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Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In spite of all emphasis on objectivity, a scientific discipline needs for its development outstanding research workers with exceptional personal qualities. A scientist with these qualities is honoured here, on the occasion of his 70th birthday, by his pupils, friends and colleagues: Arthur Linder is respected as a researcher, advisor and teacher in the field of Applied Statistics. Professor Dr. Dr. h. c. A. Linder has demonstrated the utility of statistical methods in science and technology; these are recognised today as being essen tial for an objective evaluation of data. His contacts with Sir R. A. Fisher, C. 1. Bliss, G. M. Cox, W. G. Cochran, P. C. Mahalanobis and many other ex perts, have helped him to achieve his almost legendary authority on sampling and on the evaluation of statistical data. Linder has won many friends and adherents to the cause of Biometry, Econometry and Technometry, firstly through his teaching activity at the universities of Berne, Geneva and Lausanne and the Swiss Federal Institute of Technology in Zurich, and as visiting lecturer at the Indian Statistical Institute, the International Statistical Education Centre in Calcutta, the Uni versity of North Carolina and the University of Natal in Durban, secondly through his contributions to the literature as author of the monographs 'Sta tistische Methoden' and 'Planen und Auswerten von Versuchen', as editor of METRIKA and co-editor of other journals, and thirdly through his active collaboration in the founding of The Biometric Society, to the presidency of 262 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Ten years ago interest in leukocyte chemotaxis was restricted to a relatively small group of scientists whose interests were quite circumscribed. In the past decade both the number of workers and their publications has grown at some thing approaching an exponential rate and, more importantly, the field has gradually expanded to encompass a large number of diverse areas (mediators, receptors, cell effector mechanisms, regulatory factors, etc.). It is now apparent that leukocytes are particularly useful for studies of the locomotory behavior of all cell types and of mechanisms controlling cell movement and orientation. Chemotactic factors, once discovered as substan ces able to induce directional migration in leukocytes, are now recognized as potent stimulators of a variety of cell functions. Based on our knowledge in the field of basic research in leuko cyte chemotaxis, clinical observations in combination with ex perimental studies in vivo have provided new insights into the role of leukocyte-mediator interactions. The recognition that a specific interaction between chemotactic factor and leukocyte can lead to a multitude of cellular responses and products has opened up a broad area of study. The diversity of contributions to this volume based on a conference which was held in May 1982 in Gersau, Switzerland, reflects this development and demonstra tes that leukocyte chemotaxis continues to be an area of fasci nating and highly active research. 440 pp. Englisch.

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Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The theory of the Lebesgue integral is still considered as a difficult theory, no matter whether it is based the concept of measure or introduced by other methods. The primary aim of this book is to give an approach which would be as intelligible and lucid as possible. Our definition, produced in Chapter I, requires for its background only a little of the theory of absolutely convergent series so that it is understandable for students of the first undergraduate course. Nevertheless, it yields the Lebesgue integral in its full generality and, moreover, extends automatically to the Bochner integral (by replacing real coefficients of series by elements of a Banach space). It seems that our approach is simple enough as to eliminate the less useful Riemann integration theory from regular mathematics courses. Intuitively, the difference between various approaches to integration may be brought out by the following story on shoemakers. A piece of leather, like in Figure 1, is given. The task consists in measuring its area. There are three shoemakers and each of them solves the task in his own way. A B Fig. 1 The shoemaker R. divides the leather into a finite number of vertical strips and considers the strips approximately as rectangles. The sum of areas of all rectangles is taken for an approximate area of the leather (Figure 2). If he is not satisfied with the obtained exactitude, he repeats the whole procedure, by dividing the leather into thinner strips. 