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Taschenbuch. Zustand: Neu. Neuware -Ever since the Montgolfier's hot air balloon carried a chicken, a goat, and a duck into the Parisian skies, scientists have dreamed of contraptions to explore the atmosphere. With the advent of the space age, new airborne inventions were needed. From the Soviet Venus balloons to the advanced studies of blimps and airplanes for the atmospheres of Mars and Titan, Drifting on Alien Winds surveys the many creative and often wacky ideas for exploring alien skies. Through historical photographs and stunning original paintings by the author, readers also explore the weather on planets and moons, from the simmering acid-laden winds of Venus to liquid methane-soaked skies of Titan.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 256 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This monograph presents a groundbreaking scholarly treatment of the German mathematician Jost Bürgi¿s original work on logarithms, Arithmetische und Geometrische Progreß Tabulen. It provides the first-ever English translation of Bürgi¿s text and illuminates his role in the development of the conception of logarithms, for which John Napier is traditionally given priority. High-resolution scans of each page of the his handwritten text are reproduced for the reader and as a means of preserving an important work for which there are very few surviving copies.The book begins with a brief biography of Bürgi to familiarize readers with his life and work, as well as to offer an historical context in which to explore his contributions. The second chapter then describes the extant copies of the Arithmetische und Geometrische Progreß Tabulen, with a detailed description of the copy that is the focus of this book, the 1620 ¿Graz manuscript¿. A complete facsimile of the text is included in the next chapter, along with a corresponding transcription and an English translation; a transcription of a second version of the manuscript (the ¿Gdansk manuscript¿) is included alongside that of the Graz edition so that readers can easily and closely examine the differences between the two. The final chapter considers two important questions about Bürgi¿s work, such as who was the copyist of the Graz manuscript and what the relationship is between the Graz and Gdansk versions. Appendices are also included that contain a timeline of Bürgi¿s life, the underlying concept of Napier¿s construction of logarithms, and scans of all 58 sheets of the tables from Bürgi¿s text.Anyone with an appreciation for the history of mathematics will find this book to be an insightful and interesting look at an important and often overlooked work. It will also be a valuable resource for undergraduates taking courses in the history of mathematics, researchers of the history of mathematics, and professors of mathematics education who wish to incorporate historical context into their teaching.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 272 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Applied Predictive Modeling covers the overall predictive modeling process, beginning with the crucial steps of data preprocessing, data splitting and foundations of model tuning. The text then provides intuitive explanations of numerous common and modern regression and classification techniques, always with an emphasis on illustrating and solving real data problems. The text illustrates all parts of the modeling process through many hands-on, real-life examples, and every chapter contains extensive R code for each step of the process. This multi-purpose text can be used as an introduction to predictive models and the overall modeling process, a practitioner¿s reference handbook, or as a text for advanced undergraduate or graduate level predictive modeling courses. To that end, each chapter contains problem sets to help solidify the covered concepts and uses data available in the book¿s R package.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 616 pp. Englisch.

