springer basel springer basel nov 2013 (32 Ergebnisse)

Buch. Zustand: Neu. Neuware -The book deals with continuous piecewise linear differential systems in the plane with three pieces separated by a pair of parallel straight lines. Moreover, these differential systems are symmetric with respect to the origin of coordinates. This class of systems driven by concrete applications is of interest in engineering, in particular in control theory and the design of electric circuits. By studying these particular differential systems we will introduce the basic tools of the qualitative theory of ordinary differential equations, which allow us to describe the global dynamics of these systems including the infinity. The behavior of their solutions, their parametric stability or instability and their bifurcations are described. The book is very appropriate for a first course in the qualitative theory of differential equations or dynamical systems, mainly forengineers, mathematicians, andphysicists.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 304 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -In this book, I present an expanded version of the contents of my lectures at a Seminar of the DMV (Deutsche Mathematiker Vereinigung) in Düsseldorf, June, 1986. The title 'Nonlinear methods in complex geometry' already indicates a combination of techniques from nonlinear partial differential equations and geometric concepts. In older geometric investigations, usually the local aspects attracted more attention than the global ones as differential geometry in its foundations provides approximations of local phenomena through infinitesimal or differential constructions. Here, all equations are linear. If one wants to consider global aspects, however, usually the presence of curvature Ieads to a nonlinearity in the equations. The simplest case is the one of geodesics which are described by a system of second ordernonlinear ODE; their linearizations are the Jacobi fields. More recently, nonlinear PDE played a more and more pro~inent röle in geometry. Let us Iist some of the most important ones: - harmonic maps between Riemannian and Kählerian manifolds - minimal surfaces in Riemannian manifolds - Monge-Ampere equations on Kähler manifolds - Yang-Mills equations in vector bundles over manifolds. While the solution of these equations usually is nontrivial, it can Iead to very signifi cant results in geometry, as solutions provide maps, submanifolds, metrics, or connections which are distinguished by geometric properties in a given context. All these equations are elliptic, but often parabolic equations are used as an auxiliary tool to solve the elliptic ones.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 160 pp. Englisch.

Buch. Zustand: Neu. Neuware -This volume comprises the proceedings of the Conference on Operator Theory and its Applications held in Gothenburg, Sweden, April 26-29, 2011. The conference was held in honour of Professor Victor Shulman on the occasion of his 65th birthday. The papers included in the volume covera large variety of topics, among them the theory of operator ideals, linear preservers, C\*-algebras, invariant subspaces, non-commutative harmonic analysis, and quantum groups, andreflect recent developments in these areas. The book consists of bothoriginal research papers and high quality survey articles, allofwhich werecarefully refereed. ¿Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 304 pp. Englisch.

Buch. Zustand: Neu. Neuware -This book contains a collection of research articles and surveys on recent developments on operator theory as well as its applications covered in the IWOTA 2011 conference held at Sevilla University in the summer of 2011. The topics includespectral theory, differential operators, integral operators, composition operators, Toeplitz operators, andmore.The book also presents a largenumber of techniques in operator theory.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 560 pp. Englisch.