233 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Whilst improperly posed problems appear in several branches of applied and pure mathematics, this conference concentrated mainly on the practical treatment of ill posedness. The participants came from 12 countries. The interchange of ideas reflected the spectrum of questions arising in connection with the subject of the conference, where currently progresses in research are made. This volume contains 17 papers presented at the con ference. Focal points in the programme were: Problems of regularisation, parameter identification, free boundary and inverse problems in differential equations and inte gral equations of the first kind. Problems, which appear in science, in technical fields and in medicine are dis cussed as well as general operator equations. In a jOint discussion, several open problems have been worked out which are collected at the end of the volume. The editor's thanks go to all contributors and parti cipants who made the conference a success; to the manage ment of the institute with its unique atmosphere; to the Birkhauser Verlag for the possibility to publish the vo lume in the well-known ISNM series; to Dr. P. Jochum (Mlin chen) for assistance in organization and to Mrs. Chr. Rogg (Augsburg) for her excellent typing of several manuscripts. 264 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Volume 39 of 'Progress in Drug Research' contains eight reviews and the various indexes which facilitate its use and establish the con nection with the previous volumes. The articles in this volume deal with polyamines as tumor markers; the histamine (H3)-receptor and its role as a general regulatory system; with cytokines as immunosti mulants and immunosuppressants as well as potential anticancer agents; with fibrinolysis and clinical use of thrombolytic agents; and with catechol O-methyltransferase and its inhibitors, which are of potential interest in the treatment of Parkinson's disease. An exten sive review on antihistamines (HI) provides an excellent survey of this area in drug research. In the 32 years that 'Progress in Drug Research' has existed, the Editor has enjoyed the valuable help and advice of many colleagues. Readers, the authors of the reviews, and, last but not least, the review ers have all contributed greatly to the success of the series. Although the comments received so far have generally been favorable, it is nevertheless necessary to analyze and to reassess the current position and the future direction of such a review series. 399 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Methods in protein sequence analysis constitute important fields in rapid progress. We have experienced a continuous increase in analytical sensitivity coupled with decreases in time necessary for purification and analysis. Several generations of sequencers, liquid/solid/gas-phase, have passed by and returned in other shapes during just over two decades. Similarly, the introduction of HPLC permitted an enormous leap forward in this as in other fields of biochemistry, and we now start to see new major advances in purification/analysis through capillary electrophoresis. Furthermore, progress in the field of mass spectrometry has matched that in chemical analysis and we witness continuous development, now emphasizing ion spray and other mass spectrometric approaches. In short, protein analysis has progressed in line with other developments in modern science and constitutes an indispensable, integral part of present-day molecular biology. Even the available molecular tools, in the form of proteases with different specificities, have increased in number, although we still have far to go to reach an array of 'restriction proteases' like the sets of nucleases available to the molecular geneticist. Of course, conferences have been devoted to protein sequence analysis, in particular the MPSA (Methods in Protein Sequence Analysis) series, of which the 8th conference took place in Kiruna, Sweden, July 1-6 1990. Again, we witnessed much progress, saw new instruments, and experienced further interpretational insights into protein mechanisms and functions. 398 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Reprint from Pure and Applied Geophysics (PAGEOPH), Volume 135 (1991), No. 2 199 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The Eleventh International Transport Theory Conference and Symposium in honor of the sixty-fifth birthday of Kenneth Case and the sixtieth birthday of Paul Zweifel was held in Blacksburg, Virginia, during May 22-26, 1989, on the campus of Virginia Polytechnic Institute and State University (Virginia Tech). This volume consists of a selection of the invited papers delivered at the Conference, and represents a cross section of the research currently being carried out in the field of transport theory. The volume is divided into two sections. The Symposium lectures are intended each to summarize an important aspect of transport theory, as well as to present timely new results of the author's research interest. The Conference lectures are contributions of each author on his current research. As has been the custom in this series of conferences, each lecturer was invited to participate by the organizing committee of the Conference: W. Greenberg, Virginia Tech, chairman; V. Boffi, Universita di Firenze; N. Corngold, California Institute of Technology; B. Ganapol, University of Arizona; N. McCormick, University of Washington; P. Nelson, Texas Tech; G. Pomraning, University of California, Los Angeles. The Eleventh International Transport Theory Conference was funded by generous con tributions from Science Applications International Corporation, R. Beyster, president, and from Virginia Polytechnic Institute and State University. Conference participants, and, we believe, researchers in this and related areas, are indebted to these organizations. We would like to thank Lamberto Rondoni, in the graduate program at Virginia Tech, for proofreading manuscripts of all the Italian contributors. 330 pp. Englisch.

