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Taschenbuch. Zustand: Neu. Neuware -Dr. Madry, one of the world's leading experts in the field, provides in a condensed form a quick yet comprehensive overview of satellite navigation. This book concisely addresses the latest technology, the applications, the regulatory issues, and the strategic implications of satellite navigation systems. This assesses the strengths and weaknesses of satellite navigation networks and review of all the various national systems now being deployed and the motivation behind the proliferation of these systems.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 124 pp. Englisch.

Buch. Zustand: Neu. Neuware -In this provocative text, a noted neuroscientist reexamines Freud's posthumously published Project of Scientific Psychology in the light of modern neuroscience. This expanded 'thermodynamics of the mind' model includes robust conceptions of the cellular and neural processes that accompany creation of consciousness and memory, their contributions to such conditions as depression, dissociative disorders, and schizophrenia, and implications for practice, from imaging to talk-based therapies to pharmacotherapy. Central to this construct is Freud's proposal of specific 'omega' neurons as the most volatile carriers of consciousness between mind and brain, which is applied to current issues regarding complexity and executive functioning. In addition, the book is extensively referenced, allowing readers to investigate these and related phenomena in greater detail.Among the topics covered:Neural reductionism in Freud's 'Project' and neuropsychoanalysis.Thermodynamics and brain self-organization.Conflicting information and the dissociated mind.The Cartesian model of the mind and the binding problem.Neuroendocrine and immune response to stress.The concept of omega neurons and modern chaos theory.Rigorous, challenging, and occasionally startling, The Brain and Conscious Unity is a milestone in the neuroscience and mind/brain literature to be read and discussed by psychiatrists, psychologists, and neuropsychologists.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 144 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Psychology and many of its subfields have seen a significant shift over the past 10-12 years toward a focus on hope, positive attributes, and character strengths through the positive psychology movement. This book provides a blueprint for a burgeoning subfield in neuropsychology¿positive neuropsychology. It proposes an alternative, evidence-based perspective on neuropsychology that incorporates positive psychology principles and a focus on promotion of cognitive health. It synthesizes existing research and provides novel perspectives on promotion of cognitive health in clinical, nonclinical, and academic settings. This work is a resource and reference for neuropsychologists, allied professionals, and students who see the critical role neuropsychologists can play in maintaining, promoting, and being mindful of cognitive health.TARGETED MARKET SEGMENTSNeuropsychologists, health psychologists, geriatricians, rehabilitation specialists, clinical psychologistsSpringer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 192 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This textbook serves as an introduction to fault-tolerance, intended for upper-division undergraduate students, graduate-level students and practicing engineers in need of an overview of the field. Readers will develop skills in modeling and evaluating fault-tolerant architectures in terms of reliability, availability and safety. They will gain a thorough understanding of fault tolerant computers, including both the theory of how to design and evaluate them and the practical knowledge of achieving fault-tolerance in electronic, communication and software systems. Coverage includes fault-tolerance techniques through hardware, software, information and time redundancy. The content is designed to be highly accessible, including numerous examples and exercises. Solutions and powerpoint slides are available for instructors.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 204 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Introduction to Linear Elasticity, 3rd Edition provides an applications-oriented grounding in the tensor-based theory of elasticity for students in mechanical, civil, aeronautical, biomedical engineering, as well as materials and earth science. The book is distinct from the traditional text aimed at graduate students in solid mechanics by introducing its subject at a level appropriate for advanced undergraduate and beginning graduate students. The author's presentation allows students to apply the basic notions of stress analysis and move on to advanced work in continuum mechanics, plasticity, plate and shell theory, composite materials, and finite method analysis.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 368 pp. Englisch.

Buch. Zustand: Neu. Neuware -This volume contains a compilation of techniques and laboratory protocols directly related to RNA nano technology and its applications in nano biotechnology and nano medicine. The chapters in this book cover a wide range of research methods that can be easily comprehended and carried out in a step-by-step manner by graduate students and postdoctoral fellows from diverse scientific disciplines. Some of the covered topics include various biochemical, biophysical and bioinformatics approaches for analyzing RNA structures and properties; methods to analyze the multi-step assembly process of RNA nano architectures; purification of multifunctional RNA nanoparticles by ultracentrifugation and HPLC; real-time detection of RNA nano constructs in vivo; conjugation of imaging, targeting and therapeutic modules to RNA scaffold; and design and characterization of RNA-protein nanostructures. Written in the highly successful Methods of Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and key tips on troubles troubleshooting and avoiding known pitfalls.Cutting-edge and practical, RNA Nanotechnology and Therapeutics: Methods and Protocols propels the field toward new heights by engaging researchers working in the diverse fields of physical, engineering, and life sciences.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 252 pp. Englisch.

