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Taschenbuch. Zustand: Neu. Neuware -This book contains contributions from various authors on different important topics related with probabilistic methods used for the design of structures. Initially several of the papers were prepared for advanced courses on structural reliability or on probabilistic methods for structural desi…gn. These courses have been held in different countries and have been given by different groups of lecturers. They were aimed at engineers and researchers who already had some exposure to structural reliability methods and thus they presented overviews of the work in the various topics. The book includes a selection of those contributions, which can be of support for future courses or for engineers and researchers that want to have an update on specific topics. It is considered a complement to the existing textbooks on structural reliability, which normally ensure the coverage of the basic topics but then are not extensive enough to cover some more specialised aspects. In addition to the contributions drawn from those lectures there are several papers that have been prepared specifically for this book, aiming at complementing the others in providing an overall account of the recent advances in the field. It is with sadness that in the meanwhile we have seen the disappearance of two of the contributors to the book and, in fact two of the early contributors to this field. 420 pp. Englisch.
Sprache: Englisch
Verlag: Springer, Springer Okt 2012, 2012
Serie: Buch 96 von 166 - The Patrick Moore Practical Astronomy Series
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Taschenbuch. Zustand: Neu. Neuware -Seeing Stars is written for astronomers, regardless of the depth of their theoretical knowledge, who are taking their first steps in observational astronomy. Chris Kitchin and Bob Forrest - both professional astronomers - take a conducted tour of the night sky and suggest suitable observing pr…ogrammes for everyone from beginners to experts. How is this book different We are all familiar with the beautiful images of planets and galaxies obtained by spacecraft and giant telescopes - but what can you really see with a small telescope What should you expect from a small refractor or reflector And what is the effect of observing from a site near a city The answers are all here, with many photographs that will illustrate exactly what can be seen with different instruments (everything from the naked eye to a 300mm telescope) - and from different locations.
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Taschenbuch. Zustand: Neu. Neuware -ACE inhibitors are one of the most exciting and interesting of recent medical developments. They fit the patho-physiologica1 processes of cardiovascular disease with fascinating precision and are a constant stimulus to the acquisition of greater understanding of the mechanisms involved and of…the mode of action of the drugs themselves. There is still much to be learned, especially about the wider effects of the drugs, their precise mode and site of action and about differences between the different preparations. ACE inhibitors are of proven benefit to patients with chronic congestive heart failure and are the latest in the series of drugs used in the treatment of hypertension. Interest in the treatment of hypertension has paralleled the development of hypotensive drugs and the realisation that long-term prognosis could be significantly improved. The treatment of hypertension has progressed in stages following the development of a succession of increasingly effective drugs, each allowing a greater proportion of patients to be treated with fewer and fewer side-effects. First, the ganglion-blocking agents such as hexamethonium and guan ethidine transformed the outlook for patients with malignant hypertension but proved too unpleasant for routine use in other forms of hypertension.
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Taschenbuch. Zustand: Neu. Neuware -Viruses, being obligatory parasites of their host cells, rely on a vast supply of cellular components for their replication, regardless of whether infection leads to cell death or to the state of persistence. Animal viruses are providing scientists with relatively simple models to study the mo…lecular biology of genome replication and gene expression. Whereas viruses use, in general, pathways of macromolecular biosynthesis common to the host cell, they have a cunning ability to adopt unusual mechanisms of gene expression and gene replication, provided these special pathways offer an advantage in competition for cellular resources. Any study of viral gene expression and replication is likely to lead also to new insights in cellular metabolism. The discoveries of cis-acting regulatory elements in transcription, the phenomenon of splicing of pre mRNA, and cap-dependent and cap-independent initiation of translation may be cited as examples. In addition, animal virus genomes contain elements and encode proteins that are very useful for the design of vectors for gene cloning and expression in mammalian cells. Apart from the basic interest in their biology, viruses have gained notoriety, of course, because they are pathogens. Human animal viruses may cause diseases ranging from the deadly (AIDS) to the benign (common cold). All studies on animal viruses potentially lead to the development of tools for their control, be it through prevention by immunization or treatment with antiviral drugs. Finally, viruses have yielded invaluable reagents in molecular biology as, for example, the vaccinia virus vector for the expression of foreign genes.
