Springer springer jan 2012 (Mehr als 3.700 Ergebnisse)
Sprache: Englisch
Verlag: Springer, Springer Jan 2012, 2012
Serie: Acta Neurochirurgica Supplement, Buch 28 von 91. Buch 28 von 91 - Acta Neurochirurgica Supplement
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Taschenbuch. Zustand: Neu. Neuware -This volume contains selected contributions from the XIth Meeting of the European Society for Stereotactic and Functional Neurosurgery held in September 1994 in Antalyaffurkey. Most of the papers deal with the many therapeutic and technical advancements made in this field of neurosurgery. The…emergence of new stereotactic methodologies such as frameless stereotaxy and other forms of neuronavigation have become an indispensable tool for all types of neurosurgical operations. An increasing number of young neurosurgeons takes an interest in the neurosurgical approaches to the treatment of movement disorders, chronic pain and epilepsy. This is a clear sign ofthe growing awareness of the long neglected fact that these neurosurgical treatments can be offered to large patient populations. Neurotransplantation as a novel treatment of Parkinson's disease has paved the way for the application of this technology for other indications. The pioneering work performed by the late Edward Hitchcock is reviewed here. There is a renewed interest in pallidotomy for dealing with certain forms of Parkinson's disease and certain aspects of this operation are discussed in another paper. Progress in the neurosurgical treatment of pain is dealt with by contributions on refined techniques of percutaneous cordotomy, DREZ operations and critical evaluations of spinal cord stimulation. A novel approach is a report on the experiences of treating cancer pain by intraspinal implantation of chromaffin cells. Several contributions cover the important issues of novel techniques for the study of neural dysfunction, peroperative monitoring with PET, microrecording, magneto-encephalography and other techniques. 156 pp. Englisch.
Sprache: Englisch
Verlag: Springer, Springer Jan 2012, 2012
Serie: Acta Neurochirurgica Supplement, Buch 28 von 91. Buch 28 von 91 - Acta Neurochirurgica Supplement
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Taschenbuch. Zustand: Neu. Neuware -This volume contains selected contributions from the XIth Meeting of the European Society for Stereotactic and Functional Neurosurgery held in September 1994 in Antalyaffurkey. Most of the papers deal with the many therapeutic and technical advancements made in this field of neurosurgery. The…emergence of new stereotactic methodologies such as frameless stereotaxy and other forms of neuronavigation have become an indispensable tool for all types of neurosurgical operations. An increasing number of young neurosurgeons takes an interest in the neurosurgical approaches to the treatment of movement disorders, chronic pain and epilepsy. This is a clear sign ofthe growing awareness of the long neglected fact that these neurosurgical treatments can be offered to large patient populations. Neurotransplantation as a novel treatment of Parkinson's disease has paved the way for the application of this technology for other indications. The pioneering work performed by the late Edward Hitchcock is reviewed here. There is a renewed interest in pallidotomy for dealing with certain forms of Parkinson's disease and certain aspects of this operation are discussed in another paper. Progress in the neurosurgical treatment of pain is dealt with by contributions on refined techniques of percutaneous cordotomy, DREZ operations and critical evaluations of spinal cord stimulation. A novel approach is a report on the experiences of treating cancer pain by intraspinal implantation of chromaffin cells. Several contributions cover the important issues of novel techniques for the study of neural dysfunction, peroperative monitoring with PET, microrecording, magneto-encephalography and other techniques.
Sprache: Englisch
Verlag: Springer Berlin Heidelberg, Springer Berlin Heidelberg Jan 2012, 2012
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Taschenbuch. Zustand: Neu. Neuware -The author's general aim has been to survey as wide a field of evidence as possible and this had involved excursions into subjects of which he has little first hand knowledge. This width of range also has necessitated a somewhat arbitrary selection of evidence and has prevented full discussion… of any indi vidual problem. The author trusts that he has not misrepresented anyone's results or opinions, and if this has occurred, he can only plead in excuse the peculiar difficulty of giving a brief and yet accurate account of evidence of such a wide variety. The diagrams reproduced in the article have all been redrawn and in many cases the original figures or diagrams have been modified as, for instance, by recalculating dosage on the logarithmic scale. The original authors therefore have no direct responsibility for the diagrams in their present form. The author desires to thank Messrs Arnold and Co. for permitting the repro duction of Figs. 9 and 23 from similar figures which appeared in his book 'The Mode of Action of Drugs on Cells'; portions of other figures from this book also have been reproduced in modified form. The author also desires to thank Dr. J. M. ROBSON for help in correction of the proofs. Edinburgh, July, 1937. A. J. CLARK. Contents.
