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Taschenbuch. Zustand: Neu. Neuware -Despite an enormous investment of effort throughout the world, cancer is still a major barrier to human longevity. Cancer deaths are estimated to be more than five million globally. Currently responsible for about 20% of all deaths in developed coun tries, the burden of cancer is steadily increasing in the developing world, following the control of malnutrition and infectious and parasitic diseases. Deeply impressed by the report of the Symposium on Geographic Pathology and Demography of Cancer held at Oxford in 1950, and through his preliminary work on cancer mortality statistics in Japan, Professor M. Segi decided to devote his life to the fight against cancer by establishing worldwide comparative cancer statistics-one of the landmarks in cancer studies and in cancer prevention strategies. He and his associates published six volumes of Cancer Mortality in 24 Countries with reliable mortality statistics covering 1950-1967, using the world population which he had derived as a standard. These publications rapidly became standard works of reference on the subject throughout the world. Professor Segi was a pioneer of cancer epidemiology in Japan. He cleaved a path through the jungle of cancer using epidemiological methods. By promoting cancer studies, he overcame the poor understanding of malignant disease which existed after World War II, when cancer mortality rates were still low.…

Taschenbuch. Zustand: Neu. Neuware - 1 The Chondrodystrophies.- Classification of the Chondrodystrophies.- Evaluation of the Dwarfed Patient.- Clinical, Radiographic, Genetic, and Pathological Features of the Chondrodystrophies.- Animal Models of the Chondrodystrophies.- Future Trends in Chondrodystrophy Research.- 2 New Techniques in the Study of Human Chromosomes: Methods and Applications.- Fluorescence Microscopy.- Giemsa Staining.- The Usage of Banding Techniques.- Abnormalities Detected by Banding Analysis.- Chemical Properties of the Bands.- Technical Appendix.- 3 The Thalassemias: Models for Analysis of Quantitative Gene Control.- History.- Definition.- Organization of Globin Genes.- Ontogeny of Hemoglobin Production.- Inheritance of Thalassemia.- Frequency of Thalassemia.- Regulation of Hemoglobin Synthesis and Turnover.- Transcription of Hemoglobin Genes.- Intranuclear Processing of the Primary Gene Product.- Transport of Messenger RNA to the Cytoplasm.- Cytoplasmic Metabolism of Messenger RNA.- Balance of Hemin and Globin (Protein) Synthesis in Reticulocytes.- Other Steps in Hemoglobin Synthesis and Degradation.- Pathophysiology of the Thalassemias.- Directions in Therapy.- Note Added in Proof.- 4 Spontaneous Mutation in Man.- 'Classical' Mutation Rates.- Molecular Aspects of Human Mutation.- Spontaneous Mutation in Other Organisms and Its Significance for the Understanding of Human Mutations.- 5 Genetic Screening Legislation.- The Public Health Power.- Legislation Mandating Detection of Genetic Disease.- Legislation Mandating Screening for Genetic Traits.- Future of State-Supported Genetic Screening.…

Taschenbuch. Zustand: Neu. Neuware -This volume of essays grew out of a symposium organized by Judith Hoch-Smith and Anita Spring for the 1974 American Anthropological Association meetings in Mexico City. The two-part symposium was enti tled 'Women in Ritual and Symbolic Systems: I. Midwives, Madonnas, and Mediums; ll. Prostitutes, Witches, and Androgynes. ' The sym posium participants were asked to explore theological, ritual, and sym bolic aspects-both positive and negative-of the feminine cultural do main, using ethnographic materials with which they were familiar. The resulting papers have been revised, edited, and gathered together in Women in Ritual and Symbolic Roles. The theoretical importance of these papers for the study of women's participation in culture and society rests on the assumption that reli gious ideas are paramount forces in social life, that relationships be tween the sexes, the nature of female sexuality, and the social and cul tural roles of women are in large part defined by religious ideas. That this proposition remains valid long after religion itself has ceased to be a living truth in the lives of many people can be seen from the tenacious ness of Judeo-Christian ideas about women in the contemporary West ern world. Both the expansion of life options for women and the creation of more positive cultural images of the female are intimately related to changes in the my tho-symbolic portraits that people carry around in their heads. These portraits are almost exclusively constructed from mythological and religious conceptions inherent in all facets of culture.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 308 pp. Englisch. …

Taschenbuch. Zustand: Neu. Neuware - Each of the four authors of this book has a particular interest in disorders of porphyrin metabolism and special experience in their management. Their individual involvement in the field varies from 12 to 52 years and, combined, represents more than a century of personal experience. Since it has been written by both basic scientists and practicing physicians, the book is intended to be of value to all those involved in porphyrin metab olism and the porphyrias. It is hoped that the fascination of porphyrin metabolism and the clinical challenge of the porphyrias experienced by each of the authors will be conveyed to the readers. Michael R. Moore Kenneth E. L. McColl Claude Rimington Abraham Goldberg vii CONTENTS Color Plates . xvii 1. The History, Classification, and Incidence of the Porphyrias 1 1.1. History . 1 1.1.1. Early Chemistry . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 1.1.2. Early Descriptions of Porphyria . 4 1.1.3. Biochemical Developments . 4 1.1.4. Acute Porphyria . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 1.1.5. A Complete Pathway . 8 1.2. Classification of the Porphyrias . . . . . . . . . . . . . . . . . . . . . 9 1.2.1. The Current Classification. . . . . . . . . . . . . . . 12 . . . .…