Buch. Zustand: Neu. Neuware -Chronic obstructive pulmonary disease (COPD) is a multi-component condition that results in increasingly limited airflow, usually associated with an abnormal inflammatory response of the lung. It constitutes a major public health burden worldwide, while only very few effective therapies are available.This book provides a comprehensive overview of the development of Onbrez Breezhaler, a newly approved once-daily inhaled ¿2 agonist for the treatment of COPD. It reviews the current pharmacotherapy for COPD and discusses topics such as the chemical design and the pre-clinical pharmacology of the molecule, the early clinical development, the INHANCE study (which provides a successful example of the use of an adaptive design in the confirmatory setting) and the Phase III clinical efficacy study, as well as the history and performance of the Breezhaler device. Finally, a list of emerging targets is included that could well offer future treatment options for COPD.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 156 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -InhaltsangabePart I: Stochastic Analysis.- Dirichlet forms for Poisson measures and Lévy processes: the lent particle method.- Backward stochastic difference equations with finite states.- On a forward-backward stochastic system associated to the Burgers equation.- Quantifying model uncertainties in complex systems.- On the estimate for commutators in DiPerna-Lions theory.- Approximation theorem for stochastic differential equations driven by G-Brownian motion.- Stochastic flows for nonlinear SPDEs driven by linear multiplicative space-time white noises.- Optimal stopping problem associated with jump-diffusion processes.- A review of recent results on approximation of solutions of stochastic differential equations.- Strong consistency of Bayesian estimator under discrete observations and unknown transition density.- Stability of a nonlinear equation related to a spatially-inhomogeneous branching process.- Exponentially stable stationary solutions for delay stochastic evolution equations.- Robust stochastic control and equivalent martingale measures.- Multivalued stochastic differential questions driven by point processes.- Logarithmic derivatives of densities for jump processes.- Part II: Financial Applications.- Convertible bonds in a defaultable diffusion model.- A geometric approach to option pricing with transaction costs in discrete models.- Completeness and hedging in a Lévy bond market.- Asymptotically efficient discrete hedging.- Estimating joint default probability by efficient importance sampling with applications from bottom up.- Market models of forward CDS spreads.- Optimal threshold dividend strategies under the compound Poisson model with regime switching.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 440 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This self-contained monograph presents a unified exposition of the thermodynamic formalism and some of its main extensions, with emphasis on the relation to dimension theory and multifractal analysis of dynamical systems. In particular, the book considers three different flavors of the thermodynamic formalism, namely nonadditive, subadditive, and almost additive, and provides a detailed discussion of some of the most significant results in the area, some of them quite recent. It also includes a discussion of the most substantial applications of these flavors of the thermodynamic formalism to dimension theory and multifractal analysis of dynamical systems.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 312 pp. Englisch.

