springer new york springer aug 2015 (217 Ergebnisse)

Buch. Zustand: Neu. Neuware -This is the story of the astronomer Milton La Salle Humason, whose career was integral to developing our understanding of stellar and universal evolution and who helped to build the analytical basis for the work of such notable astronomers and astrophysicists as Paul Merrill, Walter Adams, Alfred Joy, Frederick Seares, Fritz Zwicky, Walter Baade and Edwin Hubble.Humason¿s unlikely story began on the shores of the Mississippi River in Winona, Minnesota, in 1891 and led to the foot of Mount Wilson outside Los Angeles, California, twelve years later. It is there where he first attended summer camp in 1903 and was captivated by its surroundings. The mountain would become the backdrop for his life and career over the next six decades as he helped first build George Ellery Hale¿s observatory on the summit and then rose to become one of that institution¿s leading figures through the first half of the twentieth century.The story chronicles Humason¿s life on Mount Wilson, from his first trip to the mountain to his days as a muleskinner, leading teams of mules hauling supplies to the summit during the construction of the observatory, and follows him through his extraordinary career in spectroscopy, working beside Edwin Hubble as the two helped to reconstruct our concept of the universe. A patient, knowledgeable and persistent observer, Humason was later awarded an honorary doctorate for his work, despite having no formal education beyond the eighth grade. His skill at the telescope is legendary. During his career he photographed the spectra of stars, galaxies and other objects many thousands of times fainter than can be seen with the naked eye and pushed the boundary of the known universe deeper into space than any before him. His work, which included assisting in the formulation of Hubble¿s Law of redshifts, helped to set the field of cosmology solidly on its foundation.Milton Humason was one of the most charismatic characters in science during the first half of the 20th century. Uneducated, streetwise, moonshining, roguish, humble and thoroughly down to earth, he rose by sheer chance, innate ability and incredible will to become the leading deep space observer of his day. ¿The Renaissance man of Mount Wilson,¿ as Harlow Shapley once referred to him, Humason¿s extraordinary life reminds us that passion and purpose may find us at any moment.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 244 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Fundamentals of Matrix-Analytic Methods targets advanced-level students in mathematics, engineering and computer science. It focuses on the fundamental parts of Matrix-Analytic Methods, Phase-Type Distributions, Markovian arrival processes and Structured Markov chains and matrix geometric solutions.New materials and techniques are presented for the first time in research and engineering design. This book emphasizes stochastic modeling by offering probabilistic interpretation and constructive proofs for Matrix-Analytic Methods. Such an approach is especially useful for engineering analysis and design. Exercises and examples are provided throughout the book.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 368 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Brownian dynamics serve as mathematical models for the diffusive motion of microscopic particles of various shapes in gaseous, liquid, or solid environments. The renewed interest in Brownian dynamics is due primarily to their key role in molecular and cellular biophysics: diffusion of ions and molecules is the driver of all life. Brownian dynamics simulations are the numerical realizations of stochastic differential equations that model the functions of biological micro devices such as protein ionic channels of biological membranes, cardiac myocytes, neuronal synapses, and many more. Stochastic differential equations are ubiquitous models in computational physics, chemistry, biophysics, computer science, communications theory, mathematical finance theory, and many other disciplines. Brownian dynamics simulations of the random motion of particles, be it molecules or stock prices, give rise to mathematical problems that neither the kinetic theory of Maxwell and Boltzmann, nor Einstein¿s and Langevin¿s theories of Brownian motion could predict.This book takes the readers on a journey that starts with the rigorous definition of mathematical Brownian motion, and ends with the explicit solution of a series of complex problems that have immediate applications. It is aimed at applied mathematicians, physicists, theoretical chemists, and physiologists who are interested in modeling, analysis, and simulation of micro devices of microbiology. The book contains exercises and worked out examples throughout.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 344 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This SpringerBrief offers careful assessments of the appropriateness and effectiveness of currently available methodologies for fire flow. It explains the water supply requirements for firefighting including rate of flow, the residual pressure required at that flow, and the duration that is necessary to control a major fire in a specific structure. First reviewing existing fire flow calculation methodologies in the U.S. and globally, the authors determine the new information necessary to validate the existing fire flow calculation methodologies. After identifying 19 methods from the U.S., UK, France, Germany, the Netherlands, New England, and Canada, two types of methods are evaluated: those for building planning based on fire and building code requirements, and those for on-scene fire service use. Building planning methods are also examined, including an explanation of the range of building variables that determine fire flow. A survey form for fire departments is provided to help fire departments identify key predictive features based on construction and building parameters. Researchers and professionals in fire engineering will find the recommendations in Evaluation of Fire Flow Methodologies valuable.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 64 pp. Englisch.