Taschenbuch. Zustand: Neu. Neuware - This book includes the proceedings of a NATO Advanced Study Institute held at Washington State University, Pullman, Washington from July 26 until August 6, 1982. Although genetic engineering in eukaryotes is best developed in yeast and mammalian cells, the reader will find that some emphasis has been put on plant systems. Indeed, it was our position that the development of plant cell genetic transformation would benefit from the interactions between a comparatively smaller number of fungal and animal cell experts and a larger number of plant cell specialists representing various aspects of plant molecular genetic research. On the other hand, it is clear that the ultimate achievements of plant genetic engineering will have a tremendous ~pact on, among other things, food production without generating the problems of ethics encountered when one contempla-tes the genetic modification of human beings. Therefore, this slight bias in favor of the plant kingdom simply reflects our belief that a 'second green revolution' will benefit mankind to a greater extent than any other kind of genetic engine ering. The keynote lecture of the Institute was delivered by Dr. John Slaughter, Director of the National Science Foundation, whom we deeply thank for his words of encouragement and commitment to the genetic manipulation of plants.…

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Despite an enormous investment of effort throughout the world, cancer is still a major barrier to human longevity. Cancer deaths are estimated to be more than five million globally. Currently responsible for about 20% of all deaths in developed coun tries, the burden of cancer is steadily increasing in the developing world, following the control of malnutrition and infectious and parasitic diseases. Deeply impressed by the report of the Symposium on Geographic Pathology and Demography of Cancer held at Oxford in 1950, and through his preliminary work on cancer mortality statistics in Japan, Professor M. Segi decided to devote his life to the fight against cancer by establishing worldwide comparative cancer statistics-one of the landmarks in cancer studies and in cancer prevention strategies. He and his associates published six volumes of Cancer Mortality in 24 Countries with reliable mortality statistics covering 1950-1967, using the world population which he had derived as a standard. These publications rapidly became standard works of reference on the subject throughout the world. Professor Segi was a pioneer of cancer epidemiology in Japan. He cleaved a path through the jungle of cancer using epidemiological methods. By promoting cancer studies, he overcame the poor understanding of malignant disease which existed after World War II, when cancer mortality rates were still low. 240 pp. Englisch.…

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -We try in this book to provide a detailed but readable, technical but accessible monograph on energy in the United States. We treat energy as a multidisciplinary challenge and apply the standard tools of economists, physicists, engineers, policy analysts, and, some might claim, fortune tellers. We hope that it will be used in classrooms of various types, and read by the general reader as well. That increased energy efficiency should be the first priority of energy policymakers is a conclusion, not an assumption, of our analysis. Many analysts have arrived at this conclusion while working separately on energy supply problems. The magnitude and scope of supply problems, primarily problems of high prices and environmental costs, lead one inexorably back to reducing demand growth as the first, most important step in any plausible energy future. We examine, in some depth, why much of the past literature on energy still points, fallaciously in our opinion, to high energy c- v Preface vi sumption futures. This is in Part I (called 'A Short History of the Future'). We devote one-third of the book (Part II) to energy resources, their internal and external costs, and the quantities of energy to be derived from these resources. This analysis provides a context within which the economic and social value of energy conservation options can be assessed. 276 pp. Englisch.…

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The NATO Science Committee and its subsidiary Programme Panels provide support for Advanced Research Institutes (ARI) in various fields. The idea is to bring together scientists of a chosen field with the hope that they will achieve a consensus on research direc tions for the future, and make recommendations for the benefit of a wider scientific community. Attendance is therefore limited to those whose experience and expertise make the conclusions significant and acceptable to the wider community. Participants are selected on the basis of substantial track records in research or in the synthesis of research results to serve mankind. The proposal for a one-week ARIon Earth Observation and In formation Systems was initiated by the NATO Special Programme Panel on Systems Science (SPPOSS). In approving the ARI, the senior NATO Science Committee identified the subject as one of universal impor tance, requiring a broad perspective on the development of opera tional systems based on successful experimental systems. The general purpose of this ARI was to address the critical problems of integrating the relatively new science and technology of remote sensing into operational earth observation and manage ment information systems. The main problems of concern were those related to systems design, organization, development of infrastruc ture, and use of information in decision processes. The main empha sis was on problems of transferring technologies and methods from experimental to operational systems. 492 pp. Englisch.…