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Taschenbuch. Zustand: Neu. Neuware -Recent developments in various areas of chemistry have been decisively influenced by the principles of structure and mechanism and by the ideas of coordination chemistry, in particular by the donor-acceptor approach, A unified view of almost all kinds of molecular forces is provided by quantum… mechanics, and for practical purposes have been classified according to model assumptions, namely, dispersion, polarization, electrostatic, and short-range forces. The latter are divided into two- and three-center covalent chemical bonds, metallic bonds, and exchange-repulsion forces. This approach allows statements of principle and systematic analysis. However, quantitative predictions on concrete large systems are virtually impossible, and there are no general rules that account for structural and chemical changes due to intermolecular interactions. Chemists are therefore left with qualitative descriptions in which the changes in electron densities are considered. Such models as the MO theory or the resonance concept unrealistically assume that the nuclei remain in fixed positions. Further difficulties are encountered in the attempted description on the 'nature' of the chemical bond, e.g., the forces involved. In order to avoid these difficulties an extension of the donor-acceptor concept, characterized by the comparison between equilibrium structures in different molecular environments, will be presented in this book. In this way, changes in the positions of the nuclei can be taken into account and the question of the nature of the molecular forces is no longer important.
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Taschenbuch. Zustand: Neu. Neuware -VII. Multidimensional Data Structures.- 1. A Black Box Approach to Data Structures.- 2. Multi-dimensional Searching Problems.- 3. Exercises.- 4. Bibliographic Notes.- VIII. Computational Geometry.- 1. Convex Polygons.- 2. Convex Hulls.- 3. Voronoi Diagrams and Searching Planar Subdivisions.- 4…. The Sweep Paradigm.- 5. The Realm of Orthogonal Objects.- 6. Geometric Transforms.- 7. Exercises.- 8. Bibliographic Notes.- IX. Algorithmic Paradigms.
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Taschenbuch. Zustand: Neu. Neuware -Recent developments in various areas of chemistry have been decisively influenced by the principles of structure and mechanism and by the ideas of coordination chemistry, in particular by the donor-acceptor approach, A unified view of almost all kinds of molecular forces is provided by quantum… mechanics, and for practical purposes have been classified according to model assumptions, namely, dispersion, polarization, electrostatic, and short-range forces. The latter are divided into two- and three-center covalent chemical bonds, metallic bonds, and exchange-repulsion forces. This approach allows statements of principle and systematic analysis. However, quantitative predictions on concrete large systems are virtually impossible, and there are no general rules that account for structural and chemical changes due to intermolecular interactions. Chemists are therefore left with qualitative descriptions in which the changes in electron densities are considered. Such models as the MO theory or the resonance concept unrealistically assume that the nuclei remain in fixed positions. Further difficulties are encountered in the attempted description on the 'nature' of the chemical bond, e.g., the forces involved. In order to avoid these difficulties an extension of the donor-acceptor concept, characterized by the comparison between equilibrium structures in different molecular environments, will be presented in this book. In this way, changes in the positions of the nuclei can be taken into account and the question of the nature of the molecular forces is no longer important.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 296 pp. Englisch.
Sprache: Englisch
Verlag: Springer, Springer Jan 2012, 2012
Serie: Acta Neurochirurgica Supplement, Buch 28 von 91. Buch 28 von 91 - Acta Neurochirurgica Supplement
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Taschenbuch. Zustand: Neu. Neuware - This volume contains selected contributions from the XIth Meeting of the European Society for Stereotactic and Functional Neurosurgery held in September 1994 in Antalyaffurkey. Most of the papers deal with the many therapeutic and technical advancements made in this field of neurosurgery. The… emergence of new stereotactic methodologies such as frameless stereotaxy and other forms of neuronavigation have become an indispensable tool for all types of neurosurgical operations. An increasing number of young neurosurgeons takes an interest in the neurosurgical approaches to the treatment of movement disorders, chronic pain and epilepsy. This is a clear sign ofthe growing awareness of the long neglected fact that these neurosurgical treatments can be offered to large patient populations. Neurotransplantation as a novel treatment of Parkinson's disease has paved the way for the application of this technology for other indications. The pioneering work performed by the late Edward Hitchcock is reviewed here. There is a renewed interest in pallidotomy for dealing with certain forms of Parkinson's disease and certain aspects of this operation are discussed in another paper. Progress in the neurosurgical treatment of pain is dealt with by contributions on refined techniques of percutaneous cordotomy, DREZ operations and critical evaluations of spinal cord stimulation. A novel approach is a report on the experiences of treating cancer pain by intraspinal implantation of chromaffin cells. Several contributions cover the important issues of novel techniques for the study of neural dysfunction, peroperative monitoring with PET, microrecording, magneto-encephalography and other techniques.
