berlin springer international publishing springer mai 2018 (173 Ergebnisse)

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This Brief presents new approaches and innovative challenges to address bringing technology into community-oriented policing efforts. 'Community-oriented policing' is an approach that encourages police to develop and maintain personal relationships with citizens and community organizations. By developing these partnerships, the goal is to enhance trust and legitimacy of police by the community (and vice versa), and focus on engaging the community crime prevention and detection efforts for sustainable, long-term crime reduction. The contributions to this volume emphasize how technological innovations can advance community-oriented policing goals, such as: -Strengthening community policing principles through effective and efficient tools, procedures and approaches - Accelerating communication between citizens and police forces - Early identification, timely intervention, as well as better crime reporting, identification of risks, unreported and undiscovered crime through the community Contributions to this volume were developed out of the Next Generation Community Policing (NGCP) International Conference was co-organized by nine contributing research and development projects, funded by the Horizon 2020 SECURITY Program of the European Commission. It will be of interest to researchers in criminology and criminal justice, as well as related fields such as sociology, public health, security, IT and public policy.This book is open access under a CC BY license. 131 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This stimulating open access volume details the innovative work of the Pan Institution Network for Global Health in creating collaborative research-based answers to large-scale health issues. Equitable partnerships among member universities representing North America, Africa, Asia, and Europe reverse standard cross-national dynamics to develop locally relevant responses to health challenges as well as their underlying disparities. Case studies focusing on multiple morbidities and effects of urbanization on health illustrate open dialogue in addressing HIV, maternal/child health, diabetes, and other major concerns. These instructive examples model collaborations between global North and South as meaningful steps toward the emerging global future of public health.Included in the coverage: Building sustainable networks: introducing the Pan Institution Network for Global Health Fostering dialogues in global health education: a graduate and undergraduate approach Provider workload and multiple morbidities in the Caribbean and South Africa Project Redemption: conducting research with informal workers in New York City Partnership and collaboration in global health: valuing reciprocityGlobal Health Collaboration will interest faculty working within the field of global health; scholars within public health, health policy, and cognate disciplines; as well as administrators looking to develop international university partnerships around global health and graduate students in the areas of global health, health administration, and public health and related social sciences (e.g., sociology, anthropology, demography). 107 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This compact open access reference delves beyond popular concepts of educated consumers and an informed public by examining the science behind deliberative engagement. Using data from four longitudinal studies, the authors assess public engagement methods in deliberative discussions of ethical, legal, and social issues concerning innovations in nanotechnology. Coverage includes the theoretical origins of the studies, forms of engagement and variations used, and in-depth details on cognitive, affective, and social components that go into the critical thinking process and forming of opinions. Not only are the findings intriguing in and of themselves, but researchers from varied fields will also find them useful in pursuing their own projects.Featured in the coverage:Experimental methods and measures used in relation to specific outcomes.Forms of deliberative engagement affecting objective and subjective knowledge.Effects of engagement variables on attitude formation, change, and polarization.Tracing the processes leading to policy acceptance and support.Study conclusions and evaluation.Plus supplemental materials giving readers access to full study data.Since public engagement methods are widely regarded as valuable for policy input, planning purposes, and understanding societal processes, Deliberative Engagement with Science stands to have a wide audience among psychologists, researchers, academics, and policymakers, as well as professionals in the corporate sphere and the tech industries. 129 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This Brief presents new approaches and innovative challenges to address bringing technology into community-oriented policing efforts. 