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Terrorism, continuing unabated in the contemporary world, is having a serious impact on the lives of people and nations. Once, only govern ments and ruling classes possessed the power to coerce large segments of the world's peoples. Today, a handful of thugs, covered and concealed by a collection of terrorist organizations, are disturbing people every where by perpetrating dramatic criminal acts-bombings, kidnappings, assassinations, etc.-on an almost daily basis, in places specifically cho sen for their vulnerability: a railroad train, a pub, a beachfront apartment, a bus, a restaurant. Furthermore, a few of the world's most notorious terrorist groups are associated in a loose coalition, which has left around the earth a trail of violent crimes against humanity of the most heinous type. Among these outrages are random murder, including the killing of innocents, and barricade and hostage situations involving the elderly and young children. Many of the victims of these terrorists are randomly selected for the sole purpose of obtaining maximum shock action calculated to attract widespread exposure via the communications media. A dramatic example is the assassination of Lord Louis Mountbatten, one of the most distinguished soldier-statesmen of the century, by terrorists of the Pro visional Wing of the Irish Republican Army (LR.A.). 260 pp. Englisch.…

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -also many newer lines of research, to which I will return below, are represented in various chapters. And finally, I have included a sepa rate unit on methods for the study of aggression-a feature that I believe to be unique to the present volume. In these ways, I have at tempted to produce a text that is as broad and eclectic in coverage as I could make it. While the present volume grew, in part, out of my desire to pro duce what I thought might prove to be a useful teaching aid, it also developed out of a second major motive. During the past few years, a large number of new-and to me, exciting-lines of investigation have emerged in rapid order. These have been extremely varied in scope, including, among many others, such diverse topics as the effects of sexual arousal upon aggression, the impact of environmental factors (e. g. , heat, noise, crowding) upon such behavior, interracial aggres sion, and the influence of heightened self-awareness. Despite the fact that such topics have already generated a considerable amount of re search, they were not, to my knowledge, adequately represented irt any existing volume. Given this state of affairs, it seemed to me that a reasonably comprehensive summary of this newer work might prove both useful and timely. 320 pp. Englisch.…

Buch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Business process reengineering (BPR) focuses on redesigning the strategic and value-added processes which transcend the organizational boundaries. It is a cross-functional approach that requires support from almost all the departments of the organization. Business Process Reengineering: Automation Decision Points in Process Reengineering offers a new framework based process reengineering and links it to organization life cycle, process life cycle, and process management. This volume describes the fundamental concepts behind business process reengineering and examines them through case studies, and should appeal to researchers and academics interested in business process reengineering, operations strategy, and organizational restructuring and design. 272 pp. Englisch.…

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In the last few years the physics of turbulent plasma has undergone rapid development, beginning with the first works, in which the term 'turbulence' was used in various ways, and ending with the fundamental studies which provide a thorough examina tion of the turbulent state of plasma. In physics it is usually found that value is not so much contained in specific results for a partic ular field as it is in the more general outlook and overall view of the problem. Occasionally the older results take on new mean ing after the general view of things is perfected. In the case of the physics of turbulent plasma, this general picture is now com plete, for the most part. The first review devoted to the problem of plasma turbulence was written by B. B. Kadomtsev [in 'Problems in Plasma Theory,' edited by M. A. Leontovich, Volume 4, Moscow, Atomizdat (1964), p. 188; English Translation: 'Plasma Turbulence,' Academic Press, London (1965)]. 556 pp. Englisch.…