Buch. Zustand: Neu. Neuware -This volume is a concise yet comprehensive resource for physicians dealing with, and interested in, the field of molecular pathology in dermatopathology. The book includes descriptions of the techniques and their application to cutaneous diseases and describes possible future techniques and their use in dermatopathology. Special emphasis is also given to the practical application of these techniques to particular situations illustrated by demonstrative cases.Written by experts in their fields, Precision Molecular Pathology of Dermatologic Diseases is of great value to pathologists, dermatologists, resident and fellows, internists, and general practitioners who deal with dermatologic diseases.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 144 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -In creating interpretive strategies for maritime sites, archaeologists and resource managers often are required to think creatively to overcome challenges and problems. These issues include interpreting sites in inaccessible locations and extremely deep water, enabling and controlling access to fragile sites and restricted areas, monitoring visitor behavior, making information interesting to a wide audience, and creating opportunities for public engagement, among other concerns. Meeting Challenges presents cutting-edge interpretation and public education strategies for maritime resources, both on land and underwater, with emphasis on solving the unique problems often associated with presenting these fragile, limited-access sites as heritage attractions and on developing effective visitation and civic engagement opportunities. The examples presented ideally can serve as models for resource managers, archaeologists engaged in interpretation, and site administrators. This volume brings together a diverse group of heritage professionals to discuss issues they¿ve encountered and to present ideas and case studies for adapting, improvising, and overcoming them.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 228 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This monograph gives a short introduction to the relevant modern parts of discrete geometry, in addition to leading the reader to the frontiers of geometric research on sphere arrangements. The readership is aimed at advanced undergraduate and early graduate students, as well as interested researchers. It contains more than 40 open research problems ideal for graduate students and researchers in mathematics and computer science. Additionally, this book may be considered ideal for a one-semester advanced undergraduate or graduate level course.The core part of this book is based on three lectures given by the author at the Fields Institute during the thematic program on ¿Discrete Geometry and Applications¿ and contains four core topics. The first two topics surround active areas that have been outstanding from the birth of discrete geometry, namely dense sphere packings and tilings. Sphere packings and tilings have a very strong connection to number theory, coding, groups, and mathematical programming. Extending the tradition of studying packings of spheres, is the investigation of the monotonicity of volume under contractions of arbitrary arrangements of spheres. The third major topic of this book can be found under the sections on ball-polyhedra that study the possibility of extending the theory of convex polytopes to the family of intersections of congruent balls. This section of the text is connected in many ways to the above-mentioned major topics and it is also connected to some other important research areas as the one on coverings by planks (with close ties to geometric analysis). This fourth core topic is discussed under covering balls by cylinders.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 188 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This book focuses on a development of optimal, flexible, and efficient models and algorithms for cell formation in group technology. Its main aim is to provide a reliable tool that can be used by managers and engineers to design manufacturing cells based on their own preferences and constraints imposed by a particular manufacturing system. This tool could potentially lower production costs by minimizing other costs in a number of areas, thereby increasing profit in a manufacturing system.In the volume, the cell formation problem is considered in a systematic and formalized way, and several models are proposed, both heuristic and exact. The models are based on general clustering problems, and are flexible enough to allow for various objectives and constraints. The authors also provide results of numerical experiments involving both artificial data from academic papers in the field and real manufacturing data to certify the appropriateness of the models proposed.The book was intended to suit the broadest possible audience, and thus all algorithmic details are given in a detailed description with multiple numerical examples and informal explanations are provided for the theoretical results. In addition to managers and industrial engineers, this book is intended for academic researchers and students. It will also be attractive to many theoreticians, since it addresses many open problems in computer science and bioinformatics.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 220 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Intended as a self-contained introduction to measure theory, this textbook also includesa comprehensive treatment of integration on locally compact Hausdorff spaces, the analytic and Borel subsets of Polish spaces, and Haar measures on locally compact groups. This second edition includes a chapter on measure-theoretic probability theory, plus brief treatments of the Banach-Tarski paradox, the Henstock-Kurzweil integral, the Daniell integral, and the existence of liftings.Measure Theory provides a solid background for study in both functional analysis and probability theory and is an excellent resource for advanced undergraduate and graduate students in mathematics. The prerequisites for this book are basic courses in point-set topology and in analysis, and the appendices present a thorough review ofessential background material.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 480 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -At the intersection of mathematics, engineering, and computer science sits the thriving field of compressive sensing. Based on the premise that data acquisition and compression can be performed simultaneously, compressive sensing finds applications in imaging, signal processing, and many other domains. In the areas of applied mathematics, electrical engineering, and theoretical computer science, an explosion of research activity has already followed the theoretical results that highlighted the efficiency of the basic principles. The elegant ideas behind these principles are also of independent interest to pure mathematicians.A Mathematical Introduction to Compressive Sensing gives a detailed account of the core theory upon which the field is build. With only moderate prerequisites, it is an excellent textbook for graduate courses in mathematics, engineering, and computer science. It also serves as a reliable resource for practitioners and researchers in these disciplines who want to acquire a careful understanding of the subject. A Mathematical Introduction to Compressive Sensing uses a mathematical perspective to present the core of the theory underlying compressive sensing.