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Taschenbuch. Zustand: Neu. Neuware - VII. Multidimensional Data Structures.- 1. A Black Box Approach to Data Structures.- 2. Multi-dimensional Searching Problems.- 3. Exercises.- 4. Bibliographic Notes.- VIII. Computational Geometry.- 1. Convex Polygons.- 2. Convex Hulls.- 3. Voronoi Diagrams and Searching Planar Subdivisions.-…4. The Sweep Paradigm.- 5. The Realm of Orthogonal Objects.- 6. Geometric Transforms.- 7. Exercises.- 8. Bibliographic Notes.- IX. Algorithmic Paradigms.
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Taschenbuch. Zustand: Neu. Neuware - Recent developments in various areas of chemistry have been decisively influenced by the principles of structure and mechanism and by the ideas of coordination chemistry, in particular by the donor-acceptor approach, A unified view of almost all kinds of molecular forces is provided by quantu…m mechanics, and for practical purposes have been classified according to model assumptions, namely, dispersion, polarization, electrostatic, and short-range forces. The latter are divided into two- and three-center covalent chemical bonds, metallic bonds, and exchange-repulsion forces. This approach allows statements of principle and systematic analysis. However, quantitative predictions on concrete large systems are virtually impossible, and there are no general rules that account for structural and chemical changes due to intermolecular interactions. Chemists are therefore left with qualitative descriptions in which the changes in electron densities are considered. Such models as the MO theory or the resonance concept unrealistically assume that the nuclei remain in fixed positions. Further difficulties are encountered in the attempted description on the 'nature' of the chemical bond, e.g., the forces involved. In order to avoid these difficulties an extension of the donor-acceptor concept, characterized by the comparison between equilibrium structures in different molecular environments, will be presented in this book. In this way, changes in the positions of the nuclei can be taken into account and the question of the nature of the molecular forces is no longer important.
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Taschenbuch. Zustand: Neu. Neuware - The author's general aim has been to survey as wide a field of evidence as possible and this had involved excursions into subjects of which he has little first hand knowledge. This width of range also has necessitated a somewhat arbitrary selection of evidence and has prevented full discussio…n of any indi vidual problem. The author trusts that he has not misrepresented anyone's results or opinions, and if this has occurred, he can only plead in excuse the peculiar difficulty of giving a brief and yet accurate account of evidence of such a wide variety. The diagrams reproduced in the article have all been redrawn and in many cases the original figures or diagrams have been modified as, for instance, by recalculating dosage on the logarithmic scale. The original authors therefore have no direct responsibility for the diagrams in their present form. The author desires to thank Messrs Arnold and Co. for permitting the repro duction of Figs. 9 and 23 from similar figures which appeared in his book 'The Mode of Action of Drugs on Cells'; portions of other figures from this book also have been reproduced in modified form. The author also desires to thank Dr. J. M. ROBSON for help in correction of the proofs. Edinburgh, July, 1937. A. J. CLARK. Contents.
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Taschenbuch. Zustand: Neu. Neuware -Das Husserlbild der Gegenwart ist noch weitgehend gepragt von den erkenntnistheoretischen 'Logischen Untersuchungen', durch die Husserl in weitem MaBe als Begriinder einer neuen objektiven Logik gilt. Mitunter wird er sogar als einseitig orien tierter Rationalist und Aufklarer des 20. J ahrhun…derts, als der 'Cartesius unserer Tage' 1 angesehen. Dieses Bild Husserls kann wohl jederzeit durch seine Veroffent lichungen gerechtfertigt werden. Dennoch ist es einseitig und recht vordergriindig, da dabei voll und ganz iibersehen wird, daB auch der Bereich des Emotionalen flir HusserI ein entscheiden gut wie nichts des Interessengebiet darstellt, wovon bislang so veroffentlicht worden ist. Wohl werden in seinen Schriften gclegentlich Fragen der Wertlehre, der Asthetik und Ethik angeschnitten 2, aber eine eingehende Auseinandersetzung mit derartigen Fragen liegt in keinem der veroffentlichten Werke vor. In Wirklichkeit aber war ihm die Begriindung einer echten wissenschaftlichen Ethik immer ein ernstes philosophisches An liegen. Bereits vor den 'Logischen Untersuchungen' beschaf tigte sich Husserl mit ethischen Grundproblemen 3. Welche 1 Vgl. Briick, Maria, Dr. phil, Ubey das Verhiiltnis Hllsserls zu Franz Brentano, vor nehmlich mit Rucksicht auf Brentanos Psychologie, 1933, S. 7. Husserl selbst hat die Phiinomenologie in den 'Cartesianischen Meditationen' (Husscrliana, Bd. I, 1950, S. 196 pp. Englisch.