Buch. Zustand: Neu. Neuware -This textbook is the second volume of a pair that presents the latest English edition of the author¿s classic, Probability. Building on the foundations established in the preceding Probability-1, this volume guides the reader on to the theory of random processes. The new edition includes expanded material on financial mathematics and financial engineering; new problems, exercises, and proofs throughout; and a Historical Review charting the development of the mathematical theory of probability. Suitable for an advanced undergraduate or beginning graduate student with a course in probability theory, this volume forms the natural sequel to Probability-1.Probability-2 opens with classical results related to sequences and sums of independent random variables, such as the zeröone laws, convergence of series, strong law of large numbers, and the law of the iterated logarithm. The subsequent chapters go on to develop the theory of random processes with discrete time: stationary processes, martingales, and Markov processes. The Historical Review illustrates the growth from intuitive notions of randomness in history through to modern day probability theory and theory of random processes.Along with its companion volume, this textbook presents a systematic treatment of probability from the ground up, starting with intuitive ideas and gradually developing more sophisticated subjects, such as random walks, martingales, Markov chains, the measure-theoretic foundations of probability theory, weak convergence of probability measures, and the central limit theorem. Many examples are discussed in detail, and there are a large number of exercises throughout.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 360 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This volume provides a practical, comprehensive overview on benign and malignant disease of the adult kidney. The text addresses the topic of assessment and management of patients with surgical renal disease. Within this scope,it includes hereditary and spontaneous renal neoplasms, as well as non-neoplastic diseasethat manifests as a clinically relevant mass.The book is organized into chapters focusing on discrete disease entities and incorporating pathology, surgical management, oncologic therapy, radiologic findings,and molecular alterations. This text is designed to address relevant areas of clinical management of renal neoplastic and non-neoplastic disease across multiple specialties and levels of training.Written by experts in the field, The Kidney: A Comprehensive Guide to Pathologic Diagnosis and Management is a valuable resource on the diagnosis and management of patients with not only renal cell carcinoma, but also other renal processes that require surgical intervention.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 228 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Providing an integrated approach to the diagnosis and management of patients with metastatic bone disease (MBD), this comprehensive text combines discussion of the pathobiology of the disease with the latest oncological and orthopedic treatment modalities. After opening with an examination of the epidemiology and impact of MBD, the biology of bone metastases are discussed, along with considerations of the tissue of origin. Evaluation, biopsy and medical therapy, including metabolic agents and bio targeting. The heart of the book presents oncological approaches (supportive, radiation and interventional) and principles of orthopedic surgical oncology, with subsequent chapters covering specific anatomy, from the pelvis to the lower extremity and the spine. Chapters on emerging surgical technology and future directions conclude the text and redefine an integrated approach to patient care. Taken together, Metastatic Bone Disease is an excellent resource for orthopedic surgeons andcancer specialists alike.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 384 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This volume provides an understanding of the factors involved in nuclear reprogramming, which is essential for the success of reprogramming. The book is aimed at reprogramming differentiated cells and germ line transmission of pluripotent stem cells and features chapters that deal with reprogramming-related issues such as analysis of mitochondrial DNA in reprogrammed cells and the isolation of reprogramming intermediates; alternative methods for nuclear transfer; the production of germ-line chimeras from embryonic stem cells and induced pluripotent stem cells; and neonatal care and management of somatic cell nuclear transfer derived offspring.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls.Authoritative and cutting-edge,Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 284 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This authoritative volume examines immunohistochemical methods aimed at investigating the toxicologic pathology of rodent, non-human primate and aquatic animal tissues. Eleven comprehensive chapters provide pathologists and researchers in various sub-disciplines of toxicology with a comprehensive review of the methods and approaches for immunohistochemical staining in various target tissues. It explores the tissue-antigen and antibody-specific problems that may be encountered during the staining procedures and provide potential avenues for resolving various methodological issues. Special attention is paid to the latest enhancement procedures for antigen retrieval and visualization as well as image analysis and antigen quantification. Written by leading researchers in toxicology and pathology, this book is a significant resource for toxicologists and pathologists working with rodents, monkeys and aquatic animal tissues.