'Community-oriented policing' is an approach that encourages police to develop and maintain personal relationships with citizens and community organizations. By developing these partnerships, the goal is to enhance trust and legitimacy of police by the community (and vice versa), and focus on engaging the community crime prevention and detection efforts for sustainable, long-term crime reduction.The contributions to this volume emphasize the societal implications of new technologies for community-oriented policing goals, such as: -Strengthening community policing principles through strengthed community feeling and lower feeling of insecurity - Reducing the fear of crime and enhancing the perception of security in large, urban environments -Enhancing citizens feelings' of empowerment, belonging, and collective efficacy Contributions to this volume were developed out of the Next Generation Community Policing (NGCP) International Conference was co-organized by nine contributing research and development projects, funded by the Horizon 2020 SECURITY Program of the European Commission. It will be of interest to researchers in criminology and criminal justice, as well as related fields such as sociology, public health, security, IT and public policy. 102 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book identifies and analyzes the ways in which RuPaul's Drag Racehas reshaped the visibility of drag culture in the US and internationally, as well as how the program has changed understandings of reality TV. This edited volume illustrates how drag has become a significant aspect of LGBTQ experience and identity globally throughRuPaul's Drag Race, and how the show has reformed a media landscape in which competition and reality itself are understood as given. Taking on lenses addressing race, ethnicity, geographical origin, cultural identity, physicality and body image, and participation in drag culture across the globe, this volume offers critical, non-traditional, and first-hand perspectives on drag culture. 309 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book is open access under a CC BY 4.0 license.This Open Access book investigates European citizenship after Brexit, in light of the functionalist theory of citizenship. No matter its shape, Brexit will impact significantly on what has been labelled as one of the major achievements of EU integration: Citizenship of the Union. For the first time an automatic and collective lapse of status is observed. It is a form of involuntary loss of citizenship en masse, imposed by the automatic workings of the law on EU citizens of exclusively British nationality. It does not however create statelessness and it is likely to be tolerated under international law. This loss of citizenship is connected to a reduction of rights, affecting not solely the former Union citizens but also second country nationals in the United Kingdom and their family members. The status of European citizenship and connected rights are first presented. Chapter Two focuses on the legal uncertainty that afflicts second country nationals in the United Kingdom as well as British citizens, turning from expats to post-European third country nationals. Chapter Three describes the functionalist theory and delineates three ways in which it applies to Brexit. These three directions of inquiry are developed in the following chapters. Chapter Four focuses on the intension of Union citizenship: Which rights can be frozen Chapter Five determines the extension of Union citizenship: Who gets to withdraw the status The key finding is that while Member states are in principle free to revoke the status of Union citizen, former Member states are not unbounded in stripping Union citizens of their acquired territorial rights. Conclusions are drawn and policy-suggestions summed up in the final chapter. 123 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -A zebrafish, the hull of a miniature ship, a mathematical equation and a food chain - what do these things have in common They are examples of models used by scientists to isolate and study particular aspects of the world around us.This book begins by introducing the concept of a scientific model from an intuitive perspective, drawing parallels to mental models and artistic representations. It then recounts the history of modelling from the 16th century up until the present day. The iterative process of model building is described and discussed in the context of complex models with high predictive accuracy versus simpler models that provide more of a conceptual understanding. To illustrate the diversity of opinions within the scientific community, we also present the results of an interview study, in which ten scientists from different disciplines describe their views on modelling and how models feature in their work. Lastly, itincludes a number of worked examples that span different modelling approaches and techniques. It provides a comprehensive introduction to scientific models and shows how models are constructed and used in modern science. It also addresses the approach to, and the culture surrounding modelling in different scientific disciplines. It serves as an inspiration for model building and also facilitates interdisciplinary collaborations by showing how models are used in different scientific fields. The book is aimed primarily at students in the sciences and engineering, as wellas students at teacher training colleges but will also appeal to interested readers wanting to get an overview of scientific modelling in general and different modelling approaches in particular. 96 pp. Englisch.