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 644 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -The goal of this Third Edition is to update long-term data presented in earlier editions and to generate new syntheses and conclusions about the biogeochemistry of the Hubbard Brook Valley based on these longer-term data. There have been many changes, revelations, and exciting new insights generated from the longer data records. For example, the impact of acid rain peaked during the period of the HBES and is now declining. The longer-term data also posed challenges in that very marked changes in fluxes occurred in some components, such as hydrogen ion and sulfate deposition, calcium and nitrate export in stream water and biomass accumulation, during the almost 50 years of record. Thus, presenting ¿mean¿ or ¿average¿ conditions for many components for such a long period, when change was so prominent, do not make sense. In some cases, pentads or decades of time are compared to show these changes in a more smoothed and rational way for this long period. In some cases, a single period, often during periods of rapid change, such as acidification, is used to illustrate the main point(s). And, for some elements a unique mass balance approach, allowing the calculation of the Net Ecosystem Flux (NEF), is shown on an annual basis throughout the study.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 240 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -The goal of this work is to present the principles of functional analysis in a clear and concise way. The first three chapters of Functional Analysis: Fundamentals and Applications describe the general notions of distance, integral and norm, as well as their relations. The three chapters that follow deal with fundamental examples: Lebesgue spaces, dual spaces and Sobolev spaces. Two subsequent chapters develop applications to capacity theory and elliptic problems. In particular, the isoperimetric inequality and the Pólya-Szeg¿ and Faber-Krahn inequalities are proved by purely functional methods. The epilogue contains a sketch of the history of functional analysis, in relation with integration and differentiation. Starting from elementary analysis and introducing relevant recent research, this work is an excellent resource for students in mathematics and applied mathematics.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 228 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Differential geometry arguably offers the smoothest transition from the standard university mathematics sequence of the first four semesters in calculus, linear algebra, and differential equations to the higher levels of abstraction and proof encountered at the upper division by mathematics majors. Today it is possible to describe differential geometry as 'the study of structures on the tangent space,' and this text develops this point of view.This book, unlike other introductory texts in differential geometry, develops the architecture necessary to introduce symplectic and contact geometry alongside its Riemannian cousin. The main goal of this book is to bring the undergraduate student who already has a solid foundation in the standard mathematics curriculum into contact with the beauty of higher mathematics. In particular, the presentation here emphasizes the consequences of a definition and the careful use of examples and constructions in order to explore those consequences.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 428 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Visualizations are visual representations of non-visual data. They are produced for people to interact with and to make sense of the underlying data. Rapid advances in display technology and computer power have enabled researchers to produce visually appealing pictures. However, the effectiveness of those pictures in conveying the embedded information to end users has not been fully explored.Handbook of Human Centric Visualization addresses issues related to design, evaluation and application of visualizations. Topics include visualization theories, design principles, evaluation methods and metrics, human factors, interaction methods and case studies. This cutting-edge book includes contributions from well-established researchers worldwide, from diverse disciplines including psychology, visualization and human-computer interaction.This handbook is designed for a professional audience composed of practitioners, lecturers and researchers working in the field of computer graphics, visualization, human-computer interaction and psychology. Undergraduate and postgraduate students in science and engineering focused on this topic will also find this book useful as a comprehensive textbook or reference.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 768 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Presents a comprehensive synopsis of the current state of cosmic rays, their modulation and their effects in the Earth¿s atmosphere.Leading scientists in the field assess the current state of our understanding of the spatial and temporal variations of galactic and anomalous cosmic rays in the Heliosphere, and their relation to effects of the Sun. The main objective is to understand the spatial and temporal variation of galactic and anomalous cosmic rays in the light of recent observations, theory and modeling by identifying the key mechanism(s) of cosmic ray modulation and how changes on the Sun relate to changes in the observed characteristics of cosmic rays in the Heliosphere; examining the current long-lasting solar minimum and understand its implications for solar-cycle variations and long-term variations; and interpreting the long-term variations of cosmogenic radionuclides in terms of solar variability and climate change on Earth.This volume is aimed at graduate students active in the fields of solar physics, space science, and cosmic ray physics.Originally published in Space Science Reviews journal, Vol. 176/1-4, 2013.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 412 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This proceedings volume is based on papers presented at the First Annual Workshop on Inverse Problems whichwas heldin June 2011 at the Department of Mathematics, Chalmers University of Technology. The purpose of the workshop was to present new analytical developments and numerical methods for solutions of inverse problems. State-of-the-art and future challenges in solving inverse problems for a broad range of applications was also discussed.The contributions in this volume are reflective of these themes and will be beneficial to researchers in this area.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 212 pp. Englisch.