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Buch. Zustand: Neu. Neuware -The Earth's atmosphere is often portrayed as a thin and finite blanket covering our planet, separate from the emptiness of outer space. In reality, the transition is gradual and a tiny fraction of the atmophere gases is still present at the altitude of low orbiting satellites. The very high velocitie…s of these satellites ensure that their orbital motion can still be considerably affected by air density and wind. This influence can be measured using accelerometers and satellite tracking techniques.The opening chapters of this thesis provide an excellent introduction to the various disciplines that are involved in the interpretation of these observations: orbital mechanics, satellite aerodynamics and upper atmospheric physics. A subsequent chapter, at the heart of this work, covers advances in the algorithms used for processing satellite accelerometry and Two-Line Element (TLE) orbit data. The closing chapters provide an elaborate analysis of the resulting density and wind products, which are generating many opportunities for further research, to improve the modelling and understanding of the thermosphere system and its interactions with the lower atmosphere, the ionosphere-magnetosphere system and the Sun. 200 pp. Englisch.
Sprache: Englisch
Verlag: Springer Berlin Heidelberg, J.B. Metzler Jan 2012, 2012
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Taschenbuch. Zustand: Neu. Neuware -As part of its 'Programme for the prevention of health hazards caused by industrial substances', the Berufsge nossenschaft der chemischen Industrie (BG Chemie, Em ployment Accident Insurance Fund of the Chemical Indus try) began in 1977 to investigate the toxicity of those chemicals which are…widely used, have many different ap plications and are suspected of being dangerous to health, in particular of having long-term effects. The in vestigations consist of a literature search and - depending on the results - commissions of experimental studies. It is hoped by means of this testing to close gaps in our know ledge and to increase the scientific validity of the required risk assessments. The results of the toxicological in vestigations carried out by BG Chemie, and the resulting substance assessments have been published in German since 1987 in the form of 132 'Toxikologische Bewer tungen' ('Toxicological Evaluations') up to now. In order to make this useful information internation ally available, BG Chemie began in October 1990 to pub lish them as a book series in English, of which the sixth volume (containing 11 individual evaluations) is presented here. Therefore for 83 existing chemicals 'Toxicological Evaluations' are available in English at the moment, a fur ther 27 are in preparation and will be published soon.
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Taschenbuch. Zustand: Neu. Neuware - Statistics is of ever-increasing importance in Science and Technology and this book presents the essentials of the subject in a form suitable either as the basis of a course of lectures or to be read and/or used on its own. It assumes very little in the way of mathematical knowledge-just the…ability to substitute numerically in a few simple formulae. However, some mathematical proofs are outlined or given in full to illustrate the derivation of the subject; these can be omitted without loss of understanding. The book does aim at making clear the scope and nature of those essential tests and methods that a scientist or technologist is likely to need; to this end each chapter has been divided into sections with their own subheadings and some effort has been made to make the text unambiguous (if any reader finds a misleading point anywhere I hope he will write to me about it). Also with this aim in view, the equality of probability to proportion of population is stated early, then the normal distribution and the taking of samples is discussed. This occupies the first five chapters. With the principles of these chapters understood, the student can immediately learn the significance tests of Chapter 6 and, if he needs it, the analysis of variance of Chapter 7. For some scientists this will be most of what they need. However, they will be in a position to read and/or use the remaining chapters without undue difficulty.
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Taschenbuch. Zustand: Neu. Neuware - Information systems science is rapidly advancing in many directions. Di versified ideas, methodologies, and techniques as well as applications have been conceived and developed. This series intends to discuss some of the recent advances in this field. In this volume, we cover four timely topi…cs which are of great current interest. In each chapter, an attempt is made to familiarize the reader with some basic background information on the ad vances discussed. The emphasis of this volume is placed upon parallel pro gramming, data structure models in information system design, and the principles of L systems. One of the effective means to enhance computation performance is parallel information processing on multiprocessor systems. In Chapter I, V. E. Kotov discusses the practical aspects of parallel programming. He is concerned with the languages and methods of parallel programming, per formance an~lysis, and automatic synthesis of parallel programs. In Chapter 2, A. S. Narin'yani presents the formal theory of parallel computations. These two chapters attempt to correlate and classify various methods in parallel programming, thus providing the reader with a unified approach to this important subject matter. Data structures play an important role in information system design.