Buch. Zustand: Neu. Neuware -This book illustrates the broad range of Jerry Marsden¿s mathematical legacy in areas of geometry, mechanics, and dynamics, from very pure mathematics to very applied, but always with a geometric perspective. Each contribution develops its material from the viewpoint of geometric mechanics beginning at the very foundations, introducing readers to modern issues via illustrations in a wide range of topics. The twenty refereed papers contained in this volume are based on lectures and research performed during the month of July 2012 at the Fields Institute for Research in Mathematical Sciences, in a program in honor of Marsden's legacy.The unified treatment of the wide breadth of topics treated in this book will be of interest to both experts and novices in geometric mechanics. Experts will recognize applications of their own familiar concepts and methods in a wide variety of fields, some of which they may never have approached from a geometric viewpoint. Novices may choose topics that interest them among the various fields and learn about geometric approaches and perspectives toward those topics that will be new for them as well.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 516 pp. Englisch.

Buch. Zustand: Neu. Neuware -Over the past 50 years, biotechnology has been the major driving force for increasing crop productivity.Particularly, advances in plant genetic engineering technologies have opened up vast new opportunities for plant researchers and breeders to create new crop varieties with desirable traits.Recent development of precise genome modification methods, such as targeted gene knock-out/knock-in and precise gene replacement, moves genetic engineering to another level and offers even more potentials for improving crop production.The work provides an overview of the latest advances on precise genomic engineering technologies in plants. Topics include recombinase and engineered nucleases-mediated targeted modification, negative/positive selection-based homologous recombination and oligo nucleotide-mediated recombination. Finally, challenges and impacts of the new technologies on present regulations for genetic modification organisms (GMOs) will be discussed.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 176 pp. Englisch.

Buch. Zustand: Neu. Neuware -Muslims for hundreds of years have been involved in philanthropic activities targeting poor and needy people through varied types of ¿third sector¿ organizations (TSOs). Nonetheless, many people in Muslim majority countries (MMCs), not having freedom from hunger, face human security crises. Not much is known about the TSOs or their human security provisions in MMCs. To fill this knowledge gap, this Volume documents and analyses philanthropy and all types of third sector organizations including the awqaf (Muslim endowments) vis-à-vis human security in MMCs. The study is comprehensive in treating the subject matter (analyzing the legal environment, characteristics, extent and functioning of all forms of the third sector and their human security performances) and in geographic coverage (incorporating all forty-seven Muslim majority countries in Africa and Asia). It is also innovative expounding TSO density analysis, state support score (SSS) and a third-sector capability measure (TCM) tostudy their interrelationships. It is an essential unique reference book for students and scholars of the third sector and human security, international organizations, development agencies, donor governments, security experts and in particular anybody with interests in Islam and MMCs.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 384 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -The main idea of this book is that to comprehend the instructional potential of simulation and to design effective simulation-based learning environments, one has to consider both what happens inside the computer and inside the students' minds. The framework adopted to do this is model-centered learning, in which simulation is seen as particularly effective when learning requires a restructuring of the individual mental models of the students, as in conceptual change. Mental models are by themeselves simulations, and thus simulation models can extend our biological capacity to carry out simulative reasoning. For this reason, recent approaches in cognitive science like embodied cognition and the extended mind hypothesis are also considered in the book. A conceptual model called the ¿epistemic simulation cycle¿ is proposed as a blueprint for the comprehension of the cognitive activies involved in simulation-based learning and for instructional design.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 256 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Arizona has one of the fastest growing communities of Latino immigrants in the United States. In response to accusations that the Federal government was hampering the immigration enforcement actions of Arizona police, state Senator Russell Pearce introduced the ¿Support Our Law Enforcement and Safe Neighborhoods Act.¿ Better known as SB 1070, the policy allows police officers in Arizona to arrest unauthorized immigrants under the state¿s trespassing law. The law also gives officers the latitude to question and detain those that may appear suspicious, which may simply mean that they appear Latino. Under the State¿s statute, immigrants can also be criminalized for their mere presence in Arizona. The bill was signed into law on April 23, 2010, which generated a number of immensely complex issues at the local, national and international level The measure has affected an already problematic U.S.-Mexico, bi-national relationship at a time of increased security cooperation between the two countries. Furthermore, former the President of Mexico has criticized the law, issuing travel advisories, and as a sanction, trade between Arizona and Mexico has been reduced. Elected officials across the country called for a variety of economic boycotts and campaigns that would discourage the full implementation of the law. Over fifteen major cities have ended business contracts with Arizona. The State tourism industry has lost almost one billion dollars in less than six months as a result of this policy.This book examines a variety of issues and consequences of SB 1070 at the local, national and international level. It provides timely research and analysis on a topic not previously examined and from a variety of inter disciplinary approaches, making it of interest to political scientists and policy-makers alike.