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Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -During the last two decades the theory of abstract Volterra equations has under gone rapid development. To a large extent this was due to the applications of this theory to problems in mathematical physics, such as viscoelasticity, heat conduc tion in materials with memory, electrodynamics with memory, and to the need of tools to tackle the problems arising in these fields. Many interesting phenomena not found with differential equations but observed in specific examples of Volterra type stimulated research and improved our understanding and knowledge. Al though this process is still going on, in particular concerning nonlinear problems, the linear theory has reached a state of maturity. In recent years several good books on Volterra equations have appeared. How ever, none of them accounts for linear problems in infinite dimensions, and there fore this part of the theory has been available only through the - meanwhile enor mous - original literature, so far. The present monograph intends to close this gap. Its aim is a coherent exposition of the state of the art in the linear theory. It brings together and unifies most of the relevant results available at present, and should ease the way through the original literature for anyone intending to work on abstract Volterra equations and its applications. And it exhibits many prob lems in the linear theory which have not been solved or even not been considered, so far. 366 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware 196 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -These proceedings contain a selection of papers presented at the Third European Conference on Multigrid Methods which was held in Bonn on October 1-4, 1990. Following conferences in 1981 and 1985, a platform for the presentation of new Multigrid results was provided for a third time. Multigrid methods no longer have problems being accepted by numerical analysts and users of numerical methods; on the contrary, they have been further developed in such a successful way that they have penetrated a variety of new fields of application. The high number of 154 participants from 18 countries and 76 presented papers show the need to continue the series of the European Multigrid Conferences. The papers of this volume give a survey on the current Multigrid situation; in particular, they correspond to those fields where new developments can be observed. For example, se veral papers study the appropriate treatment of time dependent problems. Improvements can also be noticed in the Multigrid approach for semiconductor equations. The field of parallel Multigrid variants, having been started at the second European Multigrid Conference, is now at the centre of interest. 394 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -One of the basic interpolation problems from our point of view is the problem of building a scalar rational function if its poles and zeros with their multiplicities are given. If one assurnes that the function does not have a pole or a zero at infinity, the formula which solves this problem is (1) where Zl , ' ' Z/ are the given zeros with given multiplicates nl, ' ' n / and Wb' ' W are the given p poles with given multiplicities ml, . . . ,m , and a is an arbitrary nonzero number. p An obvious necessary and sufficient condition for solvability of this simplest Interpolation pr- lern is that Zj :f: wk(1~ j ~ 1, 1~ k~ p) and nl +. . . +n/ = ml +. . . +m ' p The second problem of interpolation in which we are interested is to build a rational matrix function via its zeros which on the imaginary line has modulus 1. In the case the function is scalar, the formula which solves this problem is a Blaschke product, namely z z. )mi n u(z) = all = l~ (2) J ( Z+ Zj where [o] = 1, and the zj's are the given zeros with given multiplicities mj. Here the necessary and sufficient condition for existence of such u(z) is that zp :f: - Zq for 1~ ]1, q~ n. 247 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Donald Kennedy President, Stanjord University Alnwst exactly a dozen years elapsed between the time I set aside (I thought temporarily!J my own interest in crustacean nervous systems and the arrival of an invitation from Konrad Wiese to participate in this symposium. The intervening years have plainly been productive ones for the field; indeed, I can only hope that there is no causal connection between its properity and my absence. Discontinuous contact with an intellectual venture, whatever