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 244 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Recent efforts to engage more explicitly with the interpretation of emotions in archaeology have sought new approaches and terminology to encourage archaeologists to take emotions seriously. This is part of a growing awareness of the importance of senses¿what we see, smell, hear, and feel¿in the constitution and reconstitution of past social and cultural lives.Yet research on emotion in archaeology remains limited, despite the fact that such states underpin many studies of socio-cultural transformation. The Archaeology of Anxiety draws together papers that examine the local complexities of anxiety as well as the variable stimuli¿class or factional struggle, warfare, community construction and maintenance, personal turmoil, and responsibilities to (and relationships with) the dead¿that may generate emotional responses of fear, anxiousness, worry, and concern.The goal of this timely volume is to present fresh research that addresses the material dimension of rites and performances related to the mitigation and negotiation of anxiety as well as the role of material culture and landscapes in constituting and even creating periods or episodes of anxiety.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 228 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This classic text, first published in 1990, is designed to introduce law students, law teachers, practitioners, and judges to the basic ideas of mathematical probability and statistics as they have been applied in the law. The third edition includes over twenty new sections, including the addition of timely topics,like New York City police stops, exonerations in death-sentence cases, projecting airline costs, and new material on various statistical techniques such as the randomized response survey technique, rare-events meta-analysis, competing risks, and negative binomial regression. The book consists of sections of exposition followed by real-world cases and case studies in which statistical data have played a role. The reader is asked to apply the theory to the facts, to calculate results (a hand calculator is sufficient), and to explore legal issues raised by quantitative findings. The authors' calculations and comments are given in the back of the book. As with previous editions, the cases and case studies reflect a broad variety of legal subjects, including antidiscrimination, mass torts, taxation, school finance, identification evidence, preventive detention, handwriting disputes, voting, environmental protection, antitrust, sampling for insurance audits, and the death penalty. A chapter on epidemiology was added in the second edition. In 1991, the first edition was selected by the University of Michigan Law Review as one of the important law books of the year.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 692 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This volume presents protocols on yeast cytokinesis that will help Molecular and Cellular Biology researchers in the use of these microorganisms to approach the study of general or specific key questions in cytokinesis. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and practical, Yeast Cytokinesis: Methods and Protocols provides practical and step-by-step detailed protocols useful for a wide audience ranging from experienced researchers to beginners in the use of yeasts.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 408 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This third edition volume expands upon the previous editions with new research topics and numerous leading-edge HIV protocols. This book contains chapters that cover various aspects of HIV-1 replication and are helpful for investigating the mechanisms of HIV-1 replication or pathogenesis. The chapters are grouped into six sections: HIV early events; HIV-1 RNA structure and RNA-protein interactions; HIV-1 post-integration events; HIV-1 pathogenesis in animal models; tools to study HIV-1 latency; and Neuro AIDS. Chapters are written by research experts who have diligently developed techniques, improved them, simplified them, or applied them to their own HIV research. Written in the highly successful Methods in Molecular Biology series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls.Authoritative and cutting-edge, HIV Protocols, Third Edition is a great resource for HIV research, and contains many significant tips and tricks rarely mentioned in standard protocols.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 404 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This volume presents an overview of recent advances, innovative applications, and future prospects of in vitro embryogenesis in higher plants. The book's chapters are divided into five parts: Part I contains reviews on general topics (microspore; zygotic and somatic embryogenesis; in vitro and in vivo asexual embryogenesis; advances on the genetic, physiological, and proteomic knowledge of somatic embryo formation; role of apoptosis and mitochondria in somatic embryogenesis; and innovation in the use of bioreactors). The remaining four parts discuss step-wise protocols on somatic embryogenesis in selected horticultural plants (Part II); forest trees (Part III); gametic embryogenesis (Part IV); and pivotal topics, such as the detection of epigenetics modifications during microspore embryogenesis, the in vitro embryogenesis and plant regenerations from isolated zygotes, the synthetics seed production, the induction and maturation of somatic embryos, and the cryostorage of embryogenic cultures (Part V). Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and thorough, In Vitro Embryogenesis in Higher Plants,is a useful source of information and ideas for plant tissue culturists, cell biologists, embryologists, horticulturists, and operators of commercial nurseries. This book will introduce the fascinating work in in vitro embryogenesis in higher plants to students and young scientists.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 576 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This extensive volume explores areas of intense activity related to the very early commitment of stem cells to particular lineages and the progression of differentiation to mature cell stages. Research on embryonic stem cells continues to move very quickly, thus the kinds of studies continue to expand and diversify, and methodologies are continuously being refined and improved, which this book reflects. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions on their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Comprehensive and fully updated, Embryonic Stem Cell Protocols, Third Edition serves as an ideal reference for researchers investigating this rich area of study.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 468 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This valuable collection aims to provide a collection of frequently used statistical methods in the field of proteomics. Although there is a large overlap between statistical methods for the different ¿omics¿ fields, methods for analyzing data from proteomics experiments need their own specific adaptations. To satisfy that need, Statistical Analysis in Proteomics focuses on the planning of proteomics experiments, the preprocessing and analysis of the data, the integration of proteomics data with other high-throughput data, as well as some special topics. Written for the highly successful Methods in Molecular Biology series, the chapters contain the kind of detail and expert implementation advice that makes for a smooth transition to the laboratory.Practical and authoritative, Statistical Analysis in Proteomics serves as an ideal reference for statisticians involved in the planning and analysis of proteomics experiments, beginners as well as advanced researchers, and also for biologists, biochemists, and medical researchers who want to learn more about the statistical opportunities in the analysis of proteomics data.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 324 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This contemporary presentation of statistical methods features extensive use of graphical displays for exploring data and for displaying the analysis. The authors demonstrate how to analyze datäshowing code, graphics, and accompanying tabular listings¿for all the methods they cover. Complete R scripts for all examples and figures are provided for readers to use as models for their own analyses.This book can serve as a standalone text for statistics majors at the master¿s level and for other quantitatively oriented disciplines at the doctoral level, and as a reference book for researchers. Classical concepts and techniques are illustrated with a variety of case studies using both newer graphical tools and traditional tabular displays.New graphical material includes:an expanded chapter on graphicsa section on graphing Likert Scale Data to build on the importance of rating scales in fields from population studies to psychometricsa discussion on design of graphics that will work for readers with color-deficient visionan expanded discussion on the design of multi-panel graphicsexpanded and new sections in the discrete bivariate statistics capter on the use of mosaic plots for contingency tables including the n×2×2 tables for which the Mantel¿Haenszel¿Cochran test is appropriatean interactive (using the shiny package) presentation of the graphics for the normal and t-tables that is introduced early and used in many chaptersSpringer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 932 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This volume aims to be a collection of essential protocols in iPS cell field. Induced Pluripotent Stem (iPS) Cells: Methods and Protocols guides readers through multiple facets of stem cell biology, lineage commitment and differentiation. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and practical, Induced Pluripotent Stem (iPS) Cells: Methods and Protocols provides protocols that can be used by both experts and novices interested in stem cells.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 512 pp. Englisch.

