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Taschenbuch. Zustand: Neu. Neuware -Despite an enormous investment of effort throughout the world, cancer is still a major barrier to human longevity. Cancer deaths are estimated to be more than five million globally. Currently responsible for about 20% of all deaths in developed coun tries, the burden of cancer is steadily incr…easing in the developing world, following the control of malnutrition and infectious and parasitic diseases. Deeply impressed by the report of the Symposium on Geographic Pathology and Demography of Cancer held at Oxford in 1950, and through his preliminary work on cancer mortality statistics in Japan, Professor M. Segi decided to devote his life to the fight against cancer by establishing worldwide comparative cancer statistics-one of the landmarks in cancer studies and in cancer prevention strategies. He and his associates published six volumes of Cancer Mortality in 24 Countries with reliable mortality statistics covering 1950-1967, using the world population which he had derived as a standard. These publications rapidly became standard works of reference on the subject throughout the world. Professor Segi was a pioneer of cancer epidemiology in Japan. He cleaved a path through the jungle of cancer using epidemiological methods. By promoting cancer studies, he overcame the poor understanding of malignant disease which existed after World War II, when cancer mortality rates were still low.

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Taschenbuch. Zustand: Neu. Neuware -This volume of essays grew out of a symposium organized by Judith Hoch-Smith and Anita Spring for the 1974 American Anthropological Association meetings in Mexico City. The two-part symposium was enti tled 'Women in Ritual and Symbolic Systems: I. Midwives, Madonnas, and Mediums; ll. Prostitut…es, Witches, and Androgynes. ' The sym posium participants were asked to explore theological, ritual, and sym bolic aspects-both positive and negative-of the feminine cultural do main, using ethnographic materials with which they were familiar. The resulting papers have been revised, edited, and gathered together in Women in Ritual and Symbolic Roles. The theoretical importance of these papers for the study of women's participation in culture and society rests on the assumption that reli gious ideas are paramount forces in social life, that relationships be tween the sexes, the nature of female sexuality, and the social and cul tural roles of women are in large part defined by religious ideas. That this proposition remains valid long after religion itself has ceased to be a living truth in the lives of many people can be seen from the tenacious ness of Judeo-Christian ideas about women in the contemporary West ern world. Both the expansion of life options for women and the creation of more positive cultural images of the female are intimately related to changes in the my tho-symbolic portraits that people carry around in their heads. These portraits are almost exclusively constructed from mythological and religious conceptions inherent in all facets of culture.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 308 pp. Englisch.

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Taschenbuch. Zustand: Neu. Neuware - Despite an enormous investment of effort throughout the world, cancer is still a major barrier to human longevity. Cancer deaths are estimated to be more than five million globally. Currently responsible for about 20% of all deaths in developed coun tries, the burden of cancer is steadily inc…reasing in the developing world, following the control of malnutrition and infectious and parasitic diseases. Deeply impressed by the report of the Symposium on Geographic Pathology and Demography of Cancer held at Oxford in 1950, and through his preliminary work on cancer mortality statistics in Japan, Professor M. Segi decided to devote his life to the fight against cancer by establishing worldwide comparative cancer statistics-one of the landmarks in cancer studies and in cancer prevention strategies. He and his associates published six volumes of Cancer Mortality in 24 Countries with reliable mortality statistics covering 1950-1967, using the world population which he had derived as a standard. These publications rapidly became standard works of reference on the subject throughout the world. Professor Segi was a pioneer of cancer epidemiology in Japan. He cleaved a path through the jungle of cancer using epidemiological methods. By promoting cancer studies, he overcame the poor understanding of malignant disease which existed after World War II, when cancer mortality rates were still low.

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Taschenbuch. Zustand: Neu. Neuware - Three articles make up Volume 10 of Methods in Membrane Biology. In the first of these, Papahadjopoulos, Poste, and Vail extensively review much of the available data on the fusion of natural membranes, model membranes (liposomes), and natural membranes with liposomes. The authors are led by…their review of the experimental methods and their interpretations of the results obtained to a general theory of membrane fusion which they believe is applicable to all systems that have been studied. Arguing that although protein and carbohydrate may serve, in some cases, to bring membranes into sufficiently close proximity for fusion to occur and, in other cases, to remove peripheral and integral proteins from the regions that are to undergo fusion, the authors conclude that membrane fusion per se is solely a property of the lipid bilayer. In their view, all the experimental observations to date can be subsumed under a unifying hypothesis in which membrane fusion is the result of a phase separation in one-half of the membrane bilayer brought about by the interaction - of calcium ions with acidic phospholipids, mostly phosphatidylserine. Where half-membranes already contain sufficient acidic phospholipids, a local increase in calcium ion concentration may suffice to induce fusion (examples might include exocytosis and fusion of intracellular membrane systems). In other cases, natural or experimentally induced events preceding fusion might be necessary to increase the local concentration of the acidic phospholipids in the half-membrane (virus-or fusogenic agent-induced cell-to-cell fusion, or endocytosis, for example).

