birkhäuser springer sep 2011 (55 Ergebnisse)

Taschenbuch. Zustand: Neu. Neuware -Dies ist ein neues Lehrbuch über Funktionentheorie, konzipiert als begleitender Text für eine einsemestrige einführende Vorlesung auf diesem Gebiet. Einige weiterführende Themen werden ebenfalls behandelt. Der Anhang enthält drei Kapitel über den Zusammenhangsbegriff, kompakte metrische Räume und harmonische Funktionen.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 228 pp. Deutsch.

Taschenbuch. Zustand: Neu. Neuware -Der heutige Hochschulunterricht für Mathematiker gründet meist auf Abstraktion und führt vom Allgemeinen zum Speziellen. Die Methode hat Vorteile, sie stärkt das Denkvermögen und meidet lästige Wiederholungen. Doch sie 'stellt den Pflug vor die Ochsen', weil Abstraktion auf Spezialfälle baut, die dem Lernenden oft fremd sind. So bleibt der Erfolg den Glücklichen vorbehalten, die den Weg von der Abstraktion zu den Beispielen finden. Dieses Lehrbuch führt von zwei Spezialfällen zur Allgemeinheit und gründet nicht auf Abstraktion. Die Beweise der abstrakten Algebra werden zuerst am konkreten Beispiel der Matrizen vorgeführt. Zur Schärfung der Anschauung wird dann die Begriffswelt der Elementargeometrie durchleuchtet. Die Auseinandersetzung mit dem Lehrstoff der Schule dient der Vorbereitung auf die geometrisch gefärbte Sprache der linearen Algebra, die am Ende des Buches erläutert wird. Dem Text sind Anwendungsbeispiele und zahlreiche historische Kommentare beigefügt.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 652 pp. Deutsch.

Taschenbuch. Zustand: Neu. Neuware -Der Astronom F.W. Bessel gilt zusammen mit dem Mathematiker C.G.J. Jacobi und dem Physiker Franz Neumann als Begründer der sogenannten 'Königsberger Schule', die auf die Universitäten in Deutsch- land, aber auch in Russland und im gesamten osteuropäischen Raum, einen grossen Einfluss hatte. Als Autodidakt erwarb sich Bessel schon in jungen Jahren mit seinen astronomischen Arbeiten die Anerkennung der führenden Gelehrten seiner Zeit. Nachdem er als Professor an die Albertina nach Königsberg berufen worden war, erhielt er bereits mit 27 Jahren auf Betreiben von Gauss die Ehren- doktorwürde der Universität Göttingen. Ihm wurde die Planung und der Bau der Königsberger Sternwarte übertragen, die sich unter seiner Leitung zu einem internationalen Zentrum der Astronomie entwickelte. Bessel leistete aber nicht nur in der Astronomie und der Geodäsie Bedeutendes, sondern auch in der Theoretischen Mathematik. Diese Biographie beschränkt sich nicht auf die Schilderung der wissenschaftlichen Leistungen Bessels, sondern stellt ihn auch als Mensch und Persönlichkeit vor. Besondere Aufmerksamkeit widmet das Buch den engen wissenschaftlichen und persönlichen Be- ziehungen, die Bessel, nachdem er schon in jungen Jahren in die Petersburger Akademie aufgenommen worden war, zur russischen Wissenschaft und zu den russischen Wissenschaftlern entwickelt hat. Engagiert und lebendig schildert der Autor Bessels Lebensgeschichte und versucht, Bessels zahlreiche, weitgespannte wissenschaftliche Arbeiten und Leistungen auch dem Nichtfachmann verständlich und spannend darzustellen.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 332 pp. Deutsch.