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In this book, the author draws on over a decade of first-hand experience as an academic-activist and on interviews with women in Malaysia's women's rights movement. Despite a considerable array of challenges to their participation in the public and political spheres, the movement is especially vibrant. Presenting insights from feminist activists in Malaysia, the book explores the Women's Candidacy Initiative's efforts to promote independent women inParliament; the work of women's coalition the Joint Action Group forGender Equality; how activists understand and experience the concept of feminism; and finally the place of men in feminism. Women's Activism in Malaysia will be of interest to students and scholars across a range of disciplines including gender studies, politics and sociology. 103 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book is about European IR theoretical traditions, their origins, and key figures. Theorizing is among the most important activities that take place within scientific disciplines. Scholars therefore routinely talk/debate about the discipline of IR and its theories, theories are often used to form the pedagogical backbone of IR and theories are also a key part of scholarly identities. Over time, theories crystalize in to schools of thought, strands of theorizing and theoretical traditions. This book and the volumes that will follow focus on the origins and trajectories of theoretical traditions, and key figures of IR thought in Europe in the 20th Century. The authors are situated in Europe, and it is thus the origins and trajectories of European theoretical traditions, its intellectual history and contemporary forms of theoretical knowledge today, that are on the agenda. In order to achieve this ambitious aim, we opt for a transnational sociological history approach, thus going beyond the national lens through which IR has been predominantly studied. The series will have an integrative function and contribute to a globalized discourse on IR as a discipline. The key benefits of this first volume is that it outlines IR theoretical traditions for the first time ever, provides a novel framework for exploring IR's theories, and contributes to define and strengthen the European identity of IR. This book is an invaluable resource for scholars of IR. 130 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book utilizes critical discourse analysis to illuminate the ways in which one of the largest agribusinesses in operation, Tyson Foods, disguises their actions whilst simultaneously presenting the image of a benign, good corporate citizen. Schally unveils how the discourses employed by Tyson gain legitimacy by drawing on and aligning with larger cultural discourses that are often taken for granted and not adequately scrutinised. This original research, situated at the intersection of green and cultural criminologies, contributes to these current perspectives as well as to the burgeoning social harm approach within criminology. A bold and engaging study, this book will be indispensable for students and scholars of green criminology, corporate crime, animals and society, and environmental sociology, as well as environmental and animal rights activists. 97 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book addresses the challenges companies face when different customer value propositions require them to pursue a differentiated supply chain strategy. It provides practical insights on how to achieve successful supply chain segmentation and presents the benefits this can yield for companies on the basis of best-in-class industry case studies from Gardena, Philips Luminaire, Siemens Healthcare and Volvo Construction Equipment. Drawing on these examples, it provides recommendations and solutions on how to define supply chain segmentation, and how to set up and implement a transformation program. Furthermore, it presents an in-depth discussion of the current theoretical background of supply chain segmentation and introduces the current trends and available frameworks.Offering readers specific, pragmatic guidance on the main challenges and opportunities and proposing ways to effectively measure efficiency and performance, the book concludes with the do's, don'ts and most important aspects to keep in mind when considering an end-to-end segmentation. 74 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book examines a basic problem in critical approaches to political and social inquiry: in what way is social inquiry animated by a practical intent This practical intent is not external to inquiry as an add-on or a choice by the inquirer, but is inherent to the process of inquiry. The practical intent in inquiry derives from the connection between social inquiry and the participant's perspective. The social inquirer, in order to grasp the sense of those who are the subject of inquiry, has to adopt the perspective of the participant in the social world. Caterino opposes the view that research is an autonomous activity distinct from or superior to a participant's perspective. He argues that since the inquirer is on the same level as the participant, all inquiry should be considered mutual critique in which those who are addressed by inquiry have an equal right and an equal capacity to criticize addressors. 117 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book analyses a middle position between single enumerations in a regular federal-like and a regular autonomy-like distribution of legislative powers by examining constitutional legislation in three countries (Canada, Denmark and Finland) that have established separate enumerations for the national level and the sub-state level. The sub-state level consists of provinces in Canada, the Faroe Islands in Denmark and the Åland Islands in Finland. The book provides interpretations of the competence line based on double enumeration between the national parliament and the sub-state entities, where relevant, on the basis of the travaux preparatoires of the fundamental norms on which the arrangements are based, judicial or quasi-judicial resolutions of competence problems, and relevant doctrine and literature. 109 pp. Englisch.