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Taschenbuch. Zustand: Neu. Neuware - 1 The Chondrodystrophies.- Classification of the Chondrodystrophies.- Evaluation of the Dwarfed Patient.- Clinical, Radiographic, Genetic, and Pathological Features of the Chondrodystrophies.- Animal Models of the Chondrodystrophies.- Future Trends in Chondrodystrophy Research.- 2 New Techniq…ues in the Study of Human Chromosomes: Methods and Applications.- Fluorescence Microscopy.- Giemsa Staining.- The Usage of Banding Techniques.- Abnormalities Detected by Banding Analysis.- Chemical Properties of the Bands.- Technical Appendix.- 3 The Thalassemias: Models for Analysis of Quantitative Gene Control.- History.- Definition.- Organization of Globin Genes.- Ontogeny of Hemoglobin Production.- Inheritance of Thalassemia.- Frequency of Thalassemia.- Regulation of Hemoglobin Synthesis and Turnover.- Transcription of Hemoglobin Genes.- Intranuclear Processing of the Primary Gene Product.- Transport of Messenger RNA to the Cytoplasm.- Cytoplasmic Metabolism of Messenger RNA.- Balance of Hemin and Globin (Protein) Synthesis in Reticulocytes.- Other Steps in Hemoglobin Synthesis and Degradation.- Pathophysiology of the Thalassemias.- Directions in Therapy.- Note Added in Proof.- 4 Spontaneous Mutation in Man.- 'Classical' Mutation Rates.- Molecular Aspects of Human Mutation.- Spontaneous Mutation in Other Organisms and Its Significance for the Understanding of Human Mutations.- 5 Genetic Screening Legislation.- The Public Health Power.- Legislation Mandating Detection of Genetic Disease.- Legislation Mandating Screening for Genetic Traits.- Future of State-Supported Genetic Screening.

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Taschenbuch. Zustand: Neu. Neuware - This is the third volume in the series of books based on the Annual Merseyside Course in Clinical Psychology. In common with its predecessors its aim is to present a number of topics of interest to practitioners, researchers, trainers and trainees in the field, with the intent not only to inf…orm but variously also to question and to guide further enquiry. Selection for this volume has taken a somewhat different stance to the previous two. Whereas in former volumes an attempt has been made to cover standard areas of general and scientific interest to psychologists and others in related professions, such as anorexia nervosa, forensic issues, long term care, mental handicap, community psychology, anxiety and de pression, in this one issues which are of equal relevance but not necessarily of equal prominence in psychological texts, are included. We have not, however, neglected those areas more readily recognized as of major clinical import which are being progressively covered in this series. This year we have the section 'Bereavement and the Care of the Dying'. Although for many this may not be a main focus, it is a subject that few helpers do not encounter either directly or indirectly with their clients. It would be impossible for this subject to not reflect the most human side of the caring professions, and it is perhaps in this field that the objective/subjective dilemma of the clinician can be seen in its most acute form.

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Taschenbuch. Zustand: Neu. Neuware - The Laser Raman Workshop on the r'eas urement of Gas Properti es i sone of aseries of occasional meetings organized in an informal workshop format through the stimulation of Project SQUID, Office of Naval Research. This workshop is the second to be organized on gas-phase applications of Raman… scattering. Both Raman workshops were supported by Project SQUID, ONR, and the Air Force Aero Propulsion Laboratory, Wright-Patterson Air Force Base. The first Raman Workshop was held at the AVCO Everett Research Laboratory, Everett, Massachusetts, with their co-sponsorship in January 1972 under the chairmanship of D. A. Leonard. The present meeting was co-sponsored by the General Electric Research and Development Center, and held at their facility in Schenectady, New York. We are grateful to Project SQUID, AFAPL, and GE for their generous financial support of this Workshop, and to Project SQUID for underwriting the publication costs of the Proceedings. As is always the case for successful meetings, many people contributed substantially to the organization and execution of this workshop. Professor Robert Goulard supported, aided, and encouraged us in the most helpful ways, and we are indebted to him. We received further valuable support and assistance from Dr. Ralph Roberts, Director, and Mr. James R. Patton, Jr., of the Power Branch, Office of Naval Research; from Dr. William H. Heiser, Chief Scientist of the Aero Propulsion Laboratory; and from Dr. James M.