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Taschenbuch. Zustand: Neu. Neuware -I have often wondered if the opposition to women's choosing to abort a pregnancy masks a fear of women choosing to have and raise children on their own. When a woman separatesmotherhood from marriage, she claims a freedom in the realm of intimate rela tionships that may be as fundamental as Fr…eedom of Conscience or Freedom of Association. Yet, we do not usually think about women's decisions concerning motherhood in these terms. In a pair of remarkable studies begun in the 1980s, Ruth Linn-pregnant at the time, and married to a medical officer in the Israeli army-took the study of moral psychology into two highly controversial arenas of moral action: Israeli soldiers who refused to serve in Lebanon and single women who refused to remain childless. While conscientious objection to war has long been recognized as an act ofmoral resistance and courage,women who question societal norms and values linking motherhood with marriage, are typically dismissed as bad women. Rather than approaching these questions in the abstract, Linn chose to inter view women who made the decision to have and raise children on their own. What she found was that in the course of making this decision, women came to see themselves as moral resisters. In freeing their childbearing capability from men's control,they were also freeing their capacity to love. The very title of this book, Mature Unwed Mothers, calls us to think about what we mean by maturity on the part of mothers.
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Taschenbuch. Zustand: Neu. Neuware -Apparatus and Method of Investigating Multiple Production at Energies of Hundreds of GeV.- Method of Treatment of Experimental Data Obtained with Cloud Chamber.- Experimental Data on Inelastic Strong Interaction at Energies of 100¿3000 GeV and Their Interpretation.- Extensive Air Showers and I…nteraction of Particles with Energies above 1013 eV.- Apparatus for Investigation of Extensive Air Showers and Nuclear Interactions of Cosmic-Ray Particles with Energy 1012¿1016 eV.- Quasi-nucleonic Nuclear Interactions of 23-GeV Protons in a Nuclear Emulsion Irradiated in a Pulsed Magnetic Field of 180 kOe.- Measurement of Energy of Electron ¿ Photon Cascades by Photometry of Spots on X-Ray Films.- Transition Effects in the Ionization Calorimeter.- Investigation of the Nuclear Component of Cosmic Rays in a Period of Minimum Solar Activity.
Sprache: Englisch
Verlag: Springer, Humana Okt 2012, 2012
Serie: Buch 126 von 170 - Undergraduate Texts in Mathematics
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Taschenbuch. Zustand: Neu. Neuware -From the reviews of the second edition:'This book covers many interesting topics not usually covered in a present day undergraduate course, as well as certain basic topics such as the development of the calculus and the solution of polynomial equations. The fact that the topics are introduced…in their historical contexts will enable students to better appreciate and understand the mathematical ideas involved.If one constructs a list of topics central to a history course, then they would closely resemble those chosen here.'(David Parrott, Australian Mathematical Society)This third edition includes new chapters on simple groups and combinatorics, and new sections on several topics, including the Poincare conjecture. The book has also been enriched by added exercises. 684 pp. Englisch.
Sprache: Englisch
Verlag: Springer Okt 2012, 2012
Serie: Buch 96 von 166 - The Patrick Moore Practical Astronomy Series
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Taschenbuch. Zustand: Neu. Neuware - Seeing Stars is written for astronomers, regardless of the depth of their theoretical knowledge, who are taking their first steps in observational astronomy. Chris Kitchin and Bob Forrest - both professional astronomers - take a conducted tour of the night sky and suggest suitable observing p…rogrammes for everyone from beginners to experts. How is this book different We are all familiar with the beautiful images of planets and galaxies obtained by spacecraft and giant telescopes - but what can you really see with a small telescope What should you expect from a small refractor or reflector And what is the effect of observing from a site near a city The answers are all here, with many photographs that will illustrate exactly what can be seen with different instruments (everything from the naked eye to a 300mm telescope) - and from different locations.
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Taschenbuch. Zustand: Neu. Neuware - ACE inhibitors are one of the most exciting and interesting of recent medical developments. They fit the patho-physiologica1 processes of cardiovascular disease with fascinating precision and are a constant stimulus to the acquisition of greater understanding of the mechanisms involved and of… the mode of action of the drugs themselves. There is still much to be learned, especially about the wider effects of the drugs, their precise mode and site of action and about differences between the different preparations. ACE inhibitors are of proven benefit to patients with chronic congestive heart failure and are the latest in the series of drugs used in the treatment of hypertension. Interest in the treatment of hypertension has paralleled the development of hypotensive drugs and the realisation that long-term prognosis could be significantly improved. The treatment of hypertension has progressed in stages following the development of a succession of increasingly effective drugs, each allowing a greater proportion of patients to be treated with fewer and fewer side-effects. First, the ganglion-blocking agents such as hexamethonium and guan ethidine transformed the outlook for patients with malignant hypertension but proved too unpleasant for routine use in other forms of hypertension.
