springer basel springer basel feb 2013 (12 Ergebnisse)

Taschenbuch. Zustand: Neu. Neuware -Differential equations with delay naturallyarise in various applications, such as control systems, viscoelasticity, mechanics, nuclear reactors, distributed networks, heat flows, neural networks, combustion, interaction of species, microbiology, learning models, epidemiology, physiology, and many others. This book systematically investigates the stability of linear as well as nonlinear vector differential equations with delay and equations with causal mappings. It presents explicit conditions for exponential, absolute and input-to-state stabilities. These stability conditions are mainly formulated in terms of the determinants and eigenvalues of auxiliary matrices dependent on a parameter; the suggested approachallows us to apply the well-known results of the theory of matrices. In addition, solution estimates for the considered equations are established which provide the bounds for regions of attraction of steady states.The main methodology presented in the book is based on a combined usage of the recent norm estimates for matrix-valued functionsand the following methods and results: the generalized Bohl-Perron principle and the integral version of the generalized Bohl-Perron principle; the freezing method; the positivity of fundamental solutions. A significant part of the book is devoted to the Aizerman-Myshkis problem and generalized Hill theory of periodic systems.The book is intended not only for specialists in the theory of functional differential equations and control theory, but also for anyone with a sound mathematical background interested in their various applications.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 272 pp. Englisch.

Buch. Zustand: Neu. Neuware -This book provides an accessible introduction to the theory of variable Lebesgue spaces. These spaces generalize the classical Lebesgue spaces by replacing the constant exponent p with a variable exponent p(x). They were introduced in the early 1930s but have become the focus of renewed interest since the early 1990s because of their connection with the calculus of variations and partial differential equations with nonstandard growth conditions, and for their applications to problems in physics and image processing.The book begins with the development of the basic function space properties. It avoids a more abstract, functional analysis approach, instead emphasizing an hands-on approach that makes clear the similarities and differences between the variable and classical Lebesgue spaces. The subsequent chapters are devoted to harmonic analysis on variable Lebesgue spaces. The theory of the Hardy-Littlewood maximal operator is completely developed, and the connections between variable Lebesguespaces and the weighted norm inequalities are introduced. The other important operators in harmonic analysis - singular integrals, Riesz potentials, and approximate identities - are treated using a powerful generalization of the Rubio de Francia theory of extrapolation from the theory of weighted norm inequalities. The final chapter applies the results from previous chapters to prove basic results about variable Sobolev spaces.¿Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 324 pp. Englisch.

Buch. Zustand: Neu. Neuware -Special functions enable us to formulate a scientific problem by reduction such that a new, more concrete problem can be attacked within a well-structured framework, usually in the context of differential equations. A good understanding of special functions provides the capacity to recognize the causality between the abstractness of the mathematical concept and both the impact on and cross-sectional importance to the scientific reality.The special functions to be discussed in this monograph vary greatly, depending on the measurement parameters examined (gravitation, electric and magnetic fields, deformation, climate observables, fluid flow, etc.) and on the respective field characteristic (potential field, diffusion field, wave field). The differential equation under consideration determines the type of special functions that are needed in the desired reduction process.Each chapter closes with exercises that reflect significant topics, mostly in computational applications. As a result, readers are not only directly confronted with the specific contents of each chapter, but also with additional knowledge on mathematical fields of research, where special functions are essential to application. All in all, the book is an equally valuable resource for education in geomathematics and the study of applied and harmonic analysis.Students who wish to continue with further studies should consult the literature given as supplements for each topic covered in the exercises.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 520 pp. Englisch.

Buch. Zustand: Neu. Neuware -Antimicrobial peptides have been the subject of intense research in the past decades, and are now considered as an essential part of the defense system in bacteria, plants, animals and humans. his book provides an update on these effector molecules of the innate immune system both for researchers who are already actively involved in the area, and for those with a general interest in the topic.The book starts with an overview of the evolution of cysteine-containing antimicrobial peptides (including defensins), and the role of these peptides in host defense in plants and micro-organisms. The realization that antimicrobial peptides also display functions distinct from their direct antimicrobial action is the focus of the next chapters, and puts these peptides center stage in immunity and wound repair. Further chapters discuss the role of antimicrobial peptides in disease, by providing an overview of mechanisms in bacterial resistance to antimicrobial peptides and a discussion of their role in inflammatory bowel disease, cystic fibrosis lung disease and chronic obstructive pulmonary disease. Finally, the book shows how knowledge of the function of antimicrobial peptides and their regulation can be used to design new therapies for inflammatory and infectious disorders. This is a very important area of research because of the increase in resistance of micro-organisms to conventional antibiotics. Therefore the use of synthetic or recombinant peptides, or agents that stimulate the endogenous production of antimicrobial peptides, provides an attractive alternative for conventional antibiotics.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 396 pp. Englisch.