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Taschenbuch. Zustand: Neu. Neuware - Volume 9 of Developments in Applied Spectroscopy pr e sents a collection of tventy-three selected papers presented during the 21st Mid-America Symposium on Spectroscopy, held in Chicago, June 2-5, 1970, In general. these papers are those of the symposium type and not papers pertaining to a sp…ecific research topic that one voul~ expect to find in the journals. The 21st Mid-America Symposium vas sponsored by the Chicago Section in cooperation vith Cincinnati, Cleveland, Indiana, Nev England, Nev York, Niagara Frontier and Ohio Vall ey Sections of the Society of Applied Spectroscopy, and the Chicago Gas Chromatography Group. Although the Mid America is stiIl occasionally thought of as a regional meet ing, its attendees and authors come from all parts of the United States and Canada as vell as other countries outside North America. Both theoretieal and applied principles vere presented in sessions on emission, molecular and atomic absorption, x-ray, mass, nuclear, electron, and nuclear magnetic and electron spin resonanee spectroscopy; air and Water pOllution analyses; biomedical technology; polymers and elastomeric materials; and computer applications. The chairmen of the Symposium Committees, Mr. E. Baclavski. Dr. W. K. Baer, Mr. J. E. Burroughs, Dr. C. R. Brundle, Mr. C. Hastings, Mr. J. B. Himes, Mr. R. Isaac, Dr. R. J. Jakobsen, Mr. J. Kinder, Dr. J. L. Koenig, Mr. W. A. Loseke, Dr. R. Mattoon, Miss V. McMahon, Dr. C.E. Moore, Mr. C. S. Naiman, Dr. M. J. Oestmann, Mr. C. R.

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Taschenbuch. Zustand: Neu. Neuware - We are pleased to present Volume 9 of our highly successful series, which now celebrates 12 years of providing the magnetic resonance community with topical, authoritative chapters on new aspects of biological magnetic resonance. As always, we try to present a diversity of topic coverage in e…ach volume, ranging from applications of in vivo magnetic resonance to more fundamental aspects of electron spin resonance and nuclear magnetic resonance. Philip Yeagle presents an eagerly awaited chapter on 31p NMR studies of membranes and membrane protein interactions. Alan Marshall has con tributed two chapters to the volume: one, with Jiejun Wu, describes magnetic resonance studies of 5S-RNA as probes of its structure and conformation; the secon.

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Taschenbuch. Zustand: Neu. Neuware - Volume 4 of Advances in Nutritional Research reflects the increased importance that recently has been attached to nutrition in many fields of clinical medicine. This heightened interest in nutrition stems from the demonstration that the intake of specific nutrients may have far-reaching conse…quences, not only for normal metabolism, but also for metabolic processes affecting clinical or subclinical disease. Conversely, many disease states have been shown to have previously unrecognized effects on nutrient function and metabolism. In addition to topics of obvious relevance to human clinical nutrition, this volume contains chapters dealing with the nutrition of cells grown in culture and of species that may provide insights into nutritional disorders of man. To gether with its predecessors, Volume 4 provides graduate students and estab lished investigators with authoritative accounts of the status of research on a range of topics of current interest in experimental and clinical nutrition. vii Contents Chapter 1. Vitamin-Responsive Genetic Abnormalities . . S. Harvey Mudd 1. Introduction. 1 2. Historical Perspective . 2 3. Genetic Abnormalities Currently Known to Be Vitamin Responsive. 3 4. Mechanisms Underlying Vitamin Responsiveness. . . . . . . . . . . . . . . . 7 4.1. Defects in the Processing of a Vitamin Prior to Its Interaction in Cofactor Form with a Particular Apoenzyme . 7 4.2. Defects in Particular Apoenzymes that Interact with the Cofactor Forms of Vitamins. . . . . . . . . . . . . . . . . . 16 . . . . . .

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Taschenbuch. Zustand: Neu. Neuware - This is not a textbook nor an encyclopedia; rather, it is a collection of papers representing a variety of points of view on contemporary is sues, controversies, and questions about female sexual development. The editor has a point of view, not a point of view as to which of the various autho…rs' positions presented in this book is correct, or even the most useful, but a point of view about the format of such a book; namely, that the definitive answers, and the experts who will provide them, are not yet identified. Therefore, many voices should be heard from different areas of expertise, training, experience, and back ground. Inevitably there are contradictions and disagreements. There should be. Several authors who were asked to provide short discus sions for papers found themselves unable to answer in less than an ad ditional paper. The editor welcomed this response. This is an area full of ancient myths, new discoveries, and alternate perspectives. It is hoped that the book reflects these ambiguities and controversies and that it will stimulate as many questions as it provides answers. You will find represented in this volume, and its forthcoming companion volume on women's sexual experience, authors not gener ally found together between the covers. When useful and where pos sible, a discussion or an addendum to a paper has been included by an author who approaches the subject from a different base of infor mation or experience.

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Taschenbuch. Zustand: Neu. Neuware - Volume 5 of this series continues its coverage of currently active re search fields in ornithology. Because an editor can never be a disin terested observer of his or her own editorial efforts, any claim for su periority of this volume is not without conflict of interest. Even so, Volume 5 ha…s certain merits that even a parent should acknowledge, and I find the current chapters not merely timely and authoritative but compelling in their demand for a reader's attention. Wolfgang and Roswitha Wiltschko provide a perceptive review of magnetic orientation in birds, a piece dedicated to Fritz Merkel, the pioneer in studies of magnetic orientation. Sergei Kharitonov and Doug las Siegel-Causey are concerned with the behavioral ecology of seabird coloniality, emphasizing their field experiences in the USSR and the United States. Ted Miller examines the application of studies of bird behavior to comparative biology, pursuing the interface of behavior and evolutionary biology adumbrated by Konrad Lorenz in the 1930s. Jeremy Raynor gives us a summary of the work over the past decade on bird flight, which is not, by turns, as complex or as simple as we had formerly believed. Carrol Henderson describes recent develop ments in nongame bird conservation, based on his pioneering work in the State of Minnesota. Alan Kamil discusses optimal experimental design for research in ornithology, a field in which experimental work is frequently difficult to pursue.