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Taschenbuch. Zustand: Neu. Neuware - This volume, the fifth of a continuing series on information systems science, covers four timely topics which are in the mainstream of this field. In each chapter, an attempt is made to familiarize the reader with basic background information on the advances discussed, so that this volume may… be used independently or in conjunction with the previous volumes. The emphasis in this volume is focused upon data organization and access methods, software for on-line minicomputer applications, advances in micropro graming, and gramm ars and recognizers for formal and natural languages. In Chapter 1, P. C. Patton presents a tutorial survey of data organiza tion and access methods which play a central role in information system design. Research in information processing has been shifted from numerical data processing to nonnumerical information handling. In the latter case, the information is carried not only by the data but also by the structure and organization of the data base. In this chapter, the author provides the reader with a comprehensive review of various data structures, including linear lists, array structures, tree structures, and multilinked structures. He also discusses the important problem of data-base design and management. This chapter concludes with several examples of information handling systems such as a matrix interpretive system, a generalized information management system, and a criminal justice information system. The rapid reduction in cost and great increase in capability of the mini computer have made it an attractive machine for information systems.
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Taschenbuch. Zustand: Neu. Neuware - The original premise of the Editors in initiating this series was that there existed a readership ofneurochemists with considerable biochemical back ground who would make use of a series dedicated to both new develop ments and specialized reviews in neurochemistry. Having selected our authors…, we have offered them virtually complete freedom to reflect and speculate in a field in which they have achieved prominence. The response to the first two volumes has been rewarding. The present one continues in this tradition. While we have not attempted to publish specialized volumes, the present volume contains two somewhat related chapters (Chapters 4 and 5, on the role of amino acid neurotransmitters). The first three chapters examine three diverse approaches, each of current interest, in neurochemi cal approaches to the molecular bases of neuronal and glial structure. B. W. Agranoff M. H. Aprison vii CONTENTS CHAPTER 1 2',3'-CYCUC NUCLEOTIDE 3'-PHOSPHODIESTERASE NEIL RAYMOND SIMS AND PATRICK ROBERT CARNEGIE 1. Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. Assay of CNPase . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. 1. Need for Activation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. 2. Comparison of Assays . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 3. Association of CNPase with Myelin . . . . . . . . . . . . . . . . . . . . . . . 7 3. 1. Historical. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 3. 2. Subcellular Fractionation. . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 3. 3. Development. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 3. 4. Mutant Mice . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 3. 5. Use as a Myelin Marker . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 3. 6. Myelin-Related Fractions and Peripheral Nerve Myelin. 11 4. CNPase in Nonmyelin Fractions. . . . . . . . . . . . . . . . . . . . . . . . . . 13 5. Activation and Isolation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 5. 1. Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 5. 2. Activation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 5. 3. Solubilization and Fractionation. . . . . . . . . . . . . . . . . . . . . . 15 6. Properties. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 6. 1. Substrate Specificity. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Taschenbuch. Zustand: Neu. Neuware - Information systems science embraces a broad spectrum of topics. It is vir tually impossible to provide comprehensive and in-depth discussion, other than simple recitals of recent results, of every important topic in each volume of this annual review series. Since we have chosen the former ap…proach, each volume will only cover certain aspects of recent advances in this bur geoning field. The emphasis in this volume, the third of a continuing series, is focussed upon pattern recognition, pictorial information manipulation, and new approaches to logical design of information networks. In Chapter 1, V. A. Kovalevsky presents a tutorial survey of practical and theoretical developments in pattern recognition. He categorizes the basic developments in three different directions. The first direction is charac terized by an empirical treatment with highly specialized recognition schemes. In the second direction, the major efforts are centered upon the cre ation of learning systems capable of improving recognition performance on the basis of past experience. The majority of the work in the third direction is devoted to the study of the basic structure of complex patterns, the con struction of mathematical models for pattern recognition, and the analysis of complex pictorial representations. The author elucidates the 'heuristics' approach and the 'science' approach to pattern recognition problems. This chapter together with Chapter 2 of this volume supplements the chapter on Engineering Principles of Pattern Recognition in Volume 1 to provide a more complete treatment of this subject.