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 184 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Now is its revised and expanded third edition, including nine new chapters, this step-by-step, state-of-the-art procedural manual covers over 50 unique surgical approaches for injuries and conditions of the spine. Generously illustrated, various surgical approaches to the cervical, thoracic and lumbar spine are clearly enumerated and described, including anterior, lateral, and posterior approaches and the worldwide movement toward the use of tubular retractors for a multitude of approaches. Written and edited by leaders in the field of spine surgery, this updated edition will be an invaluable resource for orthopedic surgeons, neurosurgeons and sports medicine practitioners alike.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 440 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Optimizing Stormwater Treatment Practices: A Handbook of Assessment and Maintenance provides the information necessary for developing and operating an effective maintenance program for stormwater treatment. The book offers instructions on how to measure the level of performance of stormwater treatment practices directly and bases proposed maintenance schedules on actual performance and historical maintenance efforts and costs. The inspection methods, which are proven in the field and have been implemented successfully, are necessary as regulatory agencies are demanding evaluations of the performance of stormwater treatment practices. The authors have developed a three-tiered approach that offers readers a standard protocol for how to determine the effectiveness of stormwater treatment practices currently in place.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 352 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Finite-dimensional optimization problems occur throughout the mathematical sciences. The majority of these problems cannot be solved analytically. This introduction to optimization attempts to strike a balance between presentation of mathematical theory and development of numerical algorithms. Building on students¿ skills in calculus and linear algebra, the text provides a rigorous exposition without undue abstraction. Its stress on statistical applications will be especially appealing to graduate students of statistics and biostatistics. The intended audience also includes students in applied mathematics, computational biology, computer science, economics, and physics who want to see rigorous mathematics combined with real applications.In this second edition the emphasis remains on finite-dimensional optimization. New material has been added on the MM algorithm, block descent and ascent, and the calculus of variations. Convex calculus is now treated in much greater depth. Advanced topics such as the Fenchel conjugate, subdifferentials, duality, feasibility, alternating projections, projected gradient methods, exact penalty methods, and Bregman iteration will equip students with the essentials for understanding modern data mining techniques in high dimensions.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 548 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This book considers the origins, performance and diffusion of national immigration policies targeting highly skilled immigrants. Unlike asylum seekers and immigrants admitted under family reunification streams, highly skilled immigrants are typically cast as ¿wanted and welcome¿ as a consequence of their potential economic contribution to the receiving society and putative assimilability. Testing the degree to which this assumption holds is the principle aim of this book. In contrast to publications which see highly skilled immigration as functional response to labor market needs, the book probes the political and sociological dimensions of policy, drawing on contributions from an international group of established and new scholars from the fields of history, law, political science, sociology, and public policy. The book is organized into four parts. Part I probes the origins of post-WWII immigration policies in Canada, Australia, and the United States. Part II analyzes recent debates on highly skilled immigration policy in the United States, whose origins go back to the 1965 Act by Congress which favored family reunification over skilled immigration. Part III considers the degree to which highly skilled immigrants are welcome, by focusing on the integration trajectories of foreign trained professionals in Canada. Paradoxically, just as Canada has succeeded in orienting its admissions system more explicitly toward privileging highly educated and skilled professionals, highly skilled immigrants have experienced worsening economic outcomes as reflected in rates of unemployment and falling earnings. Part IV considers the internationalization of highly skilled immigration policies, focusing on Europe¿s most important immigration countries, Germany and Britain. As is true in Canada, the labor market outcomes for highly skilled immigrants in Europe are disappointing, and the final chapter discusses why this is the case and what might be done to improvematters. Given its combination of cross-disciplinary insights, cross-national comparisons, and empirical richness, the book will be of interest to both scholars and policymakers concerned with immigration policy.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 320 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Translated from the original French by Bernard Sheehan; Edited and with an introduction byDr. William Sheehan, a neuroscientist and amateur astronomer who is also a research fellow of the Lowell Observatory in Flagstaff, ArizonaLe Verrier was a superb scientist. His discovery of Neptune in 1846 made him the most famous astronomer of his time. He produced a complete theory of the motions of the planets which served as a basis for planetary ephemeris for a full century. Doing this, he discovered an anomaly in the motion of Mercury which later became the first proof of General Relativity. He also founded European meteorology. However his arrogance and bad temper created many enemies, and he was even fired from his position of Director of the Paris Observatory.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 356 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -The middle ear plays a vital role in the sense and sensitivity of hearing. Of the various characteristics that distinguish mammals from other vertebrates, several pertain specifically to the middle-ear system, such as the presence of three middle-ear bones and the four-layer composite structure of the tympanic membrane. The Middle Ear attempts to elucidate the role this system plays in sound transmission, as viewed from both scientific and clinical perspectives.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 324 pp. Englisch.