Buch. Zustand: Neu. Neuware -Urban subsurface resources and particularly urban groundwater are vulnerable to environmental impacts, and their rational management is of major importance. In this book a multidisciplinary team of specialists and scientists presents innovative process-oriented approaches to the sustainable use of these resources. The included case studies from northwestern Switzerland describe representative environments and are relevant for urban areas in general. They illustrate the protection of groundwater; river restoration; engineering and hydrogeological questions related to urban infrastructure and management concepts; as well as monitoring, modeling and remediation strategies for contaminated sites; problems caused by karst in urban environments; the use of shallow geothermal energy; and natural hazards such as flood events and earthquakes.It is demonstrated that modern quantitative earth sciences can contribute significantly in finding solutions concerning the sustainable use of subsurface resources in urban environments.The book is an invaluable source of information for hydrogeologists, geologists, urban planners, water supply engineers, and environmental agencies.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 232 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -The field of neuroscience is experiencing a period of unprecedented growth. The range of ap proaches used to investigate the fundamental mechanisms underlying different aspects of somatosen sory perception has expanded substantially since the last International Symposium on Informa tion Processing in the Somatosensory System. Diversity of approach has become the hallmark of somatosensory research, and I believe that the impact of this diversity continues to be positive. of this symposium with previous symposia will show that researchers are employing Comparison an array of new methods and technologies and that they are offering new insights into old ques tions. The techniques range from studies of ionic channels, single unit recordings, functional brain imaging to psychophysics. A careful reading ofthe chapters reveals subtle and, on occasion, also obvious differences of opinion about experimental outcomes, approaches, and views. These differences are healthy signs of venture into new and uncharted territories. It is my hope that read ers will appreciate both the diversity of the research addressing somesthesis, and the personal commitment, enthusiasm, and scientific rigor of the participants who made this symposium and volume meaningful for all involved. We all look forward to tracking the progress of somatosensory research at our next Symposium at the turn of the century. OveFranzen November 1995 xv List of Contributors David T. Blake Harold Burton Krieger MindlBrain Institute Department of Anatomy and Neurobiology Department of Neuroscience Washington University The Johns Hopkins University School of Medicine Baltimore, MD 21218, USA St.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 448 pp. Englisch.

Buch. Zustand: Neu. Neuware -The book consists of solicited articles from a select group of mathematicians and physicists working at the interface between positivity andthe geometry, combinatorics or analysis of polynomials of one or several variables. It is dedicated to the memory of Julius Borcea (1968-2009), a distinguished mathematician, Professor at the University of Stockholm. With his extremely original contributions and broad vision, his impact on the topics of the planned volume cannot be underestimated. All contributors knew or have exchanged ideas with Dr. Borcea, and their articles reflect, at least partially, his heritage.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 424 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Two events have recently improved the prospects of protecting fish and their environment in Switzerland: the acceptance of a new Federal Water Protection Law in the plebiscite of May 17th 1992, and the new Federal Legislation on Fisheries, in force since January 1st 1994. With this legal framework, the possibilities for protection of nature and landscape have now considerably improved in Switzerland. The most important aims of the Federal Law on Water Protection are to safeguard the natural habitats of the native flora and fauna and water as the habitat of aquatic organisms. This includes not only the preservation or restoration of water quality in lakes and rivers, but also, in rivers used for hydroelectricity, irrigation or as industrial or other water supplies, the maintenance of sufficient water to fulfill the minimal requirements for fish. However, good quality water in sufficient quan tities alone is not enough to guarantee the survival of fish. Intact fish habitats comprise various phYsical structures including plenty of hiding places, hunting grounds, reproduction and nursery areas within suitable distances from each other. This third aspect of conservation and restoration of aquatic habitats is a central point in the new Federal Law on Fisheries. Whereas the former versions of this law were more concerned with fishery regulations, the recent legislation defines new areas of responsibility for the federal and the cantonal governments.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 360 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -The theory of integral equations has been an active research field for many years and is based on analysis, function theory, and functional analysis. On the other hand, integral equations are of practical interest because of the «boundary integral equation method», which transforms partial differential equations on a domain into integral equations over its boundary. This book grew out of a series of lectures given by the author at the Ruhr-Universitat Bochum and the Christian-Albrecht-Universitat zu Kiel to students of mathematics. The contents of the first six chapters correspond to an intensive lecture course of four hours per week for a semester. Readers of the book require background from analysis and the foundations of numeri cal mathematics. Knowledge of functional analysis is helpful, but to begin with some basic facts about Banach and Hilbert spaces are sufficient. The theoretical part of this book is reduced to a minimum; in Chapters 2, 4, and 5 more importance is attached to the numerical treatment of the integral equations than to their theory. Important parts of functional analysis (e. g. , the Riesz-Schauder theory) are presented without proof. We expect the reader either to be already familiar with functional analysis or to become motivated by the practical examples given here to read a book about this topic. We recall that also from a historical point of view, functional analysis was initially stimulated by the investigation of integral equations.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 380 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This volume grew out of the preparation and achievements of the Symposium organized by the Luxembourg Mathematical Society in June 1992, at Chateau Bourglinster (Luxembourg). We express our best thanks to Monsieur Marc Fischbach, ministre de I 'Education nationale, Luxembourg Monsieur Rene Steichen, ministre delegue aux Affaires culturelles, Luxem bourg, Academie des sciences, Paris, Academie roya1e des sciences, des lettres et des beaux-arts de Belgique, Section des sciences de l'Institut grand-ducal, Luxembourg, and all lecturers and participants. We hope that this contribution may ease a better understanding of the vitality in mathematics during the first half of the present century and provide clues for the explanation of its influence on later developments. We say our gratitude to persons who assisted us with their advice and help for the technical realization of the volume, especially Mrs. Suzanne D' Addato-Mues, Mr. Fran~ois Gaillard, Mr. Hubert Glesener. We are also grateful to Birkhauser Verlag for having accepted this publication. Now the book should speak for itself .Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 756 pp. Englisch.