Buch. Zustand: Neu. Neuware -This volume contains a collection of relevant information for drug discovery in cell cycle research. Protocols to develop screening assays or to identify novel CDK inhibitors are discussed in the first part of the book. The second part of the book describes elaborate procedures to evaluate activity and mechanism of action of new and already identified CDK inhibitors. The third part of the book talks about protocols to evaluate metabolomics changes associated to inhibitor treatment. Drug delivery strategies focused on nanoparticle development to provide alternative internalization systems for increasing inhibitor efficacy are also described. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and thorough, Cyclin-Dependent Kinase (CDK) Inhibitors: Methods and Protocols is a useful tool for scientists interested in this research field.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 240 pp. Englisch.

Buch. Zustand: Neu. Neuware -¿This volume provides simple and accessible experiment protocols to explore thymus biology. T-Cell Development: Methods and Protocols is divided into three parts presenting short reviews on T cell development, analysis strategies, protocols for cell preparation, flow cytometry analyses, and multiple aspects of thymocyte biology. As a volume in the highly successful Methods in Molecular Biology series, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls.Concise and easy-to-use, T-Cell Development: Methods and Protocols aims to ensure successful results in the further study of this vital field.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 312 pp. Englisch.

Buch. Zustand: Neu. Neuware -This volume presents a comprehensive overview of all the existing methods on analysing protein arginylation, from the early methods utilizing crude protein preparations and whole-cell assays to the latest advanced methods involving recombinant protein techniques, antibodies, high precision mass spectrometry, and chemical probes. This book also includes essays from the founders of the field, who originally discovered arginylation in the early 1960s and brought it to international recognition. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and thorough, Protein Arginylation: Methods and Protocols would interest the emerging body of scientists involved in the studies of posttranslational arginylation and the rapidly growing community of researchers working on a broad range of posttranslational modifications, the analysis of which often meets similar challenges and utilizes similar principles as posttranslational arginylation.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 160 pp. Englisch.