Sprache: Englisch
Verlag: Springer Us Dez 2012, 2012
Serie: Advances in Experimental Medicine and Biology, Buch 5 von 544. Buch 5 von 544 - Advances in Experimental Medicine and Biology
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Taschenbuch. Zustand: Neu. Neuware - The ontogeny of lymphoid cells seems the most appropriate place to start. The early events in T and B cell ontogeny are still confusing. There seems to be no agreement on the data and on the semantics of the question of progenitor vs. stem cells. Nevertheless, we are beginning to understand m…ore about progenitor cells which are committed to particular cell lines, and about stem cells in the sense of having almost unlimited capability of giving rise to undifferentiated progeny. An important future development will be to determine the nature of the substances that attract stem cells and which are produced by specialized thymus epithelium, and perhaps by the bursa. The way stem cells recognize these signals is an important question to answer. Not predictable from mammalian models has been the observation that there is a lack of cells called into the bursa even before the signal for entry of stem cells has been shut off. A likely model suggested that after a certain point in development there were no longer any cells capable of migrating into the bursa and becoming B cells. A fascinating possibility is the suggestion that a cell comes into the bursa, is not committed, then can still wander into the thymus. This cell does not appear to have B cell characteris tics; that is, immunoglobulin is not expressed on its surface.

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Taschenbuch. Zustand: Neu. Neuware - Identified Neurons and Behavior of Arthropods presents for the larger audience the papers delivered at a symposium of the same title. I organized this symposium so that a few of the many who owe him a great scientific debt could honor Professor C. A. G. (Kees) Wiersma upon his attaining the a…ge of 70 and retiring from the California Institute of Technology. Everyone of the participants publicly acknowledged his debt to Kees Wiersma, but in a sense there was no need to do so, because the research reported spoke for itself. Seldom in a rapidly developing branch of modem science has all of the recent progress so clearly stemmed from the pioneering work of a single figure. But in this subject, the role of identified nerve cells in determining behavior, Wiersma stood virtually alone for 30 years. He it was who first showed that indi vidual nerve cells are recognizable and functionally important and have 'per sonalities' of their own.

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Taschenbuch. Zustand: Neu. Neuware - We are pleased to present to our readers the proceedings of th~ Third Bari Seminars in Nephrology. The tDpic ~f these proceedi~gs deals with effects of drugs and o.yst el'll C ct i se;'Isc;- an the Id dney. Tho B rj S~~jnar5 in Nephr~logy are bi-annual meetings ~tt~~~Dd k) D large internation…al audience comprised of clinicians-scientist~ in the various displines of ~~phrnlDgy nnrl rQlated fi~ld$. The ne~t Bari S~mjnar5 of Nephrology will take place i' npril 19qn ~nd thp theme of the gathering will be Interstitial Nephritidies and Obstructive Uropathy. We are indc-bted for the goner-ells financial support of the Centro N::I~innalC' ti Pds. :'ll Pds. '', Pichp.rche, Italy. Alberto Amerio Pasquale Coratelli Vito M. Campese Shaul G. Massry vii CONTENTS Lupus Nephritis: Pathogenesis, Course and Management . . . 3 James E. Balow Prognostic Determinants in Lupus Nephritis . . 17 P. Coratelli, R. Rizzi, G. Pannarale, A. Ramunni M. Giannattasio, and G. Passavanti Thrombotic Microangiopathy in Lupus Nephritis . . . 35 . M.T. Porri, M.I. Quarenghi, F. Ferrario G. Colasanti, R. Rossi, E. Schiaffino, G. Toia, and G. D'Amico Vasculitis and the Kidney . . . . . . . . . . 41 .

