elsevier science okt 2014 (30 Ergebnisse)

Buch. Zustand: Neu. Neuware -Are we satisfied with the rate of drug development Are we happy with the drugs that come to market Are we getting our money's worth in spending for basic biomedical research In Translational Systems Biology, Drs. Yoram Vodovotz and Gary An address these questions by providing a foundational description the barriers facing biomedical research today and the immediate future, and how these barriers could be overcome through the adoption of a robust and scalable approach that will form the underpinning of biomedical research for the future. By using a combination of essays providing the intellectual basis of the Translational Dilemma and reports of examples in the study of inflammation, the content of Translational Systems Biology will remain relevant as technology and knowledge advances bring broad translational applicability to other diseases. Translational systems biology is an integrated, multi-scale, evidence-based approach that combines laboratory, clinical and computational methods with an explicit goal of developing effective means of control of biological processes for improving human health and rapid clinical application. This comprehensive approach to date has been utilized for in silico studies of sepsis, trauma, hemorrhage, and traumatic brain injury, acute liver failure, wound healing, and inflammation. 178 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware.

Buch. Zustand: Neu. Neuware - Vol 2A: Basic TechnologiesHandbook of Crystal Growth, Second Edition Volume IIA (Basic Technologies) presents basic growth technologies and modern crystal cutting methods. Particularly, the methodical fundamentals and development of technology in the field of bulk crystallization on both industrial and research scales are explored. After an introductory chapter on the formation of minerals, ruling historically the basic crystal formation parameters, advanced basic technologies from melt, solution, and vapour being applied for research and production of the today most important materials, like silicon, semiconductor compounds and oxides are presented in detail. The interdisciplinary and general importance of crystal growth for human live are illustrated.Vol 2B: Growth Mechanisms and DynamicsHandbook of Crystal Growth, Second Edition Volume IIB (Growth Mechanisms and Dynamics) deals with characteristic mechanisms and dynamics accompanying each bulk crystal growth method discussed in Volume IIA. Before the atoms or molecules pass over from a position in the fluid medium (gas, melt or solution) to their place in the crystalline face they must be transported in the fluid over macroscopic distances by diffusion, buoyancy-driven convection, surface-tension-driven convection, and forced convection (rotation, acceleration, vibration, magnetic mixing). Further, the heat of fusion and the part carried by the species on their way to the crystal by conductive and convective transport must be dissipated in the solid phase by well-organized thermal conduction and radiation to maintain a stable propagating interface. Additionally, segregation and capillary phenomena play a decisional role for chemical composition and crystal shaping, respectively. Today, the increase of high-quality crystal yield, its size enlargement and reproducibility are imperative conditions to match the strong economy.

Buch. Zustand: Neu. Neuware.

Buch. Zustand: Neu. Neuware - Solvents have a major role to play in the environmental and sustainability agenda, and many currently used solvents have to be replaced, either because of regulations or because of increasing demands for safer solvents and produce them in safer way. Some solvents previously advertised as green solvents have to be replaced according to the present regulations, and these are costly and risky operations.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Organic Chemistry Concepts: An EFL Approach provides an introductory overview of the subject, to enable the reader to understand many critical, experimental facts. Designed to cover a single-semester course or a needed review on the principles of Organic Chemistry, the book is written and organized for readers whose first language is not English. Approximately 80% of the words used are drawn from the list of the 2,000 most common English words; the remaining 20% includes necessary technical words, common chemistry terms, and well-known academic words (per the Academic Word List). The book has been class-tested internationally as well as with native English speakers, and differs from other introductory textbooks in the subject both in its coverage and organization, with a particular focus on common problem areas.Focused on a limited number of functional classes, Organic Chemistry Concepts: An EFL Approach introduces those organic compounds early in the book. Once readers have a foundation of the concepts and language of organic chemistry, they can build from that knowledge and work with relatively complex molecules, such as some natural product types covered in a later chapter. The book describes basic level reaction mechanisms when instructive, and illustrations throughout to emphasize the 3D nature of organic chemistry. The book includes multiple pedagogical features, such as chapter questions and useful appendices, to support reader comprehension. 236 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Advances in Alzheimer's disease (AD) research have been challenging and without major breakthroughs in understanding its pathological basis. The reigning hypothesis suggests AD is the result of extracellular amyloid deposition that seed to form amyloid plaques, which then grow and kill neighboring neurons. However, there are several inconsistencies with this hypothesis, not to mention the inability to show clinical benefit in several failed clinical trials by pharmaceuticals (i.e., from Pfizer, Eli Lilly, etc.), and it is in the field's best interest to explore and test multiple hypotheses for pathology rather than drive the majority of research on this single amyloid theory. Reviewing many scientifically peer-reviewed publications, this book describes the 'Inside-Out' hypothesis on how amyloid escapes the circulatory system through a dysfunctional blood-brain barrier to bind to the alpha 7 nicotinic acetylcholine receptor on pyramidal neurons. Over time, excessive amounts of amyloid appear to be internalized, resulting in neuron death and lysis. This simple mechanism readily explains plaque composition, size, shape, and location. Based on the current direction of research in the field, this hypothesis appears years from any research and development. 170 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Learning from the Impacts of Superstorm Sandy summarizes first results from studies of Superstorm Sandy, including: tide gauge measurements of storm surge, stable isotope variation in precipitation, analysis of the effect of beach nourishment among other factors on structural damage, and comparison with past storms through sediment analysis. This book gives a multi-dimensional treatment of scientific results of studies of Superstorm Sandy, and it is a valuable reference for oceanographers, coastal geologists, climatologists, dynamic meteorologists, paleotempostologists, sedimentary geologists, geomorphologists and emergency managers who need to better understand the storm and its effects in order to be prepared for similar events in the future. 140 pp. Englisch.

