Humana jun 2003 (11 Ergebnisse)

Buch. Zustand: Neu. Neuware - A concise survey by physicians and researchers of the latest thinking about the causes of diabetes and the best approaches to treating its acute and chronic complications. The authors pay special attention to explaining the molecular basis of diabetes and its complications, as well as to the many recent developments in whole pancreas and islet cell transplantation, including the means for avoiding the rejection of transplanted islets.…

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Reviews of Environmental Contamination and Toxicology attempts to provide concise, critical reviews of timely advances, philosophy, and significant areas of accomplished or needed endeavor in the total field of xenobiotics in any segment of the environment, as well as toxicological implications. 184 pp. Englisch.…

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Since the discovery of p53 as a tumor suppressor, numerous methods have evolved to reveal the unique structural features and biochemical functions of this protein. Several unique properties of p53 posed a challenge to understa- ing its normal function in the initial phase of its research. The low levels of p53 in normal cells, its stabilization under situations of genotoxic stress, induction of growth arrest, and apoptosis with stabilization of the protein, obstructed the visibility of its normal, unmutated function. The property of p53 that can sense a promoter and transactivate or inhibit is still not well understood. It is still not known whether it is the absence of the protein that causes tumorigenesis, or if its mutants have a dominant role in inducing cancer. p53 Protocols comprises eighteen chapters for the study of the diverse properties of p53 and related proteins. The methods included are invaluable for delineating the function of other proteins that may function as tumor suppr- sors or growth suppressors. The chapters are not presented in any schematic order, for the importance and diversity of the functions of p53 make it imp- sible to organize them suitably. We have made a sincere effort to collect the methods most useful to those investigators working on tumor suppressors or growth suppressors. The purpose of p53 Protocols is not only to provide investigators with methods to analyze similar biochemical functions, but also to familiarize them with the associated problems that arose during the course of investigations. 296 pp. Englisch.…

Buch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Since the discovery of p53 as a tumor suppressor, numerous methods have evolved to reveal the unique structural features and biochemical functions of this protein. Several unique properties of p53 posed a challenge to understa- ing its normal function in the initial phase of its research. The low levels of p53 in normal cells, its stabilization under situations of genotoxic stress, induction of growth arrest, and apoptosis with stabilization of the protein, obstructed the visibility of its normal, unmutated function. The property of p53 that can sense a promoter and transactivate or inhibit is still not well understood. It is still not known whether it is the absence of the protein that causes tumorigenesis, or if its mutants have a dominant role in inducing cancer. p53 Protocols comprises eighteen chapters for the study of the diverse properties of p53 and related proteins. The methods included are invaluable for delineating the function of other proteins that may function as tumor suppr- sors or growth suppressors. The chapters are not presented in any schematic order, for the importance and diversity of the functions of p53 make it imp- sible to organize them suitably. We have made a sincere effort to collect the methods most useful to those investigators working on tumor suppressors or growth suppressors. The purpose of p53 Protocols is not only to provide investigators with methods to analyze similar biochemical functions, but also to familiarize them with the associated problems that arose during the course of investigations.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 296 pp. Englisch.…

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -For decades it has been known that structured conformations are important for the proper functioning of most cellular proteins. However, appreciation that protein folding to the functional conformations as well as the structural maintenance of protein molecules are very complex processes has only emerged during the last ten years. The intimate interplay uncovered by this scientific development led us to realize that perturbations of the protein folding process and disturbances of conformational maintenance are major disease mechanisms. This development has given rise to the concept of conformational diseases and the broader signature of protein folding diseases, comprising diseases in which mutations or environmental stresses may result in a partial misfolding that leads then to alternative conformations capable of disturbing cellular processes. This may happen by self-association (aggregation), as in prion and Alzheimer's diseases, or by incorporation of alternatively folded subunits into structural entities, as in collagen diseases. Another possibility is that folding to the native structure is impaired or abolished, resulting in decreased stea- state levels of the correctly folded protein, as is observed in cystic fibrosis and 1-antitrypsin deficiency, as well as in many enzyme deficiencies. In addition, deficiencies of proteins that are engaged in assisting and supervising protein folding (protein quality control) may impair the folding of many other proteins, resulting in pathological phenotypes. Examples of this are the spastic paraplegia attributable to mutations in mitochondrial protease/chaperone complexes. 340 pp. Englisch.…

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The technique of chlorophyll fluorescence has a relatively short history, beginning with the observations by Kautsky (Kautsky and Hirsch, 1931). Since that time there have been several reviews devoted to the subject, with most of them highly theoretical (Bohlar-Nordenkampf and Oquist, 1993; Dau, 1994; Schreiber et aI. , 1994). There have also been many books devoted to generalized spectrophotometric and microscopic fluorescence techniques. However, to the best of our knowledge there has not been a book completely devoted to the practical applications and uses of chlorophyll fluorescence in plant biology. As techniques mature, applications multiply and so do their potential advantages. The chlorophyll fluorescence technique is maturing as can be seen in the increasing numbers of publications that are devoted to its use. Therefore, we considered that now was a good time to compile the existing knowledge for the applied use of this technique and provide a single volume to which a novice or experienced user could refer. Highly trained experts in the field of photobiology have primarily used the chlorophyll fluorescence technique in the past. In that work, understanding the mechanisms and controls of the photosynthetic processes was the main focus of activity and discussion. Much of the equipment used was highly specialized and expensive, or in some cases one-of-a-kind lab designed units. However, the development of several reliable commercially available chlorophyll fluorescence monitoring instruments has changed the potential user base for the technique. 280 pp. Englisch.…

