The serum TSH concentration, for example, may not accurately reflect thyroid status in many si- ations including after prolonged hyperthyroidism when serum TSH remains s- pressed for months, in the presence of hypothalamic orpituitary disease, or due to a number of interfering medications. The serum free thyroxine, measured by the analog method, is not accurate with high or low serum binding proteins and d- ing pregnancy. Hospitalized patients often have thyroid function test abnormalities that are transient and return to normal after recovery from the acute illness. Iodine excessand deficiency candramatically influence thyroid function tests. Significant insights have been gained into the regulation of thyroid hormone synthesis and especially the role of thyroid hormone metabolism in supplying t- sues locally with an adequate supply of thyroid hormone. In a number of instances, these factors influence the selection and interpretation of thyroid function tests. Polymorphisms, common sequence variations, in genes of components that regulate thyroid function and thyroid hormone action may also contribute to variability in thyroid function tests in a population. v vi Preface This volume draws on an outstanding international panel of experts in thyroid function tests and thyroid function assessment. They represent clinicians, clinical researchers, and basic science researchers, all with a focus on some aspect of the assessment of thyroid function. The chapters all provide a clinical perspective, but are informed by themost recent scientific advancements. The first section of the book (Chaps. 1-3) presents the most recent advances in thyroid physiology, a review of genetic influences on thyroid function tests, and a discussion on the influence of iodine on thyroid function. In Chap. 1, Drs. Huang and de Castro Neves describe thyroid hormone metabolism, emphasizing the key role of thyroid hormone activation and inactivation in thyroid hormone action. Dr. Visser is a world leader in studies ofthyroid metabolism and genetic influences on thyroid function. In Chap. 2, Dr. Visser and his colleagues, Drs. van der Deure, Medici, and Peeters, provide a clear view of this important and r- idly expanding field. The population variation in the TSH 'set point' (relationship between serum TSH and thyroxine in an individual), for example, is.