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Verlag: GRIN Verlag Dez 2014, 2014
ISBN 10: 3656849765ISBN 13: 9783656849766
Anbieter: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Deutschland
Buch Print-on-Demand
Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Professorial Dissertation from the year 2014 in the subject Medicine - Pharmacology, Pharmacy, grade: Passed, LMU Munich (Pharmacy/Pharmacology), language: English, abstract: Lysosomes are cell organelles involved in the breakdown of proteins, lipids, and other molecules and have been implicated not only in endolysosomal storage disorders (LSDs) such as mucolipidoses or mucopolysaccharidoses but also in metabolic diseases, neurodegenerative disorders such as Alzheimer's and Parkinson's disease, pigmentation disorders, or infectious diseases. Highly critical for the proper function of lysosomes, endosomes, and lysosome-related organelles is the tight regulation of various fusion and fission processes and the regulation of proton and other ionic concentrations within the endolysosomal system. Calcium permeable, non-selective cation channels of the TRP (transient receptor potential) superfamily, namely TRPML channels (mucolipins) and TPCs (two-pore channels) have been found to play important roles in these processes. This thesis provides insights into the function and physiology of TRPML and TPC channels, explains the molecular basis of pathologies associated with diseases caused by loss or mutation of these channels, and discusses potential therapeutic approaches. 48 pp. Englisch.
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Verlag: LAP LAMBERT Academic Publishing Sep 2022, 2022
ISBN 10: 6205498251ISBN 13: 9786205498255
Anbieter: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Deutschland
Buch Print-on-Demand
Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The Transient Receptor Potential (TRP) channel superfamily is comprised of a large group of cation-permeable channels, which display an extraordinary diversity of roles in sensory signaling and are involved in a plethora of animal behaviors. These channels are activated through a wide variety of mechanisms and participate in virtually every sensory modality. Although the physiological functions of most TRP channels are not well known, their wide distribution indicates that the biological roles and activation mechanisms for these channels are diverse. TRP channels are best recognized for their contributions to sensory transduction, response to temperature, nociceptive stimuli, touch, osmolarity, chemical substances such as pheromones or odorants, pungent natural compounds, and other stimuli from both within and outside the cell. This data clearly indicates that the specific and selective inhibition of TRP channels can be used to relieve pain and thus these channels represent promising targets for the development of further generations of novel analgesic drugs. 116 pp. Englisch.
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Verlag: MDPI AG, 2018
ISBN 10: 3038426385ISBN 13: 9783038426387
Anbieter: Ria Christie Collections, Uxbridge, Vereinigtes Königreich
Buch Print-on-Demand
Zustand: New. PRINT ON DEMAND Book; New; Fast Shipping from the UK. No. book.
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Verlag: Springer, 2011
ISBN 10: 9400702647ISBN 13: 9789400702646
Anbieter: killarneybooks, Inagh, CLARE, Irland
Buch
Hardcover. Zustand: Good. Oversized hardcover, xxiii + 1095 pages, colour illustrations in text, NOT ex-library. Yellow highlighting on 40 pages. A short pen line in side margin of one page, two lines on p.857. Other pages are clean. 6 straightened page corner folds. Binding is loosened but secure and stable. Boards show storage wear: scratches, two small areas of surface damage (rear panel), a couple of scuff-marks on lower edges, shelfwear. Published without a dust jacket. Please note: shipping weight will exceed 1kg / 2.2lb & extra postage may be required. -- Contents: Structural Biology of TRP Channels; Functional and Structural Studies of TRP Channels Heterologously Expressed in Budding Yeast; Natural Product Ligands of TRP Channels; Synthetic Modulators of TRP Channel Activity; Study of TRP Channels by Automated Patch Clamp Systems; TRPC2: Of Mice But Not Men; TRPM1: New Trends for an Old TRP; Non-selective Monovalent Cationic Channels TRPm4 and TRPM5; TRPM7, the Mg2+ Inhibited Channel and Kinase; TRPM8 in Health and Disease: Cold Sensing and Beyond; TRPML1; TRPML2 and the Evolution of Mucolipins; TRPML3 Channel: From Gene to Function; TRPV5 and TRPV6 in Transcellular Ca2+ Transport: Regulation, Gene Duplication, and Polymorphisms in African Populations; TRPV5 Promoter as a Tool for Generation of Transgenic Mouse Models; TRPP Channels and Polycystins; TRP Channels in Yeast; C. elegans TRP Channels; Investigations of the In Vivo Requirements of Transient Receptor Potential Ion Channels Using Frog and Zebrafish Model Systems; TRP Channels in Parasites; Receptor Signaling Integration by TRP Channelsomes; Gating Mechanisms of Canonical Transient Receptor Potential Channel