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Integrated Assessment of Scale Impacts of Watershed Interventions is the outcome of a multi-disciplinary research team of social scientists, hydrologists (groundwater and surface water), modellers; and bio-physical scientists who have worked together over five years to develop an integrated model of the sustainability of biophysical, economic and social impacts of watersheds. Impacts of watershed interventions are assessed at upstream, mid-stream and downstream locations of two hydrological units that are characterised with differential bio-physical attributes. The editors propose that watershed interventions, when integrated with hydro-geology and bio-physical aspects, have greater influence on the resilience of the socio-ecological system. This book takes these aspects in to consideration and in the process provides insights in to watershed design and implementation. 454 pp. Englisch.

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The fourth book of a four-part series, Design Theory and Methods using CAD/CAE integrates discussion of modern engineering design principles, advanced design tools, and industrial design practices throughout the design process. This is the first book to integrate discussion of computer design tools throughout the design process. Through this book series, the reader will: Understand basic design principles and all digital modern engineering design paradigms Understand CAD/CAE/CAM tools available for various design related tasks Understand how to put an integrated system together to conduct All Digital Design (ADD) product design using the paradigms and tools Understand industrial practices in employing ADD virtual engineering design and tools for product development The first book to integrate discussion of computer design tools throughout the design process Demonstrates how to define a meaningful design problem and conduct systematic design using computer-based tools that will lead to a better, improved design Fosters confidence and competency to compete in industry, especially in high-tech companies and design departments 516 pp. Englisch.

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The first volume in this ground-breaking series focuses on the origins and early development of numerical cognition in non-human primates, lower vertebrates, human infants, and preschool children. The text will help readers understand the nature and complexity of these foundational quantitative concepts and skills along with evolutionary precursors and early developmental trajectories. 400 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Essentials of Vehicle Dynamics explains the essential mathematical basis of vehicle dynamics in a concise and clear way, providing engineers and students with the qualitative understanding of vehicle handling performance needed to underpin chassis-related research and development.Without a sound understanding of the mathematical tools and principles underlying the complex models in vehicle dynamics, engineers can end up with errors in their analyses and assumptions, leading to costly mistakes in design and virtual prototyping activities. Author Joop P. Pauwelussen looks to rectify this by drawing on his 15 years' experience of helping students and professionals understand the vehicle as a dynamic system. He begins as simply as possible before moving on to tackle models of increasing complexity, emphasizing the critical role played by tire-road contact and the different analysis tools required to consider non-linear dynamical systems.Providing a basic mathematical background that is ideal for students or those with practical experience who are struggling with the theory, Essentials of Vehicle Dynamics is also intended to help engineers from different disciplines, such as control and electronic engineering, move into the automotive sector or undertake multi-disciplinary vehicle dynamics work. 320 pp. Englisch.

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Aimed at 'drug discoverers' - i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular - the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation, druggability, existing leads, etc.). Together these will satisfy the needs of various audiences, including in vitro biologists, pharmacologists, medicinal chemists, etc. 314 pp. Englisch.