Buch. Zustand: Neu. Neuware -Influenza continues to be an ongoing problem despite the existence of vaccines and drugs. Disease outbreaks can occur relatively quickly as witnessed with the recent emergence of the influenza virus A/H1N1 pandemic. The development of new anti-influenza drugs is thus a major challenge.This volume describes all aspects of the virus structure and function relevant to infection. The focus is on drug discovery of inhibitors to the enzyme sialidase, which plays a key role in the infectious lifecycle of the virus. Following an overview of the influenza virus, the haemagglutinin, the interactions with the cell receptors and the enzymology of virus sialidase, recent results in drug design are presented. These include a full coverage of the design, synthesis and evaluation of carbohydrate as well as non-carbohydrate influenza virus sialidase inhibitors. Further reviews of the clinical experience with influenza virus sialidase inhibitors and of the development of resistance to these inhibitor drugs complement the topic.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 188 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -These notes are based on lectures presented during the seminar on ' Asymptotic Statistics' held at SchloB Reisensburg, Gunzburg, May 29-June 5, 1988. They consist of two parts, the theory of asymptotic expansions in statistics and probabilistic aspects of the asymptotic distribution theory in nonparametric statistics. Our intention is to provide a comprehensive presentation of these two subjects, leading from elementary facts to the advanced theory and recent results. Prospects for further research are also included. We would like to thank all participants for their stimulating discussions and their interest in the subjects, which made lecturing very pleasant. Special thanks are due H. Zimmer for her excellent typing. We would also like to take this opportunity to to express our thanks to the Gesellschaft fur mathematische Forschung and to the Deutsche Mathematiker Vereinigung, especially to Professor G. Fischer, for the opportunity to present these lectures and to the Birkhauser Verlag for the publication of these lecture notes. R. Bhattacharya, M. Denker Part I: Asymptotic Expansions in Statistics Rabi Bhattacharya 11 1. CRAMER-EDGEWORTH EXPANSIONS Let Q be a probability measure on (IRk, B'), B' denoting the Borel sigmafield on IR'. Assume that the s - th absolute moment of Q is finite, (1.1) P. := J II x lis Q(dx) 00, for some integer s;::: 3, and that Q is normalized, (1.2) J x(i)Q(dx) = 0 (1 ~ i ~ k), J x(i)x(j)Q(dx) = Dij (1 ~ i,j ~ k). 122 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Das neue Lehrbuch zur Funktionentheorie, im Aufbau angelehnt an das klassische Werk von Lars Ahlfors, ist als begleitender Text für eine einsemestrige einführende Vorlesung konzipiert. Darüber hinaus behandelt der Autor aber auch einige weiterführende Themen. Der Band enthält zahlreiche Übungen sowie im Anhang drei Kapitel über den Zusammenhangsbegriff, kompakte metrische Räume und harmonische Funktionen. Besonderen Wert legt der Autor darauf, alle Beweise elegant und vollständig darzustellen. Der Band eignet sich auch für das Selbststudium. 228 pp. Deutsch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Entre Meeanique et Arehiteeture: e'est-a-dire, entre les proeedes teehniques qui, depuis des temps immemoriaux eonforment l'art et la scienee de la eonstruetion au developpement de la scienee physique et mathematique la plus generale et, peut-etre, la plus abstraite, subalternata tanturn geometriae et philosophiae naturalis, eomme le disait Tartaglia, bien que liee aux faits les plus farniliers: la statique et la meeanique des mareriaux et des struetures. Le theme qui nous eoneeme est done la relation entre la technique et la scienee dans son exemple le plus important, je crois, du point de vue historiographique mais aussi epistemologique: a savoir, la relation entre le savoir faire, qui se eonforme a la norme, en respeetant une determination et une eongruenee parfaites avee son objectif, et la theorie, qui eonfirme la norme et temoigne la neeessite de la determiner eongrfiment avec les lois de la nature. Avee une extreme perspieaeite, quelque peu offusquee par une frivolite erudite, l' Abbe Franeeseo Maria Franeesehinis, mathematieien et adepte de la philosophie des lurnieres, se peneha sur la question dans un bref traite qu'il publia a Padoue en 1808 sous 1 le titre Des Mathematiques appliquees , soutenant la nouvelle tendanee didaetique introduite a l'Universite de Padoue par l'ephemere Regne d'Italie. Simulant un eonflit entre plusieurs auteurs, Franeesehinis exposait une premiere these dans un Discours inaugural qu'il reeita peut-etre reellement en 1807, lorsqu'il devint titulaire de la Chaire de Mathematiques appliquees. 