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Taschenbuch. Zustand: Neu. Neuware - We are pleased to present to our readers the Proceedings of the Sixth International Workshop on Phosphate and Other Minerals which was held in Verona, Italy, during June 24-26, 1983. It was hosted by Professor Giuseppe Maschio, Professor of Medicine and Chief, Department of Nephrology at the…University of Verona. The Sixth Workshop maintained the tradition of the previous ones. It provided a unique and outstanding opportunity for close interaction between scientist involved in the research of the overall field of Mineral Metabolism. The current Workshop was attended by 250 scientists from 15 countries including Austria, Canada, Denmark, England, France, Germany,Holland, Israel, Italy, Japan, Spain, Sweden,Switzerland, and the United States of America. The topics discussed included the renal handling of phosphate, transport of other minerals, intestinal absorption of calcium and phosphate and phosphate homeostasis in health and disease. Two symposia dealing with the recent developments of the interactions between minerals, parathyroid hormone, and blood pressure and between minerals and myopathies were included. In addition to the 15 State-of-the-Art Lectures, there were 43 oral and 63 poster presentations selected from over 200 abstracts sub mitted to the Program Committee. The Seventh International Workshop on Phosphate and Other Minerals will be held during September, 1985, in Marseille, France. It will be hosted by Professor Michel almer, Chief of the Department of Nephrology at the University of Marseille. The theme of this coming Workshop will focus on the pathophysiology of phosphate homeostasis and the metabolism of other minerals.

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Taschenbuch. Zustand: Neu. Neuware - The International Workshop on human lactation dedicated specifically to the topic of Maternal and Environmental Effects on Lactation repre sents the recent progress of research in human lactation. Only four years ago it was clear that we do not yet have sensitive research techniques specifica…lly adapted to the study of human milk. This need was addressed by an NIH convened workshop in 1982, the concensus being that appropriate methods have to be developed for the study of the composition of human milk. The progress in the development of these techniques was the subject of the second workshop on human lactation, dedicated specifically to 'Milk Components and Methodologies. ' The workshop was held in Colorado in 1984 and resulted in the publication of the first volume in the series of 'Human Lactation. ' At the Colorado meeting it was readily apparent that considerable progress has been made in the development of sensitive techniques able to quantitate the bioactive components of human milk (enzymes, growth factors, immuno-protective agents) as well as the macro, micro and trace elements. At the Colorado workshop it became clear that these workshops greatly benefit the research of human lactation by enhancing communication and collaboration among the investigators in the field. As a result it was decided to have a future workshop about a year later on the topic of 'Maternal-Environmental Effects on Human Lacta tion', and I was charged with chairing it.

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Taschenbuch. Zustand: Neu. Neuware - Many modern geneticists attempt to elucidate the molecular basis of phenotype by utilizing a battery of techniques derived from physical chemistry on subcellular components isolated from various species of organisms. Volume 5 of the Handbook of Genetics provides explanations of the advantages… and shortcomings of some of these revolutionary tech niques, and the nonspecialist is alerted to key research papers, reviews, and reference works. Much of the text deals with the structure and func tioning of the molecules bearing genetic information which reside in the nucleus and with the processing of this information by the ribosomes resid ing in the cytoplasm of eukaryotic cells. The mitochondria, which also live in the cytoplasm of the cells of all eukaryotes, now appear to be separate little creatures. These, as Lynn Margulis pointed out in Volume 1, are the colonial posterity of migrant prokaryotes, probably primitive bacteria that swam into the ancestral precursors of all eukaryotic cells and remained as symbionts. They have maintained themselves and their ways ever since, replicating their own DNA and transcribing an RNA quite different from that of their hosts. In a similar manner, the chloroplasts in all plants are self-replicating organelles presumably derived from the blue-green algae, with their own nucleic acids and ribosomes. Four chapters are devoted to the nucleic acids and the ribosomal components of both classes of these semi-independent lodgers. Finally, data from various sources on genetic variants of enzymes are tabulated for ready reference, and an evaluation of this information is attempted.

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Taschenbuch. Zustand: Neu. Neuware - Each of the four authors of this book has a particular interest in disorders of porphyrin metabolism and special experience in their management. Their individual involvement in the field varies from 12 to 52 years and, combined, represents more than a century of personal experience. Since it…has been written by both basic scientists and practicing physicians, the book is intended to be of value to all those involved in porphyrin metab olism and the porphyrias. It is hoped that the fascination of porphyrin metabolism and the clinical challenge of the porphyrias experienced by each of the authors will be conveyed to the readers. Michael R. Moore Kenneth E. L. McColl Claude Rimington Abraham Goldberg vii CONTENTS Color Plates . xvii 1. The History, Classification, and Incidence of the Porphyrias 1 1.1. History . 1 1.1.1. Early Chemistry . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 1.1.2. Early Descriptions of Porphyria . 4 1.1.3. Biochemical Developments . 4 1.1.4. Acute Porphyria . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 1.1.5. A Complete Pathway . 8 1.2. Classification of the Porphyrias . . . . . . . . . . . . . . . . . . . . . 9 1.2.1. The Current Classification. . . . . . . . . . . . . . . 12 . . . .