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -More than 90% of wildfires are caused by human activity, but other causes include lighting, drought, wind and changing weather conditions, underground coal fires, and even volcanic activity. Wildfire Hazards, Risks, and Disasters, one of nine volumes in the Elsevier Hazards and Disasters series, provides a close and detailed examination of wildfires and measures for more thorough and accurate monitoring, prediction, preparedness, and prevention. It takes a geo-scientific and environmental approach to the topic while also discussing the impacts of human-induced causes such as deforestation, debris burning and arson-underscoring the multi-disciplinary nature of the topic. It presents several international case studies that discuss the historical, social, cultural and ecological aspects of wildfire risk management in countries with a long history of dealing with this hazard (e.g., USA, Australia) and in countries (e.g., Taiwan) where wildfire hazards represent a new and growing threat to the social and ecological landscape. 284 pp. Englisch.

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Advanced Topics in Forensic DNA Typing: Interpretation builds upon the previous two editions of John Butler's internationally acclaimed Forensic DNA Typing textbook with forensic DNA analysts as its primary audience. Intended as a third-edition companion to the Fundamentals of Forensic DNA Typing volume published in 2010 and Advanced Topics in Forensic DNA Typing: Methodology published in 2012, this book contains 16 chapters with 4 appendices providing up-to-date coverage of essential topics in this important field. Over 80 % of the content of this book is new compared to previous editions. 608 pp. Englisch.

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Hydro-Meteorological Hazards, Risks, and Disasters provides an integrated look at major atmospheric disasters that have had and continue to have major implications for many of the world's people, such as floods and droughts. . This volume takes a geoscientific approach to the topic, while also covering current thinking about some directly relevant social scientific issues that can affect lives and property. Hydro-Meteorological Hazards, Risks, and Disasters also contains new insights about how climate change affects hazardous processes. For the first time, information on the many diverse topics relevant to professionals is aggregated into one volume. 312 pp. Englisch.

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Snow and Ice-Related Hazards, Risks, and Disasters provides you with the latest scientific developments in glacier surges and melting, ice shelf collapses, paleo-climate reconstruction, sea level rise, climate change implications, causality, impacts, preparedness, and mitigation. It takes a geo-scientific approach to the topic while also covering current thinking about directly related social scientific issues that can adversely affect ecosystems and global economies. 812 pp. Englisch.

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -A professional reference title written primarily for researchers in thermal engineering, Combined Cooling, Heating and Power: Decision-Making, Design and Optimization summarizes current research on decision-making and optimization in combined cooling, heating, and power (CCHP) systems. The authors provide examples of using these decision-making tools with five examples that run throughout the book. 218 pp. Englisch.

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Landslides are the most costly geo-hazard in the world, and they're often the cause or the result of other hazards and disasters such as tsunamis, earthquakes, wildfires, and volcanic eruptions. Landslide Hazards, Risks, and Disasters makes a close and detailed examination of major mass movements and provides measures for more thorough and accurate monitoring, prediction, preparedness, and prevention. It takes a geoscientific approach to the topic while also discussing the impacts human-induced causes such as deforestation, blasting, and building construction-underscoring the multi-disciplinary nature of the topic. 492 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Implantable Electronic Medical Devices provides a thorough review of the application of implantable devices, illustrating the techniques currently being used together with overviews of the latest commercially available medical devices. This book provides an overview of the design of medical devices and is a reference on existing medical devices. The book groups devices with similar functionality into distinct chapters, looking at the latest design ideas and techniques in each area, including retinal implants, glucose biosensors, cochlear implants, pacemakers, electrical stimulation therapy devices, and much more. Implantable Electronic Medical Devices equips the reader with essential background knowledge on the application of existing medical devices as well as providing an introduction to the latest techniques being used. A catalogue of existing implantable electronic medical devices Up-to-date information on the design of implantable electronic medical devices Background information and reviews on the application and design of up-to-date implantable electronic medical devices 194 pp. Englisch.

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The third edition of Introduction to Environmental Forensics is a state-of-the-art reference for the practicing environmental forensics consultant, regulator, student, academic, and scientist, with topics including compound-specific isotope analysis (CSIA), advanced multivariate statistical techniques, surrogate approaches for contaminant source identification and age dating, dendroecology, hydrofracking, releases from underground storage tanks and piping, and contaminant-transport modeling for forensic applications. Recognized international forensic scientists were selected to author chapters in their specific areas of expertise and case studies are included to illustrate the application of these methods in actual environmental forensic investigations. This edition provides updates on advances in various techniques and introduces several new topics. 704 pp. Englisch.

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This is the 26th annual volume of Progress in Heterocyclic Chemistry and covers the literature published during 2013 on most of the important heterocyclic ring systems. This volume opens with two specialized reviews, not restricted to work published in 2013: 'Recent Developments in the Synthesis of Cyclic Guanidine Alkaloids' written by Matthew G. Donahue, and 'Heterocyclic chemistry: a complete toolbox for nanostructured carbon materials' written by Luisa Lascialfari, Stefano Fedeli, and Stefano Cicchi. The remaining chapters examine the 2013 literature on the common heterocycles in order of increasing ring size and the heteroatoms present. 632 pp. Englisch.