408 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Found in all organisms, the alpha-keto acid dehydrogenase complexes have central roles in cellular metabolism and are major sites of regulation. The understanding of the organization, function and regulation of these quintessential multienzyme complexes has been greatly advanced by studies employing molecular biology and biophysical techniques. Although these enzyme systems have some features in common, their diversity in fulfilling unique organism - or tissue - specific roles is truly amazing. These systems have medical importance in areas ranging from defects in regulation (linked to diabetes, heart disease, obesity, nutrition defects), to inherited diseases (inborn errors, maple syrup urine disease) to acquired immune diseases (primary biliary cirrhosis). This book brings together wide-ranging recent findings on the structure(function relationships, gene regulation, and genetic defects of the alpha-keto acid dehydrogenase complexes, namely the pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase and the branched-chain alpha-keto acid dehydrogenase complexes. A wide variety of experimental approaches together with new results presented in this book should serve as a resource for beginning to established investigators in the field as well as scientists who are interested in mitochondria, dehydrogenases, kinases, phosphatases, lipoic acid, thiamine pyrophosphate, and enzyme complexes. 340 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Volume 46 of 'Progress in Drug Research' contains seven reviews and the various indexes which facilitate its use and establish the connection with the previous volumes. The articles in this volume deal with endo genous sodium pump inhibition, with neurotransmitters involved in the central regulation of the cardiovascular system, with leukotrienes and development of novel anti-inflammatory agents, with antithrombotic stra tegies and drugs affecting the plasma fibrinogen levels, with natural ami noglycosides and polyamines and their effects in the mammalian orga nism, with the latest developments in antidepressant agents and with immunopharmacological and biochemical bases of Chinese herbal medi cine. These reviews provide valuable information on several new deve lopments in the complex domain of drug research. In the 37 years that PDR has existed, the Editor has enjoyed the valua ble help and advice of many colleagues. Readers, the authors of the reviews and, last but not least, the reviewers have all contributed greatly to the success of this series of monographs. Although the comments received so far have generally been favorable, it is nevertheless necessary to analyze and to reassess the current position and the future direction of such publi cations. 332 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -thrombospondin-l may be encoded by a tumor suppressor gene. Dr. O'Reilly discusses angiostatin, an exciting recently discovered factor derived from the fibrinolytic proenzyme plasminogen that inhibits tumor angiogenesis, primary tumor growth, and formation of metastases. In addition to the soluble class of angiogenesis-regulatory factors discussed above, interactions of endothelial cells with components of the extracellular matrix and with other cell types are critical for proper formation of vessels. Drs. Grant and Kleinman discuss the role of laminin and other matrix molecules in regulation of capillary formation. Dr. van Hinsbergh and colleagues describe the role of fibrin and the fibrinolytic system in angiogenesis associated with wound repair. Cell surface mole cules that interact with the extracellular matrix have been implicated in the regulation of angiogenesis. Dr. Varner discusses some exciting new studies on the roles of specific vascular cell integrins (a /33 and a /3s) in mediating v v tumor angiogenesis and angiogenesis associated with wound healing. The pericyte, a vascular smooth muscle-like cell, exerts a powerful regulatory effect during the later stages of angiogenesis in which mature capillaries are formed. These mechanisms are discussed by Drs. Hirschi and D' Amore. With all the recent progress in the molecular biology of angiogenesis, the contribution of microenvironmental conditions such as hypoxia and pH to angiogenesis is often ignored. Drs. Rockwell and Knisely review this area of investigation and present studies of experimental tumor models. 