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Taschenbuch. Zustand: Neu. Neuware - This book includes the proceedings of a NATO Advanced Study Institute held at Washington State University, Pullman, Washington from July 26 until August 6, 1982. Although genetic engineering in eukaryotes is best developed in yeast and mammalian cells, the reader will find that some emphasis…has been put on plant systems. Indeed, it was our position that the development of plant cell genetic transformation would benefit from the interactions between a comparatively smaller number of fungal and animal cell experts and a larger number of plant cell specialists representing various aspects of plant molecular genetic research. On the other hand, it is clear that the ultimate achievements of plant genetic engineering will have a tremendous ~pact on, among other things, food production without generating the problems of ethics encountered when one contempla-tes the genetic modification of human beings. Therefore, this slight bias in favor of the plant kingdom simply reflects our belief that a 'second green revolution' will benefit mankind to a greater extent than any other kind of genetic engine ering. The keynote lecture of the Institute was delivered by Dr. John Slaughter, Director of the National Science Foundation, whom we deeply thank for his words of encouragement and commitment to the genetic manipulation of plants.

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Taschenbuch. Zustand: Neu. Neuware - This is the fourth volume of Ultrasound in Medicine, the Proceedings of the Annual Scientific Meeting of the American Institute of Ultrasound in Medicine. Unless the Executive Board of the Institute change their mind, it may also be the last. Under these circumstances it is somewhat ironical…that some of the deficiencies present in previous volumes appear to have been solved in the present volume. Notably, the Programme Committee, for the first time, exercised a stringent selection procedure by means of which the number of papers selected for presentation was limited with the result that both the quality of papers accepted for presentation and publication was improved and the number of simultaneous sessions at the meeting did not exceed two. The contents of this volume have been divided into the same sections as in previous volumes except that no papers on stan dardization procedures were accepted and a new supplementary section is added consisting of papers given at the Scientific Meeting of the American Society of Ultrasound Technical Specia lists. As in previous editions the readers may consider the engin eering sections at the end of this volume are the most rewarding. Some ingenious new systems are described both in the sections on Doppler techniques and new techniques. Current interest in tissue signatures and characterization are reflected in many of the pap~rs appearing in the Tissue Interactions section.

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Taschenbuch. Zustand: Neu. Neuware - A satellite symposium entitled 'Myelination and Demyelination: Recent Chemical Advances' was held in Helsinki from August 29 to 31, 1977, after the Sixth International Meeting of the International Society for Neurochemistry (ISN) in Copenhagen. Myelin is a nervous tissue structure that is mos…t suitable as a subject of biochemical investigation. It is easy to isolate in a highly purified form, is rather stable even after death, and is af fected by a variety of neurological and other diseases. Its lesions are particularly important in the study of multiple sclerosis, a disease which is relatively prevalent in Finland and has therefore been of interest to a great many Finnish scientists. The first half of this book is concerned with the biochemical composition and molecular organization of myelin, the second half with the experimental and clinical aspects of demyelination. The comments given after each of the presentations at the symposium were not recorded as such, but each author was requested to modify his or her paper accordingly. The editing and publication of this book would not have been possible without the excellent efforts and co-operation of my wife, Mrs. L.-M. Palo, acting as general secretary and later as editorial secretary of the symposium. As Organizing Committee Chairman, I would also like to thank the members of the Committee: Dr. M. Haltia, Dr. E. Kivalo, Dr. T. Kosunen, Dr. M. Panelius, and especially Dr.

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Taschenbuch. Zustand: Neu. Neuware - In August 1979 a group of 94 physicists from 60 laboratories in 21 countries met in Erice to attend the 17th Course of the International School of Subnuclear Physics. The countries represented at the School were: Argentina, Australia, Austria, Belgium, Canada, Federal Republic of Germany, Fra…nce, Hungary, India, Italy, Japan, Korea, the Netherlands, Nor way, Poland, Rumania, Spain, Sweden, the United Kingdom, the United States of America, and Yugoslavia. The School was sponsored by the Italian Ministry of Public Education (MPI), the Italian Ministry of Scientific and Techno logical Research (MRST) , the Sicilian Regional Government, and the Weizman Institute of Science. In the theoretical sessions, as expected, Sidney Coleman's (liN) lectures provided a new masterpiece in his Erice series. Andre Martin lectured on the theory of new particles, R.L. Jaffe on the Bag Hodel and Francis E. Low on quark status at low energy. In the more specialized section we were able to reflect on the problem of asymptotic changes in gauge theory, troubles experienced with instantons and finally on the fate of false vacua, thanks to A. Patrascioiu, R. Petronzio, and H. Kleinert. A quite exceptional event this year was the special QCD session wId_ch I leave the reader to enjoy without further introduction.

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Taschenbuch. Zustand: Neu. Neuware - The study of bacterial plasmids has not always been as popular as it is today. For many years, the molecular biology of pro cary otes was focused heavily on bacteriophage and plasmid investigations which were carried out in only a few laboratories. Whatever inter est existed in plasmids conce…rned the role of these extrachromosomal elements in bacterial conjugation, genetic exchanges, and antibiotic resistance, as well as in the structure of plasmids themselves. Gradually, however, it became increasingly evident that many of the special characteristics displayed by bacteria of medical, agricul tural, industrial, and environmental importance are determined by genes carried by plasmids, and this interest in plasmid-encoded functions, such as bacterial virulence properties (exotoxin produc tion, serum resistance, adhesiveness), metabolism of organic com pounds, plant tumor formation, and biological nitrogen fixation, led to increasing study of. the plasmids that carry these genes. Inves tigations of other plasmid-related properties such as replication and recombination have yielded much information about fundamental biological processes; information having implications that extend far beyond the particular plasmids under study. Concurrently, plas mids were playing a key role in the discovery of bacterial transpos able elements and were proving to be increasingly useful in the elu cidation of mechanisms responsible for a variety of chromosomal rearrangement events in bacteria and plants. Their status as 'mini chromosomes' that could be isolated easily from bacterial cells and then reintroduced into other cells by transformation is of fundamen tal importance in this regard.