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Taschenbuch. Zustand: Neu. Neuware - The present volume is based upon the invited review lectures delivered to the European Brain and Behaviour Society's Workshop on Recovery of Function Following Brain Damage held at Goldsmiths' College, University of London, in April 1991. Coming exactly ten years after the Society's ftrst mee…ting on this subject, held at Erasmus University, Rotterdam, a major objective of the Workshop was to review progress in the intervening years. This task was begun by Professor D. G. Stein in his opening presentation. Looking ahead to possible developments in recovery research in the next decade was the subject of Professor B. Kolb's closing lecture. The intervening presentations reviewed progress made in speciftc areas of recovery research. In addition to reviewing progress over the last decade we sought to achieve an additional objective in the way that the invited review lectures were organised. This was to bring together those doing basic research, usually animal research, and those whose of the lectures were 'paired', research interests are more clinically orientated. Thus some one concentrating on the results of animal studies and one on clinical research findings.
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Taschenbuch. Zustand: Neu. Neuware - The present volume is a continuation of Volume 8 in the Annals series. Together Volumes 8 and 9 are intended to show the contribu tion of history to theory in psychology. The reader is referred to the Introduction by Hans Rappard and Pieter van Strien, and the Preface in Volume 8 that serve a…s a prelude to the papers included in both volumes. Volume 8 includes three major papers: Psychological objects, practice, and history by Kurt Danziger, with commentaries by Mitchell Ash, Franz Samelson, and John Mills; History and the psychological imagination by Irmingard Staeuble, with commentar ies by Carl Graumann and Roger Smith; and The historical practice of theory construction by Pieter 1. van Strien, with commentaries by Helmut Luck, Kenneth Gergen, and Ian Lubek. Similarly, the present volume includes three major papers and ten commentaries. In preparation of this volume and its companion, Volume 8, we gratefully acknowledge the assistance of Valerie Welch who entered the text, and Casey Boodt who proofread the text and prepared the indexes. Leendert P. Mos and William J. Baker June, 1993 vii Contents Chapter 1. History and system . . . . . . . . . . . . . . . . . . . . 1 . . . Hans V Rappard Psychology as its history . . . . . . . . . . . . . . . . . . . 41 Daniel N. Robinson Theoretical psychology, systematology, and phenomenological variation. . . . . . . . . . . . . . . . . . . . . 47 . Eckart Scheerer Systematization and history. . . . . . . . . . . . . . . . . . . . . 63 K. B. Madsen Towards the remarriage of theoretical psychology and psychology: Reply to commentators. . . . . . . . . . . . . . . . 67 Hans V Rappard Chapter 2.
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Taschenbuch. Zustand: Neu. Neuware - Advances in Clinical Child Psychology is a serial publication designed to bring together original summaries of the most important new develop ments in the field of clinical psychology and its related disciplines. Each chapter is written by a key figure in an innovative area of research or by…an individual who is particularly well qualified to comment on a topic of major contemporary importance. These chapters provide convenient, concise explorations of empirical and clinical advances in the fields of clinical child psychology, child psychiatry, and related disciplines. The chapter topics are chosen by the editors and are based on sug gestions by the advisory editors, unsolicited suggestions provided by colleagues, and all of our reading of the latest published empirical and theoretical works. They reflect our collective perception of the leading trends in the field of clinical child psychology. The contents of Volume 10 reflect multiple themes. Two chapters focus on different aspects of the child's family: the home and family environment associated with childhood psychopathology and the characteristics of parents whose parenting has become twisted into the abuse or neglect of their own children. The key topics of aggression and stealing are dealt with in two chapters, and five chapters deal with the variety of topics that were formerly under the umbrella concept of minimal brain dysfunction.