Proteins: Role of Phosphoinositols and Diacylglycerol; TRPC Ion Channels: Association with Orail and STIMI1 Proteins and Participation in Capacitative and Non-capacitative Calcium Entry; Contribution of TRPc1 and Orail to Ca2+ Entry Activated by Store Depletion; Primary Thermosensory Events in Cells; Thermo-TRP Channels: Biophysics of Polymodal Receptors; Complex Regulation of TRPv1 and Related Thermo-TRPs: Implications for Therapeutic Intervention; Voltage Sensing in Thermo-TRP Channels; TRP Channels as Mediators of Oxidative Stress; Regulation of TRP Signalling by Ion Channel Translocation Between Cell Compartments; Emerging Roles of Canonical TRP Channels in Neuronal Function; TRP Channels and Neural Persistent Activity; Role of TRP Channels in Pain Sensation; TRPV1: A Therapy Target That Attracts the Pharmaceutical Interests; Expression and Function of TRP Channels in Liver Cells; Expression and Physiological Roles of TRP Channels in Smooth Muscle Cells; TRPM Channels in the Vasculature; Molecular Expression and Functional Role of Canonical Transient Receptor Potential Channels in Airway Smooth Muscle Cells; TRP Channels in Skeletal Muscle: Gene Expression, function and Implications for Disease; TRP Channels in Vascular Endothelial Cells; TRP Channels in the Cardiopulmonary Vasculature; TRP Channels of Islets; Multiple Roles for TRPs in the Taste System: Not Your Typical TRPs; Roles of Transient Receptor Potential Proteins (TRPs) in Epidermal Keratinocytes; TRP Channels in Urinary Bladder Mechanosensation; Role of TRP Ion Channels in Testicular Function; TRP Channels in Female Reproductive Organs and Placenta; Oncogenic TRP Channels; TRPV Channels in Tumor Growth and Progression; Role of Transient Receptor Potential Channels in Respiratory Symptoms and Pathophysiology; TRP Channels and Psychiatric Disorders; Transient Receptor Potential Genes and Human Inherited Disease; Index.
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Verlag: Nova Science Pub Inc, 2019
ISBN 10: 1536165018ISBN 13: 9781536165012
Anbieter: GreatBookPrices, Columbia, MD, USA
Buch
Zustand: As New. Unread book in perfect condition.
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Verlag: Springer Netherlands, 2017
ISBN 10: 9402410864ISBN 13: 9789402410860
Anbieter: moluna, Greven, Deutschland
Buch Print-on-Demand
Gebunden. Zustand: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Discusses the findings on the physiological and pathological functions of TRPCs in the brain Covering the potential roles of TRPCs in brain disorders Providing students and investigators with comprehensive information on regulation, functio.
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Verlag: Springer Netherlands, 2018
ISBN 10: 940241486XISBN 13: 9789402414868
Anbieter: moluna, Greven, Deutschland
Buch Print-on-Demand
Zustand: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Discusses the findings on the physiological and pathological functions of TRPCs in the brain Covering the potential roles of TRPCs in brain disorders Providing students and investigators with comprehensive information on regulation, functio.
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Verlag: Springer, 2014
ISBN 10: 3319051601ISBN 13: 9783319051604
Anbieter: booksXpress, Bayonne, NJ, USA
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Hardcover. Zustand: new.
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Verlag: Springer International Publishing, 2016
ISBN 10: 3319358782ISBN 13: 9783319358789
Anbieter: moluna, Greven, Deutschland
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Zustand: New.
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Verlag: Springer Netherlands, 2016
ISBN 10: 9401778329ISBN 13: 9789401778329
Anbieter: moluna, Greven, Deutschland
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Zustand: New.
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Verlag: Springer, 2016
ISBN 10: 3662512238ISBN 13: 9783662512234
Anbieter: booksXpress, Bayonne, NJ, USA
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Soft Cover. Zustand: new.
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Verlag: Springer, 2014
ISBN 10: 364254214XISBN 13: 9783642542145
Anbieter: booksXpress, Bayonne, NJ, USA
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Hardcover. Zustand: new.
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Verlag: Springer Berlin Heidelberg, 2010
ISBN 10: 3642071147ISBN 13: 9783642071140
Anbieter: moluna, Greven, Deutschland
Buch Print-on-Demand
Zustand: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. With contributions by numerous experts|Fills a gap between pharmacology textbooks and latest manuscripts in scientific periodicalsThis volume provides up-to-date information on the molecular and functional properties and pharmacology of mammal.
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Verlag: Springer, 2007
ISBN 10: 3540348891ISBN 13: 9783540348894
Anbieter: booksXpress, Bayonne, NJ, USA
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Hardcover. Zustand: new.
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