Buch. Zustand: Neu. Neuware -Ibuprofen is one of the most successful drugs used worldwide for the treatment of mild to moderate pain and various inflammatory conditions. Over the past 40 years, ibuprofen has been proven to be as safe or even safer and also as effective as the established non-steroidal anti-inflammatory drugs (NSAIDs) and the coxibs. This well-written book reviews the pharmacology, clinical uses and the various adverse effects of Ibuprofen, the disposition and unique modes of action in relation to clinical effects of the drug as well as various formulations. The use of combinations with other drugs (e.g. paracetamol, codeine, caffeine) are critically assessed and the impact of natural products and Chinese Medicines on the safety of ibuprofen.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 264 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Growth factor receptors have long been known to drive malignant transformation and cancer progression. The epidermal growth factor receptor (EGFR, ErbB, HER) system is likely the best described membrane receptor tyrosine kinase family in malignant tumors. With implementation of the growth-inhibitory anti-HER-2 antibody trastuzumab (Herceptin) for the treatment of HER-2-positive advanced metastatic breast cancer, a new era has dawned in the therapy of this malignant disease. Unfortunately, trastuzumab-sensitive cancers invariably develop resistance to the antibody after some time. Recent clinical studies have revealed that these refractory tumors are still responsive to inhibition of the HER receptor family using dual HER-1/-2 inhibitors such as lapatinib (Tykerb/Tyverb). Moreover, a multiplicity of novel, improved irreversibly acting small molecular HER tyrosine kinase inhibitors are in the pipeline of many drug developing companies and are being evaluated in the clinical setting.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 120 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Differential equations with delay naturally arise in various applications, such as control systems, viscoelasticity, mechanics, nuclear reactors, distributed networks, heat flows, neural networks, combustion, interaction of species, microbiology, learning models, epidemiology, physiology, and many others. This book systematically investigates the stability of linear as well as nonlinear vector differential equations with delay and equations with causal mappings. It presents explicit conditions for exponential, absolute and input-to-state stabilities. These stability conditions are mainly formulated in terms of the determinants and eigenvalues of auxiliary matrices dependent on a parameter; the suggested approach allows us to apply the well-known results of the theory of matrices. In addition, solution estimates for the considered equations are established which provide the bounds for regions of attraction of steady states. The main methodology presented in the book is based on a combined usage of the recent norm estimates for matrix-valued functions and the following methods and results: the generalized Bohl-Perron principle and the integral version of the generalized Bohl-Perron principle; the freezing method; the positivity of fundamental solutions. A significant part of the book is devoted to the Aizerman-Myshkis problem and generalized Hill theory of periodic systems. The book is intended not only for specialists in the theory of functional differential equations and control theory, but also for anyone with a sound mathematical background interested in their various applications. 272 pp. Englisch.

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book provides an accessible introduction to the theory of variable Lebesgue spaces. These spaces generalize the classical Lebesgue spaces by replacing the constant exponent p with a variable exponent p(x). They were introduced in the early 1930s but have become the focus of renewed interest since the early 1990s because of their connection with the calculus of variations and partial differential equations with nonstandard growth conditions, and for their applications to problems in physics and image processing. The book begins with the development of the basic function space properties. It avoids a more abstract, functional analysis approach, instead emphasizing an hands-on approach that makes clear the similarities and differences between the variable and classical Lebesgue spaces. The subsequent chapters are devoted to harmonic analysis on variable Lebesgue spaces. The theory of the Hardy-Littlewood maximal operator is completely developed, and the connections between variable Lebesgue spaces and the weighted norm inequalities are introduced. The other important operators in harmonic analysis - singular integrals, Riesz potentials, and approximate identities - are treated using a powerful generalization of the Rubio de Francia theory of extrapolation from the theory of weighted norm inequalities. The final chapter applies the results from previous chapters to prove basic results about variable Sobolev spaces. 324 pp. Englisch.

