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Hardback. Zustand: New. Compensating for cytotoxicity in the multicellular organism by a certain level of cellular proliferation is the primary aim of homeostasis. In addition, the loss of cellular proliferation control (tumorigenesis) is at least as important as cytotoxicity, however, it is a contrasting trauma. With the disruption of the delicate balance between cytotoxicity and proliferation, confrontation with cancer can inevitably occur. This book presents important information pertaining to the molecular control of the mechanisms of cytotoxicity and cellular proliferation as they relate to cancer. It is designed for students and researchers studying cytotoxicity and its control.

Hardback. Zustand: New. Compensating for cytotoxicity in the multicellular organism by a certain level of cellular proliferation is the primary aim of homeostasis. In addition, the loss of cellular proliferation control (tumorigenesis) is at least as important as cytotoxicity, however, it is a contrasting trauma. With the disruption of the delicate balance between cytotoxicity and proliferation, confrontation with cancer can inevitably occur. This book presents important information pertaining to the molecular control of the mechanisms of cytotoxicity and cellular proliferation as they relate to cancer. It is designed for students and researchers studying cytotoxicity and its control.

Hardback. Zustand: New. Organochlorines (OC) are organic molecules with chlorine in their structure. There is a large number of organochlorine compounds known. Large amounts of chlorinated organic compounds are produced for industrial, agricultural, pharmaceutical, household purposes, etc. In many studies, the main focus is on OC that have been evaluated as environmental contaminants with toxic effects on humans. Different types of organochlorines have been produced throughout the world. Some of the most popular classes are organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), dioxins, chlorobenzenes, chlorophenols, chlorinated alkanes, etc. Organochlorine compounds are very stable. Generally, they are molecules of moderate polarity (low solubility in water). This makes OCs easily soluble in fats. They are found in almost all environments: air, water, soil, sediments and biota samples. They can spread out easily in different geographic altitudes and latitudes. Volatile and semi-volatile OCs have the ability to travel far distances from the place where they were used. Some studies have reported some organochlorines in the North Pole at the same levels as the areas where they were produced or applied. They have the ability to bioaccumulate easily in biota. Passing through the food chain levels, they increase their concentrations (biomagnifying). The main access pathways for OCs to the human body are through foods and exposures. Generally, they display their effects after a relatively long period of exposure. This is the main reason why they were produced and used for a long time before their production and use was banned. The most important health effects that organochlorines can cause are: mutagenic, endocrine-disruptor, carcinogenic and central nervous or peripheral disorders. After identification of the consequences, production of OCs and use was banned in many countries but their effects are still being seen many years later.

Hardback. Zustand: New.

Hardback. Zustand: New.

Hardback. Zustand: New.

Hardback. Zustand: New.

Hardback. Zustand: New.

Hardback. Zustand: New.

Hardback. Zustand: New.

Hardback. Zustand: New.

Hardback. Zustand: New.

Hardback. Zustand: New.

Hardback. Zustand: New. Epigenetics, which deals with the study of heritable gene expression that takes place independent of changes in DNA sequence, and optogenetics, which deals with the study of genes expressed under the influence of light, are two emerging areas of study and research that have contributed immensely to our current knowledge of mechanisms and disease processes in humans. These disciplines are interrelated in the broader picture of biology and one can be used to change or modify the other. The complexity of the techniques involved in these disciplines often leads to a lack of proper understanding by researchers from other disciplines and the scientific community at large. As such, this book provides simple and easy-to-follow explanations of some of the most exciting areas of research in these disciplines.

Hardback. Zustand: New.

Hardback. Zustand: New. This book is an unpretentious editing venture to fill the gap in our current knowledge on the ecological implications caused by anthropogenic disturbances upon benthic communities in several regions of the world, including the Western Atlantic, the Mediterranean Sea, and the Eastern Pacific Ocean, as well as the pristine environments of the Andes in South America. The common goal of the contributing authors in this book was to unravel the complex processes that make possible the life existence of bottom-living animals in different environmental scenarios. To achieve such a goal, the authors focus their attention on the emerging issues inherent to global climate change or the pollution of aquatic systems. These are all themes that might be of interest to scientists active in a wide range of oceanographic subdisciplines. Well-established researchers would appreciate the innovative approach adopted in each chapter of the book, which extends from the ecosystem level to refined molecular interpretations.

Hardback. Zustand: New.

Hardback. Zustand: New. Keratinocytes have various functions to maintain epidermal homeostasis. Many inflammatory skin diseases can develop due to suppressed or defective anti-inflammatory properties of keratinocytes. This book discusses the structural, biological, and molecular aspects of keratinocytes. Chapters discuss keratins and attachment molecules and their importance in maintaining epidermal homeostasis, skin diseases such as psoriasis and atopic dermatitis, and aging and skin regeneration.