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Urban social movements are influential agents in shaping cityscapes to reflect values and needs of communities. Alongside urban population growth, various forms of urban agriculture activity, such as community and market gardens, are expanding, globally. This book explores citizens' 'rights to city' and alternative views on urban space and the growing importance of urban food systems. 126 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This brief explores the business and global implications of the American shale energy, or natural gas, revolution. Specifically, it provides a rational, comprehensive look at the major business themes and management implications that surround the new abundance of natural gas in the United States and identifies some of the most significant geopolitical considerations globally. While acknowledging some of the controversies and hazards surrounding the extraction techniques, commonly known as 'fracking', the author also looks at the hopes this technique poses and details how shale energy will impact supply chains for firms. The discovery of new sources of domestic natural gas in recent years - coupled with innovations that facilitated their extraction - has altered the global landscape. However, the vast majority of the information out there for business students, faculty, and practitioners about the natural gas revolution is focused on the impact of 'longer and lower' energy prices; and, secondarily, opportunities within the domestic energy sector. Each of these is crucial for business people to understand, however, the natural gas revolution is about much more. Companies of all sizes, whether they see it or not, are having new opportunities open up for their products and services. Further, the globalization of shale energy will have far reaching influence beyond simply economic factors. Geopolitical considerations and the re-structuring of international relations around shale energy will impact supply chains in a myriad of ways. This book aims to examine these opportunities. Featuring case studies from contemporary companies, this book will be of interest to students, academics, researchers, professionals and policy makers who are seeking to understand the business and global implications of the shale energy revolution. 53 pp. Englisch.

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book argues that Brexit will wholly re-shape the legal framework and public policy norms relating to linguistic diversity that have dominated public life in the UK and the EU since the Treaty on European Union in 1993. First, Brexit de-anchors the linguistic actors engaged with sub-state nationalisms in the UK (in Northern Ireland, Wales and Scotland) from the ethno-linguistic imaginary of the so-called 'Europe of the regions'. This strengthens the case both for the de jure recognition of English as the official language of the UK and for embedding autochthonous minority language rights and freedoms in a transformed UK constitution. Second, Brexit strengthens the normative case for English as the lingua franca of the EU, by reducing the injustices associated with the rise of English as the EU and global lingua franca. The book will appeal to students and scholars across the fields of political science, political theory, law, language policy and planning, and sociolinguistics. 84 pp. Englisch.

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book critically engages with a long tradition of scholarly work that conceives of the European Union as a peculiar international actor that pursues a value-based, normatively oriented and development-friendly agenda in its relations with international partners.The EU is a pivotal player in international trade relations, holding formidable powerintrade but also exercising substantial powerthroughtrade. Trade policy therefore represents a strategic field for the EU to shape its image as a healthy economy and a global power. In this field, the EU has declared a twofold ambitious goal, namely that of fostering economic growth in Europe while, at the same time, promoting development and growth abroad, both in developed and developing countries. In other words, the EU aims to increase its competitiveness in world trade while acting as an ethical and normative power.Here, Poletti and Sicurelli explore the tension between these two roles. 131 pp. Englisch.