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Taschenbuch. Zustand: Neu. Neuware -'Phänomene der Wirklichkeit' ist eine Sammlung beispielhafter Weltbilder, die die Bedeutung des Wirklichkeits-Pluralismus, wie ihn der Autor im 'Kaleidoskop der Wirklichkeiten' dargestellt hat, näher illustrieren. Die angeführten Beispiele lassen die Vielfalt der möglichen Weltbilder ahnen: De…r Bogen reicht von unterschiedlichen Farbwirklichkeiten, dargestellt anhand von Goethes und Newtons Farbenlehre, über die Traditionelle Chinesische Medizin, die verschiedenen Wirklichkeiten in der japanischen Rashomon Erzählung, die magischen und schamanistischen Praktiken in Griechenland und im Vorderen Orient bis hin zu totalitären Wirklichkeiten. Diese Beispiele machen deutlich, dass die vermeintliche Sicherheit, die Wirklichkeiten oft ausstrahlen, immer nur eine Illusion ist. Eine absolute Wirklichkeit gibt es nicht - nicht im Glauben, nicht in der Kultur und nicht in der Wissenschaft.GERHARD FASCHING. Geb. 1933 in Wien, Univ.-Prof. Dipl.-Ing. Dr. techn., 1966 Habilitation, seit 1970 Ordinarius an der Technischen Universität Wien, Österreich. Er hält Vorlesungen über Aufbau und Eigenschaften der Materie und über Fragen der Erkenntnistheorie. 340 pp. Deutsch.
Sprache: Englisch
Verlag: Springer US, Springer Okt 2012, 2012
Serie: Buch 179 von 260 - The Springer International Series in Engineering and Computer Science
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Taschenbuch. Zustand: Neu. Neuware -During the academic year 2002-2003, the Faculty of Automatic Control and Computer Engineering of Ia~i (Romania), and its Departments of Automatic Control and Industrial Informatics and of Computer Engineering respectively, celebrated 25 years from the establishment of the specialization named…Automatic Control and Computer Engineering within the framework of the former Faculty of Electrical Engineering of Ia~i, and, at the same time, 40 years since the first courses on Automatic Control and Computers respectively, were introduced in the curricula of the former specializations of Electromechanical Engineering and Electrical Power Engineering at the already mentioned Faculty of Electrical Engineering. The reader interested to know some important moments ofour evolution during the last five decades is invited to see the Addendum ofthis volume, where a short history is presented. And, to highlight once more the nice coincidences, it must be noted here that in 2003 our Technical University 'Gheorghe Asachi' of Ia~i celebrated 190 years from the emergence of the first cadastral engineering degree course in Ia~i (thanks to the endeavor ofGheorghe Asachi), which is today considered to be the beginningofthe engineering higher education in Romania. Generally speaking, an anniversary is a celebration meant to mark special events ofthe past, with festivities to be performed solemnly and publicly according to a specific ritual.
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Taschenbuch. Zustand: Neu. Neuware -Low Power Design Methodologies presents the first in-depth coverage of all the layers of the design hierarchy, ranging from the technology, circuit, logic and architectural levels, up to the system layer. The book gives insight into the mechanisms of power dissipation in digital circuits and p…resents state of the art approaches to power reduction. Finally, it introduces a global view of low power design methodologies and how these are being captured in the latest design automation environments.The individual chapters are written by the leading researchers in the area, drawn from both industry and academia. Extensive references are included at the end of each chapter.Audience: A broad introduction for anyone interested in low power design. Can also be used as a text book for an advanced graduate class. A starting point for any aspiring researcher.
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Taschenbuch. Zustand: Neu. Neuware -Table of Contents of Volume I.- Articles by Plenary Speakers.- The Mathematics of M-Theory.- Probabilistic Aspects of Financial Risk.- Flags and Lattice Basis Reduction.- Moduli, Motives, Mirrors.- The Role of Oscillations in Some Nonlinear Problems.- New Families of Solutions in N-Body Proble…ms.- Irreducible Modular Representations of a Reductive p-Adic Group and Simple Modules for Hecke Algebras.- Dequantization of Real Algebraic Geometry on Logarithmic Paper.- Articles by Parallel Speakers.- Advances on Extremal Problems in Number Theory and Combinatorics.- Spectral Analysis of Nonrelativistic Quantum Electrodynamics.- Spectrum and Statistical Properties of Chaotic Dynamics.- Sampling in Complex and Harmonic Analysis.- Lower Bounds for Shape Resonance Widths of Schrödinger Operators.- A Conjecture of De Giorgi on Symmetry for Elliptic Equations in n.- The Random Graph Revisited.- Difference Fields: Model Theory and Applications to Number Theory.- Geometric Aspects of Polynomial Interpolation in More Variables and of Waring's Problem.- The Calibration Method for Free Discontinuity Problems.- Geometry on Arc Spaces of Algebraic Varieties.- Stacks for Everybody.- Multiple -Values, Galois Groups, and Geometry of Modular Varieties.- Heat Kernels on Manifolds, Graphs and Fractals.- Local Langlands Correspondences and Vanishing Cycles on Shimura Varieties.- Burgers Turbulence and Dynamical Systems.- Random Growth and Random Matrices.- Sobolev Spaces and Quasiconformal Mappings on Metric Spaces.- Understanding Skyrmions Using Rational Maps.- Models for the Leaf Space of a Foliation.- Multivariable Hypergeometric Functions.- Contact Structures, Rational Curves and Mori Theory.- Analytic Topology.- Towards Ryser's Conjecture.- The Dynamics of Algebraic d-Actions.- Self-Interacting Random Motions.- Harmonic Analysis on Reductive Symmetric Spaces.