448 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book is based on two keywords: Bioradical and ESR. Bioradical is a newly coined word which encompasses paramagnetic species in biological systems, such as active oxygen radicals and transition metal ions. Research on the structure and function of bioradicals has been attrac ting growing attention in the field of biological science, and comprehensive investigations from many fields are helping to understand the real features of these species. ESR spectroscopy also has interdisciplinary features in that its techniques have been applied to many fields, ranging from physics to medicine. It was our hope, therefore, that this book would help to clarify many aspects of bioradicals and that significant progress would be achieved in combining basic research from many different fields. This book arises from the First International Conference on Bioradicals Detected by ESR Spectroscopy (ICBES), which was held in Yamagata, a city in the Yamagata Prefecture of Japan, in 1994. About 300 participants from 16 different countries attended this conference, and about 170 papers were presented. This book is a collection of contributions from the conference and also contains eleven chapters selected by the editorial board, based on sugges tions from the members of the international editorial board of ICBES. The Yamagata Technopolis Foundation is developing a biomedical technology for the 21st century based on life science fused with material and physical science. Based on such a techno logy, the Foundation plans to share its fruits all over the world. 352 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume presents the proceedings of the Joint German-Israeli Workshop on linear one-dimensional singular integral equations, held in Tel Aviv from March 1-10, 1995. The volume contains a selection of papers in modern operator theory and its applications. The main topics of the workshop were symbol calculus, index formulas, projection and quadrature methods for Toeplitz and singular integral operators with different symbols, algebras generated by such operators and algebras generated by indempotents. The other topics discussed were inverse scattering problems for differential operators, distribution of zeros for orthogonal functions, factorization of matrix functions and calculation of norms. The book will be appreciated by a wide audience in the mathematical and engineering sciences. 328 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Why do hormone receptors arise An introduction.- The evolution of recognition.- Signal receivers and signal molecules.- Interrelation of hormone receptor evolution.- Conclusions.- Mechanisms of receptor-mediated transmembrane signaling.- Receptors, acceptors channels and the problem of transmembrane-signaling.- General mechanisms of transmembrane signaling.- Receptor dynamics and transmembrane signaling.- Receptor microclustering and cell activation.- Internalized receptor and cell activation.- Summary.- Insulin receptors: structure and function.- The molecular mechanism of insulin action.- The insulin receptor kinase.- Biochemical properties of the insulin receptor kinase.- Role of receptor phosphorylation in insulin action.- Structure-function relationship of the insulin receptor kinase.- Summary and conclusions.- Internalization of polypeptide hormones and receptor recycling.- Historical perspective.- Events at the cell surface (steps 1, 2 and 3).- Initial steps of endocytosis (steps 4 and 5).- Later steps of endocytosis (steps 6, 7 and 8).- Receptor recycling.- What determines the specificity of receptor-mediated endocytosis.- Biochemical features of receptor-mediated endocytosis.- Functional implications of receptor-mediated endocytosis.- Conclusions.- The nature and development of steroid hormone receptors.- Models of steroid hormone action.- Nuclear binding sites.- Development of steroid receptors: Ontogeny of estrogen receptors.- Receptor ontogeny and hormonal imprinting.- Receptor alterations during ontogenetic development.- Why is receptor adaptation necessary An approach based on information theory.- Experimental evidence for hormonal imprinting.- Polypeptide hormones.- Imprinting by related hormones; the disturbing effect of 'noise'.- Overlappingimprinting by steroid hormones.- Imprinting with acid type hormones.- The importance and sensitivity of imprinting.- Hormonal imprinting in cell lines.- Cell-cell transmission of hormonal imprinting.- Hormonal imprinting at enzyme level.- The mechanism of imprinting.- The four stages of the development of encoded adaptation-requiring dynamic systems in mammals.- Medicinal aspects of hormonal imprinting.- The spectal case of hormonal imprinting, the neonatal influence of sex.- Historical perspectives.- Environmental influences on sexual differentiation.- Genetic influences on sexual differentiation.- Hormonal influences on sexual differentiation.- Conclusions.- The mechanism of receptor development as implied by hormonal imprinting studies on unicellular organisms.- The role of the cell membrane in hormonal imprinting.- The role of second messengers in hormonal imprinting.- Impact of the inhibition of endocytosis, transcription and translation on hormonal imprinting.- Impact of hormone concentration and time factor on hormonal imprinting.- Which materials can induce imprinting.- Study of induced receptors in the Tetrahymena.- Receptor 'memory' in unicellular model systems.- Structural studies on membrane receptors of Tetrahymena.- Specificity of the hormone receptors of Tetrahymena.