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Taschenbuch. Zustand: Neu. Neuware - Acceptance or rejection of any edible commodity, whether it is raw or processed, is usually conditioned by sensory stimuli. The impact of these stimuli on the decision-making proce-ss is broadly termed sensory evaluation. Advances in sensory evaluation research have been slow in the past beca…use of the human factor-the necessity to use highly trained sensory panels to conduct this research. High technology in- strumentation and new understandings of sensory evaluations are now combining to make possible quantum jumps forward in sensory eval- uation research. It is widely recognized that the sensory aspects of fruits and vegeta- bles are affected by many factors, among them environment, variety, cultural practices, and handling practices. However, if one attempts to find a general reference or compilation of findings regarding this sub- ject area there seems to be few, if any, available. A survey of the literature does suggest that in the past few years research into specific factors which influence the sensory aspects of fruits and vegetables has increased significantly. This increased interest in sensory research and the renewed national awareness of the value of research into pre- and postharvest quality of fruits and vegetables prompted the Flavor Subdivision, Agricultural and Food Chemistry Division, American Chemical Society to sponsor a symposium entitled Sensory Evalua- tion of Fruits and Vegetables: Effect of Environment, Cultural Prac- tices and Variety during the 1982 meeting in Kansas City, Missouri.
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Taschenbuch. Zustand: Neu. Neuware - A. CORBIN Investigations on LHRH and its analogs have just completed their first decade. We have witnessed a veritable explosion of chemical, physiologic and pharmacologic data on this hypothalamic peptide and the approximately 1500 agonist and antagonist analogs that have been synthesized. I…n order to track this expanding field, I was asked to organize an international symposium on basic and clinical aspects of LHRH analogs as part of the Reproductive Health Care: CDS Symposium held in Maui, Hawaii, in October 1982. This meeting brought together a number of the leading investigators in the field. Much new state-of-the-art information was presented which I and my colleagues felt deserved a wider audience. Drs Vickery, Nestor, and Hafez consented to undertake this task. Upon review of the literature, it was apparent that there was no recent text which fully covered the breadth of developments in the field. Accordingly, the editors decided to use the symposium as a nucleus on which to build a singular, comprehensive state-of-the-art analysis of this rapidly growing discipline, and the application of such knowledge to reproductive medicine. As exemplified by the various areas of expertise provided by the individual contributors, it becomes obvious that the scope of the subject matter, while relating solely to a well-defined chemical class (LHRH analogs) and a circumscribed physiologic and pharmacologic entity (reproduction), has expanded enormously.
Sprache: Englisch
Verlag: Springer Berlin Heidelberg, Springer Jan 2012, 2012
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Taschenbuch. Zustand: Neu. Neuware - As part of its 'Programme for the prevention of health hazards caused by industrial substances', the Berufsge nossenschaft der chemischen Industrie (BG Chemie, Em ployment Accident Insurance Fund of the Chemical Indus try) began in 1977 to investigate the toxicity of those chemicals which are… widely used, have many different ap plications and are suspected of being dangerous to health, in particular of having long-term effects. The in vestigations consist of a literature search and - depending on the results - commissions of experimental studies. It is hoped by means of this testing to close gaps in our know ledge and to increase the scientific validity of the required risk assessments. The results of the toxicological in vestigations carried out by BG Chemie, and the resulting substance assessments have been published in German since 1987 in the form of 132 'Toxikologische Bewer tungen' ('Toxicological Evaluations') up to now. In order to make this useful information internation ally available, BG Chemie began in October 1990 to pub lish them as a book series in English, of which the sixth volume (containing 11 individual evaluations) is presented here. Therefore for 83 existing chemicals 'Toxicological Evaluations' are available in English at the moment, a fur ther 27 are in preparation and will be published soon.
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Taschenbuch. Zustand: Neu. Neuware -Recent developments in various areas of chemistry have been decisively influenced by the principles of structure and mechanism and by the ideas of coordination chemistry, in particular by the donor-acceptor approach, A unified view of almost all kinds of molecular forces is provided by quantum… mechanics, and for practical purposes have been classified according to model assumptions, namely, dispersion, polarization, electrostatic, and short-range forces. The latter are divided into two- and three-center covalent chemical bonds, metallic bonds, and exchange-repulsion forces. This approach allows statements of principle and systematic analysis. However, quantitative predictions on concrete large systems are virtually impossible, and there are no general rules that account for structural and chemical changes due to intermolecular interactions. Chemists are therefore left with qualitative descriptions in which the changes in electron densities are considered. Such models as the MO theory or the resonance concept unrealistically assume that the nuclei remain in fixed positions. Further difficulties are encountered in the attempted description on the 'nature' of the chemical bond, e.g., the forces involved. In order to avoid these difficulties an extension of the donor-acceptor concept, characterized by the comparison between equilibrium structures in different molecular environments, will be presented in this book. In this way, changes in the positions of the nuclei can be taken into account and the question of the nature of the molecular forces is no longer important. 296 pp. Englisch.