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Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Despite an enormous investment of effort throughout the world, cancer is still a major barrier to human longevity. Cancer deaths are estimated to be more than five million globally. Currently responsible for about 20% of all deaths in… developed coun tries, the burden of cancer is steadily increasing in the developing world, following the control of malnutrition and infectious and parasitic diseases. Deeply impressed by the report of the Symposium on Geographic Pathology and Demography of Cancer held at Oxford in 1950, and through his preliminary work on cancer mortality statistics in Japan, Professor M. Segi decided to devote his life to the fight against cancer by establishing worldwide comparative cancer statistics-one of the landmarks in cancer studies and in cancer prevention strategies. He and his associates published six volumes of Cancer Mortality in 24 Countries with reliable mortality statistics covering 1950-1967, using the world population which he had derived as a standard. These publications rapidly became standard works of reference on the subject throughout the world. Professor Segi was a pioneer of cancer epidemiology in Japan. He cleaved a path through the jungle of cancer using epidemiological methods. By promoting cancer studies, he overcame the poor understanding of malignant disease which existed after World War II, when cancer mortality rates were still low. 240 pp. Englisch.

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Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In the last few years the physics of turbulent plasma has undergone rapid development, beginning with the first works, in which the term 'turbulence' was used in various ways, and ending with the fundamental studies which provide a th…orough examina tion of the turbulent state of plasma. In physics it is usually found that value is not so much contained in specific results for a partic ular field as it is in the more general outlook and overall view of the problem. Occasionally the older results take on new mean ing after the general view of things is perfected. In the case of the physics of turbulent plasma, this general picture is now com plete, for the most part. The first review devoted to the problem of plasma turbulence was written by B. B. Kadomtsev [in 'Problems in Plasma Theory,' edited by M. A. Leontovich, Volume 4, Moscow, Atomizdat (1964), p. 188; English Translation: 'Plasma Turbulence,' Academic Press, London (1965)]. 556 pp. Englisch.

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Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -1. Introduction to the Mobile Receptor Hypothesis.- A. The Fluid Mosaic Model of Biological Membranes.- B. The Mobile Receptor Hypothesis.- C. Modern Collision Coupling Theory.- D. Summary and Implications.- 2. Direct Measurement of L…ateral Mobility.- A. Introduction.- B. Fluorescence Microscopy.- C. Confocal Microscopy.- D. Fluorescence Photobleaching Recovery.- E. Lateral Mobility in the Cytoplasm and Membranes of Living Cells.- F. Measurements in Artificial and Isolated Membranes.- G. Measurements of Lateral Mobility Using Other Methods.- H. Summary.- 3. Parameters Affecting Plasma Membrane Protein Lateral Mobility.- A. Mechanisms of Protein Immobilization in Biological Membranes.- B. Membrane Lipid Mobility.- C. The Cytoskeleton.- D. Anchorage Modulation.- E. Membrane Protein Sequence Motifs.- F. Domain Structure: Regions of Restricted Mobility.- G. Signal Transduction.- H. Summary.- 4. Lateral Mobility of Polypeptide Hormone Receptors and GTP-Binding Proteins.- A. Introduction.- B. Practical Considerations.- C. Lateral Mobility Measurements of Polypeptide Hormone Receptors.- D. Tyrosine Kinase Receptor-Mediated Signal Transduction.- E. GTP-Binding Protein Activating Receptor-Mediated Signal Transduction.- F. Structural Considerations.- G. Lateral Mobility Measurements of GTP-Binding Proteins.- H. Lateral Mobility of Cytokine Receptors.- I. Summary and Implications for Signal Transduction.- 5. Evidence for the Role of Membrane Receptor Lateral Movement in GTP-Binding Protein-Mediated Signal Transduction.- A. Introduction.- B. Kinetic Considerations in GTP-Binding Protein-Mediated Receptor-Effector Systems.- C. Indirect Evidence for a Role of Receptor Lateral Movement in GTP-Binding Protein-Mediated Signal Transduction.- D. Direct Evidence for a Role of Receptor Lateral Movement in GTP-Binding Protein-Mediated Signal Transduction.- E. Ga Signaling in the Cytosolic Phase.- F. Stoichiometric Considerations and Trimeric GTP-Binding Protein Immobility.- G. Amplification in GTP-Binding Protein-Mediated Receptor-Effector Systems Through Receptor Lateral Movement.- H. Summary.- 6. Evidence for the Role of Receptor Immobilization in Desensitization Subsequent to Hormonal Stimulation.- A. Introduction.- B. Receptor Internalization in Desensitization of Response.- C. Receptor Immobilization Prior to Internalization.- D. Receptor Movement Required for Internalization.- E. Kinetic Considerations with Respect to Lateral Mobility Measurements.- F. Receptor Phosphorylation.- G. Studies with Receptor Antagonists¿Receptor Immobilization Is Agonist-Dependent.- H. Summary.- 7. Evidence for the Role of Immobilization of Ligand-Occupied Membrane Receptors in Signal Transduction.- A. Introduction.- B. Receptor Immobilization in Tyrosine Kinase Receptor Signaling.- C. Receptor Immobilization in Signaling by Fc Receptors.- D. Receptor Immobilization in Cell-Cell Interaction.- E. Receptor Immobilization in Cell-Adhesion to an Extracellular Substratum.- F. Summary.- 8. The Mobile Receptor Hypothesis: A Global View.- A. Introduction.- B. Receptor Lateral Movement in Signal Transduction.- C. The Central Role of the Cytoskeleton.- D. Signal Transduction: Receptor Lateral Mobility Modulation by Heterologous Signaling.- E. Potential Pharmacological Applications of the Mobile Receptor Hypothesis.- F. Concluding Remarks. 240 pp. Englisch.