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Taschenbuch. Zustand: Neu. Neuware - It is necessary to realize that the term 'photosynthetic prokaryotes' encom passes the widest and most diverse grouping of bacteria, but in itself has no taxonomic or phylogenetic significance. It means those organisms, other than eukaryotes, which require, obligately or facultatively, light…for growth. The re cent application 16S rRNA sequencing to microbial phylogeny, asso ciated mainly with the work of Woese, emphasizes the evolutionarily dis persed nature of purpIe and green photosynthetic bacteria as weIl as the rather coherent phylogenetic connections of the cyanobacteria. It is not surprising, therefore, that a volume such as this which seeks to give an introduction to this collection of organisms must be highly selective; ac cordingly, several important features are discussed only superficiaIly, e. g. , differentiation, life cycles, and biochemical aspects of nutrition. Rather, we have attempted to provide adescription of the essential features which are common and those which are characteristic, e. g. , the physiology of photo synthesis and ecological distribution. Bearing in mind the aim of the series, we have asked our authors to emphasize aspects of the importance of these organisms in nature and their industrial applications. As will be seen from the text, these organisms have an ancient history in 'biotechnology,' having been used as foodstuffs by several cultures, but their exploitation has been limited to their natural patterns and products of growth.
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Taschenbuch. Zustand: Neu. Neuware - Artificial Neural Networks have captured the interest of many researchers in the last five years. As with many young fields, neural network research has been largely empirical in nature, relyingstrongly on simulationstudies ofvarious network models. Empiricism is, of course, essential to any…science for it provides a body of observations allowing initial characterization of the field. Eventually, however, any maturing field must begin the process of validating empirically derived conjectures with rigorous mathematical models. It is in this way that science has always pro ceeded. It is in this way that science provides conclusions that can be used across a variety of applications. This monograph by Michael Lemmon provides just such a theoretical exploration of the role ofcompetition in Artificial Neural Networks. There is 'good news' and 'bad news' associated with theoretical research in neural networks. The bad news isthat such work usually requires the understanding of and bringing together of results from many seemingly disparate disciplines such as neurobiology, cognitive psychology, theory of differential equations, largc scale systems theory, computer science, and electrical engineering. The good news is that for those capable of making this synthesis, the rewards are rich as exemplified in this monograph.
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Taschenbuch. Zustand: Neu. Neuware - After long years of work that have seen little industrial application, high-level synthesis is finally on the verge of becoming a practical tool. The state of high-level synthesis today is similar to the state of logic synthesis ten years ago. At present, logic-synthesis tools are widely used… in digital system design. In the future, high-level synthesis will play a key role in mastering design complexity and in truly exploiting the potential of ASIes and PLDs, which demand extremely short design cycles. Work on high-level synthesis began over twenty years ago. Since substantial progress has been made in understanding the basic then, problems involved, although no single universally-accepted theoretical framework has yet emerged. There is a growing number of publications devoted to high-level synthesis, specialized workshops are held regularly, and tutorials on the topic are commonly held at major conferences. This book gives an extensive survey of the research and development in high-level synthesis. In Part I, a short tutorial explains the basic concepts used in high-level synthesis, and follows an example design throughout the synthesis process. In Part II, current high-level synthesis systems are surveyed.