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Much attention has been paid to the ongoing and unpredictable Brexit negotiations between the EU and the UK, but much less on what the absence of the UK might entail for the remaining 27 EU Member States. This book explores the range of implications for the EU after Brexit, and whether it is likely to become stronger or weaker as a result. It reviews the different attitudes on the EU's future within both the member states and the individual EU institutions, and examines the impacts of Brexit on the composition of the EU institutions and on the balance of power between the member states. It also looks at linguistic and cultural impacts, the UK's wider legacy for the EU and possible changes in EU priorities. The author concludes that Brexit has reinforced the EU's unity in the short term, but that the EU will have to confront a number of key challenges if it is to be reinforced in the longer term. This book will appeal to practitioners, scholars and students interested in EU politics and integration in general, and Brexit in particular. 142 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book presents recent researchresults relating to applications of nonlinear dynamics, focusing specificallyon four topics of wide interest: heart dynamics, DNA/RNA, cell mobility, andproteins. The book derives from the First BCAM Workshop on Nonlinear Dynamicsin Biological Systems, held in June 2014 at the Basque Center of AppliedMathematics (BCAM). At this international meeting, researchers from differentbut complementary backgrounds, including molecular dynamics, physical chemistry,bio-informatics and biophysics, presented their most recent results anddiscussed the future direction of their studies using theoretical, mathematicalmodeling and experimental approaches. Such was the level of interest stimulatedthat the decision was taken to produce this publication, with the organizers ofthe event acting as editors. All of the contributing authors are researchers workingon diverse biological problems that can be approached using nonlinear dynamics.The book will appeal especially to applied mathematicians, biophysicists, andcomputational biologists. 128 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This thesis represents a decisive breakthrough in our understanding of the physics of universal quantum-mechanical three-body systems.The Efimov scenario is a prime example of how fundamental few-body physics features universally across seemingly disparate fields of modern quantum physics. Initially postulated for nuclear physics more than 40 years ago, the Efimov effect has now become a new research paradigm not only in ultracold atomic gases but also in molecular, biological and condensed matter systems. Despite a lot of effort since its first observations, the scaling behavior, which is a hallmark property and often referred to as the 'holy grail' of Efimov physics, remained hidden until recently. In this work, the author demonstrates this behavior for the first time for a heteronuclear mixture of ultracold Li and Cs atoms, and pioneers the experimental understanding of microscopic, non-universal properties in such systems. Based on the application of Born-Oppenheimer approximation, well known from molecular physics textbooks, an exceptionally clear and intuitive picture of heteronuclear Efimov physics is revealed. 125 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This monograph covers the theory of finite and infinite matrices over the fields of real numbers, complex numbers and over quaternions. Emphasizing topics such as sections or truncations and their relationship to the linear operator theory on certain specific separable and sequence spaces, the authors explore techniques like conformal mapping, iterations and truncations that are used to derive precise estimates in some cases and explicit lower and upper bounds for solutions in the other cases.Most of the matrices considered in this monograph have typically special structures like being diagonally dominated or tridiagonal, possess certain sign distributions and are frequently nonsingular. Such matrices arise, for instance, from solution methods for elliptic partial differential equations. The authors focus on both theoretical and computational aspects concerning infinite linear algebraic equations, differential systems and infinite linear programming, among others. Additionally, the authors cover topics such as Bessel's and Mathieu's equations, viscous fluid flow in doubly connected regions, digital circuit dynamics and eigenvalues of the Laplacian. 118 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book constitutes the refereed proceedings of the 8th International Workshop on Biomedical Image Registration, WBIR 2018, held in Leiden, The Netherlands, in June 2018.The 11 full and poster papers included in this volume were carefully reviewed and selected from 17 submitted papers. The papers are organized in the following topical sections: Sliding Motion, Groupwise Registration, Acceleration, and Applications and Evaluation. 127 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book introduces the underlying concepts of column dynamics and buckling, based on the latest state-of-the-art research on this innovative topic. It begins with a summary of the basic concepts behind column dynamics and buckling, before moving on to the models for studying dynamic buckling inside oil wells. Four models with increasing complexity are presented: columns without friction; columns with friction; columns inside slant wells; and columns inside offshore wells. Each model is divided into two cases, depending on whether the column is being tripped in or out. A case study is used to demonstrate these models and is further developed as each model is presented and explained. The results include comparisons between the models themselves, thus showing the implications of the adopted hypotheses of each. This book enables academic, industrial, and graduate student readers to fully understand the fundamentals of dynamic buckling and to further develop the presented models for their own research. 