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Special functions enable us to formulate a scientific problem by reduction such that a new, more concrete problem can be attacked within a well-structured framework, usually in the context of differential equations. A good understanding of special functions provides the capacity to recognize the causality between the abstractness of the mathematical concept and both the impact on and cross-sectional importance to the scientific reality.The special functions to be discussed in this monograph vary greatly, depending on the measurement parameters examined (gravitation, electric and magnetic fields, deformation, climate observables, fluid flow, etc.) and on the respective field characteristic (potential field, diffusion field, wave field). The differential equation under consideration determines the type of special functions that are needed in the desired reduction process.Each chapter closes with exercises that reflect significant topics, mostly in computational applications. As a result, readers are not only directly confronted with the specific contents of each chapter, but also with additional knowledge on mathematical fields of research, where special functions are essential to application. All in all, the book is an equally valuable resource for education in geomathematics and the study of applied and harmonic analysis.Students who wish to continue with further studies should consult the literature given as supplements for each topic covered in the exercises. 520 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Growth factor receptors have long been known to drive malignant transformation and cancer progression. The epidermal growth factor receptor (EGFR, ErbB, HER) system is likely the best described membrane receptor tyrosine kinase family in malignant tumors. With implementation of the growth-inhibitory anti-HER-2 antibody trastuzumab (Herceptin) for the treatment of HER-2-positive advanced metastatic breast cancer, a new era has dawned in the therapy of this malignant disease. Unfortunately, trastuzumab-sensitive cancers invariably develop resistance to the antibody after some time. Recent clinical studies have revealed that these refractory tumors are still responsive to inhibition of the HER receptor family using dual HER-1/-2 inhibitors such as lapatinib (Tykerb/Tyverb). Moreover, a multiplicity of novel, improved irreversibly acting small molecular HER tyrosine kinase inhibitors are in the pipeline of many drug developing companies and are being evaluated in the clinical setting. 120 pp. Englisch.

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Antimicrobial peptides have been the subject of intense research in the past decades, and are now considered as an essential part of the defense system in bacteria, plants, animals and humans. his book provides an update on these effector molecules of the innate immune system both for researchers who are already actively involved in the area, and for those with a general interest in the topic. The book starts with an overview of the evolution of cysteine-containing antimicrobial peptides (including defensins), and the role of these peptides in host defense in plants and micro-organisms. The realization that antimicrobial peptides also display functions distinct from their direct antimicrobial action is the focus of the next chapters, and puts these peptides center stage in immunity and wound repair. Further chapters discuss the role of antimicrobial peptides in disease, by providing an overview of mechanisms in bacterial resistance to antimicrobial peptides and a discussion of their role in inflammatory bowel disease, cystic fibrosis lung disease and chronic obstructive pulmonary disease. Finally, the book shows how knowledge of the function of antimicrobial peptides and their regulation can be used to design new therapies for inflammatory and infectious disorders. This is a very important area of research because of the increase in resistance of micro-organisms to conventional antibiotics. Therefore the use of synthetic or recombinant peptides, or agents that stimulate the endogenous production of antimicrobial peptides, provides an attractive alternative for conventional antibiotics. 396 pp. Englisch.

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Ibuprofen is one of the most successful drugs used worldwide for the treatment of mild to moderate pain and various inflammatory conditions. Over the past 40 years, ibuprofen has been proven to be as safe or even safer and also as effective as the established non-steroidal anti-inflammatory drugs (NSAIDs) and the coxibs. This well-written book reviews the pharmacology, clinical uses and the various adverse effects of Ibuprofen, the disposition and unique modes of action in relation to clinical effects of the drug as well as various formulations. The use of combinations with other drugs (e.g. paracetamol, codeine, caffeine) are critically assessed and the impact of natural products and Chinese Medicines on the safety of ibuprofen. Ibuprofen is one of the most successful drugs used worldwide for the treatment of mild to moderate pain and various inflammatory conditions, even in a low-dose form for over-the-counter (OTC), non-prescription sale. Over the past 40 years, ibuprofen has been proven to be as safe or safer and just as effective as established non-steroidal anti-inflammatory drugs (NSAIDs) or coxibs. This book reviews the pharmacology, clinical uses and adverse effects of ibuprofen. Its disposition and unique modes of action in relation to clinical effects are discussed as well as various formulations and the impact of food and other variables on its actions and gastro-intestinal safety. The use of combinations of ibuprofen with other drugs (e.g. paracetamol, codeine and caffeine) are critically assessed. There are already some indications of potential therapeutic benefits of the drug combinations in treating certain painful conditions, while still retaining the relative safety benefits of ibuprofen (at least at OTC dosages). The impact of natural products and Chinese Medicines on the safety of ibuprofen is also reviewed. The book is written in a more general style, including explanatory diagrams, for anyone interested in the properties, actions and uses of ibuprofen. 264 pp. Englisch.