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Taschenbuch. Zustand: Neu. Neuware - In summary, the technical, scientific and medical aspects of transfusion me dicine continue to be critical. We all must find ways to provide a safer unit of blood and blood components. However, there must be a realization by all in volved in the profession that the management and administrati…on aspects of transfusion medicine deserve equal attention, respect and support. Why It is very simple! Without all aspectsoftransfusion medicine working togetherfor the common good - care ofthe patient - we will all fail. References 1. Standards for Blood Banks and Transfusion Services, American Association of Blood Banks, 14th edition, Arlington, VA, USA, 1991. 2. Blood Assurance Act of 1979 (S.161O), Senator Richard S. Schweiker, United States Senate, Washington, DC, USA, July 31,1979. 3. Administrative Guidelines for Blood Banks, American Association of Blood Banks, Arlington, VA, 1989. 4. 'You're absolutely right: We goofed'. Howard Upton, Southwest Airlines Spirit, September 1991:24. 5. Administrative Manual, Volume II, American Association of Blood Banks, Arlington, VA, USA, 1987.
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Taschenbuch. Zustand: Neu. Neuware - 'Et moi, . , si j'avait su comment en revenir, je One service mathematics bas rendered the human race. It bas put common sense back n'y serais point all~.' where it belongs, on the topmost shelf next to lu1esVeme the dusty canister labelled 'discarded nonsense'~ Eric T. Bell 1be series is div…ergent; therefore we may be able to do something with it O. Heaviside Mathematics is a tool for thought. A highly necessary tool in a world where both feedback and nonlineari ties abound. Similarly, all kinds of parts of mathematics serve as tools for other parts and for other sci ences. Applying a simple rewriting rule to the quote on the right above one finds such statements as: 'One ser vice topology has rendered mathematical physics . '; 'One service logic has rendered computer science . .'; 'One service category theory has rendered mathematics . .'. All arguably true. And all statements obtainable this way form part of the raison d 'etre of this series.
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Taschenbuch. Zustand: Neu. Neuware - The papers in this volume are in honor of Bowman L. Clarke. Bowman Clarke earned degrees from Millsaps College, the University of Mississippi, and Emory University in Atlanta, Georgia, including the PhD in philosophy from Emory in 1961. He spent most of his academic career, a total of twenty-…nine years, as a member of the Philosophy Department of the University of Georgia, Athens, Georgia, from which he retired in 1990. He also served as Head of the Department for several years. He has held many positions of distinction in professional societies, including President of the Georgia Philosophical Society, President of the Society for the Philosophy of Religion, and President of the Southern Society for Philosophy and Psychology. He also served as Editor-in Chief of the International Journal for the Philosophy of Religion from 1975-1989. Professor Clarke is the author of Language and Natural Theology (The Hague: Mouton and Co. , 1966) as well as numerous articles in professional journals. He has made major contributions in the areas of the philosophy of religion, the study of the philosophy of Alfred North Whitehead, and the development of the calculus of individuals. ix J. F. Harris (ed. ), Logic, God and Metaphysics, ix. 1992 Kluwer Academic Publishers. Introduction The title for this volume, Logic, God, and Metaphysics, was chosen very carefully and deliberately. The papers in this volume are directed at the issues and problems which lie in the domain of the juncture of these three different areas of philosophical inquiry.
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Taschenbuch. Zustand: Neu. Neuware - Montreal has had a longstanding interest in somatostatin. Two years ago when the final planning began for the International Con gress of Endocrinology in Quebec City in July 1984, we seized the op portunity for having a separate Satellite Symposium on somatostatin here in Montreal. We felt th…at after a decade of uniformly vigorous growth in somatostatin research, the opportune moment had arrived for a review of the most significant past developments and for setting the directions for the future. Knowing the futility of trying to cover every aspect of the burgeoning somatostatin field in a two day scientific program, we opted for a detailed analysis of selected areas which were reasonably mature and of areas of greatest new activity. To attain these objectives, 27 leading international experts actively involved in their fields were invited to present an indepth review of their work in one of five major categories of somatostatin research. Thirty minutes at the end of each session were assigned for a three way, comprehensive discussion of some of the core concepts between the session moderators, the panellists and the audience. The feedback that we have received from the particip ants leaves little doubt that the meeting was a scientific and social success. This book fulfills our final commitment towards the Meeting which was to record the proceedings in a timely publication.