Buch. Zustand: Neu. Neuware -This comprehensive update of the now classic text applies the most current findings across disciplines to the treatment of pathogenic human stress arousal. New and revised chapters bring together the art and science of intervention, based in up-to-date neuroscience, starting with an innovative model tracing the stress-to-disease continuum throughout the systems of the human body. The authors detail the spectrum of physiological and psychological treatments for the stress response, including cognitive therapy, neuromuscular relaxation, breathing exercises, nutritional interventions, and pharmacotherapy. They also assess the strengths and limitations of widely-used measures of the stress response and consider the value of personality factors, cultural considerations, and resilience in stress mediation.Included in the coverage:The anatomy and physiology of the human stress response.Advances in neuroscience: implications for stress.Crisis intervention and psychological first aid.Neurophysiological rationale for the use of the relaxation response.Physical exercise and the human stress response.The pharmacological management of stress reactions.Disaster Mental Health Planning.Cultural Awareness and Stress.The Fourth Edition of A Clinical Guide to the Treatment of Human Stress Response offers readers a dual perspective, exceedingly useful in examining the origins of the stress response, and in preventing and treating the response itself. This rich integrative volume will join its predecessors in popularity among practitioners and students across disciplines and specialties.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 652 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This volume covers a large area, from the description of methodologies for data analysis to the real application. Chapters focus on methodologies for preprocessing of microarray data, a survey of miRNA Data analysis, Cloud-based approaches, application of data mining techniques for data analysis, biclustering to query different datasets, web-based tool to analyze the evolution of miRNA clusters, application of biclustering to mine patterns of co-regulated genes ontologies, microarray and proteomic Data, Gene Regulatory Network Inference, Gene Regulatory Network methods, analysis of Mouse data for metabolomics studies, analysis of microRNA data in Multiple Myeloma, microarray data analysis in Gliobastomas, and microRNA data in Cardiogenesis.Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and practical, Microarray Data Analysis: Methods and Applications, Second Edition aims to ensure successful results in the further study of this vital field.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 240 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This expert reference provides a broad, comprehensive review of the major domains of sexual offending. Beginning with an integrated etiological model of sexual offending, chapters follow addressing the primary predisposing conditions related to sexual offending (e.g. pedophilic, hebephilic, paraphilic rape and non-contact paraphilic disorders, hyper sexuality and personality factors). In addition, special subgroups of sexual offenders (females, youth and the intellectually disable) are considered. Both broad and specific perspectives on the assessment of sexual offenders are provided. Overviews are offered of clinical and forensic evaluations of such offenders and the utility of structured psychological assessment. A novel conceptual model of risk assessment is proposed. More specifically, each of the primary approaches or instruments related to risk assessment of sexual offending are addressed: the Static risk assessment measures, the Sex Offender Risk Appraisal Guide, structured professional judgment, and the varied measures of dynamic or criminogenic needs assessment. Finally, multiple aspects of management of sexual offenders are discussed including models of psychosocial treatment, the question of the effectiveness of such treatment, biological interventions, civil commitment, circles of support, and the containment approach to community management. Chapters are authored by both prominent experts and experienced professionals for a breadth of perspective.Among the topics covered: Pedophilic, Hebephilic, Rape Paraphilic Disorders and the variety of Non Contact sexual offending conditionsPersonality, related conditions, & their association with sexual offending: motivators and disinhibition in context.Disorders of hyper sexuality.Assessments of sexual offenders, including the role of psychological testing, clinical & interview approaches, as well as forensic evaluationsConceptual models of risk assessment & discussion of specific static, dynamic & structured clinical risk assessment approachesModels of & reviews of treatment outcome with sexual offenders, including psychotherapy, psychopharmacology and castration, the containment approach, civil commitment & circles of supportOverview of public policy issues & an evidence-based perspective on sex offender registration and residential restrictions.This breadth of material in Sexual Offenders will help practitioners gain multiple levels of clinical insight as well as giving them up-to-date practical tools and techniques for working with this problematic class of individuals.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 912 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This book compiles andexplores cutting-edge research in degenerative skeletal disorders, such asDuchenne muscular dystrophy and congenital myopathy, and new stem-cell basedtherapies and gene replacement therapy. Twelve expertly-authored chapters navigatethe nuances of these treatments in an array of contexts and biological systems.The topics covered include: How are urine cells from a patient with Duchennemuscular dystrophy transformed into beating heart cells What can reprogrammedcells tell us about heart muscle failure What do gene mutations mean for thoseborn with a muscle disease How are manufacturing methods applied to human stemcells Does therapeutic exercise benefit those patients who receive engineeredlimb muscle Is there practical advice about nutrition to enhance musclefunction for the Duchenne patient Can microRNAs be useful to regeneratediseased muscle RegenerativeMedicine for Degenerative Muscle Diseases is ideal for scientistsand clinicians from varying disciplines in genetics, cell biology, virologycell-based manufacturing, rehabilitation medicine, nutrition, veterinarymedicine and neurosurgery. The reader will see how transformative changes occurin medicine that can powerfully impact the future for patients suffering frominherited disorders affecting muscles of the body, including the heart.