- The phylogeny of the endocrine system.- The scope of phylogeny.- Thyroidal phylogenesis.- The steroid ring system.- Peptide hormones.- Pathways of endocrine diversification.- Multiple sites and actions.- Invertebrates.- Challenging perspectives.- A new approach to the molecular evolution of hormones: the receptorial aspect.- The signal molecule potential of amino acids.- The signal molecule potential of oligopeptides.- Common origin and phylogenetic diversification of animal hormonalsystems.- The significance of the evolutionary history of hormones.- The approach of comparative physiology.- The common base of intercellular messenger substances in multicellular organisms.- The different evolutions of animal and plant hormonal systems.- Diversification of hormonal systems in multicellular animals.- The evolutionary history of neurosecretion.- Neuroendocrine and epithelial endocrine gland 204 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Volume I provides an in-depth discussion of the most recent developments of crucical biosensor components. It concentrates on the interface between the analyte phase and the detector, namely, the implementation of novel recognition elements, including nucleic acids, and of leading-edge technology in the construction of responsive thin layers. Thus, the reader can obtain a foretaste of achievable future progress in the field. 300 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -New methods for solving classical problems in the theory of nonlinear operator equations (solvability, multiple solutions, bifurcations, nonlinear resonance, potential methods, etc) are introduced and discussed. The general abstract theorems are illustrated by various applications to differential equations and boundary value problems. In particular, the problem on forced periodic oscillations is considered for equations arising in control theory. 292 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The last twenty years have witnessed enormous efforts by the pharmaceutical industry in the search for new drugs for the treatment of asthma. During this time, as a result of the efforts of asthma researchers in many disciplines, there has been an unprecedented increase in our knowledge about asthma as a disease and about the pharmacology of the existing anti-asthma drugs. This increase in knowledge should have generated information from which directions for future anti-asthma drug research and development might be predicted. Thus, we felt it was timely to invite a group of leading international pharmacologists to meet together on the occasion of the Xth International Congress of Pharmacology, being held for the first time in Australia (in Sydney August 23- 28th, 1987), for a satellite meeting to discuss the topic 'New drugs for asthma'. The proceedings of this small workshop are presented in this book. The meeting was unique in that leading pharmacologists from most of the pharmaceutical companies involved in the development of anti-asthma drugs were present. All participants, whether from the industry or from academia, were active researchers involved in providing the animal data and in carrying out human pharmacological studies, on new anti asthma drugs. Although the proceedings have been subtitled into 'symptomatic' and 'prophylactic' anti-asthma drugs for the purposes of presentation, this is not meant to pinpoint the idea that we believe such clear cut differences necessarily exist. In fact, they may not exist. 328 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Our knowledge of cholinergic synaptic transmission in the peripheral nervous system (PNS) has expanded enormously since the early 1930's, at which time O. Loewi discovered chemical neurotransmission through acetylcholine (ACh) and the pharmacological actions of ACh were described by H. Dale and his colleagues. Description of ACh's actions and receptors in various parts of the brain was followed by a detailed analysis of ACh's synthesis, release mechanism, removal from the synaptic cleft, modes of agonist-receptor interactions, properties of regulated conductances and of the pre-and postsynaptic modulation of cholinergic synapses. Our knowledge has been increasingly consolidat ing, leading us to the recent clarification of the structure of the periph eral nicotinic receptor-ion channel and its functional properties. It is appropriate to maintain the claim that the fundamentals of our under standing of synaptic transmission come from studies on cholinergic synapses in the PNS. Contrastingly, views held on the role of cholinergic synapses in the mammalian central nervous system (CNS) are extremely controversial, although it has been clear for some time that ACh is present in the brain. Illustrating this, no unanimous view is held on the role of nicotinic receptors in the CNS. There is one notable exception to this confusion: Studies begun by J. C. Eccles and associates in the 1960's and completed by D. R. Curtis and