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Taschenbuch. Zustand: Neu. Neuware - Sixteen volumes and one supplement have now appeared in the series known as Evolutionary Biology. The editors continue to seek critical re views, original papers, and commentaries on controversial topics. It is our aim to publish papers primarily of greater length and depth than those normall…y published by society journals and quarterlies. The editors make every attempt to solicit manuscripts on an international scale and to see that every facet of evolutionary biology-classical or modern-is cov ered. Manuscripts should be sent to anyone of the following: Max K. Hecht, Department of Biology, Queens College of the City University of New York, Flushing, New York 11367; Bruce Wallace, Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061; Ghillean T. Prance, New York Botanical Garden, Bronx, New York 10458. The Editors vii Contents 1. Darwinian Selection of Self-Replicating RNA Molecules 1 Christ(~r K. Biehricher Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Replication of Virus RNA in Vitro. . . . . . . . . . . . . . . . . . . . . . . . 2 Extracellular Darwinian Experiments. . . . . . . . . . . . . . . . . . . . . . 5 Characterization of the QI3 Replicase. . . . . . . . . . . . . . . . . . . . . . 9 Nonviral RNA Templates of QI3 Replicase. . . . . . . . . . . . . . . . . . II The Mechanism of RNA Replication . . . . . . . . . . . . . . . . . . . . . . 14 Initiation of Replication and Template Specificity . . . . . . . . . . . 14 Mechanism of Replica Chain Elongation. . . . . . . . . . . . . . . . . . 17 Termination of Replication. . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 Replication of RNA Variants . . . . . . . . . . . . . . . . . . . . . . . . . . 21 TheQuasispecies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 De NOl'O Synthesis of Self-Replicating RNA. . . . . . . . . . . . . . . . . 27 The Mechanism of Selection . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32 Selection in the Exponential Growth Phase. . . . . . . . . . . . . . . . 32 Selection in the Linear Growth Phase. . . . . . . . . . . . . . . . . . . . 35 Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41 Appendix I. Replication. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 42 Appendix II. The Quasispecies. . . . . . . . . . . . . . . . . . . . . . . . . . . 43 Appendix III. Selection under Various Conditions . . . . . . . . . . . . 44 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Taschenbuch. Zustand: Neu. Neuware - In transfusion medicine the scientific fundamentals of immunology have had a considerable clinical impact. Transfusion may suppress the immunity but some patients could suffer disadvantages including GvHD, alloimmunisation and possible cancer, where white cells (WBC) play pivotal roles in thi…s phenomenon, presenting antigens and producing cytokines. A clinical application of this practice is LAK-cells targeted against cancer. MHC on the WBC may provide additional immunological modulations through series of secondary messengers. Thus reduction of WBC in the blood and bone marrow may be advantageous for patients. On the other hand, sharing a part of MHC or making the transplanted white cells anergic by storage may be even more advantageous for patients. CMV infection could mimic part of this MHC. UV radiation is effective in the inactivation of the WBC although filters are easy means for such removal. However, their accurate quantification requires flow cytometry that has considerable potential application in blood transfusions. Idiotypic antibody could play an important role in platelet theory. However, the potential infection risks in transfusion like HIV and HCV remain, but application of molecular biological methods like PCR or RT/PCR has great potentials in detection of infectious diseases, transplantation and genetic disorders. Immuno affinity purified concentrates, like factor IX and protein C, could reduce patients' immune functions, where in the future protein C could be derived from transgenic animals. Advances are sure to emerge through adoptive immunotherapy and gene therapies are exciting prospects when genes transferred into lymphocytes could be used to correct cell mediated immune deficiency, as in ADA.
Sprache: Deutsch
Verlag: Springer Fachmedien Wiesbaden, Springer Gabler Okt 2012, 2012
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Taschenbuch. Zustand: Neu. Neuware -Was ist Kognitive Psychologie Wie funktioniert und arbeitet Kognitive Psychologie Das Buch liefert Antworten und verschafft einen fundierten Überblick. Kritisch und nachdenklich werden z.B. die Stellung der Kognitiven Psychologie innerhalb der Psychologie, ihre Entwicklung zu einer modernen Wi…ssenschaft, methodische Bezüge und ihre klassischen Gebiete erläutert und reflektiert. Historische Exkurse, Schilderungen von berühmten Experimenten und zahlreiche Beispiele tragen zum lebendigen und verständlichen Stil dieser Einführung bei. 220 pp. Deutsch.