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -1. Introduction to the Mobile Receptor Hypothesis.- A. The Fluid Mosaic Model of Biological Membranes.- B. The Mobile Receptor Hypothesis.- C. Modern Collision Coupling Theory.- D. Summary and Implications.- 2. Direct Measurement of Lateral Mobility.- A. Introduction.- B. Fluorescence Microscopy.- C. Confocal Microscopy.- D. Fluorescence Photobleaching Recovery.- E. Lateral Mobility in the Cytoplasm and Membranes of Living Cells.- F. Measurements in Artificial and Isolated Membranes.- G. Measurements of Lateral Mobility Using Other Methods.- H. Summary.- 3. Parameters Affecting Plasma Membrane Protein Lateral Mobility.- A. Mechanisms of Protein Immobilization in Biological Membranes.- B. Membrane Lipid Mobility.- C. The Cytoskeleton.- D. Anchorage Modulation.- E. Membrane Protein Sequence Motifs.- F. Domain Structure: Regions of Restricted Mobility.- G. Signal Transduction.- H. Summary.- 4. Lateral Mobility of Polypeptide Hormone Receptors and GTP-Binding Proteins.- A. Introduction.- B. Practical Considerations.- C. Lateral Mobility Measurements of Polypeptide Hormone Receptors.- D. Tyrosine Kinase Receptor-Mediated Signal Transduction.- E. GTP-Binding Protein Activating Receptor-Mediated Signal Transduction.- F. Structural Considerations.- G. Lateral Mobility Measurements of GTP-Binding Proteins.- H. Lateral Mobility of Cytokine Receptors.- I. Summary and Implications for Signal Transduction.- 5. Evidence for the Role of Membrane Receptor Lateral Movement in GTP-Binding Protein-Mediated Signal Transduction.- A. Introduction.- B. Kinetic Considerations in GTP-Binding Protein-Mediated Receptor-Effector Systems.- C. Indirect Evidence for a Role of Receptor Lateral Movement in GTP-Binding Protein-Mediated Signal Transduction.- D. Direct Evidence for a Role of Receptor Lateral Movement in GTP-Binding Protein-Mediated Signal Transduction.- E. Ga Signaling in the Cytosolic Phase.- F. Stoichiometric Considerations and Trimeric GTP-Binding Protein Immobility.- G. Amplification in GTP-Binding Protein-Mediated Receptor-Effector Systems Through Receptor Lateral Movement.- H. Summary.- 6. Evidence for the Role of Receptor Immobilization in Desensitization Subsequent to Hormonal Stimulation.- A. Introduction.- B. Receptor Internalization in Desensitization of Response.- C. Receptor Immobilization Prior to Internalization.- D. Receptor Movement Required for Internalization.- E. Kinetic Considerations with Respect to Lateral Mobility Measurements.- F. Receptor Phosphorylation.- G. Studies with Receptor Antagonists¿Receptor Immobilization Is Agonist-Dependent.- H. Summary.- 7. Evidence for the Role of Immobilization of Ligand-Occupied Membrane Receptors in Signal Transduction.- A. Introduction.- B. Receptor Immobilization in Tyrosine Kinase Receptor Signaling.- C. Receptor Immobilization in Signaling by Fc Receptors.- D. Receptor Immobilization in Cell-Cell Interaction.- E. Receptor Immobilization in Cell-Adhesion to an Extracellular Substratum.- F. Summary.- 8. The Mobile Receptor Hypothesis: A Global View.- A. Introduction.- B. Receptor Lateral Movement in Signal Transduction.- C. The Central Role of the Cytoskeleton.- D. Signal Transduction: Receptor Lateral Mobility Modulation by Heterologous Signaling.- E. Potential Pharmacological Applications of the Mobile Receptor Hypothesis.- F. Concluding Remarks. 240 pp. Englisch.…

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In marriage, partners bring together preexisting psychological and cul tural histories which may be quite disparate. The idea that 'love con quers all' does not account for the complexities involved in the development of a contemporary partnership. Societal changes over the past few decades have resulted in impor tant shifts in patterns of relationships. Lengthened life spans, decreased incidence and severity of illness and disability, and the availability of contraception have affected our lives and plans substantially. Among the effects are marriages that last longer than they ever have and produce fewer children, despite the high divorce rate. Values and expectations in marriage have also changed over the past several decades, shifting from an emphasis on survival and eco nomic security to a focus on companionship, love, and communication. The desire for self-fulfillment has superseded more traditional concerns about family loyalty Zlnd responsibility. Thus, divorce is often sought as a solution to frustration, disappointment, and conflict. A societal change that has had considerable influence on individ uals and their relationships has been the emergence of the women's movement and changing roles and expectations for women. This change has brought new demands, fulfillments, and conflicts. Current styles of marriage have shifted from an automatic acceptance of clearly designated gender-determined roles toward more egalitarian and interdependent relationships with partners also expressing their own goals, styles, and personalities. The dual career or dual worker family has emerged as the dominant family structure in the United States. 256 pp. Englisch.…

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The Workshop on 'Evolutionary Tinkering in Gene Expression' which was held at the end of August 1988. was planned to celebrate 20 successful Advanced Study Institutes (A. S. I.) in Molecular and Cell Biology. The first Institute was held in 1966 on the Island of Spetsai. after a N. A. T. O. suggestion and was entirely financed by N. A. T. O. The success was immediately so great that the Institute grew very rapidly and in the following years. N. A. T. O .- E. M. B. O. (since 1972) and F. E. B. S. (since 1981) co-sponsored it. Since the start of the AS! the U. S. National Science Foundation has granted travel money for a limited number of American participants each year. In addition. the course was supported by minor industrial subsidies of varying amounts which enabled the organizers to improve some of the local facilities particularly with respect to the lecture hall. In particular. Boehringer Mannheim has contributed since 1966. Furthermore. the Greek Ministry of Science and Culture has provided support at least for a social event during each ASI. 288 pp. Englisch.…

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book contains the papers presented at the Twenty-Seventh Annual Biology Division Research Conference which was held April 1-4, 1974 in Gatlinburg, Tennessee. The topic of the symposium was Mechanisms in Recombination and it follows by exactly twenty years the previous Gatlinburg Symposium on Genetic Recombination. During this interval, and the preceding years as well, the process of recombination has remained a central and tantalizing problem for geneticists. The subject assumes added significance with the recent appeal by a committee of leading scientists for a moratorium on the construction of certain types of recombinant molecules. That autonomously replicating molecules linking portions of pro karyotic and eukaryotic DNA can now be produced in vitro attests to the technical advances that have taken place in this field. Nevertheless, the details underlying the process in vivo continue to be elusive. This symposium brought together individuals studying recombi nation in organisms as widely separated as bacteriophage and mammals and using disciplinary approaches of comparable diversity. Conse quently the present volume summarizes much of current strategies and concepts concerning the subject. The meeting was sponsored by the Biology Division of the Oak Ridge National Laboratory (operated by the Union Carbide Corporation for the U. S. Atomic Energy Commission) with the support and encour agement of its director, H. I. Adler. The organizing committee was chaired by J. K. Setlow and included R. F. Grell, R. D. Hotchkiss and E. Volkin. Special thanks are due to the speakers, to I. R. 476 pp. Englisch.…