Sprache: Englisch
Verlag: Springer, Springer Jan 2012, 2012
Serie: Boston Studies in the Philosophy and History of Science, Buch 92 von 214. Buch 92 von 214 - Boston Studies in the Philosophy and History of Science
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Taschenbuch. Zustand: Neu. Neuware -This book is the final outcome of two projects. My first project was to publish a set of texts written by Schrodinger at the beginning of the 1950's for his seminars and lectures at the Dublin Institute for Advanced Studies. These almost completely forgotten texts contained important insights…into the interpretation of quantum mechanics, and they provided several ideas which were missing or elusively expressed in SchrOdinger's published papers and books of the same period. However, they were likely to be misinterpreted out of their context. The problem was that current scholarship could not help very much the reader of these writings to figure out their significance. The few available studies about SchrOdinger's interpretation of quantum mechanics are generally excellent, but almost entirely restricted to the initial period 1925-1927. Very little work has been done on Schrodinger's late views on the theory he contributed to create and develop. The generally accepted view is that he never really recovered from his interpretative failure of 1926-1927, and that his late reflections (during the 1950's) are little more than an expression of his rising nostalgia for the lost ideal of picturing the world, not to say for some favourite traditional picture. But the content and style of Schrodinger's texts of the 1950's do not agree at all with this melancholic appraisal; they rather set the stage for a thorough renewal of accepted representations. In order to elucidate this paradox, I adopted several strategies.
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Taschenbuch. Zustand: Neu. Neuware - More and more biologists, chemists, pharmacologists, toxicologists, gov ernmental agencies, and 'food control' (regulatory) officials around the world are finding it increasingly difficult to keep abreast of the technical literature in the pesticide field; indeed, many libraries do not have e…ven a small proportion of the journals and other sources that now regularly contain research, development, and application information about all aspects of modern chemical pest control. As a result, a very large number of requests has come to 'Residue Reviews' to publish detailed digests of information on single pesticide chemicals so that the interested person in any part of the world could easily be brought up to date with all available important in formation without having to search probably several hundred literature sources, many of them obscure or simply not available except in very large libraries. The service and convenience rendered the readership by such a series of volumes on major individual pesticide chemicals would therefore be considerable. Type and scope of coverage in this series of single-pesticide volumes will of course vary with available information. The coverage should be as com plete as possible, however, to be of maximum value to all interested indi viduals, industries, research institutions, and governmental agencies con cerned with the continuing production of an adequately large yet safe food supply for the world. Among the topics bracketed for a single pesticide should ideally be: I. Introduction II.
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Taschenbuch. Zustand: Neu. Neuware - Ten years ago, de Loor and co-workers at TNO, The Netherlands, were the first to report bottom topography patterns in real aperture radar (RAR) images of the southern North Sea. At that time, this was a real puzzle. The skin depth of microwaves for sea water is only of the order of centimeter…s while the sea bottom is about 20 meters below the surface. Electromagnetic radiation therefore cannot probe the bottom directly. Similar phenomena were found in radar imagery from SEASAT and SIR-AlB synthetic aperture radars (SAR's) of Nantucket Shoals, the English Channel and many other coastal areas. Since then theory and ocean field experiments (Le., Phelps Bank, Georgia Straits, SARSEX, TOWARD, FASINEX, etc.) have advanced our understanding considerably. We now know that these surface signatures are the results of surface currents, perturbed by the bottom topography, which refract the propagation and modulate the energy of (short) surface waves so as to cause microwave backscatter power variations. Hence, any large scale ocean features containing nonuniform surface currents (i.e. internal waves, eddies, fronts, etc.) will cause similar manifestations in the radar imagery by means of current-wave-microwave interactions. Observations confirm this.