Buch. Zustand: Neu. Neuware -This book summarizes the state-of-the art in the development of T cell-based in vitro assays, which offer useful tools for hazard identification, risk assessment and improvement of diagnostics. It will be of interest to scientists, the chemical and pharmaceutical industry, and regulators involved in the replacement of animal testing methods.The identification of hazardous chemicals and drugs is essential to ensuring human health. The ban on animal testing for the cosmetics industry since 2009 and international efforts to reduce and replace animal testing in research and immunotoxicology call for alternative in vitro methods. The most specific immune response to chemicals and drugs that cause allergic contact dermatitis, respiratory disease and adverse drug reactions is the highly antigen-specific T lymphocyte response. Therefore the use of T cells as tools for identifying contact allergens and drugs that may cause health problems is of great interest.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 192 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -The book presents a comprehensive exposition of extension results for maps between different geometric objects and of extension-trace results for smooth functions on subsets with no a priori differential structure (Whitney problems). The account covers development of the area from the initial classical works of the first half of the 20th century to the flourishing period of the last decade. Seemingly very specific these problems have been from the very beginning a powerful source of ideas, concepts and methods that essentially influenced and in some cases even transformed considerable areas of analysis. Aside from the material linked by the aforementioned problems the book also is unified by geometric analysis approach used in the proofs of basic results. This requires a variety of geometric tools from convex and combinatorial geometry to geometry of metric space theory to Riemannian and coarse geometry and more. The necessary facts are presented mostly with detailed proofs to make thebook accessible to a wide audience.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 588 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This book is an introduction to the subject of mean curvature flow of hypersurfaces with special emphasis on the analysis of singularities. This flow occurs in the description of the evolution of numerous physical models where the energy is given by the area of the interfaces. These notes provide a detailed discussion of the classical parametric approach (mainly developed by R. Hamilton and G. Huisken). They are well suited for a course at PhD/PostDoc level and can be useful for any researcher interested in a solid introduction to the technical issues of the field. All the proofs are carefully written, often simplified, and contain several comments. Moreover, the author revisited and organized a large amount of material scattered around in literature in the last 25 years.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 180 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -The inflammasome was first described in 2002 as a molecular complex activating proinflammatory caspases and therefore regulating the maturation and biological activities of cytokines such as IL-1¿ and IL-18. This finding was substantiated by the identification of several mutations in the cias1 gene, encoding the human NLRP3 protein, responsible for several autoinflammatory disorders such as the Muckle Wells syndrome. Since, the interest for this complex has constantly increased and several inflammasome complexes with different specificities have been described. These inflammasomes sense a wide variety of pathogens and danger signals and are key players in the inflammatory response. With the contributions of leading international experts in the field, this book provides an extensive overview of the current knowledge of inflammasome biology and their role in health and disease.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 240 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware 548 pp. Deutsch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The book provides a comprehensive introduction to compact finite difference methods for solving boundary value ODEs with high accuracy. The corresponding theory is based on exact difference schemes (EDS) from which the implementable truncated difference schemes (TDS) are derived. The TDS are now competitive in terms of efficiency and accuracy with the well-studied numerical algorithms for the solution of initial value ODEs. Moreover, various a posteriori error estimators are presented which can be used in adaptive algorithms as important building blocks. The new class of EDS and TDS treated in this book can be considered as further developments of the results presented in the highly respected books of the Russian mathematician A. A. Samarskii. It is shown that the new Samarskii-like techniques open the horizon for the numerical treatment of more complicated problems.The book contains exercises and the corresponding solutions enabling the use as a course text or for self-study. Researchers and students from numerical methods, engineering and other sciences will find this book provides an accessible and self-contained introduction to numerical methods for solving boundary value ODEs. 260 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Mit dem vorliegenden dritten Band findet die vor zwei J ahren gegrtindete Reihe «Fortschritte der Arzneimittelforschung» ihre planmassige Fortsetzung. Wiederum ist versucht worden, zusammenfassend tiber einige Gebiete der Arz neimittelforschung zu berichten, wobei diesmal organische Fluorverbindungen als Medikamente, Struktur und Wirkung bei verschiedenen Anthelmintica, 5-Hydroxy-tryptamin und verwandte Indolalkylamine, die pharmakologischen Aspekte der Allergie, krebswirksame Antibiotica aus Actinomyceten und neue ste Arzneimittel behandelt werden. Der dritte Band hat an Umfang gegentiber den beiden vorhergehenden etwas abgenommen; dies geschah einerseits aus dem Wunsche heraus, sein Erscheinen zu beschleunigen und dem Leser die Referate so frUh wie moglichnach deren Nie derschrift zuganglich zu machen, andererseits aus dem Bestreben, die einzelnen Bande nicht tiber Gebtihr anschwellen zu lassen. Als Neuerung enthalt der vor liegende Band erstmals ein Sachverzeichnis. Der Herausgeber hoHt, damit dem zum Teil ausgesprochenen Wunsche zahlreicher Fachkollegen nachzukommen und die Brauchbarkeit der Reihe auch als Nachschlagwerk steigem zu konnen. Das Sachverzeichnis ftihrt deutsche, franzosische und englische Stichworter ge meinsam auf; sein jetziger Aufbau solI als ein Versuch betrachtet werden, und der Herausgeber hofft auf Anregungen, Vorschlage und Kritik aus dem Leserkreise.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 564 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The book presents a comprehensive exposition of extension results for maps between different geometric objects and of extension-trace results for smooth functions on subsets with no a priori differential structure (Whitney problems). The account covers development of the area from the initial classical works of the first half of the 20th century to the flourishing period of the last decade. Seemingly very specific these problems have been from the very beginning a powerful source of ideas, concepts and methods that essentially influenced and in some cases even transformed considerable areas of analysis. Aside from the material linked by the aforementioned problems the book also is unified by geometric analysis approach used in the proofs of basic results. This requires a variety of geometric tools from convex and combinatorial geometry to geometry of metric space theory to Riemannian and coarse geometry and more. The necessary facts are presented mostly with detailed proofs to make the book accessible to a wide audience. 436 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The book consists of solicited articles from a select group of mathematicians and physicists working at the interface between positivity and the geometry, combinatorics or analysis of polynomials of one or several variables. It is dedicated to the memory of Julius Borcea (1968-2009), a distinguished mathematician, Professor at the University of Stockholm. With his extremely original contributions and broad vision, his impact on the topics of the planned volume cannot be underestimated. All contributors knew or have exchanged ideas with Dr. Borcea, and their articles reflect, at least partially, his heritage. 424 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Proteases are everywhere from prokaryotes to eukaryotes, from virus to bacteria and in all human tissues, playing a role in many biological functions. Among these functions, the inflammatory reaction is of particular interest. In inflamed tissues, proteases can have a microbial and/or host origin and are involved not only in tissue remodeling, but also in specific signaling to resident or inflammatory cells, thereby contributing to the innate immune response.This volume presents all advances in our knowledge of the role proteases and their inhibitors play in various diseases associated with inflammatory response. Mechanisms involved in protease signaling to cells are presented, and the different types of proteases that are present at inflammatory sites and their effects on the course of inflammation are discussed. Finally, the evidence for considering proteases and their receptors as potential molecular targets for therapeutic interventions in the treatment of inflammatory diseases is discussed in the context of specific organ inflammatory pathologies (the lung, gastrointestinal tract, skin, joints, etc.). 324 pp. Englisch.