Buch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -For decades it has been known that structured conformations are important for the proper functioning of most cellular proteins. However, appreciation that protein folding to the functional conformations as well as the structural maintenance of protein molecules are very complex processes has only emerged during the last ten years. The intimate interplay uncovered by this scientific development led us to realize that perturbations of the protein folding process and disturbances of conformational maintenance are major disease mechanisms. This development has given rise to the concept of conformational diseases and the broader signature of protein folding diseases, comprising diseases in which mutations or environmental stresses may result in a partial misfolding that leads then to alternative conformations capable of disturbing cellular processes. This may happen by self-association (aggregation), as in prion and Alzheimer¿s diseases, or by incorporation of alternatively folded subunits into structural entities, as in collagen diseases. Another possibility is that folding to the native structure is impaired or abolished, resulting in decreased stea- state levels of the correctly folded protein, as is observed in cystic fibrosis and 1-antitrypsin deficiency, as well as in many enzyme deficiencies. In addition, deficiencies of proteins that are engaged in assisting and supervising protein folding (protein quality control) may impair the folding of many other proteins, resulting in pathological phenotypes. Examples of this are the spastic paraplegia attributable to mutations in mitochondrial protease/chaperone complexes.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 340 pp. Englisch.…

Buch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Peace of mind is a most precious resource, without which neither rich nor poor can know happiness. Yet mental health is undervalued and routinely taken for granted. Moreover, we allow war, torture, violence, poverty, d- ease, discrimination, and domestic abuse to undermine it. The wounds inflicted by these great human ills sicken the individual psyche, tear f- ilies apart, and send shock waves through society. Natural disasters, too, can cause sudden and acute trauma. Often, the damage¿a chronic and relentless loss of dignity, self-esteem, and hope¿is transmitted from one generation to the next: a sad and painful legacy indeed. Scientists, scholars, and medical and other professionals are seeking continuously to know more about mental health, and to apply their kno- edge. All of us, vulnerable human beings that we are, need to work together to ensure that the environment we live in is conducive to peace of mind, and free of the horrors that jeopardize mental well-being. This publication grew out of the commitment of the United Nations and others to this cause, and is the product of a series of lively meetings that the authors held at UN Headquarters with civil society groups, government officials, and United Nations staff¿a dialogue that coincided with the World Health Organization's focus on mental health in 2001. I hope it will be a valuable resource for practitioners, policymakers, and United Nations field and headquarters staff wherever trauma strikes, and wherever peace of mind is threatened.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 416 pp. Englisch. …

Taschenbuch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Peace of mind is a most precious resource, without which neither rich nor poor can know happiness. Yet mental health is undervalued and routinely taken for granted. Moreover, we allow war, torture, violence, poverty, d- ease, discrimination, and domestic abuse to undermine it. The wounds inflicted by these great human ills sicken the individual psyche, tear f- ilies apart, and send shock waves through society. Natural disasters, too, can cause sudden and acute trauma. Often, the damage¿a chronic and relentless loss of dignity, self-esteem, and hope¿is transmitted from one generation to the next: a sad and painful legacy indeed. Scientists, scholars, and medical and other professionals are seeking continuously to know more about mental health, and to apply their kno- edge. All of us, vulnerable human beings that we are, need to work together to ensure that the environment we live in is conducive to peace of mind, and free of the horrors that jeopardize mental well-being. This publication grew out of the commitment of the United Nations and others to this cause, and is the product of a series of lively meetings that the authors held at UN Headquarters with civil society groups, government officials, and United Nations staff¿a dialogue that coincided with the World Health Organization's focus on mental health in 2001. I hope it will be a valuable resource for practitioners, policymakers, and United Nations field and headquarters staff wherever trauma strikes, and wherever peace of mind is threatened.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 416 pp. Englisch. …

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In this greatly enlarged and thoroughly updated edition of his much praised Cardiac Markers, Alan Wu and his contributors focus on the use of markers in the practice of cardiology and-for the first time-on the use of natriuretic peptides for congestive heart failure. Here, leading international authorities in clinical chemistry and laboratory medicine, cardiology, emergency medicine, and the in vitro diagnostics industry describe the state-of-the-art uses of cardiac markers when treating coronary artery disease, and discuss in detail how they may be optimally used in a clinical setting. Comprehensive and cutting-edge, Cardiac Markers, Second Edition offers physicians a complete guide to the use of cardiac markers in clinical practice and clinical laboratorians a close-up view of the new markers now becoming standard. 488 pp. Englisch.…

Buch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -In this greatly enlarged and thoroughly updated edition of his much praised Cardiac Markers, Alan Wu and his contributors focus on the use of markers in the practice of cardiology and-for the first time-on the use of natriuretic peptides for congestive heart failure. Here, leading international authorities in clinical chemistry and laboratory medicine, cardiology, emergency medicine, and the in vitro diagnostics industry describe the state-of-the-art uses of cardiac markers when treating coronary artery disease, and discuss in detail how they may be optimally used in a clinical setting. Comprehensive and cutting-edge, Cardiac Markers, Second Edition offers physicians a complete guide to the use of cardiac markers in clinical practice and clinical laboratorians a close-up view of the new markers now becoming standard.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 488 pp. Englisch.…