Buch. Zustand: Neu. Neuware -This volume explores the application of Quality by Design (QbD) to biopharmaceutical drug product development. Twenty-eight comprehensive chapters cover dosage forms, liquid and lyophilized drug products. The introductory chapters of this book define key elements of QbD and examine how these elements are integrated into drug product development. These chapters also discuss lessons learned from the FDA Office of Biotechnology Products pilot program. Following chapters demonstrate how QbD is used for formulation development ranging from screening of formulations to developability assessment to development of lyophilized and liquid formats. The next few chapters study the use of small-scale and surrogate models as well as QbD application to drug product processes such as drug substance freezing and thawing, mixing, sterile filtration, filling, lyophilization, inspection and shipping and handling.Later chapters describe more specialized applications of QbD in the drug product realm. This includes the use of QbD in primary containers, devices and combination product development. The volume also explores QbD applied to vaccine development, automation, mathematical modeling and monitoring, and controlling processes and defining control strategies. It concludes with a discussion on the application of QbD to drug product technology transfer as well as overall regulatory considerations and lifecycle management. Quality by Design for Biopharmaceutical Drug Product Development is an authoritative resource for scientists and researchers interested in expanding their knowledge on QbD principles and uses in creating better drugs.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 732 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -In this thoroughly revised and expanded third edition of the highly praised classic, The Principles of Clinical Cytogenetics, a panel of hands-on experts update their descriptions of the basic concepts and interpretations involved in chromosome analysis to include the many advances that have occurred in the field. Among the highlights are a full chapter devoted to advances in chromosome microarray, soon to become a standard of care in this field, as well as an update on chromosome nomenclature as reflected in ISCN 2009. Other features include an update on automation to reflect the current state of the art, an update on hematopoietic neoplasms to reflect the new WHO guidelines, and updates on all regulatory changes that have been implemented.Cutting edge and readily accessible, The Principles of Clinical Cytogenetics, Third Edition offers physicians who depend on the cytogenetics laboratory for the diagnosis of their patients, students in cytogenetics programs, graduate and medical students studying for board examinations, cytogenetics technologists, and cytogeneticists a clear understanding of what happens in the cytogenetics laboratory to facilitate accurate and timely diagnoses.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 580 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Children with nonverbal learning disabilities (NVLD) have needs that can take many forms and may, over time, require consultation and collaboration with professionals from several fields. Given that multiple specialists may be involved in working with children with NVLD ¿ as well as the array of treatment variables ¿ even seasoned practitioners may find themselves in confusing situations.Treating NVLD in Children takes a developmental view of how the problems and needs of young people with nonverbal learning disabilities evolve and offers a concise guide for professionals who are likely to contribute to treatment. Expert practitioners across specialties in psychology, education, and rehabilitative therapy explain their roles in treatment, the decisions they are called on to make, and their interactions with other professionals. Collaborative interventions and teamwork are emphasized, as are transitions to higher learning, employment, and the adult world.Among the book¿s key features are:A new four-subtype model of NVLD, with supporting research.A brief guide to assessment, transmitting results, and treatment planning.Chapters detailing the work of psychologists, therapists, coaches, and others in helping children with NVLD.Material specific to improving reading, writing, and mathematics.Overview of issues in emotional competency and independent living.An instructive personal account of growing up with NVLD.Treating NVLD in Children: Professional Collaborations for Positive Outcomes is a key resource for a wide range of professionals working with children, including school and clinical child psychologists; educational psychologists and therapists; pediatricians; social workers and school counselors; speech and language therapists; child and adolescent psychiatrists; and marriage and family therapists.