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -of Volume 2.- 8. Flowing Afterglow Studies.- 1. Introduction.- 2. Studies Bearing on Intermediate Complex Formation in Thermal Energy Collisions.- 2.1. Temperature Dependence of Slow Ion¿Molecule Reactions.- 2.2. Three-Body Reaction Rate Constants.- 2.3. Rotational Excitation in Ion¿Neutral Reactions.- 2.4. Miscellaneous Considerations of Intermediate Complex Processes.- 3. Studies Bearing on Negative-Ion Resonance Formation.- 4. Studies Bearing on Energetics.- 5. Conclusions.- References.- 9. Ion Cyclotron Resonance Spectrometry.- 1. Introduction.- 1.1. General Characteristics.- 2. Theoretical Basis for ICR.- 2.1. Ion Motion in a Magnetic Field.- 2.2. Ion Motion in an rf Electric Field Normal to a Magnetic Field.- 2.3. Ion Kinetic Energy.- 2.4. Power Absorption.- 2.5. Ion Drift.- 2.6. General Behavior of Ions in the ICR Cell.- 2.7. Ion Trapping.- 2.8. Methods of Ion Detection.- 3. Ion Intensities.- 3.1. Low Pressure¿No Collisions.- 3.2. Simple Spectra.- 3.3. Relative Intensities.- 3.4. Low-Pressure Reactions (Autoionization¿Unimolecular Fragmentation).- 3.5. Nonreactive Collisions and Charge Exchange.- 3.6. Ion¿Molecule Reactions.- 3.7. Rate Constants.- 3.8. Extension of ¿Low-Pressure¿ Theory to Include Tertiary Ions.- 3.9. Effects of Space Charge.- 4. Double Resonance.- 4.1. General Description.- 4.2. Use of Double Resonance for Identifying Specific Reactions.- 4.3. Blanking Experiments.- 4.4. Variation of Product Distribution with Ion Energy.- 5. Other ICR Techniques.- 5.1. Ionization Efficiency Curves.- 5.2. Electronic Spectra from Scattered Electrons.- 6. Summary.- References.- Appendix I.- Appendix II.- Appendix III.- 10. Mass Spectra and Appearance Potentials Studied by Use of Charge Exchange in a Tandem Mass Spectrometer.- 1 Introduction.- 2. Charge-Exchange Processes.- 3. The Tandem Mass Spectrometer of Perpendicular Type.- 4. Recombination Energies of Positive Ions.- 5. Recombination Energies of Doubly-Charged Positive Ions.- 6. Transfer of Translational Energy in Charge Exchange.- 7. Some Charge-Exchange Mass Spectra.- 7.1. Ethane.- 7.2. Ethylene.- 7.3. Methanol.- 7.4. Ammonia.- 7.5. Benzene.- 8. Appearance Potentials Measured by Use of Charge Exchange.- 9. Charge-Exchange Mass Spectra at Increased Pressure in the Collision Chamber.- References.- 11. Tandem Mass Spectrometric Studies of Ion¿Molecule Reactions.- 1. Introduction.- 2. Saturated Hydrocarbons.- 2.1. Propane.- 3. Unsaturated Molecules.- 3.1. Acetylene.- 3.2. Ethylene.- 3.3. Propylene and the Butenes.- 3.4. Vinyl Chloride.- 3.5. Cyclobutane.- 3.6. Structure and Reactivity of Cyclobutane Parent Ions.- 3.7. Collision-Induced Dissociation Reactions at Low Kinetic Energies.- 3.8. N+ Production from Dissociation of NO+.- 3.9. O+ Production from NO+.- 3.10. O+ Production from O2+.- 3.11. Evidence for Excited States from Ionic Dissociation Thresholds.- 3.12. Isotopic Experiments.- 4. Negative-Ion¿Molecule Reactions.- 4.1. Simple Inorganic Systems.- 4.2. Comparison of Rate Data from the Tandem Mass Spectrometer with Data Reported for Thermal-Energy Ions.- 4.3. Studies with Accelerated Ions.- 4.4. Reactions of O- with Organic Systems.- 4.5. Determination of Relative Acidities from Negative-Ion¿Molecule Reactions.- Acknowledgments.- References.- 12. Beam Studies of Ion¿Molecule Reactions.- 1. Introduction.- 2. Apparatus and Techniques.- 2.1. Survey of Typical Apparatus.- 2.2. Critique of Components.- 2.3. The Presentation of Data.- 3. Observations and Reaction Models.- 3.1. Direct versus Persistent-Intermediate Mechanisms.- 3.2. Direct Reactions.- 3.3. Reactions Involving Persistent-Intermediate Complexes.- 3.4. Criteria for Persistent-Complex Formation.- 4. Isotope Effects.- 5. Nonreactive Processes.- Acknowledgment.- References.- 13. Ionizing Collision Reactions of Electronically Excited Atoms and Molecules.- 1. Introduction: Definitions and Limitations.- 2. Background Work Prior to 1950.- 2.1. A.…