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Progress in Filtration and Separation contains reference content on fundamentals, core principles, technologies, processes, and applications. It gives detailed coverage of the latest technologies and research, models, applications and standards, practical implementations, case studies, best practice, and process selection. Extensive worked examples are included that cover basic calculations through to process design, including the effects of key variables. Techniques and topics covered include pervaporation, electrodialysis, ion exchange, magnetic (LIMS, HIMS, HGMS), ultrasonic, and more. 698 pp. Englisch.

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Fed-batch Fermentation is primarily a practical guide for recombinant protein production in E. coli using a Fed-batch Fermentation process. Ideal users of this guide are teaching labs and R&D labs that need a quick and reproducible process for recombinant protein production. It may also be used as a template for the production of recombinant protein product for use in clinical trials. The guide highlights a method whereby a medium cell density - final Ods = 30-40 (A600) - Fed-batch Fermentation process can be accomplished within a single day with minimal supervision. This process can also be done on a small (2L) scale that is scalable to 30L or more. All reagents (media, carbon source, plasmid vector and host cell) used are widely available and are relatively inexpensive. This method has been used to produce three different protein products following cGMP guidelines for Phase I clinical studies. 188 pp. Englisch.

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Colour and appearance perceptions are very complex psychological phenomena. Written by one of the foremost authorities in the field, this major two-volume work addresses the key topics required to understand the issues and manage colour effectively. Principles of colour appearance and measurement Volume 2 addresses the visual measurement of colour, methods of comparing colours, and the management of colour in industry. Volume 2 begins with an overview of the visual measurement of colour. Chapter 1 discusses means of colour communication and various visual attributes of colour. Chapter 2 then focuses on several popular colour order systems, and chapter 3 discusses various colour difference formulae and their use in colour comparison and control. Subsequent chapters review instrumental colorant formulation, metamerism, chromatic adaptation and colour constancy, methods of shade sorting and digital colour reproduction. 330 pp. Englisch.

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The use of bioresorbable polymers in stents, fixation devices and tissue engineering is revolutionising medicine. Both industry and academic researchers are interested in using computer modelling to replace some experiments which are costly and time consuming. This book provides readers with a comprehensive review of modelling polymers and polymeric medical devices as an alternative to practical experiments. Chapters in part one provide readers with an overview of the fundamentals of biodegradation. Part two looks at a wide range of degradation theories for bioresorbable polymers and devices. The final set of chapters look at advances in modelling biodegradation of bioresorbable polymers. This book is an essential guide to those concerned with replacing tests and experiments with modelling. 260 pp. Englisch.

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Gasification involves the conversion of carbon sources without combustion to syngas, which can be used as a fuel itself or further processed to synthetic fuels. The technology provides a potentially more efficient means of energy generation than direct combustion. This book provides an overview of gasification science and engineering and the production of synthetic fuels by gasification from a variety of feedstocks. Part one introduces gasification, reviewing the scientific basis of the process and gasification engineering. Part two then addresses gasification and synthentic fuel production processes. Finally, chapters in part three outline the different applications of gasification, with chapters on the conversion of different types of feedstock. 348 pp. Englisch.

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Ion Beam Treatment of Polymers, Second Edition presents the results of polymer investigations and technique development in the field of polymer modification by high-energy ion beams. It shows how to use ion beam equipment in the polymer industry, as well as how to use it to produce new polymer materials. The authors, scientists and researchers active in the field, provide analysis and data from their work, and give an overview of related work by others. The authors focus on wetting, adhesion, hardness, chemical activity, environmental stability, biocompatibility, new synthesis methods, and space flight construction. The technologies of material modification by a beam of high energy ions have wide applications in different fields, from microelectronics to medicine. Historically, ion beam treatment of polymers had fewer applications due to high costs of ion beam equipment and low costs of polymer materials. The modern development of new pulse sources with a high current density and wide ion beams increase the effectiveness of ion beam technology for polymers. 268 pp. Englisch.

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Alkaloids are a large group of structurally complex natural products displaying a wide range of biological activities. The purpose of Alkaloids: A Treasury of Poisons and Medicines is to classify, for the first time, the alkaloids isolated from the natural sources until now. The book classifies all of the alkaloids by their biosynthetic origins. Of interest to the organic chemistry and medicinal chemistry communities involved in drug discovery and development, this book describes many alkaloids isolated from the medicinal plants, including those used in Japanese Kampo medicine. 294 pp. Englisch.