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 388 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This book, designed for professionals, introduces a psychobiological model for understanding the paths that lead people to illness and provides recommendations for alterations of maladaptive pathways so that health is regained. Research findings are incorporated to identify causal variables for illness that can be targets for change. Evidence based recommendations for healthy behaviors and therapies are described. Throughout the book, the authors emphasize recognition of turning points on the path to illness that, through informed decision making and implementation of behavioral change, can be re-directed to pathways to health. This book presents case material to illustrate the directions that lead people to illness or to health. The pathways metaphor provides an organizing force, both in addressing variables contributing to illness onset, and in identifying interventions to restore health. This approach will guide the clinician to understanding how people become ill and the types of interventions that are appropriate for stress related illnesses. The clinician will also become better informed about ways to help clients make better decisions, mobilize clients¿ survival skills, and implement an interactive model of care. The book includes chapters on stress-related illnesses with high prevalence in today¿s society. For each illness, the genetic-psychobiological etiology is explored with enough detail so that the clinician understands the best method of patient assessment and treatment. One of the strengths of the book is the step-wise system of interventions that are applied to the stress-related illnesses. Beginning with re-establishment of normal daily psychobiological rhythms and continuing to evidence based state of the art interventions, the professional is presented with detailed intervention plans.For example, the section on 'Applications to common illnesses: metabolic disorders of behavior: diabetes, hypertension, and hyperlipidemia'considers the confluence of genetics, behavior, and maladaptive mind body interactions to produce the metabolic syndrome. Then the personal and professional assessments are described to establish the baseline for recommending treatment while fully engaging the patient. Finally, multilevel interventions are formulated for these disorders. The plan begins with clinician guided self care recommendations to re-establish the normal rhythm of appetite and satiety. The next level of interventions consists of skill building techniques, such as relaxation and imagery. Lastly, psychotherapy and advanced applied psychophysiological interventions are detailed. Case examples are used throughout to illustrate the pathways to illness, the turning points, and the pathways to health. From the patients¿ viewpoints, the pathways metaphor is a motivator. The patient is guided to understand the paths that led to illness. Subsequently, the patient becomes empowered by the pathways framework to begin to make choices that lead to health.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 280 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The turbulent year of 2011 has brought the appearance of mass popular unrest and the collapse of long lived autocratic regimes in Egypt, Tunisia, Libya and possibly Syria. The sudden and unanticipated fall of these regimes ¿ often thought of as exemplars of authoritarian resilience - has brought much of the conventional wisdom on the durability and vulnerability of nondemocratic regimes into question. This book seeks to advance the existing literature by treating the autocratic state not as a unitary actor characterized by strength or weakness but rather as a structure or terrain that can alternatively inhibit or facilitate the appearance of national level forms of protests. In the mode of the Arab Spring, the color revolutions of the former Soviet Union, and the people power movement of the Philippines, such movements overcome the daunting impediments presented by autocrats, appeal to likeminded counterparts across society, and overwhelm the ability of regimes to maintain order. Conversely, in other settings, such as contemporary China, decentralized state structures provide an inhospitable environment for national-level protest, leading collective actors to opt for more local and parochial forms of contention. This outcome produces paradoxical situations, such as in the PRC, where protests are frequent but national-level mobilization and coordination is absent.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 256 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Asymptotic Geometric Analysis is concerned with the geometric and linear properties of finite dimensional objects, normed spaces, and convex bodies, especially with the asymptotics of their various quantitative parameters as the dimension tends to infinity. The deep geometric, probabilistic, and combinatorial methods developed here are used outside the field in many areas of mathematics and mathematical sciences. The Fields Institute Thematic Program in the Fall of 2010 continued an established tradition of previous large-scale programs devoted to the same general research direction. The main directions of the program included: \* Asymptotic theory of convexity and normed spaces \* Concentration of measure and isoperimetric inequalities, optimal transportation approach \* Applications of the concept of concentration \* Connections with transformation groups and Ramsey theory \* Geometrization of probability \* Random matrices \* Connection with asymptotic combinatorics and complexity theory These directions are represented in this volume and reflect the present state of this important area of research. It will be of benefit to researchers working in a wide range of mathematical sciences¿in particular functional analysis, combinatorics, convex geometry, dynamical systems, operator algebras, and computer science.