springer us apr 2010 (15 Ergebnisse)

Buch. Zustand: Neu. Neuware -Nonlinear Optimization is an intriguing area of study where mathematical theory, algorithms and applications converge to calculate the optimal values of continuous functions. Within this subject, Global Optimization aims at finding global optima for difficult problems in which many local optima might exist.This book provides a compelling introduction to global and non-linear optimization providing interdisciplinary readers with a strong background to continue their studies into these and other related fields. The book offers insight in relevant concepts such as 'region of attraction' and 'Branch-and-Bound' by elaborating small numerical examples and exercises for the reader to follow.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 220 pp. Englisch.

Buch. Zustand: Neu. Neuware - This book arose from the need to develop accessible research-based case study material which addresses contemporary issues and problems in the rapidly evolving field of human ecology. Academic, political, and, indeed, public interest in the environmental sciences is on the rise. This is no doubt spurred by media coverage of climate change and global warming and attendant natural disasters such as unusual drought and flood conditions, toxic dust storms, pollution of air and water, and the like. But there is also a growing intellectual awareness of the social causes of anthropogenic environmental impacts, political vectors in determining conser- tion outcomes, and the role of local representations of ecological knowledge in resource management and sustainable yield production. This is reflected in the rapid increase of ecology courses being taught at leading universities in the fa- growing developing countries much as was the case a decade or two ago in Europe and North America. The research presented here is all taken from recent issues of Human Ecology: An Interdisciplinary Journal. Since the journal itself is a leading forum for cont- porary research, the articles we have selected represent a cross-section of work which brings the perspectives of human ecology to bear on current problems being faced around the world. The chapters are organized in such a way to facilitate the use of this volume either to teach a course or to introduce an informed reader to the field.

Buch. Zustand: Neu. Neuware -As a career sociologist I rst became interested in neurosociology around 1987 when a graduate student lent me Michael Gazzanigäs The Social Brain. Ifthe biological human brain was really social, I thought sociologists and their students should be the rst, not the last, to know. As I read on I found little of the clumsy reductionism of the earlier biosociologists whom I had learned to see as the arch- emy of our eld. Clearly, reductionism does exist among many neuroscientists. But I also found some things that were very social and quite relevant for sociology. After reading Descarte¿s Error by Antonio Damasio, I learned how some types of emotion were necessary for rational thought ¿ a very radical innovation for the long-honored ¿objective rationalist. ¿ I started inserting some things about split-brain research into my classes, mispronouncing terms like amygdala and being corrected by my s- dents. That instruction helped me realize how much we professors needed to catch up with our students. I also wrote a review of Leslie Brothers¿ Fridays Footprint: How Society Shapes the Human Mind. I thought if she could write so well about social processes maybe I could attempt to do something similar in connection with my eld. For several years I found her an e-mail partner with a wonderful sense of humor. She even retrieved copies of her book for the use of my graduate students when I had assigned it for a seminar.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 232 pp. Englisch.

Buch. Zustand: Neu. Neuware -The Springer Handbook of Auditory Research presents a series of comprehensive and synthetic reviews of the fundamental topics in modern auditory research. The v- umes are aimed at all individuals with interests in hearing research including advanced graduate students, post-doctoral researchers, and clinical investigators. The volumes are intended to introduce new investigators to important aspects of hearing science and to help established investigators to better understand the fundamental theories and data in fields of hearing that they may not normally follow closely. Each volume presents a particular topic comprehensively, and each serves as a synthetic overview and guide to the literature. As such, the chapters present neither exhaustive data reviews nor original research that has not yet appeared in pe- reviewed journals. The volumes focus on topics that have developed a solid data and conceptual foundation rather than on those for which a literature is only beg- ning to develop. New research areas will be covered on a timely basis in the series as they begin to mature.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 296 pp. Englisch.

Buch. Zustand: Neu. Neuware -view, showing that multiple molecular pathways must be affected for cancer to develop, but with different specific proteins in each pathway mutated or differentially expressed in a given tumor (The Cancer Genome Atlas Research Network 2008; Parsons et al. 2008). Different studies demonstrated that while widespread mutations exist in cancer, not all mutations drive cancer development (Lin et al. 2007). This suggests a need to target only a deleterious subset of aberrant proteins, since any tre- ment must aim to improve health to justify its potential side effects. Treatment for cancer must become highly individualized, focusing on the specific aberrant driver proteins in an individual. This drives a need for informatics in cancer far beyond the need in other diseases. For instance, routine treatment with statins has become widespread for minimizing heart disease, with most patients responding to standard doses (Wilt et al. 2004). In contrast, standard treatment for cancer must become tailored to the molecular phenotype of an individual tumor, with each patient receiving a different combination of therapeutics aimed at the specific aberrant proteins driving the cancer. Tracking the aberrations that drive cancers, identifying biomarkers unique to each individual for molecular-level di- nosis and treatment response, monitoring adverse events and complex dosing schedules, and providing annotated molecular data for ongoing research to improve treatments comprise a major biomedical informatics need.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 372 pp. Englisch.