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Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The convening of the 3rd International Workshop on Monoclonal Antibodies and Breast Cancer had the character of a self-search exercise. After almost a decade of research in the basic and applied aspects of the use of serological means… to diagnose and possibly treat breast cancer several milestones have been reached. Among them a clear understanding of immunopathological use and limitations of monoclonal antibodies against breast epithelium, the complete development and clinical use of immunoassays for circulating breast epithelial antigens, the striking advances in the diagnostic use of monoclonal antibodies to estrogen and progesterone receptor proteins and the first communications on proposed immunotherapeutic use of different conjugates of anti-breast antibodies. New areas of investigation have developed in our field, some which are reaching a full blossom while others are still facing obstacles and at times a re-definition of their goals and objectives. These meetings have acted in a way as a clearing house and have permitted their attendees to derive predictions that have helped shape future research and fine-tune objectives. But above all, the re-evaluation of past research at these Workshops and the renewed excitement brought to them by new information has helped generate a momentum and enthusiasm that assures for the future large scientific gains. 272 pp. Englisch.

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Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book presents an ac count of the NATO Advanced Study Institute on 'Collective Excitations in Solids,' held in Erice, Italy, from June 15 to June 29, 1981. This meeting was organized by the International School of Atomic and Molec…ular Spectroscopy of the 'Ettore Majorana' Centre for Scientific Culture. The objective of the Institute was to formulate a unified and coherent treatment of various collective excitation processes by drawing on the current advances in various branches of the physics of the solid state. A total of 74 participants came from 54 laboratories and 20 nations (Australia, Belgium, Burma, Canada, China, France, F. R. Germany, Greece, Israel, Italy, Mexico, The Netherlands, Pakistan, Poland, Portugal, Romania, Switzerland, Turkey, The Uni ted Kingdom, and The United States). The secretaries of the course were: Joseph Danko for the scientific aspects and Nino La Francesca for the administrative aspects of the meeting. Fourty-four lectures divided in eleven series were given. Nine 'long' seminars and eight 'short' seminars were also presented. In addition, two round-table discussions were held. 740 pp. Englisch.

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Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Thi's book collects the contributions to the NATO Advanced Research WJrkshop on 'FundaIrental Aspects of Quantum 'Iheory', held at the Centro di Cultura Scientifica 'Alessandro Volta', Villa Olma, Carro, Italy, 2-7 September 1985. The… rreeting was dedicated to the rremory of the late pro fessor Piero Caldirola, a prominent member of the Physics Departrrent of the University of r1ilan and a native of Como. The aim of the workshop has been to present several recent experi rrental results and theoretical developrrents concerning the various fa cets of quantum physics. The breadth of scope of the rreeting was in accordance with Professor Caldirola's vast scientific interests, and fostered communication among experirrental physicists, theoretical and mathematical physicists, and nEthematicians, working in different but related fields. Indeed, lectu rers endeavoured to make their contributions understandable to people acquainted with the problem but not necessarily familiar with the tech nical details; and these efforts were successful, as indicated by the frequent private discussions which took place among participants belon ging to different breeds and brands. 1ne rreeting was made up of six one-day sessions, each of them addres sing to a specific aspect of quantum theory: 1. General Problems and Crucial Experinents; with emphasis on sin gle-particle interference eh~rirrents of neutrons and of photons, and on the rreasurerrent problem. 2. Quantization and Stochastic Processes; including stochastic quan tization of gauge fields, stochastic description of supersyrnmetric fields, quantum stochastic calculus and stochastic mechanics. 480 pp. Englisch.