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The convening of the 3rd International Workshop on Monoclonal Antibodies and Breast Cancer had the character of a self-search exercise. After almost a decade of research in the basic and applied aspects of the use of serological means to diagnose and possibly treat breast cancer several milestones have been reached. Among them a clear understanding of immunopathological use and limitations of monoclonal antibodies against breast epithelium, the complete development and clinical use of immunoassays for circulating breast epithelial antigens, the striking advances in the diagnostic use of monoclonal antibodies to estrogen and progesterone receptor proteins and the first communications on proposed immunotherapeutic use of different conjugates of anti-breast antibodies. New areas of investigation have developed in our field, some which are reaching a full blossom while others are still facing obstacles and at times a re-definition of their goals and objectives. These meetings have acted in a way as a clearing house and have permitted their attendees to derive predictions that have helped shape future research and fine-tune objectives. But above all, the re-evaluation of past research at these Workshops and the renewed excitement brought to them by new information has helped generate a momentum and enthusiasm that assures for the future large scientific gains. 272 pp. Englisch.…

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book presents an ac count of the NATO Advanced Study Institute on 'Collective Excitations in Solids,' held in Erice, Italy, from June 15 to June 29, 1981. This meeting was organized by the International School of Atomic and Molecular Spectroscopy of the 'Ettore Majorana' Centre for Scientific Culture. The objective of the Institute was to formulate a unified and coherent treatment of various collective excitation processes by drawing on the current advances in various branches of the physics of the solid state. A total of 74 participants came from 54 laboratories and 20 nations (Australia, Belgium, Burma, Canada, China, France, F. R. Germany, Greece, Israel, Italy, Mexico, The Netherlands, Pakistan, Poland, Portugal, Romania, Switzerland, Turkey, The Uni ted Kingdom, and The United States). The secretaries of the course were: Joseph Danko for the scientific aspects and Nino La Francesca for the administrative aspects of the meeting. Fourty-four lectures divided in eleven series were given. Nine 'long' seminars and eight 'short' seminars were also presented. In addition, two round-table discussions were held. 740 pp. Englisch.…

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Thi's book collects the contributions to the NATO Advanced Research WJrkshop on 'FundaIrental Aspects of Quantum 'Iheory', held at the Centro di Cultura Scientifica 'Alessandro Volta', Villa Olma, Carro, Italy, 2-7 September 1985. The rreeting was dedicated to the rremory of the late pro fessor Piero Caldirola, a prominent member of the Physics Departrrent of the University of r1ilan and a native of Como. The aim of the workshop has been to present several recent experi rrental results and theoretical developrrents concerning the various fa cets of quantum physics. The breadth of scope of the rreeting was in accordance with Professor Caldirola's vast scientific interests, and fostered communication among experirrental physicists, theoretical and mathematical physicists, and nEthematicians, working in different but related fields. Indeed, lectu rers endeavoured to make their contributions understandable to people acquainted with the problem but not necessarily familiar with the tech nical details; and these efforts were successful, as indicated by the frequent private discussions which took place among participants belon ging to different breeds and brands. 1ne rreeting was made up of six one-day sessions, each of them addres sing to a specific aspect of quantum theory: 1. General Problems and Crucial Experinents; with emphasis on sin gle-particle interference eh~rirrents of neutrons and of photons, and on the rreasurerrent problem. 2. Quantization and Stochastic Processes; including stochastic quan tization of gauge fields, stochastic description of supersyrnmetric fields, quantum stochastic calculus and stochastic mechanics. 480 pp. Englisch. …

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Concanavalin A (Con A), a plant lectin, has become an object of extensive research not only for the biochemist, but also for the bi ologist, biophysicist, pathologist, immunologist and others. On April 19-20, 1974 a group of scholars from four continents met on the campus of the University of Oklahoma for an International Symposium on Con A. This volume contains all lectures presented by the invited speakers on this occasion, as well as the abstracts for all shorter technical papers which were presented. Further, the edi tors invited additional contributions from a few selected laboratories to cover the areas not covered in the symposium itself. This volume then reports the present status of research with Con A. In a sense it is encyclopedic and should be a useful reference tool to the worker in this field. The newcomer to this area will find that a careful study of this book will bring him up-to-date with the latest techniques, ap proaches and the 'state of the art' in this specialized area of re search, as well as with traps and ensnarements in which he need not get entangled again. Starting at the molecular level and advancing from there to the organismic level as well as to a number of highly specialized areas, this volume presents the most complete survey of research findings with Con A available today. The editors wish to acknowledge the generous financial support provided by the University of Oklahoma through its President, Dr. 380 pp. Englisch.…