R. W. 336 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Research of discrete event systems is strongly motivated by applications in flex ible manufacturing, in traffic control and in concurrent and real-time software verification and design, just to mention a few important areas. Discrete event system theory is a promising and dynamically developing area of both control theory and computer science. Discrete event systems are systems with non-numerically-valued states, inputs, and outputs. The approaches to the modelling and control of these systems can be roughly divided into two groups. The first group is concerned with the automatic design of controllers from formal specifications of logical requirements. This re search owes much to the pioneering work of P.J. Ramadge and W.M. Wonham at the beginning of the eighties. The second group deals with the analysis and op timization of system throughput, waiting time, and other performance measures for discrete event systems. The present book contains selected papers presented at the Joint Workshop on Discrete Event Systems (WODES'92) held in Prague, Czechoslovakia, on Au gust 26-28, 1992 and organized by the Institute of Information Theory and Au tomation of the Czechoslovak Academy of Sciences, Prague, Czechoslovakia, by the Automatic Control Laboratory of the Swiss Federal Institute of Technology (ETH) , Zurich, Switzerland, and by the Department of Computing Science of the University of Groningen, Groningen, the Netherlands. 244 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume is dedicated to A.C. Zaanen, one of the pioneers of functional analysis, and eminent expert in modern integration theory and the theory of vector lattices, on the occasion of his 80th birthday. The book opens with biographical notes, including Zaanen's curriculum vitae and list of publications. It contains a selection of original research papers which cover a broad spectrum of topics about operators and semigroups of operators on Banach lattices, analysis in function spaces and integration theory. Special attention is paid to the spectral theory of operators on Banach lattices; in particular, to the one of positive operators. Classes of integral operators arising in systems theory, optimization and best approximation problems, and evolution equations are also discussed. The book will appeal to a wide range of readers engaged in pure and applied mathematics. 324 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Volume 31 of 'Progress in Drug Research' contains 13 articles, a sub ject index, an index for all articles that have been published so far in this series of monographs, as well as an author and subject index for all 31 volumes. The reviews in this volume are particularly concerned with the therapy of helminth diseases, with pyramidinones as biody namic agents, and with quinolones which are of interest in the treat ment of infections. For a deeper understanding of the pharmacokinet ic actions of modem drugs, the articles on cooperative binding of drug molecules to DNA, on in vitro models for the study of antibiotic activi ties, on inhibitors of the renin-angiotensin system, on GAB A-drug in teractions, and on the mechanism of action of anxiolytic drugs provide a wealth offacts and new findings. The pharmacology of caffeine is re viewed from the viewpoint of its role in combination with other phy siologically active substances, and the chapter on high resolution nuc lear magnetic resonance spectroscopy demonstrates the importance of this method in the development of new drugs. Finally, the article on light and dark touches border problems of the therapy of psychic dis orders. With these contributions, the authors aim to summarize latest achieve ments in important and actual fields of drug research. Researchers who are actively engaged in the same or in similar fields of research are sure to benefit from these efforts. 532 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Since the rheumatic diseases are among the most prevalent of conditions, the anti-rheumatic drugs make up one of the largest groups of drugs prescribed. They vary from the non-steroidal anti-inflammatory drugs through to the complex imrnunomodulators. There are significant differences between these groups of drugs as regards their mechanism of action and within each spectrum of adverse reactions, yet there is also some overlap. class there are also subtle individual differences between the drugs despite a sharing of the basic mechanisms of action and range of side effects. It is this individual variation and, in particular, the individual reaction of the patient to the drug that we attempted to address at this symposium. The first symposium on Individual Variation in Response to Non Steroidal Anti-inflammatory Drugs was held at Leura, New South Wales, Australia as a satellite symposium to the XVI International Congress of Rheumatology in August, 1985. Following a successful meeting, proceedings of which were published in a supplement to Agents and Actions (Suppl. 