disappointments it may present. does oifer one virtue; it provides a nwre dramatic. alnwst stroboscopic view of progress. To the lapsed practitioner, the rate of advance in crustacean neurobiology over the decade seems remarkable; equally remarkable is the number of able young researchers. many of them the scientific progeny of my colleagues from the 'sixties' and 'seventies' . How to summarize the changes they have wrought Those of us who began working with crustacean nervous systems thirty years 090 or so were attracted by several features. First of alt there was a limited nwtor system with readily identifiable neurons. It was diJft.cult to look at those old methylene blue stains of Retzius and not want to do an experiment immediately! Kees Wiersma ojten did, and it was he who nwst persuasively called our attention to the advantages oifered by neuronal parsinwny in combination with stereotyped motor output patterning. Ted Bullock exploited these features in his elegant early experiments on cardiac ganglia. 563 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Tamari lattices originated from weakenings or reinterpretations of the familar associativity law. This has been the subject of Dov Tamari's thesis at the Sorbonne in Paris in 1951 and the central theme of his subsequent mathematical work. Tamari lattices can be realized in terms of polytopes called associahedra, which in fact also appeared first in Tamari's thesis. By now these beautiful structures have made their appearance in many different areas of pure and applied mathematics, such as algebra, combinatorics, computer science, category theory, geometry, topology, and also in physics. Their interdisciplinary nature provides much fascination and value. On the occasion of Dov Tamari's centennial birthday, this book provides an introduction to topical research related to Tamari's work and ideas. Most of the articles collected in it are written in a way accessible to a wide audience of students and researchers in mathematics and mathematical physics and are accompanied by high quality illustrations. 456 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -FirstEdition DUE TO THE necessity to save weight and materialin the design ofmodern structures and machines, stability problems have become increasingly im portant. The classicalengineering approach to this type of problem has been characterized by the tacit assumption that structures are nongyroscopic conservative systems,that is, bythegeneraladoptionofthemethodsdeveloped for this particular case. During the last decades numerous stability problems of a more complicated nature have become important, and it has therefore become necessary to correlate the various types of problems with the ap proaches to be used in their solution. The principal object ofthis little bookisthis correlation between the systems to be investigated and the methods to be used for this purpose, In other words, our main concern is the choice of a correct approach. It is evident that this idea renders it necessary to distinguish between the various types of problems or systems. At the same time the similarities and the connections between apparently quite different problems will become obvious, and it will be evident that there islittle differencebetween, say, the buckling of a column, thecritical speed of a turbine shaft, and the stability of an airplane, a control mechanism, or an electric circuit. 150 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This monograph brings together a collection of results on the non-vanishing of L functions. The presentation, though based largely on the original papers, is suitable for independent study. A number of exercises have also been provided to aid in this endeavour. The exercises are of varying difficulty and those which require more effort have been marked with an asterisk. The authors would like to thank the Institut d'Estudis Catalans for their encouragement of this work through the Ferran Sunyer i Balaguer Prize. We would also like to thank the Institute for Advanced Study, Princeton for the excellent conditions which made this work possible, as well as NSERC, NSF and FCAR for funding. Princeton M. Ram Murty August, 1996 V. Kumar Murty Introduction Since the time of Dirichlet and Riemann, the analytic properties of L-functions have been used to establish theorems of a purely arithmetic nature. The distri bution of prime numbers in arithmetic progressions is intimately connected with non-vanishing properties of various L-functions. With the subsequent advent of the Tauberian theory as developed