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Ever since the first volume appeared in 1969, this series has received good reviews in a variety of periodicals published in different corners of 'the world. It would seem that the work has fulfilled its purpose as outlined in the Preface to Volume 1. The rapidly increasing interest in surface and colloid science by people engaged in industrial research and development, and in environmental, ecological, medical, pharmaceutical, and other areas, justifies the continuation of such an effort. After nine volumes with John Wiley and Sons, this and subsequent volumes will-by mutual consent-be published by Plenum Press. The editor will do his best to maintain and, if possible, improve the quality of the contributions. While the fundamental philosophy will be preserved, some moderate graphical changes have taken place. These changes were done to enhance the readability and uniformity of the volumes. Occasionally, volumes may appear under the editorship of other scientists in the field. These volumes will be mainly devoted to techniques in surface and colloid science. For reasons of continuity a sequential numbering system will be used. 324 pp. Englisch.…

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Although physiological and anatomical evidence had clearly indicated for many years that the secretion of anterior pituitary hormones is under control by the central nervous system, it is only recently that the isolation and determination of structure of three hypo thalamic hypophysiotropic hormones have been accomplished. This has brought the concept of neurohormonal control of adenohypophyseal function into precise biochemical and chemical terms. The relative ease of synthesis of TRH (thyrotropin-releasing hormone), LH-RH (luteinizing hormone-releasing hormone), somatostatin and their analogues has opened a new era in the field of endocri nology and has led to a rapid expansion of our knowl- ge of the control of anterior pituitary function. The rapid evolution of fundamental and clinical research on hypothalamic hormones and the many potential clinical applications indicate the importance of inte grating the knowledge gained in recent years. This is well illustrated in the Proceedings of the International Symposium on Hypothalamus and Endocrine Functions held in Quebec City on September 21-24th, 1975, which indi cates that impressive progress has been made in large variety of aspects of hypothalamic hormone research. 524 pp. Englisch.…

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Volume 8 in the series Progress in AnaZyticaZ Chemistry presents a selection of the papers given at the 1975 Eastern Analytical Symposium. The analytical chemist is under constant pressure not only from the research chemist whose sampIes he must characterize and control, but also from an ever-increasing group of governmental agencies stimulated by public concern over health and environmental problems, to determine the most sophisticated kinds of compounds as lower and lower levels. The subjects covered in these papers are wide-ranging, from the analysis of incinerator effluents to the determination of drugs in blood, but through them runs a common theme, the appli cation of the latest instrumental techniques to the problems of analysis. The authors show how successful they have been in rising to the analytical challenges pre sented by an increasingly complex world. The editors take this opportunity to thank them for their efforts in producing such excellent papers for publication in so short a time. Dur special appreciation goes to Dr. M. W. Miller, who acted as program chairman, and his team of session chairmen: P. R. Brown, L. J. Cline Love, C. Horvath, J. R. Lindsay, and T. C. Rains. 348 pp. Englisch.…

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume presents lecture notes from the session of the International School of Pharmacology, at the 'Ettore Majorana' Centre, on Advances in Prostaglandins that took place in Erice (Sicily), October 4 to October 15, 1976. The School was a NATO Advanced Study Institute. The aim of this international course was a compre hensive discussion by experts in various disciplines of the present status of our knowledge of the biological role of prostaglandins and thromboxanes. The synthesis, metabolism, and function of prosta glandins have been evaluated at the cellular level, in isolated tissues, and/or in the intact organism. The mode of action of prostaglandins and their interactions, particularly with cyclic nucleotides, in normal and pathological conditions, has been discussed with the aim of understanding the possible role of these compounds in hormonal regulation and cell response. The prostaglandin biosynthetic capacity of different tissues, under various experimental conditions, in the presence of specific precursors, and the inhibitory ac tivity of different agents have been examined to ascer tain the relationship between function and metabolism. For these reasons the discussion has also been extended to the methods (biological, immunological, and spectrometric) available for the direct and specific determination of prostaglandins and the evaluation of their synthesis and metabolism. The Editors hope that the book will be useful both to beginners and to those with a long-time interest in prostaglandins. F. Berti B. Samuelsson G. P. Velo v CONTENTS Chemistry of Prostaglandins and Thromboxanes . . 460 pp. Englisch.…

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Meningeal leukemia (ML) is a well-known and rather frequent complication of leukemia especially since the advent of chemotherapy. The first report of neurological complications of leukemia was in 1823 by Burnsl. Before leukemia chemotherapy, there had been only sporadic and relatively few case reports. However, since 1948, the incidence of meningeal leukemia has increased to where it is now one of the most frequent complications of the disease. This review will discuss in depth the pathology, clinical characteristics, and results of treatment of meningeal leukemia. An attempt will be made to assess the relative values of different modes of therapy and suggest new ones in light of animal studies and theoretical models for meningeal leukemia, and to define what parameters are necessary in evaluating the results of therapy, which would be helpful in future studies. This is especially cogent since many of the more recent chemotherapy proto cols are utilizing combinations of radiotherapy and intrathecal therapy both in treatment of meningeal leu kemia and as prophylaxis against its development. 144 pp. Englisch.…