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 352 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -The purpose of this text is to provide not only the science and current knowledge of pediatric pain management but a rationale for intervention. The book is ground-breaking in that it provides pearls for the recognition and management of multiple childhood chronic pain syndromes. Also, uncommon yet confounding issues such as pain management for epidermolysis bullosa are adequately addressed. Concerns unique to pediatric patients are reviewed. While there are no firm standards in pediatric chronic pain, a care plan is offered to help guide practitioners when possible.The book will consist of 24 chapters, many co-written by a physician and a psychologist. Chapter 1 covers the history of pediatric chronic pain, the advancement pediatric pain as a clinical subspecialty, development of pediatric pain clinics, and characterization of the common pain syndromes. Chapters 2-4 cover, respectively, the research on early pain exposure and neuroplasticity, theories on the common adolescent pain syndromes, and the demographics of chronic pain in children. Chapters 5-16 discuss approaches to assessment and intervention for specific pediatric and adolescent pain syndromes. Chapters 17-23 address interventional techniques such as therapeutic blocks, neurablation, implantable systems, physical therapy, complementary therapy, and pharmacology including opioid tolerance. The final chapter discusses the role of the nurse practitioner in pediatric chronic pain.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 436 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -This book presents cutting edge methods that provide insights into the pathways by which salt and water traverse cell membranes and flow in an orchestrated fashion amongst the many compartments of the body. It focuses on a number of molecular, cellular and whole animal studies that involve multiple physiological systems and shows how the internal milieu is regulated by multifactorial gene regulation, molecular signaling, and cell and organ architecture.Topics covered include: water channels, the urinary concentrating mechanism, angiotensin, the endothelin system, miRNAs and MicroRNA in osmoregulation, desert-adapted mammals, the giraffe kidney, mosquito Malpighian tubules, and circadian rhythms. The book highlights how different approaches to explaining the same physiological processes greatly increase our understanding of these fundamental processes. Greater integration of comparative, evolutionary and genetic animal models in basic science and medical science will improve our overall grasp of the mechanisms of sodium and water balance.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 332 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Neuromechanics is a new, quickly growing field of neuroscience research that merges neurophysiology, biomechanics and motor control and aims at understanding living systems and their elements through interactions between their neural and mechanical dynamic properties. Although research in Neuromechanics is not limited by computational approaches, neuromechanical modeling is a powerful tool that allows for integration of massive knowledge gained in the past several decades in organization of motion related brain and spinal cord activity, various body sensors and reflex pathways, muscle mechanical and physiological properties and detailed quantitative morphology of musculoskeletal systems. Recent work in neuromechanical modeling has demonstrated advantages of such an integrative approach and led to discoveries of new emergent properties of neuromechanical systems. Neuromechanical Modeling of Posture and Locomotion will cover a wide range of topics from theoretical studies linking the organization of reflex pathways and central pattern generating circuits with morphology and mechanics of the musculoskeletal system (Burkholder; Nichols; Shevtsova et al.) to detailed neuromechanical models of postural and locomotor control (Bunderson; Edwards, Marking et al., Ting). Furthermore, uniquely diverse modeling approaches will be presented in the book including a theoretical dynamic analysis of locomotor phase transitions (Spardy and Rubin), a hybrid computational modeling that allows for in vivo interactions between parts of a living organism and a computer model (Edwards et al.), a physical neuromechanical model of the human locomotor system (Lewis), and others.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 380 pp. Englisch.

Buch. Zustand: Neu. Neuware -This detailed second edition volume expands upon the prior edition by addressing newly emerged technologies as well as improved existing protocols in nucleic acid delivery via nanotechnology. The book addresses topics ranging from chemical synthesis of macromolecules and bioconjugates, novel and established nanoformulations, characterization of these nanoformulations for biophysical, biological and toxicological aspects, and also protocols dealing with application and imaging of such carrier systems in vivo. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective chapters, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 424 pp. Englisch.