by Wiener and Ikehara, these arithmetical the orems have been shown to be equivalent to the non-vanishing of these L-functions on the line Re(s) = 1. In the 1950's, a new theme was introduced by Birch and Swinnerton-Dyer. 196 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The primary objective of this monograph is to develop an elementary and self contained approach to the mathematical theory of a viscous incompressible fluid in a domain 0 of the Euclidean space ]Rn, described by the equations of Navier Stokes. The book is mainly directed to students familiar with basic functional analytic tools in Hilbert and Banach spaces. However, for readers' convenience, in the first two chapters we collect without proof some fundamental properties of Sobolev spaces, distributions, operators, etc. Another important objective is to formulate the theory for a completely general domain O. In particular, the theory applies to arbitrary unbounded, non-smooth domains. For this reason, in the nonlinear case, we have to restrict ourselves to space dimensions n = 2,3 that are also most significant from the physical point of view. For mathematical generality, we will develop the lin earized theory for all n 2 2. Although the functional-analytic approach developed here is, in principle, known to specialists, its systematic treatment is not available, and even the diverse aspects available are spread out in the literature. However, the literature is very wide, and I did not even try to include a full list of related papers, also because this could be confusing for the student. In this regard, I would like to apologize for not quoting all the works that, directly or indirectly, have inspired this monograph. 367 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -When Richard Goldschmidt emigrated to the United States in 1936, he had influenced a whole generation of young biologists, and had stimulated their research by his revolutionary ideas. Stern (1967, see p. 21) called him: 'Contributor of permanent parts, some very large; preceptor and critic of his era; designer of frameworks for the future'. In 1958 Goldschmidt's obituary was prefaced by the following statement: 'Der nachstehende Nekrolog erscheint gleichzeitig in Science und Ex perientia, damit das universale Heimatrecht Richard Goldschmidts zum Ausdruck bringend. Die Leser von Experientia erinnern sich dankbar der verschiedenen genetischen Aufsiitze dieses immer anregenden Geistes, dem unsere Wissenschaft grosse Impulse verdankt.' (Translation: The following obituary appears simultaneously in Science and in Experientia, a symbol of Richard Goldschmidt's right to be called a world citizen. Readers of Experientia will recall with appreciation several of the papers of this highly stimulating author to whom our science owes a great deal. (Experientia 14, 307, 1958). In commemoration of the 20th anniversary of Richard Goldschmidt's death (April 24, 1958) and the 100th anniversary of his birth (April 12, 1878) Experientia presents a contemporary evaluation of several of Goldschmidt's major scientific theories. We believe that some of these theories were far ahead of his time and that the controversies which they aroused are of considerable didactic interest to biologists today. Further more, they represent an important chapter in the history of biology. 154 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book brings together lmportant work on the structure and function of the dehydrogenases requiring nicotinamide coenzymes. The structure and function of lactate dehydrogen ase, alcohol dehydrogenase, and glyceraldehyde 3-phosphate dehydrogenase are compared. These are the relatively simple oligomeric dehydrogenases for which very extensive structural and mechanistic information is available. Kinetic studies are dealt with in general terms, with selected examples. Genetic and structural relationships revealed by primary structure are discussed. General features of the specificity of dehydrogen ase reactions are described. The pyridine nucleotide - disulphide oxidoreductases exemplify a type of multicomponent enzyme complex. Lipoamide dehydrogenase, glutathione reductase, and thioredoxin reduct ase are described and compared. The fatty acid synthesizing systems of some organ isms are nonaggregated, whereas in other organisms they are multienzyme complexes containing, in animal tissues for example, two closely related multifunctional polypeptide chains. The dehydrogenase activities of the fatty acid syn thesizing systems afford many points of interest, which are described and discussed. Hydroxymethylglutaryl-CoA reductase occupies a key position in the synthesis of isoprenoid compounds, including cholesterol. It probably occurs in all forms of life; in animal cells it is a microsomal enzyme. Its properties are reviewed. 