91 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book focuses on the development and set-up of fibre Bragg grating (FBG) and no-core fibre (NCF) sensors. It discusses the properties of the sensors and modelling of the resulting devices, which include electronic, optoelectronic, photovoltaic, and spintronic devices. In addition to providing detailed explanations of the properties of FBG and NCF sensors, it features a wealth of instructive illustrations and tables, helping to visualize the respective devices' functions. 82 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book explains how energy demand and energy consumption in new buildings can be predicted and how these aspects and the resulting CO2 emissions can be reduced. It is based upon the authors' extensive research into the design and energy optimization of office buildings in Chile. The authors first introduce a calculation procedure that can be used for the optimization of energy parameters in office buildings, and to predict how a changing climate may affect energy demand. The prediction of energy demand, consumption and CO2 emissions is demonstrated by solving simple equations using the example of Chilean buildings, and the findings are subsequently applied to buildings around the globe.An optimization process based on Artificial Neural Networks is discussed in detail, which predicts heating and cooling energy demands, energy consumption and CO2 emissions. Taken together, these processes will show readers how to reduce energy demand, consumption and CO2 emissions associated with office buildings in the future. Readers will gain an advanced understanding of energy use in buildings and how it can be reduced. 78 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book focuses on one of the most important aspects of electrical propulsion systems - the creation of highly reliable safety-critical traction electrical drives. It discusses the methods and models for analysis and optimization of reliability and fault tolerance indices, based on which, it proposes and assesses methods for improving the availability, fault tolerance and performance of traction electric drives. 103 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In this work the development of a new geometrically detailed finite element head model is presented. Special attention is given to sulci and gyri modelling, making this model more geometrically accurate than others currently available. The model was validated against experimental data from impact tests on cadavers, specifically intracranial pressure and brain motion. Its potential is shown in an accident reconstruction case with injury evaluation by effectively combining multibody kinematics and finite element methodology. 98 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book deals with a natural convective heat transfer situation of significant practical importance that has not been adequately dealt with in existing texts or widely available review papers: natural convective heat transfer from horizontal and near horizontal surfaces. The aim is to provide the reader with an understanding of past studies of natural convective heat transfer from horizontal surfaces and a more detailed review of contemporary studies. The more recent work deals with heat transfer from surfaces that have more complex shapes than previously considered, with heat transfer in situations in which laminar, transitional, and turbulent flow occur; in situations where the surface is inclined at a relatively small angle to the horizontal; and in situations where there is a covering surface above the heated surface. The authors further present methods for predicting heat transfer rates in all of the situations. 121 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware - This book describes and characterizes an extension to the classical path coupling method applied to statistical mechanical models, referred to as aggregate path coupling. In conjunction with large deviations estimates, the aggregate path coupling method is used to prove rapid mixing of Glauber dynamics for a large class of statistical mechanical models, including models that exhibit discontinuous phase transitions which have traditionally been more difficult to analyze rigorously. The book shows how the parameter regions for rapid mixing for several classes of statistical mechanical models are derived using the aggregate path coupling method. 96 pp. Englisch.

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Accelerated Path to Cures provides a transformative perspective on the power of combining advanced computational technologies, modeling, bioinformatics and machine learning approaches with nonclinical and clinical experimentation to accelerate drug development. This book discusses the application of advanced modeling technologies, from target identification and validation to nonclinical studies in animals to Phase 1-3 human clinical trials and post-approval monitoring, as alternative models of drug development. As a case of successful integration of computational modeling and drug development, we discuss the development of oral small molecule therapeutics for inflammatory bowel disease, from the application of docking studies to screening new chemical entities to the development of next-generation in silico human clinical trials from large-scale clinical data. Additionally, this book illustrates how modeling techniques, machine learning, and informatics can be utilized effectively at each stage of drug development to advance the progress towards predictive, preventive, personalized, precision medicine, and thus provide a successful framework for Path to Cures. 82 pp. Englisch.