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 408 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -It is impossible to measure the full economic and psychological benefits of the sewing machine, the polio vaccine, or the Internet. What we know is that these products have changed our lives for the better, generating net benefits well beyond the metric of corporate profits. As forces such as financial market volatility and fragmented markets demonstrate the fragility of the global economy, the imperative to develop products and services that contribute to the well-being of the many¿rather than the few¿is more pronounced than ever.In this book, A. Coskun Samli explores this imperative of an ¿innovation culture¿ and how it can be encouraged at all levels, from the individual to the nation or region. He argues that without a global innovation culture, committed to generating socially valuable products, we are likely to face a deteriorating quality of life, as wealth is concentrated at the top. Integrating insights from management, economics, policy, and psychology, Samli demonstrates how creativity can be channeled into innovation and innovation can be channeled, in turn, toward economic development. He discusses how national policies can be oriented toward encouraging such socially beneficial innovations as sustainable energy, communication technology, and medical discoveries. The aim is to promote the development of products and services that improve quality of life and generate profits for those who invest in them. He argues that all innovations, whether radical or incremental, must demonstrate social value in order to be truly profitable.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 152 pp. Englisch.

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The new edition of this influential textbook, geared towards graduate or advanced undergraduate students, teaches the statistics necessary for financial engineering. In doing so, it illustrates concepts using financial markets and economic data, R Labs with real-data exercises, and graphical and analytic methods for modeling and diagnosing modeling errors. These methods are critical because financial engineers now have access to enormous quantities of data. To make use of this data, the powerful methods in this book for working with quantitative information, particularly about volatility and risks, are essential. Strengths of this fully-revised edition include major additions to the R code and the advanced topics covered. Individual chapters cover, among other topics, multivariate distributions, copulas, Bayesian computations, risk management, and cointegration. Suggested prerequisites are basic knowledge of statistics and probability, matrices and linear algebra, and calculus. There is an appendix on probability, statistics and linear algebra and an Instructor s Manual with solutions to all exercises and problems in the R labs. Practicing financial engineers will also find this book of interest. 748 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Operations research tools are ideally suited to providing solutions and insights for the many problems health policy-maker's face. Indeed, a growing body of literature on health policy analysis, based on operations research methods, has emerged to address the problems mentioned above and several others. The research in this field is often multi-disciplinary, being conducted by teams that include not only operations researchers but also clinicians, economists and policy analysts. The research is also often very applied, focusing on a specific question driven by a decision-maker and many times yielding a tool to assist in future decisions.The goal of this volume was to bring together a group of papers by leading experts that could showcase the current state of the field of operations research applied to health-care policy. There are 18 chapters that illustrate the breadth of this field. The chapters use a variety of techniques, including classical operations research tools, such as optimization, queuing theory, and discrete event simulation, as well as statistics, epidemic models and decision-analytic models. The book spans the field and includes work that ranges from highly conceptual to highly applied. An example of the former is the chapter by Kimmel and Schackman on building policy models, and an example of the latter is the chapter by Coyle and colleagues on developing a Markov model for use by an organization in Ontario that makes recommendations about the funding of new drugs. The book also includes a mix of review chapters, such as the chapter by Hutton on public health response to influenza outbreaks, and original research, such as the paper by Blake and colleagues analyzing a decision by Canadian Blood Services to consolidate services. This volume could provide an excellent introduction to the field of operations research applied to health-care policy, and it could also serve as an introduction to new areas for researchers already familiarwith the topic.The book is divided into six sections. The first section contains two chapters that describe several different applications of operations research in health policy and provide an excellent overview of the field. Sections 2 to 4 present policy models in three focused areas. Section 5 contains two chapters on conceptualizing and building policy models. The book concludes in Section 6 with two chapters describing work that was done with policy-makers and presenting insights gained from working directly with policy-makers.