Buch. Zustand: Neu. Neuware -This volume discusses the latest technologies used to study all aspects of Fragile-X Syndrome (FXS). The chapters in this book cover topics such as monitoring for epigenetic modifications at the FMR1 locus; modeling FXS with human pluripotent stem cells, mouse neural progenitors; mouse versus human-based models for FXS pre-clinical research; and Fragile-X associated with Tremor/Ataxia Syndrome (FXTAS). Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 204 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Electrophysiological methods are used at nearly all levels of biological research today. From basic science investigation to bringing new drugs to market, electrophysiology is an indispensable research technique that provides essential insights into cellular and molecular functions. This work is intended to be a practical guide for understanding and using contemporary electrophysiological manipulations and assays in brain research. New researchers attempting to learn electrophysiological techniques are confronted with a lack of adequate guiding resources. Currently, most electrophysiology-based research knowledge is passed on by experienced individuals to others within the same laboratory. But, this master-apprentice scenario has many inherent difficulties, as it is both a time intensive process and also leads to incomplete knowledge transfer, or even superstitious and maladaptive practices. Few external guiding resources exist for a budding researcher who wishes to gain the skills necessary to conduct responsible and competent electrophysiology research. Dr. Yan Dong, an expert in utilizing electrophysiological techniques for brain research with fifteen years of experience, and Peter Neumann hope this work can act as a concise and practical aid to remedy the current situation. This book will cover both basic methods and advanced techniques clearly and in depth, as well as the essential background and theory necessary to understand the methods. Additionally, this book also covers conventional and contemporary patch-clamp methods, experimental design, data collection and analysis, common pitfalls to avoid, important nuances, technical concerns, practical applications, and advice for teaching new researchers. Together, this represents a contemporary best-practices guide for collecting and interpreting electrophysiological data for brain research. ¿Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 280 pp. Englisch.

Taschenbuch. Zustand: Neu. Neuware -Peter Angelos Numerous ethical issues arise in the care of oncology patients. Although much has been written in the last several decades on ethical issues in caring for patients, few volumes have sought to focus the exploration on ethical issues particularly relevant to the care of cancer patients. In 1999, the first edition of this book was published. Since that time, many changes have occurred in how some cancers are diagnosed and treated, but the central ethical issues have continued to challenge patients, families, and their health care providers. All of the chapters from the prior edition have been updated and there are seven new chapters in this expanded edition. In this second edition, the perspectives on what is an ethical issue have been broadened by bringing authors of differing backgrounds into the discussion. In Chapter 1, the perspective of a cancer patient is provided as an open letter to physicians. Although Parvez Kamangar is providing only one patient¿s perspective, this is an essential voice that is not often heard in texts on medical ethics. In Chapters 2 and 3, the issues of communication and the physician-patient relationship are explored in order to better understand how the needs of patients and families can be met. In Chapter 4, Professor Tod Chambers highlights the challenges to providing ethical care to patients in a multicultural society.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 272 pp. Englisch.

Buch. Zustand: Neu. Neuware -This volume looks at the study of oligodendrocytes through in vitro and in vivo techniques, multiple model organisms, using approaches that bridge scales from molecular through system. Chapters in this book cover topics such as fundamental molecular analyses of oligodendrocytes and myelin; in vitro, ex vivo, and in vivo molecular-cellular-electrophysiology-based techniques; oligodendrocyte formation, homeostasis, and disruption in zebrafish and Xenopus; and parallel system-level imaging of animal and human models. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and thorough, Oligodendrocytes: Methods and Protocols is a valuable reference guide that highlights the expansive and fast-paced nature of research into oligodendrocyte biology underlying health and function.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 424 pp. Englisch.

Buch. Zustand: Neu. Neuware -This detailed volume guides readers through strategic planning and user-friendly guidelines in order to select the most suitable CRISPR-Cas system and target sites with high activity and specificity. Methods covering CRISPR gRNA design, CRISPR delivery, CRISPR activity quantification (indel quantification), and examples of applying CRISPR gene editing in human pluripotent stem cells, primary cells, gene therapy, and genetic screening are included. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 376 pp. Englisch.