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The Fifth International Symposium on Human Purine and Pyrimidine Metabolism was held in San Diego, California (U. S. A. ) in July and August of 1985. Previous meetings in this series were held in Tel Aviv (Israel), Baden (Austria), Madrid (Spain) and Maastricht (The Netherlands). The proceedings of each of these meetings were published by Plenum. The next meeting will be in Japan. This Symposium differed from those that went before in that it per mitted us to honor Dr. J. E. Seegmiller, Professor of Medicine at the University of California San Diego, for his many contributions to our understanding of purine metabolism in man. This publication is dedicated as a Festschrift to Jay. Dr. Richard W. E. Watts delivered the keynote address outlining in scholarly fashion the history of Dr. Seegmiller's accomplishments in research on purine metabolism and the great number of currently active scientists in this field who have worked with him. This address is published as the first contribution to Volume I. Dr. Dewitt Stetten, Jr. , was scheduled to be the speaker at our banquet. Unfortunate ly, he could not be with us. Dr. Seegmiller has written an appreciation of Dr. Stetten and his contributions to our field, and this has been pub lished following Dr. Watts' paper. The growth of knowledge in purine and pyrimidine metabolism continues to be exponential. The variety of subjects included in these volumes is impressive. 720 pp. Englisch.…

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Scientists from 25 count ries came together at the Hyatt Regency Hotel on October 21-25, 1984, for the 4th International Kinin Congress in the beautiful city of Savannah, Georgia. Many of the delegates enjoyed southern hospitality for the first time. The friendly city with its streets lined with the Live Oak Tree (symbol of the Congress), the balmy weather, and the excellent facilities of the hotel set the stage for scientific events and exchange that proved so successful. The organ ization of the meeting was the result of many hours, days and weeks of effort by many, including from Augusta Drs. James H. Sutherland, John Catravas, William Davis, Jr. , and Hiroshi Okamoto; and from Charleston, SC, Julie Chao, Ronald Mayfield and Donald Miller. Special thanks go to Ms. Cher Cornett of the Department of Medical Illustration at the Medical College of Georgia for her talent in the design of the logo, as well as the graphics of the program and abstracts. We are indeed indebted to Dr. Paul Brucker, Director of the Division of Health Communi cations at the Medical College of Georgia, for his considerable aid in spending time with us to arrange the programming format and continuity. Ms. Sandra Usry provided very excellent and devoted secretarial help for several years while the Congress was in the making. 596 pp. Englisch.…

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The present collection of articles follows the arrangement used in previous volumes. Solutions are discussed first, surfaces and double layers second, electrode kinetics third, and then the applied subjects. The introduction of spectroscopic methods to electrochemistry is well exemplified by NMR studies of ionic solutions, as represented here in the detailed article by E. von Goldammer. Correspondingly, the spectroscopic approach can be applied to surfaces, and B. G. Baker has written an introduction to this topic for electrochemists from the point of view of gas phase measurements. One of the topics which begins to reach a degree of sophistica tion in electrode process chemistry is the adsorption of organic species on electrodes, and this topic is described in our volume by the well-known electrochemist M. W. Breiter. The work has much rele vance to the corresponding electrode kinetics and oxidation of organic materials. Much less sophisticated is the position in the electrochemistry of sulfide minerals, but it has seemed worthwhile to have the present record described by D. F. A. Koch; his chapter demonstrates the value of qualitative electrochemical studies in this field. The Hydrogen Economy is perhaps an example of straw fire in electrochemistry, for its great popularity beginning in 1973 reflects an interest which can hardly grow larger. However, much discussion of the Hydrogen Economy is concerned with its nonelectrochemical v vi Preface aspects and D. P. Gregory gives here the latest from the hydrogen front, with emphasis on the electrochemistry. 468 pp. Englisch.…

Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This NATO Advanced Study Institute, held in Geilo between March 29th and April 9th 1981, was the sixth in a series devoted to the subject of phase transitions and instabilities. The present institute was intended to provide a forum for discussion of the importance of nonlinear phenomena associated with instabilities in systems as seemingly disparate as ferroelectrics and rotating buckets of oil. Ten years ago, at the first Geilo school, the report of a central peak in the fluctuation spectrum of SrTi0 close to its 3 106 K structural phase transition demonstrated that the simple soft-mode theory of such transitions was incomplete. The missing ingredient was the essential nonlinearity of the system. Parti cipants at this year's Geilo school heard assessments of a decade of experimental and theoretical effort which has been expended to elucidate the nature of this nonlinearity. The importance of order ed clusters and the walls which bound them was stressed in this con text. A specific type of wall, the soliton, was discussed by a number of speakers. New experimental results which purport to demonstrate the existence of solitons in a one-dimensional ferromagnet were presented. A detailed discussion was given of the role of solitons in transport phenomena in driven multistable systems, typified by a sine-Gordon chain. 496 pp. Englisch.…