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 440 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This edited book focuses on recent developments in Dynamic Network Modeling, including aspects of route guidance and traffic control as they relate to transportation systems and other complex infrastructure networks. Dynamic Network Modeling is generally understood to be the mathematical modeling of time-varying vehicular flows on networks in a fashion that is consistent with established traffic flow theory and travel demand theory. Dynamic Network Modeling as a field has grown over the last thirty years, with contributions from various scholars all over the field. The basic problem which many scholars in this area have focused on is related to the analysis and prediction of traffic flows satisfying notions of equilibrium when flows are changing over time. In addition, recent research has also focused on integrating dynamic equilibrium with traffic control and other mechanism designs such as congestion pricing and network design. Recently, advances in sensor deployment, availability of GPS-enabled vehicular data and social media data have rapidly contributed to better understanding and estimating the traffic network states and have contributed to new research problems which advance previous models in dynamic modeling. A recent National Science Foundation workshop on ¿Dynamic Route Guidance and Traffic Control¿ was organized in June 2010 at Rutgers University by Prof. Kaan Ozbay, Prof. Satish Ukkusuri , Prof. Hani Nassif, and Professor Pushkin Kachroo. This workshop brought together experts in this area from universities, industry and federal/state agencies to present recent findings in this area. Various topics were presented at the workshop including dynamic traffic assignment, traffic flow modeling, network control, complex systems, mobile sensor deployment, intelligent traffic systems and data collection issues. This book is motivated by the research presented at this workshop and the discussions that followed.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 328 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -This work addresses the topic of optical networks cross-layer design with a focus on physical-layer-impairment-aware design. Contributors captures both the physical-layer-aware network design as well as the latest advances in service-layer-aware network design. Treatment of topics such as, optical transmissions which are prone to signal impairments, dense packing of wavelengths, dispersion, crosstalk, etc., as well as how to design the network to mitigate such impairments, are all covered.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 388 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The discovery of stress-induced mutagenesis has changed ideas about mutation and evolution, and revealed mutagenic programs that differ from standard spontaneous mutagenesis in rapidly proliferating cells. The stress-induced mutations occur during growth-limiting stress, and can include adaptive mutations that allow growth in the otherwise growth-limiting environment. The stress responses increase mutagenesis specifically when cells are maladapted to their environments, i.e. are stressed, potentially accelerating evolution then. The mutation mechanism also includes temporary suspension of post-synthesis mismatch repair, resembling mutagenesis characteristic of some cancers. Stress-induced mutation mechanisms may provide important models for genome instability underlying some cancers and genetic diseases, resistance to chemotherapeutic and antibiotic drugs, pathogenicity of microbes, and many other important evolutionary processes.This book covers pathways of stress-induced mutagenesis in all systems. The principle focus is mammalian systems, but much of what is known of these pathways comes from non-mammalian systems.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 292 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Recherches Chimiques sur la Végétation was a seminal work in the development of the understanding of photosythesis and plant chemistry. The original publication, which was the first concise summation of the basics of plant nutrition, was a landmark in plant science. It was twice translated into German during the nineteenth century, but no English translation has been published. This translation will interest those in the plant, chemical, agricultural, and soil sciences, and the history of science, who find English more accessible than French or German and who wish to learn more about the early research on photosynthesis and plant science.A further note about the translation: This project is more than just a translation because it includes an extensive introduction as well as notes that provide explanations for archaic terminology and other background material.In the twentieth century, eminent photosynthesis researcher Eugene Rabinowitch described Recherches Chimiques sur la Végétation as the first modern book on plant nutrition. Historian of chemistry Henry Leicester called the book a classic, noting that the first important generalization about biochemistry in the nineteenth century came from it. Plant physiologist P. E. Pilet stated that the book laid the foundations of a new science, phytochemistry. Soil scientist E. Walter Russell attributed to de Saussure the quantitative experimental method, which more than anything else made modern agricultural chemistry possible. Chemist Leonard K. Nash stated that de Saussure brought the studies of plant nutrition begun by Priestley, Ingen-Housz, and Senebier close to completion, finishing the basic experimental work and providing a convincing theoretical interpretation of the field, and also opened up new vistas of experiment and thought.In the two centuries since Recherches Chimiques sur la Végétation was published, luminaries in various branches of science, including plant biology, chemistry, and soil science, have consistently praised it highly. In the nineteenth century, noted botanist Alphonse de Candolle and equally noted plant physiologist Julius von Sachs expressed great admiration for it. Although de Saussure¿s ideas were forgotten for a time, famed chemist Justus von Liebig, who invented artificial fertilizer, rediscovered them in the 1840s and brought them to the attention of the agricultural community, stressing their importance for increasing crop yields.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 252 pp. Englisch.