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Taschenbuch. Zustand: Neu. Neuware - It is only relatively recently that neurochemists and neurobiologists have shown appreciable interest in the class of macromolecules now generally re ferred to as complex carbohydrates, although gangliosides were, of course, first identified and studied in brain. The glycosaminoglycans fell c…hiefly within the province of connective-tissue biochemists, and earlier informa tion concerning the structure and metabolism of glycoproteins was largely limited to the more accessible glycoproteins and oligosaccharides (such as those found in plasma, milk, and urine), or ones which are relatively simple to prepare in a soluble and manageable form. Techniques were later devised for the isolation and purification of tightly bound membrane glycoproteins, where initial studies concentrated mainly on the erythrocyte, for which large amounts of a single cell population are available. Because of the structural complexity of nervous tissue and the large numbers, low concentrations, and membrane-bound form of many of its complex carbohydrates, progress has occurred more slowly in this area.
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Taschenbuch. Zustand: Neu. Neuware - The time seems ripe for a critical compendium of that segment of the biological universe we call viruses. Virology, as a science, having passed only recently through its descriptive phase of naming and num bering, has probably reached that stage at which relatively few new truly new-viruses w…ill be discovered. Triggered by the intellectual probes and techniques of molecular biology, genetics, biochemical cytology, and high resolution microscopy and spectroscopy, the field has experienced a genuine information explosion. Few serious attempts have been made to chronicle these events. This comprehensive series, which will comprise some 6000 pages in a total of about 18 volumes, represents a commitment by a large group of active investigators to analyze, digest, and expostulate on the great mass of data relating to viruses, much of which is now amorphous and disjointed, and scattered throughout a wide literature. In this way, we hope to place the entire field in perspective, and to develop an invalua ble reference and sourcebook for researchers and students at all levels. This series is designed as a continuum that can be entered anywhere, but which also provides a logical progression of developing facts and integrated concepts.
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Taschenbuch. Zustand: Neu. Neuware - What is the best way to plan surgical research What problems are most often encountered in clinical research How should a research report be presented at a scientific meeting These questions and more are all answered in Principles and Practice of Research.The second edition has added new sect…ions on animal research models, the molecular and cellular dimension of surgical research, and practical guidelines for obtaining government and third-party funding. Other improvements include a friendlier discussion of statistics and updated material about on-line computer literature searches. This book provides every clinical researcher with a roadmap around the pitfalls of poorly designed studies, through the jungle of incomprehensible statistics, and over the hurdles of research reporting to a successful study from start to finish. From the reviews of the first edition: 'For me, it is a bible and a must for every Ph.D. or M.D. involved in clinical research, especially in the field of surgery. It should be on the table - not on the book shelf - of both the young as well as the experienced investigator as a readily accessible source of information to avoid the trial-and-error approach to problems in surgical research.' #World Journal of Surgery#1 '.a carefully conceived, concise blend of factual theory and principles, practical guidelines, and philosophical perspective. .I have found it hard to identify any omission (even a selected bibliography on laboratory animals, their care, handling, and anatomy is included) and impossible to single out any individual contribution: each is a treasure - well written, concise, and complete.' #The Lancet#2 'The feature of the book is that, despite attention to detail, it maintains a clear and practical approach to the whole field, beginning with the reasons for carrying out research, the types of research, and above all the reporting of research. .Almost all aspects of researchare covered, from small retrospective studies to departmental, institutional, national and international projects. .The chapter on writing for publication should be compulsory reading for all budding authors.' #Journal of Bone and Joint Surgery#3.
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Buch. Zustand: Neu. Neuware - This interdisciplinary textbook encompasses all clinically relevant aspects of the disease and is designed to be as user-friendly as possible in order to meet the needs of the busy practitioner. To this end, the informative text is complemented by helpful boxed sections that present essential 'take…home' points and illustrative patient-oriented cases. Original high-quality images, some in color, are included whenever necessary to simplify particularly complex material. The authors are an international group of acknowledged experts in kidney cancer epidemiology, molecular biology, pathology, diagnosis, clinical features, staging, prognostic and predictive factors, surgery, systemic therapy, and emerging investigational approaches, among others. This clinically oriented volume will be of great interest to clinicians, researchers, residents, and fellows, as well as to students and knowledgeable lay people.
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Taschenbuch. Zustand: Neu. Neuware - Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car cinoma. Since that time, the concept that arachidonic acid meta…bolites may be in volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from arachidonic acid) via the cyclooxygenase and lipoxygenase pathways, respec tively. Cyclooxygenase products consist of diverse products such as prosta glandin Ez (PGEz), prostacyclin (PGIz) and thromboxane Az (TXAz), whereas lipoxygenase products consist of hydroperoxy fatty acids and mono-, di- and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lipoxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengt Samuelsson's extensive study of the metabolism of pros taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids.