Buch. Zustand: Neu. Neuware -The potential of human embryonic stem cells to advance not only regenerative medicine applications but also our fundamental understanding of stem cell biology continues to drive interest in research with these cells. This detailed volume collects some of the most interesting and useful protocols that have emerged in the area over the last several years. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and expert tips on troubleshooting and avoiding known pitfalls.Thorough and practical, Human Embryonic Stem Cell Protocols, Third Edition serves as a valuable resource to all those interested in exploring stem cell biology questions in a research setting.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 416 pp. Englisch.

Buch. Zustand: Neu. Neuware -Thisvolume provides methods for characterization of muscarinic receptor in crystallography studies that advanced our understanding of structural properties and activation mechanism of muscarinic receptors and are cornerstone in molecular modeling and computer¿based approaches to study muscarinic receptors. Muscarinic Receptor: From Structure to Animal Models guides readers through binding techniques, protocols to investigate molecular properties of muscarinic receptors, protocols to study muscarinic receptors in the central nervous system using autoradiography and PET studies and protocols on animals with knock-out and knock-in muscarinic genes to study role of muscarinic receptors in physiology and behavior. Written in the popular Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your own laboratory.Concise and easy-to-use, Muscarinic Receptor: From Structure to Animal Models aims to ensure successful results in the further study of this vital field.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 300 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -¿¿Advances in science and technology are driven by the development of rigorous mathematical foundations for the study of both theoretical and experimental models.With certain methodological variations, this type of study always comes down to the application of analytic or computational integration procedures, making such tools indispensible. With a wealth of cutting-edge research in the field, Integral Methods in Science and Engineering: Progress in Numerical and Analytic Techniquesprovides a detailed portrait of both the construction of theoretical integral techniques and their application to specific problems in science and engineering.The chapters in this volume are based on talks given by well-known researchers at the Twelfth International Conference on Integral Methods in Science and Engineering, July 23¿27, 2012, in Porto Alegre, Brazil. They address a broad range of topics, from problems of existence and uniqueness for singular integral equations on domain boundaries to numerical integration via finite and boundary elements, conservation laws, hybrid methods, and other quadrature-related approaches. The contributing authors bring their expertise to bear on a number of topical problems that have to date resisted solution, thereby offering help and guidance to fellow professionals worldwide.Integral Methods in Science and Engineering: Progress in Numerical and Analytic Techniques will be a valuable resource forresearchers in applied mathematics, physics, and mechanicaland electrical engineering, forgraduate students in these disciplines, and for various other professionals who use integration as an essential tool in their work.¿Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 424 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This book describes an approach for designing Systems-on-Chip such that the system meets precise mathematical requirements. The methodologies presented enable embedded systems designers to reuse intellectual property (IP) blocks from existing designs in an efficient, reliable manner, automatically generating correct SoCs from multiple, possibly mismatching, components.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 168 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This book provides a comprehensive guide to the design of sustainable and green computing systems (GSC). Coverage includes important breakthroughs in various aspects of GSC, including multi-core architectures, interconnection technology, data centers, high performance computing (HPC), and sensor networks. The authors address the challenges of power efficiency and sustainability in various contexts, including system design, computer architecture, programming languages, compilers and networking.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 248 pp. Englisch.

Buch. Zustand: Neu. Neuware -This detailed volume provides an overview of recent techniques employed in the field of G protein-coupled receptors (GPCRs) to screen for new drugs and to derive information about their receptor structure, dynamics, and function for the purpose of developing improved therapeutics. Owing to remarkable recent advances in the structural, biophysical and biochemical analyses of these receptors, as well as a growing body of evidence hinting at the possible relevance of allosteric modulators, biased agonists and oligomer-selective ligands as improved therapeutic agents, drug discovery for GPCRs has recently taken a completely new direction. For this book, expert contributors have shared their protocols and views on the impact of these methodologies on modern drug discovery. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls.Practical and fully updated, G Protein-Coupled Receptors in Drug Discovery: Methods and Protocols, Second Edition serves as an ideal guide for a diverse audience from structural and molecular biologists to pharmacologists and drug designers who wish to explore this extensive class of key drug targets.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 340 pp. Englisch.