276 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Die erste internationale Tagung 'Allgemeine Ungleichungen' fand vom 9. bis 15. Mai im Mathematischen Forschungsinstitut Oberwolfach statt. Da Herr Bellman leider aus gesundheitlichen Gründen nicht teilnehmen konnte, hat sich glÜcklicherweise Herr Beckenbach (Los Angeles) bereiterklärt, zusammen mit den Herren Aczel (Waterloo, Onterio) und Aumann (München) die Tagung zu leiten. Als Tagungssekratär wirkte Herr Ger (Ka.towice). Die :{ Teilnehmer kamen aus Europa, Amerika und Australien. Erfreulicherweise hat sich eine grtlßere Zahl von Teilnehmern aus Polen eingefunden; leider konnten keine Wissenschaftler aus Jugoslawien, Rumänien, der TBchechoslawakai und Ungarn kommen. Die Tagtmg wurde von Herrn Aczel eröffnet und von Herrn Aumann geschlossen. Zu der durch den Titel gegebenen allgemeinen Thematik haben die Teil nehmer in sehr verschiedene Weise beigetragen. Trotzdem bildeten sich einige Schwerpunkte heraus: Funktionalungleichungen, inbesondere iterativen ~s, konvexe und verallgemejnert konvexe Funktionen, Differentialungleichungen, Ungleichungen der Funktionentheorie, Funktionalanalysis und Geometrie. Ferner wurden Anwendungen von Ungleichungen auf Differentialgleichungen, Physik, Warscheinlichkeits-, Informations- und Wirtschaftstheorie gebracht. Die als besondere Tagungspunkte augesetzten 'Bemerkungen und Probleme' haben sich als äußerst fruchtbar erwiesen, ja sogar in einem Fall zur vollständigen LÖsung eines aufgeworfenen Problems geführt. Die Tagung hat nicht nur gezeigt, daß das Netz von Ungleichungen, das die. gesamte Analysis durchzieht, verdient in eigenständiger Weise und im Sinne allgemeiner Methoden behandelt zu werden, sondern auch bestätigt, wie viel schneller und wirksamer der Ideenaustausch ist, der durch die Vorträge und durch den persönlichen Kontakt der Wissenschaftler untereinander zustande kommt, als die unpersönliche, nur literarische Information. 332 pp. Englisch.

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Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In this volume three important papers of M.G. Krein appear for the first time in English translation. Each of them is a short self-contained monograph, each a masterpiece of exposition. Although two of them were written more than twenty years ago, the passage of time has not decreased their value. They are as fresh and vital as if they had been written only yesterday. These papers contain a wealth of ideas, and will serve as a source of stimulation and inspiration for experts and beginners alike. The first paper is dedicated to the theory of canonical linear differential equations, with periodic coefficients. It focuses on the study of linear Hamiltonian systems with bounded solutions which stay bounded under small perturbations of the system. The paper uses methods from operator theory in finite and infinite dimensional spaces and complex analysis. For an account of more recent literature which was generated by this paper see AMS Translations (2), Volume 93, 1970, pages 103-176 and Integral Equations and Operator Theory, Volume 5, Number 5, 1982, pages 718-757. 302 pp. Englisch.

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Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Non-steroidal anti-inflammatory drugs (NSAIDs) are among the mostfrequently prescribed drugs in the Western world. During the past decade a large number of new compounds were marketed, some of which had to be withdrawn after a short while because of adverse drug reactions. These experiences led to an under standing that a complete picture of the safety of these drugs can only be obtained after their introduction into the marketplace. Differentmethods ofpost-marketing surveillance (PMS) serve as important tools for monitoring the frequency of adverse reactions and for generating and corroborating hypotheses. Experience with PMS has thusfar been quite limited in Germany. In 1987 a non-profit organization, 'Verein zur Langzeituntersuchung von Arzneimittel wirkungen auf dem Gebiet der Rheumatologie e. V. ' (VLAR) was founded by interested physicians and pharmacologists to raise funds and perform investiga tions on the safety of NSAIDs. The first project by the VLAR, SPALA ('Safety Profile of Antirheumatics in Long-Term Administration'), was sponsored by F. Hoffmann-La Roche AG (Basel, Switzerland). In July 1990, when the project was successfully terminated, almost 30,000 patients had been completely docu mented and their medical records entered into a computer for subsequent review by a select panel of experts with experience in monitoring adverse reactions to NSAIDs. The comments, criticisms, and ideas of these experts were brought togetherat a symposium organized by the VLAR at the Klinikum Steglitz (Berlin, Germany) on 12 October 1990. 