Hardback. Zustand: New. Staphylococcus spp. and Streptococcus spp. have not only got pathogenic isolates, but also non-pathogenic isolates. Staphylococcus spp. and Streptococcus spp. that are Gram positive cocci are the main pathogens in several infections. Virulence factors such as usual and unusual surface proteins encoded by resistance genes are the main causes of pathogenesis. Multidrug-resistant pathogens that are the main causes of morbidity and mortality worldwide have the ability to synthesize a number of destructive enzymes encoded by resistance genes such as ?-lactamases. Resistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA), Streptococcus pneumoniae, Group A, and Group B Streptococcus have emerged throughout the world. To eliminate these resistant pathogens that cause untreatable, acute, and chronic infections, different new antimicrobials must be developed and used. The goal of this book is to provide the latest information about the above topics.

Hardback. Zustand: New.

Hardback. Zustand: New. Bacteriophages are viruses that utilise bacterial cells as factories for their own propagation and as safe havens for their genomic material. They are capable of equipping bacteria with properties that bestow environmental advantages. They are also capable of specifically and efficiently killing bacteria.Bacteriophages are resilient in a wide diversity of environments, presumed to be as ancient as life itself, and are estimated to be the most numerous biological entities on the planet. Their overarching capacity to survive via molecular adaptation is supported by an arsenal of encoded enzymatic tools, which also enabled biotechnology. This volume includes contributions that describe bacteriophages as nanomachines, genetic engineers, and also as medicines and technologies of the future, including relevant production and process issues.

Hardback. Zustand: New. Organic crop production is the science and art of growing field crops, fruits, vegetables, and flowers by adopting the essential principles of organic agriculture in soil building and conservation, pest management, and heirloom variety conservation. This book provides detailed insights into organic farming in agriculture, biological efficacy in the management of plant diseases, organic nutrient management, socio-economic dimensions of adoption of conservation practices, nonchemical weed control, plant growth promoting fungi for phytostimulation, nanotechnological approaches, and finally vermicomposting. The book primarily focuses on research and development based organic agriculture and horticulture production technologies, and has attempted to abridge information on organic crop production of the major food grain crops. The book also contains comprehensive information on the various related dimensions of organic crop production.

Hardback. Zustand: New. The concept of endocarditis has evolved significantly over the years. While initially associated with patients with advanced co-morbidities, such as renal failure and chronic immunosuppression, endocarditis now spans many diverse disciplines. As such, the importance of advanced diagnostic imagining tools, a better understanding of the pathophysiology of not only the infectious (and non-infectious) disease process but also of cardiac structural abnormalities, and the growing literature on management cannot be underemphasized. This book broadens our collective understanding of the spectrum of diagnostic and therapeutic challenges that all areas of medicine must appreciate when faced with the challenging clinical problem of endocarditis.

Hardback. Zustand: New. Endocarditis is a disease process that involves an infection of the heart, cardiac structures, or implantable cardiac support devices and can be a difficult clinical problem. As patients get older and have more comorbidities, their risks for infection increase. In addition, the growing problem of intravenous substance abuse has led to a considerable increase in these patients developing endocarditis. Advances in medical technology have facilitated diagnosis and management, particularly with greater emphasis on early surgical intervention. Nevertheless, success requires a team approach and individualization of care in the setting of very complex medical, surgical, and ethical problems. The goal of this book is to illustrate some of the evolving challenges and controversies in managing these very complex and often extremely sick patients.

Hardback. Zustand: New. Environmental Impact of Aviation and Sustainable Solutions is a compilation of review and research articles in the broad field of aviation and the environment. Over three sections and thirteen chapters, this book covers topics such as aircraft design and materials, combustor modeling, atomization, airport pollution, sonic boom and street noise pollution, emission mitigation strategies, and environmentally friendly contributions from a Russian aviation pioneer. This volume is a useful reference for both researchers and students interested in learning about various aspects of aviation and the environment.

Hardback. Zustand: New.

Hardback. Zustand: New. Some marine propulsion systems are based on thermal machines that operate under the diesel cycle. Their main advantages, compared to other propulsion systems based on thermal machines, are low specific fuel consumption and greater thermal efficiency. However, their main disadvantages lie in the emissions produced by combustion, such as carbon dioxide (CO2), sulfur oxide (SOx), and nitrogen oxide (NOx). Over the last decade, the International Maritime Organization (IMO) has adopted a series of regulations to reduce these emissions based on the introduction of several energy efficiency designs and operational indicators. In this context, this book focuses on the design and operation efficiency of ships through an analysis of the main propulsion systems. It discusses the use of alternative fuels as well as the integration of hybrid and fully electric propulsion systems.

Hardback. Zustand: New. Computer graphics development is so quick that it has expanded from devices designed for military and top industrial applications to equipment for schools and households as common information media for education and entertainment. Computer graphics helps to mass expand computers and remove the barriers that ordinary people experience when working with them. In this book, modern approaches, procedures, algorithms, as well as devices in the area of light and colors, shading and lighting, realistic and photorealistic imaging, definition of graphical scenes or objects, and security based on graphical objects are presented. Graphical transformations and projections, spatial imaging, curves and surfaces, filling and texturing, image filtering, and virtual reality are also covered.

Hardback. Zustand: New.

Hardback. Zustand: New.