Buch. Zustand: Neu. Neuware - The past two decades have seen an ever accelerating growth in knowledge about molecular pathology of human diseases, which received a large boost with the sequencing of the human genome in 2003. Mole- lar diagnostics, molecular targeted therapy, and genetic therapy are now routine in many medical centers. The molecular field now impacts every field in medicine, whether clinical research or routine patient care. There is a great need for basic researchers to understand the potential clinical implications of their research whereas private practice clinicians of all types (general internal medicine and internal medicine specialists, medical oncologists, radiation oncologists, surgeons, pediatricians, family practitioners), clinical inves- gators, pathologists and medical laboratory directors, and radiologists require a basic understanding of the fundamentals of molecular pathogenesis, diagnosis, and treatment for their patients. Traditional textbooks in molecular biology deal with basic science and are not readily applicable to the medical setting. Most medical textbooks that include a mention of molecular pathology in the clinical setting are limited in scope and assume that the reader already has a working knowledge of the basic science of molecular biology. Other texts emphasize technology and testing procedures without integrating the clinical perspective. There is an urgent need for a text that fills the gap between basic science books and clinical practice.

Buch. Zustand: Neu. Neuware -The past two decades have seen an ever-accelerating growth in knowledge about molecular pathology of human diseases, which received a large boost with the sequencing of the human genome in 2003. Molecular diagnostics, molecular targeted therapy and genetic therapy, are now routine in many medical centers. The molecular field now impacts every field in medicine, whether clinical research or routine patient care. There is a great need for basic researchers to understand the potential clinical implications of their research whereas private practice clinicians of all types (general internal medicine and internal medicine specialists, me- cal oncologists, radiation oncologists, surgeons, pediatricians, family practitioners), clinical investigators, pathologists and medical laboratory directors and radiologists require a basic understanding of the fundam- tals of molecular pathogenesis, diagnosis, and treatment for their patients. Traditional textbooks in molecular biology deal with basic science and are not readily applicable to the medical setting. Most medical textbooks that include a mention of molecular pathology in the clinical s- ting are limited in scope and assume that the reader already has a working knowledge of the basic science of molecular biology. Other texts emphasize technology and testing procedures without integrating the clinical perspective. There is an urgent need for a text that fills the gap between basic science books and clinical practice. In the Molecular Pathology Library series, the basic science and the technology is integrated with the medical perspective and clinical application.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 644 pp. Englisch.

Buch. Zustand: Neu. Neuware -Although rare, retinoblastoma has been at the fore- fortunate; while in the developed world eye preser- front of cancer research and treatment for the last tion has become a priority, developing countries c- three decades. The two-hit hypothesis of oncogenesis tinue to face delays in diagnosis, poor access to care, proposed by Alfred Knudson provided the conceptual and suboptimal treatment ¿ the problem in the less framework for tumor suppressor gene research and developed world is cure. led to the discovery of the retinoblastoma pathway as In this book, we have invited a team of experts to a key element in cancer development. More recently, address all those important aspects of retinoblastoma the treatment of children with retinoblastoma has also research and therapy - from biology to epidemiology provided a model for modern approach to the can- to treatment. We hope that in subsequent editions we cer patient; state of the art retinoblastoma treatment will be able to continue to provide updates on such can only be conceived in the context of the multidis- exciting subjects.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 172 pp. Englisch.

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This is an introduction to molecular and atomistic modeling techniques applied to fracture and deformation of solids, focusing on a variety of brittle, ductile, geometrically confined and biological materials. The overview includes computational methods and techniques operating at the atomic scale, and describes how these techniques can be used to model cracks and other deformation mechanisms. The book aims to make new molecular modeling techniques available to a wider community. 560 pp. Englisch.

Buch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -In The Earth as a Distant Planet, the authors become external observers of our solar system from a distance and try to determine how one can understand how Earth, the third in distance to the central star, is essentially unique and capable of sustaining life. The knowledge gained from this original perspective is then applied to the search for other planets outside the solar system, or exoplanets.Since the discovery in 1992 of the first exoplanet, the number of planet detections has increased exponentially and ambitious missions are already being planned for the future. The exploration of Earth and the rest of the rocky planets are Rosetta stones in classifying and understanding the multiplicity of planetary systems that exist in our galaxy. In time, statistics on the formation and evolution of exoplanets will be available and will provide vital information for solving some of the unanswered questions about the formation, as well as evolution of our own world and solar system. Special attention is paid to the biosignatures (signs of life) detectable in the Earth's reflected spectra and the search for life in the universe.The authors are experts on the subject of extrasolar planets. They provide an introductory but also very much up-to-date text, making this book suitable for researchers and for advanced students in astronomy and astrophysics.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 440 pp. Englisch.