Buch. Zustand: Neu. Neuware -This detailed volume covers molecular biology, cellular biology, biomarkers, imaging, and neuropathological methods and techniques to explore multiple sclerosis (MS), with a special emphasis on disease models. With so much effort needed to elucidate basic disease mechanisms, to clone disease relevant genes, to define novel biomarkers, and to discover novel and improved therapeutic and curative treatments, this book serves to aid researchers in accomplishing these enormous goals. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Practical and easy to use, Multiple Sclerosis: Methods and Protocols will empower the reader to perform novel research regarding pathophysiology and treatment for MS.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 244 pp. Englisch.

Buch. Zustand: Neu. Neuware -This volume provides a collection of protocols for studying and manipulating VEGF signaling pathways in vitro and in vivo, and in particular, aims to present a range of both firmly established and newly emerging technologies, including those that are amenable to aiding in drug discovery or pre-clinical investigations. Each of the three sections begins with an introductory overview followed by supporting relevant methods. A major advantage of this book is that each chapter not only contains methodological detail rarely seen in other literature, but also contains a section on key notes and troubleshooting advice. Part I focuses on quantification of specific VEGF and VEGF receptor isoforms, beginning with a summary on VEGF splice variants, their function and their regulation. Part II relates to the study of VEGF dependent signaling in vitro, starting with a comprehensive overview of VEGF-mediated signal transduction in the cardiovascular system that highlights recent discoveries in the field. Part III first details genetic mouse models, then discusses techniques for studying physiological angiogenesis in the developing mouse embryo. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and thorough, VEFG Signaling: Methods and Protocolsis a useful tool for researching and understanding the basic biology of VEGF signaling and translating it into the clinic.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 236 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Collective view prediction is to judge the opinions of an active web user based on unknown elements by referring to the collective mind of the whole community. Content-based recommendation and collaborative filtering are two mainstream collective view prediction techniques. They generate predictions by analyzing the text features of the target object or the similarity of users¿ past behaviors. Still, these techniques are vulnerable to the artificially-injected noise data, because they are not able to judge the reliability and credibility of the information sources. Trust-based Collective View Prediction describes new approaches for tackling this problem by utilizing users¿ trust relationships from the perspectives of fundamental theory, trust-based collective view prediction algorithms and real case studies.The book consists of two main parts ¿ a theoretical foundation and an algorithmic study. The first part will review several basic concepts and methods related to collective view prediction, such as state-of-the-art recommender systems, sentimental analysis, collective view, trust management, the Relationship of Collective View and Trustworthy, and trust in collective view prediction. In the second part, the authors present their models and algorithms based on a quantitative analysis of more than 300 thousand users¿ data from popular product-reviewing websites. They also introduce two new trust-based prediction algorithms, one collaborative algorithm based on the second-order Markov random walk model, and one Bayesian fitting model for combining multiple predictors.The discussed concepts, developed algorithms, empirical results, evaluation methodologies and the robust analysis framework described in Trust-based Collective View Prediction will not only provide valuable insights and findings to related research communities and peers, but also showcase the great potential to encourage industries and business partners tointegrate these techniques into new applications.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 160 pp. Englisch.

Buch. Zustand: Neu. Neuware -¿ This volume brings together a unique collection of protocols that cover standard, novel, and specialized techniques. Cell Cycle Oscillators: Methods and Protocols guides readers through recent progress in the field from both holistic and reductionist perspectives, providing the latest developments in molecular biology techniques, biochemistry, and computational analysis used for studying oscillatory networks. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and cutting-edge, Cell Cycle Oscillators: Methods and Protocols will serve as an invaluable reference to gain further insight into the complex and incompletely understood processes that are involved in the cell cycle and its regulation by oscillatory networks.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 368 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -¿Commingled and Disarticulated Human Remains:Working Toward Improved Theory, Method, and Data brings together research that provides innovative methodologies for the analysis of commingled human remains. It has temporal and spatial breadth, with case studies coming from pre-state to historic periods, as well as from both the New and Old World. Highlights of this volumeinclude:standardizes methods and presents best practices in the field using a case study approachdemonstrates how data gathered from commingled human remains can be incorporated into the overall interpretation of a siteexplores best way to formulate population size, using commingled remainsField archaeologists, bioarchaeologists, academic anthropologists, forensic anthropologists, zoo archaeologists, and students of anthropology and archaeology will find this to be an invaluable resource.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 304 pp. Englisch.