17, 1986), it was decided to organise a second symposium as a satellite meeting of the International Congressof Pharmacology Meeting in Sydney, August, 1987. The meeting was held at the Manly Pacific and focused on variability in response to anti-rheumatic drugs in general rather than just concentrating on the non-steroidal drugs. 288 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The last twenty years have witnessed enormous efforts by the pharmaceutical industry in the search for new drugs for the treatment of asthma. During this time, as a result of the efforts of asthma researchers in many disciplines, there has been an unprecedented increase in our knowledge about asthma as a disease and about the pharmacology of the existing anti-asthma drugs. This increase in knowledge should have generated information from which directions for future anti-asthma drug research and development might be predicted. Thus, we felt it was timely to invite a group of leading international pharmacologists to meet together on the occasion of the Xth International Congress of Pharmacology, being held for the first time in Australia (in Sydney August 23- 28th, 1987), for a satellite meeting to discuss the topic 'New drugs for asthma'. The proceedings of this small workshop are presented in this book. The meeting was unique in that leading pharmacologists from most of the pharmaceutical companies involved in the development of anti-asthma drugs were present. All participants, whether from the industry or from academia, were active researchers involved in providing the animal data and in carrying out human pharmacological studies, on new anti asthma drugs. Although the proceedings have been subtitled into 'symptomatic' and 'prophylactic' anti-asthma drugs for the purposes of presentation, this is not meant to pinpoint the idea that we believe such clear cut differences necessarily exist. In fact, they may not exist.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 328 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Entre Meeanique et Arehiteeture: e'est-a-dire, entre les proeedes teehniques qui, depuis des temps immemoriaux eonforment l'art et la scienee de la eonstruetion au developpement de la scienee physique et mathematique la plus generale et, peut-etre, la plus abstraite, subalternata tanturn geometriae et philosophiae naturalis, eomme le disait Tartaglia, bien que liee aux faits les plus farniliers: la statique et la meeanique des mareriaux et des struetures. Le theme qui nous eoneeme est done la relation entre la technique et la scienee dans son exemple le plus important, je crois, du point de vue historiographique mais aussi epistemologique: a savoir, la relation entre le savoir faire, qui se eonforme a la norme, en respeetant une determination et une eongruenee parfaites avee son objectif, et la theorie, qui eonfirme la norme et temoigne la neeessite de la determiner eongrfiment avec les lois de la nature. Avee une extreme perspieaeite, quelque peu offusquee par une frivolite erudite, l' Abbe Franeeseo Maria Franeesehinis, mathematieien et adepte de la philosophie des lurnieres, se peneha sur la question dans un bref traite qu'il publia a Padoue en 1808 sous 1 le titre Des Mathematiques appliquees , soutenant la nouvelle tendanee didaetique introduite a l'Universite de Padoue par l'ephemere Regne d'Italie. Simulant un eonflit entre plusieurs auteurs, Franeesehinis exposait une premiere these dans un Discours inaugural qu'il reeita peut-etre reellement en 1807, lorsqu'il devint titulaire de la Chaire de Mathematiques appliquees.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 408 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The ~ecent Vitamin Be-Meeting in Tu~ku, FinLand, has continued a Long-standing t1'O.dition; it ws the seventh intemationaL congNss devoted to the 'ChemicaL and BioLogicaL Aspects of Vitamin Be-Cata Lysis'. The fi~st meeting ws heLd 1962 in Rome foUo1JJed by the meetings in Moscow (1966), Nagoya (1967), Lening1'O.d (1974), To~onto (1979), and Athens (1983). The p~oceedings of a meeting p~ovide a 'snapshot' of a pa~ticuLa~ fieLd of science. Not unLike the photog~phic p~oduct they affo~d a topicaL ~eco~ of the goings-on, at pe~haps the expense of some inforrmation on detaUs. These Proceedings focus on the st~uctu~L and mechanistic aspects of vitamin B6-dependent enaymes; h01JJeve~, othe~ topics discussed ~nge f~om nonenaymic ~eactions of vitamin B6 compounds to nut~tionaL, medicaL, and even appLied indust~aL as pects. The Opening Session of the Meeting ws dedicated to the memo~y of the Late ALe:x:ande~ E. B~unstein, who fifty yea~s ago discove~ed t~nsamination as a metaboUc ~eaction. The contT'ibutions honoT'ing P~ofesso~ B~unstein and his Ufewo~k a~e coUected in the fi~st section of the ~oceedings.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 500 pp. Englisch.