104 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Wiener-Hopf Factorization in the Inverse Scattering Theory for the n-D Schr¿dinger Equation.- Existence and Regularity of Solutions of Cauchy Problems for Inhomogeneous Wave Equations with Interaction.- Interpolation Problems, Extensions of Symmetric Operators and Reproducing Kernel Spaces I.- Some Extremal Problems Related to Majorization.- De Branges-Rovnyak Operator Models and Systems Theory: A Survey.- Band Matrices and Dichotomy.- Invertibility of Systems of Toeplitz Operators.- A Hermite Theorem for Matrix Polynomials.- On a Singularly Perturbed Eigenvalue Problem in the Theory of Elastic Rods.- Matrix Polynomials with prescribed zero structure in the finite complex plane.- On Structured Matrices, Generalized Bezoutians and Generalized Christoffel-Darboux Formulas.- Numerical Ranges for Partial Matrices.- On the Rational Homogeneous Manifold Structure of the Similarity Orbits of Jordan Elements in Operator Algebras.- Planar Faces of Operator Spaces in L P .- Spectral Theory of Selfadjoint Wiener-Hopf Operators with Rational Symbols. 380 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The highly topical problems of radioprotection will be treated in the following issues of 'Experientia' by competent experts in this field. Before printing the papers have been exchanged among the authors to allow them for commenting upon the articles so that a Symposium by Correspondence on Radioprotective Means and Compounds arose. As organizers and editors of this symposium acted A. LOCKER (Vienna) and K. FLEMMING (Freiburg, Br. ). Contents 9 J. D. Chapman and A. P. Reuvers: The Time-Scale of Radioprotection in Mammalian Cells 19 J. Calkins: General Patterns of DNA Repair and their possible Signif icance as Necessary Protection from Environmental Radiation Exposure 31 S. Homsey: Protection by Hypoxia and the Effect of Low Oxygen Tensions on Radiosensitivity 45 L. Revesz and B. Littbrand: Radioprotection by Radiosensitizers 53 T. Sugahara, M. Horikawa, M. H. Ikita and N. Nagata: Studies on a Sulfhydryl Radioprotector of Low Toxicity 63 J. M. Yuhas: Systemic Factors Affecting the Radioprotective Effec tiveness of Phosphorothioates 71 C. Streffer: Studies on the Mechanism of 5-Hydroxytryptamine in Radioprotection of Mammals 79 K. Flemming: Some Ideas Concerning the Mode of Action of Radio protective Agents 87 A. Locker and K. Flemming: Some General Aspects of Radioprotection (A Summary) 9 The Time-Scale of Radioprotection in Mammalian Cells J. D. Chapman and A. P. 90 pp. Englisch.

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Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -A condensing (or densifying) operator is a mapping under which the image of any set is in a certain sense more compact than the set itself. The degree of noncompactness of a set is measured by means of functions called measures of noncompactness. The contractive maps and the compact maps [i.e., in this Introduction, the maps that send any bounded set into a relatively compact one; in the main text the term 'compact' will be reserved for the operators that, in addition to having this property, are continuous, i.e., in the authors' terminology, for the completely continuous operators] are condensing. For contractive maps one can take as measure of noncompactness the diameter of a set, while for compact maps can take the indicator function of a family of non-relatively com pact sets. The operators of the form F( x) = G( x, x), where G is contractive in the first argument and compact in the second, are also condensing with respect to some natural measures of noncompactness. The linear condensing operators are characterized by the fact that almost all of their spectrum is included in a disc of radius smaller than one. The examples given above show that condensing operators are a sufficiently typical phenomenon in various applications of functional analysis, for example, in the theory of differential and integral equations. As is turns out, the condensing operators have properties similar to the compact ones. 252 pp. Englisch.