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Taschenbuch. Zustand: Neu. Neuware - Low Power Design Methodologies presents the first in-depth coverage of all the layers of the design hierarchy, ranging from the technology, circuit, logic and architectural levels, up to the system layer. The book gives insight into the mechanisms of power dissipation in digital circuits and…presents state of the art approaches to power reduction. Finally, it introduces a global view of low power design methodologies and how these are being captured in the latest design automation environments. The individual chapters are written by the leading researchers in the area, drawn from both industry and academia. Extensive references are included at the end of each chapter. Audience: A broad introduction for anyone interested in low power design. Can also be used as a text book for an advanced graduate class. A starting point for any aspiring researcher.
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Taschenbuch. Zustand: Neu. Neuware - Since the third Workshop on 'Laser Interaction and Related Plasma Phenomena' in 1973, one area within the scope of this con ference received increased attention: laser fusion. This possi bility was emphasized in February 1977 in a Seminar on US energy policies at The Hartford Graduate Center…by John F. O'Leary, Head of the Federal Energy Administration, who said that 'by the year 2100, --- laser fusion will be coming along, giving us a new age of choice'. Efforts in research and development were stepped up to investigate new concepts of laser ignition of controlled nuclear reactions. Here, one expects no radioactive waste from fuel. Th~ deuterium-tritium reaction - the only one which may be possible with magnetic field confinement in tokamaks - has a highly radio active tritium cycle, while, in principle, laser reactions are possible with pure deuterium, hydrogen-boron or others. The worldwide progress in laser compression was not only stim ulated by the energy crisis, but also by its advancements. In our first Workshop in 1969 F. Floux of the French Limeil Laboratories described his experiments, which led, only one month later, to the production of fusion neutrons in such large numbers as had not been achieved up to then (see appendix of Vol. I these Proceedings).
Sprache: Englisch
Verlag: Springer, Humana Okt 2012, 2012
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Taschenbuch. Zustand: Neu. Neuware -Earth date, August 11, 1997 'Beam me up Scottie!' 'We cannot do it! This is not Star Trek's Enterprise. This is early years Earth.' True, this is not yet the era of Star Trek, we cannot beam captain James T. Kirk or captain Jean Luc Pickard or an apple or anything else anywhere. What we can do… though is beam information about Kirk or Pickard or an apple or an insurance agent. We can beam a record of a patient, the status of an engine, a weather report. We can beam this information anywhere, to mobile workers, to field engineers, to a track loading apples, to ships crossing the Oceans, to web surfers. We have reached a point where the promise of information access anywhere and anytime is close to realization. The enabling technology, wireless networks, exists; what remains to be achieved is providing the infrastructure and the software to support the promise. Universal access and management of information has been one of the driving forces in the evolution of computer technology. Central computing gave the ability to perform large and complex computations and advanced information manipulation. Advances in networking connected computers together and led to distributed computing. Web technology and the Internet went even further to provide hyper-linked information access and global computing. However, restricting access stations to physical location limits the boundary of the vision.
Sprache: Englisch
Verlag: Springer Netherlands, Springer Netherlands Okt 2012, 2012
Serie: Buch 202 von 253 - Developments in Cardiovascular Medicine
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Taschenbuch. Zustand: Neu. Neuware -The most salient feature of the infor last four chapters of the book evaluate the mation provided by nuclear medicine is its information from an analytical and pathophysiological and functional charac statistical point of view. This approach is ter. For adequate experimental or clinical requir…ed for correct decision-making. interpretation, such information should This book is therefore the result of necessarily be interpreted alongside the accumulated experience in nuclear cardiology views of the clinical cardiologist, who is with the invaluable cooperation of medical able to apply it to the individual patient. statisticians. It is directed to physicians This approach, which is routine in every with an interest in nuclear cardiology, to day clinical practice, reaches its plenitude nuclear medicine specialists wishing to when the whole process is completed and learn the uses and limitations of these an intimate cooperation is established procedures in everyday clinical cardiology, between the nuclear medicine specialist and to cardiologists who feel the need to and the clinical cardiologist. In such understand the rationale and methodology instances, each one of these professionals of the studies which benefit their patients. understands the needs, limits and possi We understand that the ultimate reason bilities of the other. for any scientific book is the transmission The present book is the fruit of such of knowledge, and we are fully conscious cooperation. In our hospital, an efficient of the enthusiasm of the authors of the nuclear cardiology team has been made up present text to achieve that aim.
